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  1. Artikel ; Online: The relationship between pulmonary large cell neuroendocrine carcinoma and CEA.

    Xu, Xiaohui / Wu, Xiaohong / Wang, Xinlan / Li, Shihui

    Asian journal of surgery

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-04-29
    Erscheinungsland Netherlands
    Dokumenttyp Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2024.04.052
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  2. Artikel ; Online: Association Between Systemic Immune Inflammation Indexes and DVT in Patients With Malignancy Requiring PICC Insertion.

    Li, Na / Huang, Jing / Feng, You / Yan, Hucheng / Min, Shihui / Chen, Xin

    Biological research for nursing

    2024  , Seite(n) 10998004241252468

    Abstract: ... ...

    Abstract Background
    Sprache Englisch
    Erscheinungsdatum 2024-05-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2145107-2
    ISSN 1552-4175 ; 1099-8004
    ISSN (online) 1552-4175
    ISSN 1099-8004
    DOI 10.1177/10998004241252468
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Cellulolytic

    Liao, Yixiao / Wu, Shihui / Zhou, Guixian / Mei, Shihui / Yang, Zemin / Li, Shuang / Jin, Zhengyu / Deng, Yongjun / Wen, Ming / Yang, Ying

    Microbiology spectrum

    2024  Band 12, Heft 4, Seite(n) e0326723

    Abstract: Cellulolytic bacteria ferment dietary fiber into short-chain fatty acids, which play an important role in improving fiber utilization and maintaining intestinal health. Safe and effective cellulolytic bacteria are highly promising probiotic candidates. ... ...

    Abstract Cellulolytic bacteria ferment dietary fiber into short-chain fatty acids, which play an important role in improving fiber utilization and maintaining intestinal health. Safe and effective cellulolytic bacteria are highly promising probiotic candidates. In this study, we isolated three strains of
    Importance: Short-chain fatty acids are crucial constituents of the intestinal tract, playing an important and beneficial role in preserving the functional integrity of the intestinal barrier and modulating both immune responses and the structure of the intestinal flora. In the intestine, short-chain fatty acids are mainly produced by bacterial fermentation of cellulose. Therefore, we believe that safe and efficient cellulolytic bacteria have the potential to be novel probiotics. In this study, we systematically evaluated the safety and biological characteristics of the cellulolytic bacterium
    Mesh-Begriff(e) Animals ; Swine ; Mice ; Bacillus cereus/genetics ; Probiotics ; Fatty Acids, Volatile ; Intestines ; Cellulose
    Chemische Substanzen Fatty Acids, Volatile ; Cellulose (9004-34-6)
    Sprache Englisch
    Erscheinungsdatum 2024-03-05
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.03267-23
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  4. Artikel: Chinese pine (Pinus tabuliformis Carr.).

    Niu, Shihui / Li, Wei / Li, Yue

    Trends in genetics : TIG

    2022  Band 38, Heft 4, Seite(n) 409–411

    Mesh-Begriff(e) China ; Gene Expression Regulation, Plant ; Pinus/genetics ; Pinus/metabolism ; Plant Proteins/genetics
    Chemische Substanzen Plant Proteins
    Sprache Englisch
    Erscheinungsdatum 2022-02-15
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 619240-3
    ISSN 1362-4555 ; 0168-9525 ; 0168-9479
    ISSN (online) 1362-4555
    ISSN 0168-9525 ; 0168-9479
    DOI 10.1016/j.tig.2022.01.006
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  5. Artikel ; Online: Multimodal Co-attention Fusion Network with Online Data Augmentation for Cancer Subtype Classification.

    Ding, Saisai / Li, Juncheng / Wang, Jun / Ying, Shihui / Shi, Jun

    IEEE transactions on medical imaging

    2024  Band PP

    Abstract: It is an essential task to accurately diagnose cancer subtypes in computational pathology for personalized cancer treatment. Recent studies have indicated that the combination of multimodal data, such as whole slide images (WSIs) and multi-omics data, ... ...

