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  1. Artikel ; Online: Using artificial intelligence to improve COVID-19 rapid diagnostic test result interpretation.

    Mendels, David-A / Dortet, Laurent / Emeraud, Cécile / Oueslati, Saoussen / Girlich, Delphine / Ronat, Jean-Baptiste / Bernabeu, Sandrine / Bahi, Silvestre / Atkinson, Gary J H / Naas, Thierry

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Band 118, Heft 12

    Abstract: Serological rapid diagnostic tests (RDTs) are widely used across pathologies, often providing users a simple, binary result (positive or negative) in as little as 5 to 20 min. Since the beginning of the COVID-19 pandemic, new RDTs for identifying SARS- ... ...

    Abstract Serological rapid diagnostic tests (RDTs) are widely used across pathologies, often providing users a simple, binary result (positive or negative) in as little as 5 to 20 min. Since the beginning of the COVID-19 pandemic, new RDTs for identifying SARS-CoV-2 have rapidly proliferated. However, these seemingly easy-to-read tests can be highly subjective, and interpretations of the visible "bands" of color that appear (or not) in a test window may vary between users, test models, and brands. We developed and evaluated the accuracy/performance of a smartphone application (xRCovid) that uses machine learning to classify SARS-CoV-2 serological RDT results and reduce reading ambiguities. Across 11 COVID-19 RDT models, the app yielded 99.3% precision compared to reading by eye. Using the app replaces the uncertainty from visual RDT interpretation with a smaller uncertainty of the image classifier, thereby increasing confidence of clinicians and laboratory staff when using RDTs, and creating opportunities for patient self-testing.
    Mesh-Begriff(e) COVID-19/diagnosis ; COVID-19 Serological Testing ; Humans ; Machine Learning ; Mobile Applications ; SARS-CoV-2
    Sprache Englisch
    Erscheinungsdatum 2021-03-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2019893118
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Evaluating 10 Commercially Available SARS-CoV-2 Rapid Serological Tests by Use of the STARD (Standards for Reporting of Diagnostic Accuracy Studies) Method.

    Dortet, Laurent / Ronat, Jean-Baptiste / Vauloup-Fellous, Christelle / Langendorf, Céline / Mendels, David-Alexis / Emeraud, Cécile / Oueslati, Saoussen / Girlich, Delphine / Chauvin, Anthony / Afdjei, Ali / Bernabeu, Sandrine / Le Pape, Samuel / Kallala, Rim / Rochard, Alice / Verstuyft, Celine / Fortineau, Nicolas / Roque-Afonso, Anne-Marie / Naas, Thierry

    Journal of clinical microbiology

    2021  Band 59, Heft 2

    Abstract: Numerous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapid serological tests have been developed, but their accuracy has usually been assessed using very few samples, and rigorous comparisons between these tests are scarce. In this study, ...

    Abstract Numerous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rapid serological tests have been developed, but their accuracy has usually been assessed using very few samples, and rigorous comparisons between these tests are scarce. In this study, we evaluated and compared 10 commercially available SARS-CoV-2 rapid serological tests using the STARD (Standards for Reporting of Diagnostic Accuracy Studies) methodology. Two hundred fifty serum samples from 159 PCR-confirmed SARS-CoV-2 patients (collected 0 to 32 days after the onset of symptoms) were tested with rapid serological tests. Control serum samples (
    Mesh-Begriff(e) Antibodies, Viral/blood ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/pathology ; COVID-19 Serological Testing/methods ; Diagnostic Tests, Routine/methods ; Diagnostic Tests, Routine/standards ; Female ; Humans ; Immunoassay ; Immunoglobulin G/blood ; Immunoglobulin M/blood ; Male ; Middle Aged ; Practice Guidelines as Topic ; Retrospective Studies ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Sensitivity and Specificity
    Chemische Substanzen Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M
    Sprache Englisch
    Erscheinungsdatum 2021-01-21
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Evaluation Study ; Journal Article
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.02342-20
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: LAM-1 from Lysobacter antibioticus: A potent zinc-dependent activity that inactivates β-lactam antibiotics.

    Stroek, Rozanne / Wilson, Liam / Goracke, William / Kang, Taeuk / Vermue, Febe / Krco, Stefan / Mendels, Yonatan / Douw, Andrew / Morris, Marc / Knaven, Esmee G / Mitić, Nataša / Gutierrez, Maria C R / Schenk, Elaine B / Clark, Alice / Garcia, David / Monteiro Pedroso, Marcelo / Schenk, Gerhard

    Journal of inorganic biochemistry

    2021  Band 226, Seite(n) 111637

    Abstract: Resistance to β-lactam antibiotics, including the "last-resort" carbapenems, has emerged as a major threat to global health. A major resistance mechanism employed by pathogens involves the use of metallo-β-lactamases (MBLs), zinc-dependent enzymes that ... ...

