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  1. Artikel ; Online: Air Pollution and the Novel Covid-19 Disease: a Putative Disease Risk Factor.

    Martelletti, Luigi / Martelletti, Paolo

    SN comprehensive clinical medicine

    2020  Band 2, Heft 4, Seite(n) 383–387

    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-04-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2947211-8
    ISSN 2523-8973 ; 2523-8973
    ISSN (online) 2523-8973
    ISSN 2523-8973
    DOI 10.1007/s42399-020-00274-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Air Pollution and the Novel Covid-19 Disease

    Martelletti, Luigi / Martelletti, Paolo

    SN Comprehensive Clinical Medicine

    a Putative Disease Risk Factor

    2020  Band 2, Heft 4, Seite(n) 383–387

    Schlagwörter covid19
    Sprache Englisch
    Verlag Springer Science and Business Media LLC
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 2947211-8
    ISSN 2523-8973
    ISSN 2523-8973
    DOI 10.1007/s42399-020-00274-4
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Air pollution and the novel covid-19 disease. a putative disease risk factor

    Martelletti, Luigi / Martelletti, Paolo

    2020  

    Abstract: ... ...

    Abstract Editorial
    Schlagwörter air pollution ; COVID-19 ; risk factors ; covid19
    Sprache Englisch
    Verlag SpringerNature
    Erscheinungsland it
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel: Association of COVID-19 distribution with air quality, sociodemographic factors, and comorbidities: an ecological study of US states.

    Sarmadi, Mohammad / Moghanddam, Vahid Kazemi / Dickerson, Aisha S / Martelletti, Luigi

    Air quality, atmosphere, & health

    2020  Band 14, Heft 4, Seite(n) 455–465

    Abstract: This ecological study investigated the association between COVID-19 distribution and air quality index (AQI), comorbidities and sociodemographic factors in the USA. The AQI factors included in the study are total AQI, ozone, carbon monoxide, sulfur ... ...

    Abstract This ecological study investigated the association between COVID-19 distribution and air quality index (AQI), comorbidities and sociodemographic factors in the USA. The AQI factors included in the study are total AQI, ozone, carbon monoxide, sulfur dioxide, and nitrogen dioxide (NO
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-10-14
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2424084-9
    ISSN 1873-9326 ; 1873-9318
    ISSN (online) 1873-9326
    ISSN 1873-9318
    DOI 10.1007/s11869-020-00949-w
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  6. Artikel: Association of COVID-19 distribution with air quality, sociodemographic factors, and comorbidities: an ecological study of US states

    Sarmadi, Mohammad / Moghanddam, Vahid Kazemi / Dickerson, Aisha S / Martelletti, Luigi

    Air Qual Atmos Health

    Abstract: This ecological study investigated the association between COVID-19 distribution and air quality index (AQI), comorbidities and sociodemographic factors in the USA. The AQI factors included in the study are total AQI, ozone, carbon monoxide, sulfur ... ...

    Abstract This ecological study investigated the association between COVID-19 distribution and air quality index (AQI), comorbidities and sociodemographic factors in the USA. The AQI factors included in the study are total AQI, ozone, carbon monoxide, sulfur dioxide, and nitrogen dioxide (NO2). Other demographic, socioeconomic, and geographic variables were included as covariates. The correlations of COVID-19 variables-proportion of cases and deaths in each population, as well as case fatality rate with independent variables were determined by Pearson and Spearman correlation and multiple linear regression analyses. The results revealed that AQI-NO2, population density, longitude, gross domestic product per capita, median age, total death of disease, and pneumonia per population were significantly associated with the COVID-19 variables (P < 0.05). Air pollutants, especially NO2 in the US case, could be addressed as an important factor linked with COVID-19 susceptibility and mortality.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #880347
    Datenquelle COVID19

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  7. Artikel ; Online: Myosteatosis is closely associated with sarcopenia and significantly worse outcomes in patients with cirrhosis.

    Di Cola, Simone / D'Amico, Gennaro / Caraceni, Paolo / Schepis, Filippo / Loredana, Simone / Lampertico, Pietro / Toniutto, Pierluigi / Martini, Silvia / Maimone, Sergio / Colecchia, Antonio / Svegliati Barone, Gianluca / Alessandria, Carlo / Aghemo, Alessio / Crocè, Saveria Lory / Adinolfi, Luigi Elio / Rendina, Maria / Lapenna, Lucia / Pompili, Enrico / Zaccherini, Giacomo /
    Saltini, Dario / Iavarone, Massimo / Tosetti, Giulia / Martelletti, Carolina / Nassisi, Veronica / Ferrarese, Alberto / Giovo, Ilaria / Masetti, Chiara / Pugliese, Nicola / Campigotto, Michele / Nevola, Riccardo / Merli, Manuela

    Journal of hepatology

    2024  

    Abstract: Background and aim: Sarcopenia and myosteatosis are common in patients with cirrhosis. This study aimed to determine the prevalence of these muscle changes, their interrelations and their prognostic impact over a 12-month period.: Methods: We ... ...

