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  1. Artikel ; Online: PLAG1 interacts with GPX4 to conquer vulnerability to sorafenib induced ferroptosis through a PVT1/miR-195-5p axis-dependent manner in hepatocellular carcinoma.

    Li, Jiarui / Li, Yilan / Wang, Denghui / Liao, Rui / Wu, Zhongjun

    Journal of experimental & clinical cancer research : CR

    2024  Band 43, Heft 1, Seite(n) 143

    Abstract: Background: Sorafenib is a standard first-line treatment for advanced hepatocellular carcinoma (HCC), yet its effectiveness is often constrained. Emerging studies reveal that sorafenib triggers ferroptosis, an iron-dependent regulated cell death (RCD) ... ...

    Abstract Background: Sorafenib is a standard first-line treatment for advanced hepatocellular carcinoma (HCC), yet its effectiveness is often constrained. Emerging studies reveal that sorafenib triggers ferroptosis, an iron-dependent regulated cell death (RCD) mechanism characterized by lipid peroxidation. Our findings isolate the principal target responsible for ferroptosis in HCC cells and outline an approach to potentially augment sorafenib's therapeutic impact on HCC.
    Methods: We investigated the gene expression alterations following sgRNA-mediated knockdown induced by erastin and sorafenib in HCC cells using CRISPR screening-based bioinformatics analysis. Gene set enrichment analysis (GSEA) and the "GDCRNATools" package facilitated the correlation studies. We employed tissue microarrays and cDNA microarrays for validation. Ubiquitination assay, Chromatin immunoprecipitation (ChIP) assay, RNA immunoprecipitation (RIP) assay, and dual-luciferase reporter assay were utilized to delineate the specific mechanisms underlying ferroptosis in HCC cells.
    Results: Our study has revealed that pleiomorphic adenoma gene 1 (PLAG1), a gene implicated in pleomorphic adenoma, confers resistance to ferroptosis in HCC cells treated with sorafenib. Sorafenib leads to the opposite trend of protein and mRNA levels of PLAG1, which is not caused by affecting the stability or ubiquitination of PLAG1 protein, but by the regulation of PLAG1 at the transcriptional level by its upstream competitive endogenous long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1). Data from 139 HCC patients showed a significant positive correlation between PLAG1 and GPX4 levels in tumor samples, and PLAG1 is instrumental in redox homeostasis by driving the expression of glutathione peroxidase 4 (GPX4), the enzyme that reduces lipid peroxides (LPOs), which further leads to ferroptosis inhibition.
    Conclusions: Ferroptosis is a promising target for cancer therapy, especially for patients resistant to standard chemotherapy or immunotherapy. Our findings indicate that PLAG1 holds therapeutic promise and may enhance the efficacy of sorafenib in treating HCC.
    Mesh-Begriff(e) Humans ; Sorafenib/pharmacology ; Sorafenib/therapeutic use ; Ferroptosis/drug effects ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Carcinoma, Hepatocellular/genetics ; Liver Neoplasms/drug therapy ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Liver Neoplasms/genetics ; Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism ; Phospholipid Hydroperoxide Glutathione Peroxidase/genetics ; DNA-Binding Proteins/metabolism ; DNA-Binding Proteins/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Mice ; Animals ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/drug effects ; Male
    Sprache Englisch
    Erscheinungsdatum 2024-05-14
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 803138-1
    ISSN 1756-9966 ; 0392-9078
    ISSN (online) 1756-9966
    ISSN 0392-9078
    DOI 10.1186/s13046-024-03061-4
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  2. Artikel ; Online: Achilles' Heel of currently approved immune checkpoint inhibitors: immune related adverse events.

    Yan, Ting / Yu, Lun / Zhang, Jiwen / Chen, Yun / Fu, Yilan / Tang, Jingyi / Liao, Dehua

    Frontiers in immunology

    2024  Band 15, Seite(n) 1292122

    Abstract: Immunotherapy has revolutionized the cancer treatment landscape by opening up novel avenues for intervention. As the use of immune checkpoint inhibitors (ICIs) has exponentially increased, so have immune-related adverse events (irAEs). The mechanism of ... ...

