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Artikel ; Online: Editorial Comment on Retreatment for Lower Urinary Tract Symptoms (LUTS) After Water Vapor Thermal Therapy.

Manalo, Tad A / Lloyd, Granville L

2024

Sprache	Englisch
Erscheinungsdatum	2024-05-31
Erscheinungsland	United States
Dokumenttyp	Editorial
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2024.05.040
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The Temporal Association of Depression and Anxiety in Young Men With Erectile Dysfunction.

Manalo, Tad A / Biermann, Henry D / Patil, Dattatraya H / Mehta, Akanksha

The journal of sexual medicine

2021 Band 19, Heft 2, Seite(n) 201–206

Abstract: ... ED diagnosis in comparison to young men without ED. Manalo TA, Biermann HD, Patil DH, et al ...

Abstract	Background: Erectile dysfunction (ED) is a multidimensional sexual disorder that is being increasingly diagnosed in younger men. Although mental illnesses such as depression and anxiety are known risk factors for ED, the association between these conditions and ED has been understudied in young men. Aim: To explore the temporal association between depression, anxiety, and ED in a population-based cohort of young men. Methods: Using 2009-2018 MarketScan Commercial Claims data, we identified all men with ED aged 18-40 years (cases). Using ICD-9/-10 codes and prescription data, we evaluated the prevalence and incidence of depression and anxiety in this cohort. Cases were matched with men without a diagnosis of ED (controls) based on age, Charlson Comorbidity Index, history of hypertension, geographic region, and year of presentation. We examined the prevalence of depression and anxiety within 12 months prior to ED diagnosis and incidence of depression and anxiety up to 36 months after ED diagnosis in cases vs controls. Differences between cases and controls were tested with Wilcoxon rank-sum test for numerical covariates, and chi-square test for categorical covariates. Significance was set at P < .05. Outcomes: Prevalence and incidence of depression and anxiety in young men with and without ED. Results: Within the 12-month period preceding ED diagnosis, the prevalence of depression and anxiety in cases vs controls were 17.1% vs 12.9%, respectively (P < .001). The incidence of depression and anxiety were higher amongst cases vs controls at 12- (11.7% vs 6.3%), 24- (14.5% vs 9.0%,) and 36- (15.9% vs 10.6%) months following ED diagnosis (P < .001). Clinical implications: High incidence and prevalence of depression and anxiety in young men diagnosed with ED highlight the importance of normalizing mental health screenings and routine psychiatric follow-up in this population. Strengths & limitations: Our contemporary, case-control study utilizes a population-based cohort of young men with ED to study the temporal association between depression, anxiety, and ED, which is understudied to date. The MarketScan commercial claims database used in this analysis includes men covered by private insurers only and lacks data on symptoms and treatments. Conclusion: Young men with ED had significantly higher rates of depression and anxiety both before and after ED diagnosis in comparison to young men without ED. Manalo TA, Biermann HD, Patil DH, et al. The Temporal Association of Depression and Anxiety in Young Men With Erectile Dysfunction. J Sex Med 2022;19:201-206.
Mesh-Begriff(e)	Adolescent ; Adult ; Anxiety/epidemiology ; Anxiety Disorders ; Case-Control Studies ; Depression/epidemiology ; Erectile Dysfunction/etiology ; Humans ; Male ; Young Adult
Sprache	Englisch
Erscheinungsdatum	2021-12-27
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	2251959-2
ISSN	1743-6109 ; 1743-6095
ISSN (online)	1743-6109
ISSN	1743-6095
DOI	10.1016/j.jsxm.2021.11.011
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A missense SNP in the tumor suppressor SETD2 reduces H3K36me3 and mitotic spindle integrity in Drosophila.

Brockett, Jovan S / Manalo, Tad / Zein-Sabatto, Hala / Lee, Jina / Fang, Junnan / Chu, Philip / Feng, Harry / Patil, Dattatraya / Davidson, Priscilla / Ogan, Kenneth / Master, Viraj A / Pattaras, John G / Roberts, David L / Bergquist, Sharon H / Reyna, Matthew A / Petros, John A / Lerit, Dorothy A / Arnold, Rebecca S

Genetics

2024 Band 226, Heft 4

Abstract: Mutations in SETD2 are among the most prevalent drivers of renal cell carcinoma (RCC). We identified a novel single nucleotide polymorphism (SNP) in SETD2, E902Q, within a subset of RCC patients, which manifests as both an inherited or tumor-associated ... ...