    Abstract Background and aim: Sarcopenia and myosteatosis are common in patients with cirrhosis. This study aimed to determine the prevalence of these muscle changes, their interrelations and their prognostic impact over a 12-month period.
    Methods: We conducted a prospective multicentre study involving 433 patients. Sarcopenia and myosteatosis were evaluated using computed tomography scans. The 1-year cumulative incidence of relevant events was assessed by competing risk analysis. We used a Fine-Gray model adjusted for known prognostic factors, to evaluate the impact of sarcopenia and myosteatosis on mortality, hospitalization, and liver decompensation.
    Results: At enrolment, 166 patients presented with isolated myosteatosis, 36 with isolated sarcopenia, 135 with combined sarcopenia and myosteatosis and 96 patients showed no muscle changes. The 1-year cumulative incidence of death in patients with either sarcopenia and myosteatosis (13.8%) or isolated myosteatosis (13.4%) was over twice that of patients without muscle changes (5.2%) or with isolated sarcopenia (5.6%). The adjusted subhazard ratio for death in patients with muscle changes was 1.36 (95% CI 0.99, 1.86) (P=0.058). The cumulative incidence of hospitalization was significantly higher in patients with combined sarcopenia and myosteatosis than in patients without muscle changes (adjusted subhazard ratio 1.18, 95% CI 1.04 to 1.35). The cumulative incidence of liver decompensation was greater in patients with combined sarcopenia and myosteatosis (p=0.018) and those with isolated sarcopenia (p=0.046) than in patients without muscle changes. Lastly, we found a strong correlation between function tests and frailty scores with the presence of muscle changes.
    Conclusions: Myosteatosis, whether alone or combined with sarcopenia, is highly prevalent in patients with cirrhosis and is associated with significantly worse outcomes. The prognostic role of sarcopenia should always be evaluated in relation to the presence of myosteatosis.
    Impact and implications: This study investigates the prognostic role of muscle changes in patients with liver cirrhosis. The novelty of this study is the multicentre, prospective nature and the distinguishing impact of individual muscle changes and their combination on prognosis in cirrhosis. This study highlights the prognostic role of myosteatosis, especially when combined with sarcopenia. On the other hand, the relevance of sarcopenia could be mitigated when considered together with myosteatosis. The implication from these findings is that sarcopenia should never be evaluated individually and that myosteatosis may have a dominant role in the prognosis of patients with liver cirrhosis.
    Sprache Englisch
    Erscheinungsdatum 2024-05-21
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2024.05.020
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: A Critical Evaluation on MOH Current Treatments.

    Negro, Andrea / Curto, Martina / Lionetto, Luana / Guerzoni, Simona / Pini, Luigi Alberto / Martelletti, Paolo

    Current treatment options in neurology

    2017  Band 19, Heft 9, Seite(n) 32

    Abstract: Opinion statement: Migraine is the most frequent neurological disorder observed in clinical practice characterized by moderate to severe pain attacks associated with neurological, gastrointestinal, and dysautonomic symptoms. Each year, 2.5% of patients ... ...

    Abstract Opinion statement: Migraine is the most frequent neurological disorder observed in clinical practice characterized by moderate to severe pain attacks associated with neurological, gastrointestinal, and dysautonomic symptoms. Each year, 2.5% of patients with episodic migraine develop chronic migraine (CM). CM is characterized by high frequency of the attacks that may result into chronic intake of abortive medications. Nearly, the 70% of CM patients referring to tertiary head centers show acute pain medications overuse that may lead to the development of medication overuse headache (MOH). The management of MOH requires three steps: (1) education, (2) withdrawal of the overuse drug and detoxification, and (3) re-prophylaxis. In the last years, several real-life prospective studies provided further evidence in clinical setting of the onabotulinumtoxinA 155-195 U efficacy for the headache prophylaxis in CM with MOH patients. There is a general agreement on two factors: (1) withdrawal of the overuse drug is condicio sine qua non to reverse the pattern to medium-low-frequency migraine, and (2) the focus of management needs to shift from acute treatment of pain to prevention of headache. CM patients close to developing MOH, patients with high-frequency episodic migraine, and those already abusing of drugs require special attention and should refer to tertiary headache centers. For all of them, a solution could be an "early treatment." Early should be their referral to a tertiary headache center, early should be the withdrawal of the overuse drug and a proper detoxification, and perhaps early should be the start of a preventative therapy.
    Sprache Englisch
    Erscheinungsdatum 2017-08-15
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2057342-X
    ISSN 1534-3138 ; 1092-8480
    ISSN (online) 1534-3138
    ISSN 1092-8480
    DOI 10.1007/s11940-017-0465-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Long-term Treatment Benefits and Prolonged Efficacy of OnabotulinumtoxinA in Patients Affected by Chronic Migraine and Medication Overuse Headache over 3 Years of Therapy.