    Abstract Immunotherapy has revolutionized the cancer treatment landscape by opening up novel avenues for intervention. As the use of immune checkpoint inhibitors (ICIs) has exponentially increased, so have immune-related adverse events (irAEs). The mechanism of irAEs may involve the direct damage caused by monoclonal antibodies and a sequence of immune responses triggered by T cell activation. Common side effects include dermatologic toxicity, endocrine toxicity, gastrointestinal toxicity, and hepatic toxicity. While relatively rare, neurotoxicity, cardiotoxicity, and pulmonary toxicity can be fatal. These toxicities pose a clinical dilemma regarding treatment discontinuation since they can result in severe complications and necessitate frequent hospitalization. Vigilant monitoring of irAEs is vital in clinical practice, and the principal therapeutic strategy entails the administration of oral or intravenous glucocorticoids (GSCs). It may be necessary to temporarily or permanently discontinue the use of ICIs in severe cases. Given that irAEs can impact multiple organs and require diverse treatment approaches, the involvement of a multidisciplinary team of experts is imperative. This review aims to comprehensively examine the pathogenesis, clinical manifestations, incidence, and treatment options for various irAEs.
    Mesh-Begriff(e) Humans ; Immune Checkpoint Inhibitors/adverse effects ; Antineoplastic Agents, Immunological/adverse effects ; Neoplasms ; Antibodies, Monoclonal/adverse effects ; Drug-Related Side Effects and Adverse Reactions/etiology ; Drug-Related Side Effects and Adverse Reactions/drug therapy
    Chemische Substanzen Immune Checkpoint Inhibitors ; Antineoplastic Agents, Immunological ; Antibodies, Monoclonal
    Sprache Englisch
    Erscheinungsdatum 2024-02-12
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1292122
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  3. Artikel ; Online: Comparative analysis of shotgun metagenomics and 16S rDNA sequencing of gut microbiota in migratory seagulls

    Feng Liao / Yilan Xia / Wenpeng Gu / Xiaoqing Fu / Bing Yuan

    PeerJ, Vol 11, p e

    2023  Band 16394

    Abstract: Background Shotgun metagenomic and 16S rDNA sequencing are commonly used methods to identify the taxonomic composition of microbial communities. Previously, we analysed the gut microbiota and intestinal pathogenic bacteria configuration of migratory ... ...

    Abstract Background Shotgun metagenomic and 16S rDNA sequencing are commonly used methods to identify the taxonomic composition of microbial communities. Previously, we analysed the gut microbiota and intestinal pathogenic bacteria configuration of migratory seagulls by using 16S rDNA sequencing and culture methods. Methods To continue in-depth research on the gut microbiome and reveal the applicability of the two methods, we compared the metagenome and 16S rDNA amplicon results to further demonstrate the features of this animal. Results The number of bacterial species detected by metagenomics gradually increased from the phylum to species level, consistent with 16S rDNA sequencing. Several taxa were commonly shared by both sequencing methods. However, Escherichia, Shigella, Erwinia, Klebsiella, Salmonella, Escherichia albertii, Shigella sonnei, Salmonella enterica, and Shigella flexneri were unique taxa for the metagenome compared with Escherichia-Shigella, Hafnia-Obesumbacterium, Catellicoccus marimammalium, Lactococcus garvieae, and Streptococcus gallolyticus for 16S rDNA sequencing. The largest differences in relative abundance between the two methods were identified at the species level, which identified many pathogenic bacteria to humans using metagenomic sequencing. Pearson correlation analysis indicated that the correlation coefficient for the two methods gradually decreased with the refinement of the taxonomic levels. The high consistency of the correlation coefficient was identified at the genus level for the beta diversity of the two methods. Conclusions In general, relatively consistent patterns and reliability could be identified by both sequencing methods, but the results varied following the refinement of taxonomic levels. Metagenomic sequencing was more suitable for the discovery and detection of pathogenic bacteria of gut microbiota in seagulls. Although there were large differences in the numbers and abundance of bacterial species of the two methods in terms of taxonomic levels, the patterns and ...
    Schlagwörter Metagenome ; 16S rDNA sequencing ; Migratory seagulls ; Gut microbiota ; Comparative analysis ; Medicine ; R ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 2023-11-01T00:00:00Z
    Verlag PeerJ Inc.
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Comparative analysis of shotgun metagenomics and 16S rDNA sequencing of gut microbiota in migratory seagulls.