Abstract	Mutations in SETD2 are among the most prevalent drivers of renal cell carcinoma (RCC). We identified a novel single nucleotide polymorphism (SNP) in SETD2, E902Q, within a subset of RCC patients, which manifests as both an inherited or tumor-associated somatic mutation. To determine if the SNP is biologically functional, we used CRISPR-based genome editing to generate the orthologous mutation within the Drosophila melanogaster Set2 gene. In Drosophila, the homologous amino acid substitution, E741Q, reduces H3K36me3 levels comparable to Set2 knockdown, and this loss is rescued by reintroduction of a wild-type Set2 transgene. We similarly uncovered significant defects in spindle morphogenesis, consistent with the established role of SETD2 in methylating α-Tubulin during mitosis to regulate microtubule dynamics and maintain genome stability. These data indicate the Set2 E741Q SNP affects both histone methylation and spindle integrity. Moreover, this work further suggests the SETD2 E902Q SNP may hold clinical relevance.
Mesh-Begriff(e)	Animals ; Humans ; Carcinoma, Renal Cell/genetics ; Carcinoma, Renal Cell/metabolism ; Carcinoma, Renal Cell/pathology ; Histones/genetics ; Histones/metabolism ; Drosophila/metabolism ; Drosophila melanogaster/genetics ; Drosophila melanogaster/metabolism ; Polymorphism, Single Nucleotide ; Kidney Neoplasms/genetics ; Kidney Neoplasms/metabolism ; Kidney Neoplasms/pathology ; Spindle Apparatus/genetics ; Spindle Apparatus/metabolism ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism
Chemische Substanzen	Histones ; Set2 protein, Drosophila (EC 2.1.1.43) ; Histone-Lysine N-Methyltransferase (EC 2.1.1.43) ; Drosophila Proteins
Sprache	Englisch
Erscheinungsdatum	2024-02-06
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2167-2
ISSN	1943-2631 ; 0016-6731
ISSN (online)	1943-2631
ISSN	0016-6731
DOI	10.1093/genetics/iyae015
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Mayo Adhesive Probability Score Does Not Have Prognostic Ability in Locally Advanced Renal Cell Carcinoma.

Schmeusser, Benjamin N / Manalo, Tad A / Liu, Yuan / Shah, Yash B / Ali, Adil / Armas-Phan, Manuel / Patil, Dattatraya H / Nabavizadeh, Reza / Ogan, Kenneth / Master, Viraj A

Journal of kidney cancer and VHL

2023 Band 10, Heft 1, Seite(n) 19–25

Abstract: Nephrectomy remains standard treatment for renal cell carcinoma (RCC). The Mayo Adhesive Probability (MAP) score is predictive of adherent perinephric fat and associated surgical complexity, and is determined by assessing perinephric fat and stranding. ... ...

Abstract	Nephrectomy remains standard treatment for renal cell carcinoma (RCC). The Mayo Adhesive Probability (MAP) score is predictive of adherent perinephric fat and associated surgical complexity, and is determined by assessing perinephric fat and stranding. MAP has additionally predicted progression-free survival (PFS), though primarily reported in stage T1-T2 RCC. Here, we examine MAP's ability to predict overall survival (OS) and PFS in T3-T4 RCC. From our prospectively maintained RCC database, patients that underwent radical nephrectomy (2009-2016) with available abdominal imaging (<90 days preop) and T3/T4 RCC underwent MAP scoring. Survival analyses were conducted with MAP scores as individual (0-5) and dichotomized (0-3 vs 4-5) using Kaplan-Meier method. Multivariable Cox proportional hazard regression models for PFS and OS were built with backward elimination. 141 patients were included. 134 (95%) and 7 (5%) had pT3 and pT4 disease, respectively. 46.1% of patients had an inferior vena cava thrombus. Mean MAP score was 3.22±1.52, with 75 (53%) patients having a score between 0-3 and 66 (47%) having a score of 4-5. Both male gender (p=0.006) and clear cell histology (p=0.012) were associated with increased MAP scores. On Kaplan-Meier and multivariable analysis, no significant associations were identified between MAP and PFS (HR=1.01, 95% CI 0.85-1.20, p=0.93) or OS (HR=1.01, 95% CI 0.84-1.21, p=0.917). In this cohort of patients with locally advanced RCC, high MAP scores were not predictive of worse PFS or OS.
Sprache	Englisch
Erscheinungsdatum	2023-03-21
Erscheinungsland	Australia
Dokumenttyp	Journal Article
ZDB-ID	2803342-5
ISSN	2203-5826 ; 2203-5826
ISSN (online)	2203-5826
ISSN	2203-5826
DOI	10.15586/jkcvhl.v10i1.269
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A Strategy for Undergraduate Medical Education in Urology During the COVID-19 Pandemic.

