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  1. Artikel ; Online: The role of hybrid operating room (HOR) in the management of complicated gynecologic surgery.

    Law, Kim-Seng / Lee, Chih Hsien / Lee, Cheng Chun

    Taiwanese journal of obstetrics & gynecology

    2021  Band 60, Heft 5, Seite(n) 967–968

    Mesh-Begriff(e) Adenomyosis/surgery ; Adult ; Biopsy ; Female ; Gynecologic Surgical Procedures/methods ; Humans ; Hysterectomy ; Iliac Vein ; Middle Aged ; Operating Rooms ; Salpingectomy ; Sarcoma/surgery ; Thrombectomy ; Thrombosis/surgery
    Sprache Englisch
    Erscheinungsdatum 2021-09-10
    Erscheinungsland China (Republic : 1949- )
    Dokumenttyp Case Reports ; Letter
    ZDB-ID 2202946-1
    ISSN 1875-6263 ; 1028-4559
    ISSN (online) 1875-6263
    ISSN 1028-4559
    DOI 10.1016/j.tjog.2021.07.042
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  2. Artikel: Serum Cardiotrophin-1 Concentration Is Negatively Associated with Controlled Attenuation Parameters in Subjects with Non-Alcoholic Fatty Liver Disease.

    Liao, Yi-Chun / Wu, Juei-Seng / Chou, Hsuan-Wen / Kuo, Hsin-Yu / Lee, Chun-Te / Wu, Hung-Tsung / Li, Chung-Hao / Ou, Horng-Yih

    Journal of clinical medicine

    2023  Band 12, Heft 7

    Abstract: Background: Since non-alcoholic fatty liver disease (NAFLD) is highly associated with obesity, cardiovascular disease, and diabetes, biomarkers for the diagnosis of NAFLD have become an important issue. Although cardiotrophin-1 (CT-1) has a protective ... ...

    Abstract Background: Since non-alcoholic fatty liver disease (NAFLD) is highly associated with obesity, cardiovascular disease, and diabetes, biomarkers for the diagnosis of NAFLD have become an important issue. Although cardiotrophin-1 (CT-1) has a protective effect on the liver in NAFLD animal models, the serum levels of CT-1 in human subjects with NAFLD were still unknown.
    Objective: The present study aimed to investigate the relationship between the circulating concentration of CT-1 and the severity of hepatic steatosis graded by the value of the controlled attenuation parameter (CAP) in humans.
    Design and methods: The study was designed as a cross-sectional study, and a total of 182 subjects were enrolled. Hepatic steatosis measurement was carried out with a Firoscan
    Results: Body mass index, percentage of body fat, systolic and diastolic blood pressure, alanine aminotransferase (ALT), cholesterol, triglyceride, hemoglobin A1c and homeostatic model assessment for insulin resistance (HOMA-IR) were significantly increased in groups with higher CAP value, whereas high-density lipoprotein cholesterol was significantly decreased. In addition, serum CT-1 concentrations were significantly decreased in subjects with higher CAP values. In multivariate linear regression models, including age, sex, body fat percentage, CAP, high sensitivity- C reactive protein, uric acid, creatinine, ALT, total cholesterol, and HOMA-IR, only age, CAP and uric acid independently associated with CT-1 levels. Moreover, having NAFLD was independently associated with CT-1 after adjustment for sex, obesity and type 2 diabetes.
    Conclusions: Serum CT-1 concentrations are decreased in subjects with NAFLD and negatively associated with CAP.
    Sprache Englisch
    Erscheinungsdatum 2023-04-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12072741
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  3. Artikel ; Online: Being Creative Makes You Happier: The Positive Effect of Creativity on Subjective Well-Being.

    Tan, Cher-Yi / Chuah, Chun-Qian / Lee, Shwu-Ting / Tan, Chee-Seng

    International journal of environmental research and public health

    2021  Band 18, Heft 14

    Abstract: The impact of happiness on creativity is well-established. However, little is known about the effect of creativity on well-being. Two studies were thus conducted to examine the impact of creativity on subjective well-being. In the first study, 256 ... ...