    Liao, Feng / Xia, Yilan / Gu, Wenpeng / Fu, Xiaoqing / Yuan, Bing

    PeerJ

    2023  Band 11, Seite(n) e16394

    Abstract: Background: Shotgun metagenomic and 16S rDNA sequencing are commonly used methods to identify the taxonomic composition of microbial communities. Previously, we analysed the gut microbiota and intestinal pathogenic bacteria configuration of migratory ... ...

    Abstract Background: Shotgun metagenomic and 16S rDNA sequencing are commonly used methods to identify the taxonomic composition of microbial communities. Previously, we analysed the gut microbiota and intestinal pathogenic bacteria configuration of migratory seagulls by using 16S rDNA sequencing and culture methods.
    Methods: To continue in-depth research on the gut microbiome and reveal the applicability of the two methods, we compared the metagenome and 16S rDNA amplicon results to further demonstrate the features of this animal.
    Results: The number of bacterial species detected by metagenomics gradually increased from the phylum to species level, consistent with 16S rDNA sequencing. Several taxa were commonly shared by both sequencing methods. However,
    Conclusions: In general, relatively consistent patterns and reliability could be identified by both sequencing methods, but the results varied following the refinement of taxonomic levels. Metagenomic sequencing was more suitable for the discovery and detection of pathogenic bacteria of gut microbiota in seagulls. Although there were large differences in the numbers and abundance of bacterial species of the two methods in terms of taxonomic levels, the patterns and reliability results of the samples were consistent.
    Mesh-Begriff(e) Humans ; Animals ; Gastrointestinal Microbiome/genetics ; DNA, Ribosomal/genetics ; Reproducibility of Results ; Sequence Analysis, DNA/methods ; RNA, Ribosomal, 16S/genetics ; Salmonella enterica/genetics
    Chemische Substanzen DNA, Ribosomal ; RNA, Ribosomal, 16S
    Sprache Englisch
    Erscheinungsdatum 2023-11-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2703241-3
    ISSN 2167-8359 ; 2167-8359
    ISSN (online) 2167-8359
    ISSN 2167-8359
    DOI 10.7717/peerj.16394
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: The influence of community park characteristics on satisfaction in Guangzhou: Moderating and mediating effects analysis.

    Xiao, Jia Xin / Liao, Jieying / Zhao, Bi / Long, YiLan / Xu, Xuan / Liang, XinYi / Xia, Tiansheng

    Heliyon

    2024  Band 10, Heft 10, Seite(n) e31043

    Abstract: Community parks in old urban areas have problems such as outdated facilities and low quality, which inhibit the development of healthy aging. However, limited research has examined the correlation between such park characteristics and park satisfaction ... ...

    Abstract Community parks in old urban areas have problems such as outdated facilities and low quality, which inhibit the development of healthy aging. However, limited research has examined the correlation between such park characteristics and park satisfaction among elderly individuals. Additionally, the mechanisms underlying this association remain unclear. In this investigation, a moderated mediation framework grounded in self-determination theory was formulated to probe the interplay between these variables, with a specific focus on the mediating influence of social self-efficacy among the elderly and the moderating effect of use intention. A questionnaire survey (N = 319) was conducted in Shamian Park, Guangzhou, employing structural equation modeling for data analysis. Findings indicate that, even after controlling for demographic factors, park characteristics not only exert a direct influence on satisfaction but also exhibit an indirect impact through the mediation of social self-efficacy, with both pathways being moderated by use intention. This study has implications for how to improve the design of community parks in old urban areas in developing countries to better meet the basic needs of the elderly and promote healthy aging.
    Sprache Englisch
    Erscheinungsdatum 2024-05-10
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e31043
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  6. Artikel ; Online: Pollution zone identification research during ozone pollution processes.

    Li, Dongyue / Liao, Yilan

    Environmental monitoring and assessment

    2020  Band 192, Heft 9, Seite(n) 591

    Abstract: Identifying an ozone pollution zone during the pollution processes is significant for ozone pollution management and environmental health risk assessment. However, few studies have focused on ozone pollution zone identification during pollution processes. ...