Manalo, Tad A / Higgins, Michelle I / Pettitt-Schieber, Brian / Pettitt, Barbara J / Mehta, Akanksha / Hartsell, Lindsey M

Journal of surgical education

2020 Band 78, Heft 3, Seite(n) 746–750

Abstract: Objective: To provide a framework for a virtual curriculum during the COVID-19 pandemic for medical student educators that introduces and teaches clinical concepts important in urology and surgical specialties in general.: Methods: We created a 1- ... ...

Abstract	Objective: To provide a framework for a virtual curriculum during the COVID-19 pandemic for medical student educators that introduces and teaches clinical concepts important in urology and surgical specialties in general. Methods: We created a 1-week virtual urology course utilizing interactive lectures, case-based exercises, and faculty-proctored surgical video reviews. Students were assigned self-study modules and participated in case-based discussions and presentations on a topic of their choice. Students' perceptions of urology as a specialty and the utility of the course was evaluated through pre- and postcourse surveys. Understanding of urologic content was evaluated with a multiple-choice exam. Results: A total of nine students were enrolled in the course. All students reported increased understanding of the common urologic diagnoses and of urology as a specialty by an average of 2.5 points on a 10-point Likert scale (Cohen's measure of effect size: 3.2). Additionally, 56% of students reported increased interest, 22% reported no change and 22% reported a decreased interest in pursuing urology as a specialty following the course. Students self-reported increased knowledge of a variety of urologic topics on a 10-point Likert scale. The average exam score on the multiple-choice exam improved from 50% before the course to 89% after the course. Conclusions: Various teaching techniques can be employed through a virtual platform to introduce medical students to the specialty of urology and increase clinical knowledge surrounding common urologic conditions. As the longevity of the COVID-19 pandemic becomes increasingly apparent and virtual teaching is normalized, these techniques can have far-reaching utility within the traditional medical student surgical curriculum.
Mesh-Begriff(e)	COVID-19 ; Curriculum ; Education, Medical, Undergraduate ; Humans ; Pandemics ; SARS-CoV-2 ; Students, Medical ; Urology/education
Sprache	Englisch
Erscheinungsdatum	2020-09-14
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2277538-9
ISSN	1878-7452 ; 1931-7204
ISSN (online)	1878-7452
ISSN	1931-7204
DOI	10.1016/j.jsurg.2020.09.011
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: How I Do It

Manalo, Tad A. / Higgins, Michelle I. / Pettitt-Schieber, Brian / Pettitt, Barbara J. / Mehta, Akanksha / Hartsell, Lindsey M.

Journal of Surgical Education ; ISSN 1931-7204

A Strategy for Undergraduate Medical Education in Urology During the COVID-19 Pandemic

2020

Schlagwörter	Surgery ; Education ; covid19
Sprache	Englisch
Verlag	Elsevier BV
Erscheinungsland	us
Dokumenttyp	Artikel ; Online
DOI	10.1016/j.jsurg.2020.09.011
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: Implementation and evaluation of eight virtual surgical electives for medical students during the COVID-19 pandemic.

Pettitt-Schieber, Brian / Kuo, Marissa / Steehler, Andrew / Dong, Andy / Fakunle, Omolola / Manalo, Tad / Mercury, Oblaise / Simpson, Francis / Guissé, Ndéye / Studer, Matthew / Poirier, Marie-Veronique / Philbrick, Brandon / Grady, Zachary / Higgins, Michelle / Gallo, Lindsay / Danko, Dora / Dawoud, Reem / Pettitt, Barbara

American journal of surgery

2021 Band 222, Heft 2, Seite(n) 248–253

Abstract: Background: Eight novel virtual surgery electives (VSEs) were developed and implemented in April-May 2020 for medical students forced to continue their education remotely due to COVID-19.: Methods: Each VSE was 1-2 weeks long, contained specialty- ... ...

