Artikel: Noncanonical DNA structures are drivers of genome evolution.
2023 Band 39, Heft 2, Seite(n) 109–124
Abstract: In addition to the canonical right-handed double helix, other DNA structures, termed 'non-B DNA', can form in the genomes across the tree of life. Non-B DNA regulates multiple cellular processes, including replication and transcription, yet its presence ... ...
Abstract | In addition to the canonical right-handed double helix, other DNA structures, termed 'non-B DNA', can form in the genomes across the tree of life. Non-B DNA regulates multiple cellular processes, including replication and transcription, yet its presence is associated with elevated mutagenicity and genome instability. These discordant cellular roles fuel the enormous potential of non-B DNA to drive genomic and phenotypic evolution. Here we discuss recent studies establishing non-B DNA structures as novel functional elements subject to natural selection, affecting evolution of transposable elements (TEs), and specifying centromeres. By highlighting the contributions of non-B DNA to repeated evolution and adaptation to changing environments, we conclude that evolutionary analyses should include a perspective of not only DNA sequence, but also its structure. |
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Mesh-Begriff(e) | Humans ; DNA Transposable Elements/genetics ; Base Sequence ; Genomics ; Genomic Instability/genetics ; Evolution, Molecular |
Chemische Substanzen | DNA Transposable Elements |
Sprache | Englisch |
Erscheinungsdatum | 2023-01-03 |
Erscheinungsland | England |
Dokumenttyp | Journal Article ; Review ; Research Support, N.I.H., Extramural |
ZDB-ID | 619240-3 |
ISSN | 1362-4555 ; 0168-9525 ; 0168-9479 |
ISSN (online) | 1362-4555 |
ISSN | 0168-9525 ; 0168-9479 |
DOI | 10.1016/j.tig.2022.11.005 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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