    Abstract It is an essential task to accurately diagnose cancer subtypes in computational pathology for personalized cancer treatment. Recent studies have indicated that the combination of multimodal data, such as whole slide images (WSIs) and multi-omics data, could achieve more accurate diagnosis. However, robust cancer diagnosis remains challenging due to the heterogeneity among multimodal data, as well as the performance degradation caused by insufficient multimodal patient data. In this work, we propose a novel multimodal co-attention fusion network (MCFN) with online data augmentation (ODA) for cancer subtype classification. Specifically, a multimodal mutual-guided co-attention (MMC) module is proposed to effectively perform dense multimodal interactions. It enables multimodal data to mutually guide and calibrate each other during the integration process to alleviate inter- and intra-modal heterogeneities. Subsequently, a self-normalizing network (SNN)-Mixer is developed to allow information communication among different omics data and alleviate the high-dimensional small-sample size problem in multi-omics data. Most importantly, to compensate for insufficient multimodal samples for model training, we propose an ODA module in MCFN. The ODA module leverages the multimodal knowledge to guide the data augmentations of WSIs and maximize the data diversity during model training. Extensive experiments are conducted on the public TCGA dataset. The experimental results demonstrate that the proposed MCFN outperforms all the compared algorithms, suggesting its effectiveness.
    Sprache Englisch
    Erscheinungsdatum 2024-05-27
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 622531-7
    ISSN 1558-254X ; 0278-0062
    ISSN (online) 1558-254X
    ISSN 0278-0062
    DOI 10.1109/TMI.2024.3405535
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Isolation, Identification, and Biological Characterization of Phage vB_KpnM_KpVB3 Targeting Carbapenem-Resistant Klebsiella pneumoniae ST11.

    Liu, Shihui / Xu, Hao / Cao, Ruonan / Yang, Zhenghai / Li, Xiaoning

    Journal of global antimicrobial resistance

    2024  Band 37, Seite(n) 179–184

    Abstract: Objectives: This study aimed to isolate a phage capable of lysing carbapenem-resistant Klebsiella pneumoniae (CRKP) and to analyse its biological characteristics and whole-genome sequence.: Methods: The phage was isolated and purified from the sewage. ...

    Abstract Objectives: This study aimed to isolate a phage capable of lysing carbapenem-resistant Klebsiella pneumoniae (CRKP) and to analyse its biological characteristics and whole-genome sequence.
    Methods: The phage was isolated and purified from the sewage. Transmission electron microscopy (TEM) was employed to observe the bacteriophage's morphology. Phenotypic characterization of the bacteriophages was determined. The genomic information was analysed. Evolutionary relationships were established through comparative genomics, proteomics, and phylogenetic analysis.
    Results: The isolation of a virulent phage, named Klebsiella phage vB_KpnM_KpVB3, was notable for forming 6-7 mm transparent circular zones, each surrounded by a distinct halo. The phage had a head diameter of ca. 30 nm and a tail length of ca. 20 nm, being identified as a member of the Myoviridae family and the Caudovirales order. The optimal multiplicity of infection (MOI) was 0.00001, with an incubation period of 20 minutes and a lysis period of 60 minutes, and the number of released phages after lysis was 133±35 PFU/cell. The phage was relatively stable at temperatures ranging from 10°C to 40°C and at pH values ranging from 3 to 11. Its lytic efficiency against CRKP was 30.30%. It has been shown to be able to destroy the biofilm of host bacteria. The bacteriophage genome consists of double-stranded DNA (dsDNA) with a total length of 48,394 base pairs, a GC content of 48.99%, and 78 open reading frames (ORFs).
    Conclusion: The study resulted in the isolation vB_KpnM_KpVB3, a phage demonstrating potential therapeutic efficacy against infections caused by CRKP.
    Sprache Englisch
    Erscheinungsdatum 2024-03-30
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2024.03.007
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: miR-25 promotes cell migration and invasion by inhibiting the expression of CDH1 in rectal carcinoma.