    Abstract The impact of happiness on creativity is well-established. However, little is known about the effect of creativity on well-being. Two studies were thus conducted to examine the impact of creativity on subjective well-being. In the first study, 256 undergraduate students (Study 1a) and 291 working adults (Study 1b) self-reported their creativity, stress, and subjective well-being. Hierarchical multiple regression analysis showed a positive relationship between creativity and subjective well-being after controlling the effect of self-perceived stress and demographics in both samples. Study 2 then employed an experimental design to examine the causal relationship between creativity and subjective well-being. Half of the 68 undergraduates underwent a creativity priming task followed by a divergent thinking test as well as self-reported stress and subjective well-being. The priming task was found to boost creative performance in the pilot study (Study 2a) and the actual study (Study 2b). Moreover, after controlling the effect of self-perceived stress, ANCOVA analysis showed that participants receiving the priming reported higher subjective well-being scores than their counterparts in the control group. The overall findings not only shed light on the facilitative effect of creativity on subjective well-being but also highlight the necessity of considering the reciprocal relationship of the two constructs in future research.
    Mesh-Begriff(e) Adult ; Creativity ; Happiness ; Humans ; Pilot Projects ; Students ; Thinking
    Sprache Englisch
    Erscheinungsdatum 2021-07-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph18147244
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  4. Artikel ; Online: Intractable Vomiting in a 20-Month-Old Boy.

    Lee, Chee-Seng / Chen, Ke-Chi / Yu, Chun-Hsien

    Gastroenterology

    2019  Band 157, Heft 2, Seite(n) e1–e2

    Mesh-Begriff(e) Antiemetics/pharmacology ; Antiemetics/therapeutic use ; Drug Resistance ; Failure to Thrive/etiology ; Failure to Thrive/surgery ; Gastric Outlet Obstruction/etiology ; Gastric Outlet Obstruction/surgery ; Gastroscopy ; Humans ; Infant ; Male ; Metoclopramide/pharmacology ; Metoclopramide/therapeutic use ; Pyloric Antrum/abnormalities ; Pyloric Antrum/diagnostic imaging ; Pyloric Antrum/surgery ; Treatment Outcome ; Vomiting/etiology ; Vomiting/therapy
    Chemische Substanzen Antiemetics ; Metoclopramide (L4YEB44I46)
    Sprache Englisch
    Erscheinungsdatum 2019-04-05
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2019.03.059
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Transpulmonary Expression of Exosomal microRNAs in Idiopathic and Congenital Heart Disease-Related Pulmonary Arterial Hypertension.

    Chang, Wei-Ting / Lee, Wei-Chieh / Lin, Yu-Wen / Shih, Jhih-Yuan / Hong, Chon-Seng / Chen, Zhih-Cherng / Chu, Chun-Yuan / Hsu, Chih-Hsin

    Journal of the American Heart Association

    2023  Band 12, Heft 23, Seite(n) e031435

    Abstract: Background: Pulmonary artery hypertension (PAH) is a fatal disease characterized by a complex pathogenesis. Exosomes containing microRNAs (miRs) have emerged as a novel biomarker. Transpulmonary exosomal miRs offer valuable insights into pulmonary ... ...