    Abstract Resistance to β-lactam antibiotics, including the "last-resort" carbapenems, has emerged as a major threat to global health. A major resistance mechanism employed by pathogens involves the use of metallo-β-lactamases (MBLs), zinc-dependent enzymes that inactivate most of the β-lactam antibiotics used to treat infections. Variants of MBLs are frequently discovered in clinical environments. However, an increasing number of such enzymes have been identified in microorganisms that are less impacted by human activities. Here, an MBL from Lysobacter antibioticus, isolated from the rhizosphere, has been shown to be highly active toward numerous β-lactam antibiotics. Its activity is higher than that of some of the most effective MBLs linked to hospital-acquired antibiotic resistance and thus poses an interesting system to investigate evolutionary pressures that drive the emergence of such biocatalysts.
    Mesh-Begriff(e) Anti-Bacterial Agents/chemistry ; Lysobacter/enzymology ; Zinc/chemistry ; beta-Lactamases/chemistry ; beta-Lactams/chemistry
    Chemische Substanzen Anti-Bacterial Agents ; beta-Lactams ; beta-Lactamases (EC 3.5.2.6) ; Zinc (J41CSQ7QDS)
    Sprache Englisch
    Erscheinungsdatum 2021-10-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 162843-4
    ISSN 1873-3344 ; 0162-0134
    ISSN (online) 1873-3344
    ISSN 0162-0134
    DOI 10.1016/j.jinorgbio.2021.111637
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Evaluating ten commercially-available SARS-CoV-2 rapid serological tests using the STARD (Standards for Reporting of Diagnostic Accuracy Studies) method.

    Dortet, Laurent / Ronat, Jean-Baptiste / Vauloup-Fellous, Christelle / Langendorf, Céline / Mendels, David-Alexis / Emeraud, Cécile / Oueslati, Saoussen / Girlich, Delphine / Chauvin, Anthony / Afdjei, Ali / Bernabeu, Sandrine / Le Pape, Samuel / Kallala, Rim / Rochard, Alice / Verstuyft, Celine / Fortineau, Nicolas / Roque-Afonso, Anne-Marie / Naas, Thierry

    medRxiv

    Abstract: Numerous SARS-CoV-2 rapid serological tests have been developed, but their accuracy has usually been assessed using very few samples, and rigorous comparisons between these tests are scarce. In this study, we evaluated and compared 10 commercially- ... ...

    Abstract Numerous SARS-CoV-2 rapid serological tests have been developed, but their accuracy has usually been assessed using very few samples, and rigorous comparisons between these tests are scarce. In this study, we evaluated and compared 10 commercially-available SARS-CoV-2 rapid serological tests using the STARD methodology (Standards for Reporting of Diagnostic Accuracy Studies). 250 sera from 159 PCR-confirmed SARS-CoV-2 patients (collected from 0 to 32 days after onset of symptoms) were tested with rapid serological tests. Control sera (N=254) were retrieved from pre-COVID periods from patients with other coronavirus infections (N=11), positive rheumatoid factors (N=3), IgG/IgM hyperglobulinemia (N=9), malaria (n=5), or no documented viral infection (N=226). All samples were tested using rapid lateral flow immunoassays (LFIA) from ten manufacturers. Only four tests achieved ≥98% specificity, with other tests ranging from 75.7%-99.2%. Sensitivities varied by the day of sample collection, from 31.7%-55.4% (Days 0-9), 65.9%-92.9% (Days 10-14), and 81.0%-95.2% (>14 days) after the onset of symptoms, respectively. Only three tests evaluated met French Health Authorities9 thresholds for SARS-CoV-2 serological tests (≥90% sensitivity + ≥98% specificity). Overall, the performances between tests varied greatly, with only a third meeting acceptable specificity and sensitivity thresholds. Knowing the analytical performance of these tests will allow clinicians to use them with more confidence, could help determine the general population9s immunological status, and may diagnose some patients with false-negative RT-PCR results.
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-09-11
    Verlag Cold Spring Harbor Laboratory Press
    Dokumenttyp Artikel ; Online
    DOI 10.1101/2020.09.10.20192260
    Datenquelle COVID19

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  5. Artikel ; Online: A Study of Growth Hormone Release in Depression

    Maany, Iradj / Mendels, Joseph / Frazer, Alan / Brunswick, David

    Neuropsychobiology - International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography

    1979  Band 5, Heft 5, Seite(n) 282–289

    Abstract: Interest in biogenic amine function in affective disorders has stimulated a variety of research strategies including the measurement of hormonal response to a variety of stimuli as an indirect method of investigating the integrity of aminergic function ... ...