    Xu, Xiaohui / Jiang, Danqi / Lin, Fangcai / Li, Shihui

    Asian journal of surgery

    2023  Band 46, Heft 11, Seite(n) 4796–4797

    Mesh-Begriff(e) Humans ; MicroRNAs/metabolism ; Cell Line, Tumor ; Cell Movement ; Carcinoma ; Neoplasm Invasiveness/pathology ; Antigens, CD ; Cadherins
    Chemische Substanzen MicroRNAs ; CDH1 protein, human ; Antigens, CD ; Cadherins ; MIRN25 microRNA, human
    Sprache Englisch
    Erscheinungsdatum 2023-06-07
    Erscheinungsland Netherlands
    Dokumenttyp Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.05.097
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Lewis Acids Activated Spontaneous Alternating Copolymerization of Maleic Anhydride and Styrene Derivatives.

    Li, Shihui / Cai, Ling / Cui, Dongmei

    Chemistry, an Asian journal

    2023  Band 18, Heft 4, Seite(n) e202201079

    Abstract: Synthesis of maleic anhydride (MA) and styrene (St) copolymers possessing ultra-high molecular weight, strictly alternating regularity and high glass transition temperature simultaneously is still an issure with great challenge. Herein, the spontaneous ... ...

    Abstract Synthesis of maleic anhydride (MA) and styrene (St) copolymers possessing ultra-high molecular weight, strictly alternating regularity and high glass transition temperature simultaneously is still an issure with great challenge. Herein, the spontaneous alternating copolymerization of MA and St derivatives were investigated by using various Lewis acids. In the presence of alkyl aluminum or butyl magnesium, the MA-St alternating copolymers with ultra-high molecular weight (M
    Sprache Englisch
    Erscheinungsdatum 2023-01-16
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2233006-9
    ISSN 1861-471X ; 1861-4728
    ISSN (online) 1861-471X
    ISSN 1861-4728
    DOI 10.1002/asia.202201079
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  9. Artikel: Comparison of percutaneous balloon compression and microvascular decompression in the treatment of trigeminal neuralgia.

    Li, Zhenyong / Xie, Zhuqing / Tang, Guoqiang / Jin, Shihui

    Pakistan journal of medical sciences

    2023  Band 39, Heft 5, Seite(n) 1451–1455

    Abstract: Objective: To compare the effect of percutaneous balloon compression (PBC) and microvascular decompression (MVD) in the treatment of trigeminal neuralgia (TN).: Methods: Data of 98 patients with TN, admitted to Chenzhou First People's Hospital from ... ...

    Abstract Objective: To compare the effect of percutaneous balloon compression (PBC) and microvascular decompression (MVD) in the treatment of trigeminal neuralgia (TN).
    Methods: Data of 98 patients with TN, admitted to Chenzhou First People's Hospital from May 2020 to May 2022, were retrospectively collected. Patients were divided into two groups based on the surgical method. A total of 53 patients treated with PBC comprised the PBC-group and 45 patients treated with MVD comprised the MVD-group. The immediate pain relief, long-term efficacy, surgical complications, and masticatory muscle strength of the two groups were compared and analyzed.
    Results: There was no significant difference in the immediate pain relief and long-term e efficacy, between the two groups (
    Conclusions: Compared with MVD, PBC has the same effect in the treatment of TN. PBC is a minimally invasive, safe, and effective method with a low complication rate. Although masticatory muscle strength is slightly impacted by PBC, it gradually recovers within six months after the operation.
    Sprache Englisch
    Erscheinungsdatum 2023-09-07
    Erscheinungsland Pakistan
    Dokumenttyp Journal Article
    ZDB-ID 2032827-8
    ISSN 1681-715X ; 1682-024X ; 1017-4699
    ISSN (online) 1681-715X
    ISSN 1682-024X ; 1017-4699
    DOI 10.12669/pjms.39.5.8049
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  10. Artikel ; Online: Lipotoxic hepatocyte derived LIMA1 enriched small extracellular vesicles promote hepatic stellate cells activation via inhibiting mitophagy.