    Abstract Identifying an ozone pollution zone during the pollution processes is significant for ozone pollution management and environmental health risk assessment. However, few studies have focused on ozone pollution zone identification during pollution processes. A spatial-temporal clustering framework for identifying pollution zones during ozone pollution processes was initially proposed in this study, and an ozone pollution process in China in May 2017 was selected as a case. The results showed that the framework can help selecting one more accurate method to identify the pollution zone according to the pollution characteristics of air pollution process. In addition, different ozone pollution zone identification methods work well in different scenarios: The self-organizing map (SOM) method was suitable for identifying the zone with the duration of pollution between 24 and 48 h, the image fusion based on wavelet transform (IFbWT) method for the zone with the duration of pollution over 48 h and the Apriori method for the zone with obvious boundaries between high-value and low-value ozone concentrations. The proposed procedure can also be applied to identify the pollution zone of the pollution process of other pollutants.
    Mesh-Begriff(e) Air Pollutants/analysis ; Air Pollution/analysis ; China ; Environmental Monitoring ; Ozone/analysis
    Chemische Substanzen Air Pollutants ; Ozone (66H7ZZK23N)
    Sprache Englisch
    Erscheinungsdatum 2020-08-20
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 782621-7
    ISSN 1573-2959 ; 0167-6369
    ISSN (online) 1573-2959
    ISSN 0167-6369
    DOI 10.1007/s10661-020-08552-3
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  7. Artikel ; Online: Anterior peri-sacroiliac joint osteotomy in the treatment of malunion and nonunion of complex pelvic ring fracture: techniques and preliminary results.

    Fan, Shicai / Liao, Yilan / Xiao, Zhipeng / Chen, Yuhui / Li, Tao / Mai, Qiguang / Chen, Sheqiang / Xiang, Haibo / Hou, Zhiyong / Zhang, Yingze

    International orthopaedics

    2024  

    Abstract: Purpose: To introduce anterior peri-sacroiliac joint osteotomy (APSJO) through the lateral-rectus approach (LRA) for treating pelvic fracture malunion and nonunion, and to evaluate the safety, feasibility, and potential effectiveness.: Methods: Data ... ...

    Abstract Purpose: To introduce anterior peri-sacroiliac joint osteotomy (APSJO) through the lateral-rectus approach (LRA) for treating pelvic fracture malunion and nonunion, and to evaluate the safety, feasibility, and potential effectiveness.
    Methods: Data of 15 patients with pelvic fracture malunion and nonunion who underwent treatment by APSJO were selected and analyzed. The reduction quality was assessed using the Mears and Velyvis criteria, while the pre-operative and post-operative function was revealed by the Majeed scoring system. The British Medical Research Council (BMRC) grading system was recruited for the evaluation of lumbosacral plexus function.
    Results: The average operative duration was 264.00 ± 86.75 min, while the intra-operative blood loss was 2000 (600, 3000) mL. Anatomical reduction was complete in three cases, satisfactory in ten cases, and unsatisfactory in two cases. Among the seven patients with lumbosacral plexus injury, the pre-operative Majeed grades were good in two cases, fair in two cases, and poor in three cases, while the post-operative Majeed grades were excellent in three cases, good in three cases, and fair in one case. Muscle strength recovered to M5 in two cases, M4 in three cases, and showed no recovery in two cases. The pre-operative Majeed grades were good in five cases, fair in two cases, and poor in one case of the series without lumbosacral plexus injury, while the post-operative Majeed grades were excellent in seven cases and good in one case.
    Conclusion: APSJO through LRA may be a feasible strategy for treating pelvic fracture malunion and nonunion with promising application.
    Sprache Englisch
    Erscheinungsdatum 2024-04-17
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 80384-4
    ISSN 1432-5195 ; 0341-2695
    ISSN (online) 1432-5195
    ISSN 0341-2695
    DOI 10.1007/s00264-024-06173-w
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  8. Artikel ; Online: The risks of death and hospitalizations associated with SARS-CoV-2 Omicron declined after lifting testing and quarantining measures.