    Abstract Background: Pulmonary artery hypertension (PAH) is a fatal disease characterized by a complex pathogenesis. Exosomes containing microRNAs (miRs) have emerged as a novel biomarker. Transpulmonary exosomal miRs offer valuable insights into pulmonary circulation microenvironments. Hereby, we aimed to explore the potentials of transpulmonary exosomal miRs as differentiating factors between idiopathic PAH and congenital heart disease (CHD)-related PAH.
    Methods and results: During right heart catheterization, we collected exosomes at pulmonary arteries in 25 patients diagnosed with idiopathic PAH and 20 patients with CHD-related PAH. Next-generation sequencing identified several candidate exosomal miRs. Using quantitative polymerase chain reaction, we validated the expressions of these miRs and revealed significantly elevated expressions of miR-21, miR-139-5p, miR-155-5p, let-7f-5p, miR-328-3p, miR-330-3p, and miR-103a-3p in patients with CHD-related PAH, in contrast to patients with idiopathic PAH. Among these miRs, miR-21 exhibited the highest expression in patients with CHD-related PAH. These findings were further corroborated in an external cohort comprising 10 patients with idiopathic PAH and 8 patients with CHD-related PAH. Using an in vitro flow model simulating the shear stress experienced by pulmonary endothelial cells, we observed a significant upregulation of miR-21. Suppressing miR-21 rescued the shear stress-induced downregulation of the RAS/phosphatidylinositol 3-kinase/protein kinase B pathway, leading to a mitigation of apoptosis.
    Conclusions: Our study identified a pronounced expression of transpulmonary exosomal miR-21, particularly in patients with CHD-related PAH, through next-generation sequencing analysis. Further investigation is warranted to elucidate the regulatory mechanisms involving miR-21 in the pathophysiology of PAH.
    Mesh-Begriff(e) Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Pulmonary Arterial Hypertension/genetics ; Pulmonary Arterial Hypertension/metabolism ; Endothelial Cells/metabolism ; Familial Primary Pulmonary Hypertension/metabolism ; Heart Defects, Congenital/metabolism
    Chemische Substanzen MicroRNAs ; MIRN139 microRNA, human ; MIRN330 microRNA, human
    Sprache Englisch
    Erscheinungsdatum 2023-11-28
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.031435
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  6. Artikel ; Online: Dietary SYNSEA probiotic improves the growth of white shrimp, Litopenaeus vannamei and reduces the risk of Vibrio infection via improving immunity and intestinal microbiota of shrimp.

    Lee, Jai-Wei / Chiu, Shieh-Tsung / Wang, Sz-Tsan / Liao, Yi-Chu / Chang, Hsiao-Tung / Ballantyne, Rolissa / Lin, Jin-Seng / Liu, Chun-Hung

    Fish & shellfish immunology

    2022  Band 127, Seite(n) 482–491

    Abstract: The growth performance, immunological status, and intestinal microbiology of white shrimp, Litopenaeus vannamei, were evaluated after dietary administration of the commercial probiotic SYNSEA. Shrimp were fed a control diet (without probiotic supplement) ...

    Abstract The growth performance, immunological status, and intestinal microbiology of white shrimp, Litopenaeus vannamei, were evaluated after dietary administration of the commercial probiotic SYNSEA. Shrimp were fed a control diet (without probiotic supplement) and two levels of SYNSEA probiotic, a low concentration of SYNSEA (LSL) containing 10
    Mesh-Begriff(e) Animal Feed/analysis ; Animals ; Diet/veterinary ; Disease Resistance ; Gastrointestinal Microbiome ; Immunity, Innate ; Lactobacillales ; Penaeidae ; Probiotics ; Vibrio Infections/prevention & control ; Vibrio Infections/veterinary ; Vibrio parahaemolyticus/physiology
    Sprache Englisch
    Erscheinungsdatum 2022-07-03
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1067738-0
    ISSN 1095-9947 ; 1050-4648
    ISSN (online) 1095-9947
    ISSN 1050-4648
    DOI 10.1016/j.fsi.2022.06.071
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  7. Artikel ; Online: Serum Cardiotrophin-1 Concentration Is Negatively Associated with Controlled Attenuation Parameters in Subjects with Non-Alcoholic Fatty Liver Disease

    Yi-Chun Liao / Juei-Seng Wu / Hsuan-Wen Chou / Hsin-Yu Kuo / Chun-Te Lee / Hung-Tsung Wu / Chung-Hao Li / Horng-Yih Ou

    Journal of Clinical Medicine, Vol 12, Iss 2741, p

    2023  Band 2741

    Abstract: Background: Since non-alcoholic fatty liver disease (NAFLD) is highly associated with obesity, cardiovascular disease, and diabetes, biomarkers for the diagnosis of NAFLD have become an important issue. Although cardiotrophin-1 (CT-1) has a protective ... ...