Abstract	Background: Eight novel virtual surgery electives (VSEs) were developed and implemented in April-May 2020 for medical students forced to continue their education remotely due to COVID-19. Methods: Each VSE was 1-2 weeks long, contained specialty-specific course objectives, and included a variety of teaching modalities. Students completed a post-course survey to assess changes in their interest and understanding of the specialty. Quantitative methods were employed to analyze the results. Results: Eighty-three students participated in the electives and 67 (80.7%) completed the post-course survey. Forty-six (68.7%) respondents reported "increased" or "greatly increased" interest in the course specialty completed. Survey respondents' post-course understanding of each specialty increased by a statistically significant amount (p-value = <0.0001). Conclusion: This initial effort demonstrated that VSEs can be an effective tool for increasing medical students' interest in and understanding of surgical specialties. They should be studied further with more rigorous methods in a larger population.
Mesh-Begriff(e)	COVID-19/epidemiology ; COVID-19/prevention & control ; Career Choice ; Communicable Disease Control/standards ; Curriculum ; Education, Distance/methods ; Education, Distance/organization & administration ; Education, Distance/standards ; Education, Distance/statistics & numerical data ; Education, Medical, Undergraduate/methods ; Education, Medical, Undergraduate/organization & administration ; Education, Medical, Undergraduate/standards ; Education, Medical, Undergraduate/statistics & numerical data ; Educational Measurement/statistics & numerical data ; Humans ; Learning ; Pandemics/prevention & control ; Program Evaluation ; Smartphone ; Specialties, Surgical/education ; Students, Medical/statistics & numerical data ; Videoconferencing/instrumentation
Sprache	Englisch
Erscheinungsdatum	2021-02-04
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2953-1
ISSN	1879-1883 ; 0002-9610
ISSN (online)	1879-1883
ISSN	0002-9610
DOI	10.1016/j.amjsurg.2021.01.032
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: How I Do It: A Strategy for Undergraduate Medical Education in Urology During the COVID-19 Pandemic

Manalo, Tad A. / Higgins, Michelle I. / Pettitt-Schieber, Brian / Pettitt, Barbara J. / Mehta, Akanksha / Hartsell, Lindsey M.

Journal of Surgical Education

Abstract: Objective To provide a framework for a virtual curriculum during the COVID-19 pandemic for medical student educators that introduces and teaches clinical concepts important in urology and surgical specialties in general Methods We created a one-week ... ...

Abstract	Objective To provide a framework for a virtual curriculum during the COVID-19 pandemic for medical student educators that introduces and teaches clinical concepts important in urology and surgical specialties in general Methods We created a one-week virtual urology course utilizing interactive lectures, case-based exercises, and faculty-proctored surgical video reviews Students were assigned self-study modules and participated in case-based discussions and presentations on a topic of their choice Students’ perceptions of urology as a specialty and the utility of the course was evaluated through pre- and post-course surveys Understanding of urologic content was evaluated with a multiple-choice exam Results A total of nine students were enrolled in the course All students reported increased understanding of the common urologic diagnoses and of urology as a specialty by an average of 2 6 points (standard deviation 1 2) on a 10-point Likert scale (p= 0 0002) Additionally, 56% of students reported increased interest, 22% reported no change and 22% reported a decreased interest in pursuing urology as a specialty following the course Students self-reported increased knowledge of a variety of urologic topics on a 10-point Likert scale The average exam score on the multiple-choice exam improved from 50% before the course to 89% after the course Conclusions Various teaching techniques can be employed through a virtual platform to introduce medical students to the specialty of urology and increase clinical knowledge surrounding common urologic conditions As the longevity of the COVID-19 pandemic becomes increasingly apparent and virtual teaching is normalized, these techniques can have far-reaching utility within the traditional medical student surgical curriculum
Schlagwörter	covid19
Verlag	WHO
Dokumenttyp	Artikel
Anmerkung	WHO #Covidence: #756844
Datenquelle	COVID19

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