    Abstract Interest in biogenic amine function in affective disorders has stimulated a variety of research strategies including the measurement of hormonal response to a variety of stimuli as an indirect method of investigating the integrity of aminergic function in clinically depressed patients. Apomorphine and levodopa are known to stimulate growth hormone release via a dopaminergic pathway in median eminence. Administration of these agents to groups of depressed patients and age, sex-matched normal control subjects did not indicate any significant abnormality in this dopaminergic system.
    Schlagwörter Human growth hormone ; Depression ; Apomorphine ; Levodopa ; Neuroendocrine studies
    Sprache Englisch
    Verlag S. Karger AG
    Erscheinungsort Basel
    Erscheinungsland Switzerland
    Dokumenttyp Artikel ; Online
    ZDB-ID 442239-9
    ISSN 1423-0224 ; 0302-282X ; 0302-282X
    ISSN (online) 1423-0224
    ISSN 0302-282X
    DOI 10.1159/000117691
    Datenquelle Karger Verlag

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  6. Artikel ; Online: Efficacy and Safety of Fezolamine in Depressed Patients

    Zisook, Sidney / Mendels, Joseph / Janowsky, David / Feighner, John / Lee, John C.M. / Fritz, Alan

    Neuropsychobiology - International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography

    1987  Band 17, Heft 3, Seite(n) 133–138

    Abstract: Forty-two outpatients with major depressive disorder were treated with oral fezolamine in a 6-week, three-center open-label study. Therapy was initated at 100 mg/day; thereafter dosage was increased based on the response of the patient. Maintenance ... ...

    Abstract Forty-two outpatients with major depressive disorder were treated with oral fezolamine in a 6-week, three-center open-label study. Therapy was initated at 100 mg/day; thereafter dosage was increased based on the response of the patient. Maintenance dosage usually ranged between 100 and 450 mg/day. Clinically significant improvement relative to the patient’s prestudy state was observed after 2 weeks in both patient and physician-rating scales. Fifty-five percent of patients improved their Hamilton Psychiatric Rating Scale for Depression (HAM-D) scores by more than 50%. The median dose associated with a clinically significant response was 245 mg/day. Five of the 6 patients who dropped out did so because of gastrointestinal adverse effects. The most common adverse effects were nausea (36%), headache (29%), constipation (26%), and dry mouth (24%).
    Schlagwörter Antidepressant medication ; Efficacy ; Fezolamine ; Depressive disorder, major ; Side effects
    Sprache Englisch
    Verlag S. Karger AG
    Erscheinungsort Basel
    Erscheinungsland Switzerland
    Dokumenttyp Artikel ; Online
    ZDB-ID 442239-9
    ISSN 1423-0224 ; 0302-282X ; 0302-282X
    ISSN (online) 1423-0224
    ISSN 0302-282X
    DOI 10.1159/000118353
    Datenquelle Karger Verlag

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  7. Artikel ; Online: Red Blood Cell Li to Plasma Li+ Ratios

    Brunswick, David J. / Frazer, Alan / Mendels, Joe / Ramsey, Alan

    Neuropsychobiology - International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography

    Are They Related to Plasma Li Concentrations?

    1978  Band 4, Heft 2, Seite(n) 121–127

    Abstract: The relationship between the lithium ratio (ratio of lithium in blood cells to that in plasma) and plasma lithium concentration was examined in a group of male inpatients taking lithium carbonate for affective disorders. The lithium ratio was found to ... ...

    Abstract The relationship between the lithium ratio (ratio of lithium in blood cells to that in plasma) and plasma lithium concentration was examined in a group of male inpatients taking lithium carbonate for affective disorders. The lithium ratio was found to increase in the majority of these patients as plasma lithium concentration increased. However, the magnitude of variation of the lithium ratio with plasma lithium concentration observed in these patients is not sufficient to seriously affect the value of determining the lithium ratio in the clinical situation.
    Schlagwörter Plasma lithium ; Lithium ratio ; Compliance
    Sprache Englisch
    Verlag S. Karger AG
    Erscheinungsort Basel
    Erscheinungsland Switzerland
    Dokumenttyp Artikel ; Online
    ZDB-ID 442239-9
    ISSN 1423-0224 ; 0302-282X ; 0302-282X
    ISSN (online) 1423-0224
    ISSN 0302-282X
    DOI 10.1159/000117626
    Datenquelle Karger Verlag

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