Artikel ; Online: Evaluation of nine active components of Lu-Jiao Fang in normal and hypertrophic rat myocardia via LC-MS/MS.
Biomedical chromatography : BMC
2020 Band 34, Heft 5, Seite(n) e4814
Abstract: Lu-Jiao Fang (LJF), a traditional Chinese medicine prescription, can improve the cardiac function ...
| Abstract | Lu-Jiao Fang (LJF), a traditional Chinese medicine prescription, can improve the cardiac function of chronic heart failure (CHF) patients; however, knowledge about the cardiac distribution of LJF, especially in CHF animal models, is rather limited. This work aimed to explore the cardiac distribution of LJF in pressure overload-induced CHF rats at the last gavage administration of LJF after 30 weeks of treatment. LC-MS/MS methods for analyzing nine active components (i.e. loganin, hesperidin, epimedin C, icariin, psoralen, isopsoralen, baohuoside I, morroniside and specnuezhenide) of LJF in cardiac tissue samples were established, and the components were then analyzed in left ventricular wall (LVW) and right ventricular wall (RVW) in parallel at same time point postdose for three dose groups. The results showed that most analytical component levels in LVW (hypertrophic myocardium) were only 39-74% of those in RVW (normal myocardium); however, psoralen and isopsoralen levels in LVW were equal to or even greater than the levels in RVW, suggesting that the hypertrophic myocardium tissue affinity of psoralen and isopsoralen might overcome the negative effect of decreased blood flow on distribution. This study indicated that the pathological state may influence drug distribution, and the efficacy of psoralen and isopsoralen for improving CHF deserves further investigation. |
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| Mesh-Begriff(e) | Animals ; Cardiomyopathy, Hypertrophic/drug therapy ; Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/chemistry ; Heart/drug effects ; Heart Failure/drug therapy ; Humans ; Male ; Rats ; Rats, Wistar ; Tandem Mass Spectrometry/methods |
| Chemische Substanzen | Drugs, Chinese Herbal |
| Sprache | Englisch |
| Erscheinungsdatum | 2020-03-13 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article |
| ZDB-ID | 632848-9 |
| ISSN | 1099-0801 ; 0269-3879 |
| ISSN (online) | 1099-0801 |
| ISSN | 0269-3879 |
| DOI | 10.1002/bmc.4814 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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