    Abstract Background: Since non-alcoholic fatty liver disease (NAFLD) is highly associated with obesity, cardiovascular disease, and diabetes, biomarkers for the diagnosis of NAFLD have become an important issue. Although cardiotrophin-1 (CT-1) has a protective effect on the liver in NAFLD animal models, the serum levels of CT-1 in human subjects with NAFLD were still unknown. Objective: The present study aimed to investigate the relationship between the circulating concentration of CT-1 and the severity of hepatic steatosis graded by the value of the controlled attenuation parameter (CAP) in humans. Design and Methods: The study was designed as a cross-sectional study, and a total of 182 subjects were enrolled. Hepatic steatosis measurement was carried out with a Firoscan ® device and recorded by CAP. The enrolled study subjects were categorized into CAP < 238 dB/m, 238 ≤ CAP ≤ 259 dB/m, 260 ≤ CAP ≤ 290 dB/m, and CAP > 290 dB/m. Serum CT-1 concentrations were determined by enzyme-linked immunosorbent assay. The association between the serum CT-1 concentration and NAFLD was examined by multivariate linear regression analysis. Results: Body mass index, percentage of body fat, systolic and diastolic blood pressure, alanine aminotransferase (ALT), cholesterol, triglyceride, hemoglobin A1c and homeostatic model assessment for insulin resistance (HOMA-IR) were significantly increased in groups with higher CAP value, whereas high-density lipoprotein cholesterol was significantly decreased. In addition, serum CT-1 concentrations were significantly decreased in subjects with higher CAP values. In multivariate linear regression models, including age, sex, body fat percentage, CAP, high sensitivity- C reactive protein, uric acid, creatinine, ALT, total cholesterol, and HOMA-IR, only age, CAP and uric acid independently associated with CT-1 levels. Moreover, having NAFLD was independently associated with CT-1 after adjustment for sex, obesity and type 2 diabetes. Conclusions: Serum CT-1 concentrations are decreased in subjects ...
    Schlagwörter cardiotrophin-1 ; controlled attenuation parameter ; diabetes ; non-alcoholic fatty liver disease ; obesity ; Medicine ; R
    Thema/Rubrik (Code) 630 ; 571
    Sprache Englisch
    Erscheinungsdatum 2023-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Dietary administration of a postbiotic, heat-killed Pediococcus pentosaceus PP4012 enhances growth performance, immune response and modulates intestinal microbiota of white shrimp, Penaeus vannamei.

    Ballantyne, Rolissa / Lee, Jai-Wei / Wang, Sz-Tsan / Lin, Jin-Seng / Tseng, Deng-Yu / Liao, Yi-Chu / Chang, Hsiao-Tung / Lee, Ting-Yu / Liu, Chun-Hung

    Fish & shellfish immunology

    2023  Band 139, Seite(n) 108882

    Abstract: The efficacy of postbiotics on the immune-related gene expression and gut microbiota of white shrimp, Penaeus vannamei remains unexplored. A commercial heat-killed postbiotic Pediococcus pentosaceus PP4012 was used to evaluate the growth performance, ... ...

    Abstract The efficacy of postbiotics on the immune-related gene expression and gut microbiota of white shrimp, Penaeus vannamei remains unexplored. A commercial heat-killed postbiotic Pediococcus pentosaceus PP4012 was used to evaluate the growth performance, intestinal morphology, immunological status, and microbial community of white shrimp after dietary administration in this study. White shrimp (0.040 ± 0.003 g) were divided into three treatments; a control, inanimate P. pentosaceus (10
    Mesh-Begriff(e) Animals ; Pediococcus pentosaceus ; Gastrointestinal Microbiome ; Penaeidae ; Immunity, Innate ; Hot Temperature ; Diet/veterinary ; Animal Feed/analysis ; Dietary Supplements/analysis
    Sprache Englisch
    Erscheinungsdatum 2023-06-04
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1067738-0
    ISSN 1095-9947 ; 1050-4648
    ISSN (online) 1095-9947
    ISSN 1050-4648
    DOI 10.1016/j.fsi.2023.108882
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    Verfügbar in ZB MED Bonn

    Z 5917: Hefte anzeigen

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  9. Artikel ; Online: Being Creative Makes You Happier

    Cher-Yi Tan / Chun-Qian Chuah / Shwu-Ting Lee / Chee-Seng Tan

    International Journal of Environmental Research and Public Health, Vol 18, Iss 7244, p

    The Positive Effect of Creativity on Subjective Well-Being

    2021  Band 7244

    Abstract: The impact of happiness on creativity is well-established. However, little is known about the effect of creativity on well-being. Two studies were thus conducted to examine the impact of creativity on subjective well-being. In the first study, 256 ... ...