    Deng, Yamin / Han, Shasha / Liu, Jue / Guo, Li / Feng, Luzhao / Liao, Yilan / Peng, Zhixing / Ren, Lili / Yang, Weizhong / Wang, Jianwei

    The Journal of infection

    2023  Band 86, Heft 5, Seite(n) e123–e125

    Mesh-Begriff(e) Humans ; COVID-19 ; Lifting ; SARS-CoV-2 ; Hospitalization
    Sprache Englisch
    Erscheinungsdatum 2023-02-28
    Erscheinungsland England
    Dokumenttyp Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 424417-5
    ISSN 1532-2742 ; 0163-4453
    ISSN (online) 1532-2742
    ISSN 0163-4453
    DOI 10.1016/j.jinf.2023.02.033
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  9. Artikel ; Online: Scope and inclination of voluntary service for urban community-living older adults provided by volunteers with nursing background: A qualitative study.

    Huang, Lei / Wu, Hongyan / Zhang, Fengjian / Peng, Xiao / Guo, Lin / Liao, Lulu / Hu, Mengyun / Wang, Shuang / Guan, Chunyan / Liu, Yilan

    Health expectations : an international journal of public participation in health care and health policy

    2024  Band 27, Heft 1, Seite(n) e13990

    Abstract: Background: With the growing challenge of an aging population, addressing the needs of elderly individuals who face living difficulties and lack family support becomes increasingly difficult. Volunteer services are crucial in this context, yet their ... ...

    Abstract Background: With the growing challenge of an aging population, addressing the needs of elderly individuals who face living difficulties and lack family support becomes increasingly difficult. Volunteer services are crucial in this context, yet their effectiveness is hindered by unclear service scopes and uncertain volunteer inclinations.
    Aim: To explore the role and specific preference of volunteers with nursing backgrounds in support of older adults living in the urban community. DESIGN, SETTING AND PARTICIPANTS: A descriptive qualitative study was conducted between September and October 2022. Twenty-three participants (hospital nurses [10], community nurses [4], nursing teachers [4] and nursing students [5]) were selected. Data analysis followed conventional content analysis.
    Results: Nine major themes were identified based on interview data. Four themes described the service scope of nursing volunteers: (1) environment domain, (2) physiological domain, (3) psychosocial domain and (4) health-related behaviours domain. Another five themes highlighted the service inclination of these volunteers: (1) service frequency, (2) service duration per person/time, (3) service coverage, (4) service place and (5) service object.
    Conclusion: This study clarifies the service focus and scope of necessary support for volunteers, exploring the potential service capabilities of scarce volunteers to the greatest extent. Meanwhile, the results of this study also provide a foundation for stakeholders to fully exploit the synergy. The important findings of this study will help the government and relevant authorities better understand the service attributes of nursing volunteers, allowing them to develop detailed training plans and provide nursing volunteers with targeted support and assistance to meet the health expectations of urban community-living older adults in need.
    Patient or public contribution: Developing research questions, participation and conduct and provision and interpretation of evidence.
    Mesh-Begriff(e) Aged ; Humans ; Qualitative Research ; Volunteers ; Independent Living
    Sprache Englisch
    Erscheinungsdatum 2024-02-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2119434-8
    ISSN 1369-7625 ; 1369-6513
    ISSN (online) 1369-7625
    ISSN 1369-6513
    DOI 10.1111/hex.13990
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  10. Artikel ; Online: A dataset of a proxy variable for the poultry trade flows in China

    Lingcai Kong / Xuan Zhou / Mengwei Duan / Xinyi Yang / Caifeng Zhou / Yilan Liao

    Scientific Data, Vol 9, Iss 1, Pp 1-

    2022  Band 7

    Abstract: Measurement(s) poultry trade flows Technology Type(s) poultry food product Factor Type(s) poultry product • poultry consumption Sample Characteristic - Organism poultry Sample Characteristic - Environment poultry food product Sample Characteristic - ... ...

    Abstract Measurement(s) poultry trade flows Technology Type(s) poultry food product Factor Type(s) poultry product • poultry consumption Sample Characteristic - Organism poultry Sample Characteristic - Environment poultry food product Sample Characteristic - Location China
    Schlagwörter Science ; Q
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag Nature Portfolio
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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