    Li, Shihui / Yang, Fuji / Cheng, Fang / Zhu, Ling / Yan, Yongmin

    Cellular & molecular biology letters

    2024  Band 29, Heft 1, Seite(n) 82

    Abstract: Background: Hepatic stellate cells (HSCs) play a crucial role in the development of fibrosis in non-alcoholic fatty liver disease (NAFLD). Small extracellular vesicles (sEV) act as mediators for intercellular information transfer, delivering various ... ...

    Abstract Background: Hepatic stellate cells (HSCs) play a crucial role in the development of fibrosis in non-alcoholic fatty liver disease (NAFLD). Small extracellular vesicles (sEV) act as mediators for intercellular information transfer, delivering various fibrotic factors that impact the function of HSCs in liver fibrosis. In this study, we investigated the role of lipotoxic hepatocyte derived sEV (LTH-sEV) in HSCs activation and its intrinsic mechanisms.
    Methods: High-fat diet (HFD) mice model was constructed to confirm the expression of LIMA1. The relationship between LIMA1-enriched LTH-sEV and LX2 activation was evaluated by measurement of fibrotic markers and related genes. Levels of mitophagy were detected using mt-keima lentivirus. The interaction between LIMA1 and PINK1 was discovered through database prediction and molecular docking. Finally, sEV was injected to investigate whether LIMA1 can accelerate HFD induced liver fibrosis in mice.
    Results: LIMA1 expression was upregulated in lipotoxic hepatocytes and was found to be positively associated with the expression of the HSCs activation marker α-SMA. Lipotoxicity induced by OPA led to an increase in both the level of LIMA1 protein in LTH-sEV and the release of LTH-sEV. When HSCs were treated with LTH-sEV, LIMA1 was observed to hinder LX2 mitophagy while facilitating LX2 activation. Further investigation revealed that LIMA1 derived from LTH-sEV may inhibit PINK1-Parkin-mediated mitophagy, consequently promoting HSCs activation. Knocking down LIMA1 significantly attenuates the inhibitory effects of LTH-sEV on mitophagy and the promotion of HSCs activation.
    Conclusions: Lipotoxic hepatocyte-derived LIMA1-enriched sEVs play a crucial role in promoting HSCs activation in NAFLD-related liver fibrosis by negatively regulating PINK1 mediated mitophagy. These findings provide new insights into the pathological mechanisms involved in the development of fibrosis in NAFLD.
    Mesh-Begriff(e) Animals ; Humans ; Male ; Mice ; Diet, High-Fat/adverse effects ; Disease Models, Animal ; Extracellular Vesicles/metabolism ; Extracellular Vesicles/genetics ; Hepatic Stellate Cells/metabolism ; Hepatocytes/metabolism ; Hepatocytes/pathology ; Liver Cirrhosis/pathology ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/genetics ; Mice, Inbred C57BL ; Mitophagy/genetics ; Non-alcoholic Fatty Liver Disease/metabolism ; Non-alcoholic Fatty Liver Disease/pathology ; Non-alcoholic Fatty Liver Disease/genetics ; Protein Kinases/metabolism ; Protein Kinases/genetics
    Chemische Substanzen Protein Kinases (EC 2.7.-) ; PTEN-induced putative kinase (EC 2.7.11.1) ; D15Ertd366e protein, mouse
    Sprache Englisch
    Erscheinungsdatum 2024-05-31
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2108724-6
    ISSN 1689-1392 ; 1689-1392
    ISSN (online) 1689-1392
    ISSN 1689-1392
    DOI 10.1186/s11658-024-00596-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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