    Abstract The impact of happiness on creativity is well-established. However, little is known about the effect of creativity on well-being. Two studies were thus conducted to examine the impact of creativity on subjective well-being. In the first study, 256 undergraduate students (Study 1a) and 291 working adults (Study 1b) self-reported their creativity, stress, and subjective well-being. Hierarchical multiple regression analysis showed a positive relationship between creativity and subjective well-being after controlling the effect of self-perceived stress and demographics in both samples. Study 2 then employed an experimental design to examine the causal relationship between creativity and subjective well-being. Half of the 68 undergraduates underwent a creativity priming task followed by a divergent thinking test as well as self-reported stress and subjective well-being. The priming task was found to boost creative performance in the pilot study (Study 2a) and the actual study (Study 2b). Moreover, after controlling the effect of self-perceived stress, ANCOVA analysis showed that participants receiving the priming reported higher subjective well-being scores than their counterparts in the control group. The overall findings not only shed light on the facilitative effect of creativity on subjective well-being but also highlight the necessity of considering the reciprocal relationship of the two constructs in future research.
    Schlagwörter creativity ; employees ; experiment ; priming ; subjective well-being ; Medicine ; R
    Thema/Rubrik (Code) 150 ; 710
    Sprache Englisch
    Erscheinungsdatum 2021-07-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel: Perception and Mental Health Status Regarding COVID-19 Vaccination Among Taiwanese Adolescents and Their Caregivers.

    Hwang, Jade Winjei / Chien, Shao Ju / Wang, Chih-Chi / Kuo, Kuang-Che / Tang, Kuo-Shu / Lee, Yu / Chen, Yi-Chun / Lo, Mao-Hung / Lee, Ing-Kit / Chuah, Seng-Kee / Lee, Chien-Te / Kung, Chia-Te / Wang, Liang-Jen

    Adolescent health, medicine and therapeutics

    2023  Band 14, Seite(n) 195–204

    Abstract: Background: Vaccinating adolescents is a vital strategy to enhance population protection without imposing overly restrictive measures on our daily lives during the COVID-19 pandemic. As teenagers gain more independence, their willingness to get ... ...

    Abstract Background: Vaccinating adolescents is a vital strategy to enhance population protection without imposing overly restrictive measures on our daily lives during the COVID-19 pandemic. As teenagers gain more independence, their willingness to get vaccinated may depend on their own understanding of the pandemic, vaccines, and mental well-being, as well as that of their caregivers. Our study aimed to examine how Taiwanese adolescents and their caregivers perceive COVID-19 vaccination and assess their mental health status.
    Methods: We invited a total of 138 vaccinated adolescents and their caregivers to complete several questionnaires, including the Drivers of COVID-19 Vaccination Acceptance Scale (DrVac-COVID19S), Impact of Event Scale (IES), and Chinese Health Questionnaire (CHQ).
    Results: Among the adolescents, 76.8% considered the BNT162b2 vaccine (Pfizer-BioNTech) as the ideal option for COVID-19 vaccination, while 27.5% of caregivers expressed acceptance of any available vaccine. Adolescents scored higher than caregivers in terms of vaccine value (p<0.001) and autonomy (p<0.001), but lower in knowledge (p<0.001), as assessed by the DrVac-COVID19S subscales. The adolescents' intention to get vaccinated against COVID-19 (DrVac-COVID19S total score) showed a positive correlation with their perception of the pandemic's impact (IES scores, r=0.214, p=0.012) and their caregivers' vaccination intention (r=0.371, p<0.001). Furthermore, adolescents' mental health demonstrated a positive association with the mental health of their caregiver (CHQ total scores, r=0.481, p<0.001).
    Conclusion: During the COVID-19 outbreak, caregivers have encountered heightened levels of mental stress, and this stress has been found to be positively correlated with the mental stress experienced by adolescents and their intentions regarding vaccination. These findings can serve as crucial references for healthcare providers and governments when formulating vaccination policies for adolescents in the future.
    Sprache Englisch
    Erscheinungsdatum 2023-10-05
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ZDB-ID 2587456-1
    ISSN 1179-318X
    ISSN 1179-318X
    DOI 10.2147/AHMT.S429238
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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