    Guerzoni, Simona / Pellesi, Lanfranco / Baraldi, Carlo / Cainazzo, Michela Maria / Negro, Andrea / Martelletti, Paolo / Pini, Luigi Alberto

    Frontiers in neurology

    2017  Band 8, Seite(n) 586

    Abstract: Background: Chronic migraine (CM) affects about the 2% of the general population and it has been recognized as one of the most-disabling conditions worldwide by the World Health Organization. CM is often associated with the overuse of abortive ... ...

    Abstract Background: Chronic migraine (CM) affects about the 2% of the general population and it has been recognized as one of the most-disabling conditions worldwide by the World Health Organization. CM is often associated with the overuse of abortive medication, which determines the worsening of headache itself and the development of a secondary headache called medication overuse headache. The management of these associated conditions is difficult, but a growing amount of evidence is pointing out the effectiveness and the good safety profile of OnabotulinumtoxinA (OnabotA). Despite this, data on OnabotA effects and safety in long-term use lack. The purpose of the present article is to retrospectively assess the efficacy and safety of OnabotA in a cohort of chronic migraineurs with drug overuse from the 18th month of treatment until the third year.
    Materials and methods: 90 chronic migraineurs with medication overuse were enrolled between January 2013 and February 2017. All patients were treated with OnabotA according to PREEMPT dictates. Before every injection session the headache index, the analgesic consumption, the visual analog scale for pain score, the 36-items short form health survey questionnaire score, the 6-items headache impact test (HIT-6) score and the Zung self-rating anxiety and depression scale scores were collected. Adverse events were carefully registered. A simple linear regression was performed to explore the mean changes in the abovementioned parameters for a single injection session and mean comparison tests were performed using the one-way analysis of variance followed by Tukey-Kramer post-hoc test.
    Results: A significantly improvement for a single injection was registered for all the above-mentioned parameters. Headache index, analgesic consumption, visual analog pain scale, and 6-items HIT-6 scores were significantly lower than baseline from the 18th month of treatment onwards. The 36-items short form health survey questionnaire scores were significantly higher than baseline at every injections session from the 18th months onwards. Zung scales did not change. No serious adverse events were assessed and no adverse events-related drop-outs were seen.
    Conclusion: OnabotA effectiveness and safety last until 3 years of therapy, raising the possibility of the use of this therapy even for many years in CM prevention.
    Sprache Englisch
    Erscheinungsdatum 2017-11-03
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2017.00586
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Current and emerging evidence-based treatment options in chronic migraine: a narrative review.

    Agostoni, Elio Clemente / Barbanti, Piero / Calabresi, Paolo / Colombo, Bruno / Cortelli, Pietro / Frediani, Fabio / Geppetti, Pietrangelo / Grazzi, Licia / Leone, Massimo / Martelletti, Paolo / Pini, Luigi Alberto / Prudenzano, Maria Pia / Sarchielli, Paola / Tedeschi, Gioacchino / Russo, Antonio

    The journal of headache and pain

    2019  Band 20, Heft 1, Seite(n) 92

    Abstract: Background: Chronic migraine is a disabling condition that is currently underdiagnosed and undertreated. In this narrative review, we discuss the future of chronic migraine management in relation to recent progress in evidence-based pharmacological ... ...

    Abstract Background: Chronic migraine is a disabling condition that is currently underdiagnosed and undertreated. In this narrative review, we discuss the future of chronic migraine management in relation to recent progress in evidence-based pharmacological treatment.
    Findings: Patients with chronic migraine require prophylactic therapy to reduce the frequency of migraine attacks, but the only currently available evidence-based prophylactic treatment options for chronic migraine are topiramate and onabotulinumtoxinA. Improved prophylactic therapy is needed to reduce the high burden of chronic migraine in Italy. Monoclonal antibodies that target the calcitonin gene-related peptide (CGRP) pathway of migraine pathogenesis have been specifically developed for the prophylactic treatment of chronic migraine. These anti-CGRP/R monoclonal antibodies have demonstrated good efficacy and excellent tolerability in phase II and III clinical trials, and offer new hope to patients who are currently not taking any prophylactic therapy or not benefitting from their current treatment.
    Conclusions: Treatment of chronic migraine is a dynamic and rapidly advancing area of research. New developments in this field have the potential to improve the diagnosis and provide more individualised treatments for this condition. Establishing a culture of prevention is essential for reducing the personal, social and economic burden of chronic migraine.
    Mesh-Begriff(e) Antibodies, Monoclonal/therapeutic use ; Botulinum Toxins, Type A/therapeutic use ; Chronic Disease ; Disabled Persons ; Humans ; Migraine Disorders/drug therapy ; Migraine Disorders/prevention & control ; Randomized Controlled Trials as Topic ; Topiramate/therapeutic use
    Chemische Substanzen Antibodies, Monoclonal ; Topiramate (0H73WJJ391) ; Botulinum Toxins, Type A (EC 3.4.24.69)
    Sprache Englisch
    Erscheinungsdatum 2019-08-30
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2036768-5
    ISSN 1129-2377 ; 1129-2369
    ISSN (online) 1129-2377
    ISSN 1129-2369
    DOI 10.1186/s10194-019-1038-4
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