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  1. Article ; Online: Conservative management of bilateral persistent pupillary membranes with 18 years of follow-up.

    Meyer-Rüsenberg, Birthe / Thill, Michelle / Vujancevic, Snjezana / Meyer-Rüsenberg, Hans-Werner

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2010  Volume 248, Issue 7, Page(s) 1053–1054

    MeSH term(s) Adolescent ; Astigmatism/etiology ; Astigmatism/therapy ; Female ; Follow-Up Studies ; Humans ; Infant ; Pupil Disorders/complications ; Strabismus/etiology ; Strabismus/therapy ; Treatment Outcome ; Visual Acuity
    Language English
    Publishing date 2010-02-25
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-010-1318-9
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Endothelial progenitor cells and plasma vascular endothelial growth factor and stromal cell-derived factor-1 during ranibizumab treatment for neovascular age-related macular degeneration.

    Grierson, Rebecca / Meyer-Rüsenberg, Birthe / Kunst, Frank / Berna, Marc J / Richard, Gisbert / Thill, Michelle

    Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics

    2013  Volume 29, Issue 6, Page(s) 530–538

    Abstract: Purpose: To evaluate endothelial progenitor cell [late outgrowth endothelial progenitor cells (OECs)], vascular endothelial growth factor (VEGF), and stromal cell-derived factor 1α (SDF-1α) plasma levels as potential biomarkers before and during ... ...

    Abstract Purpose: To evaluate endothelial progenitor cell [late outgrowth endothelial progenitor cells (OECs)], vascular endothelial growth factor (VEGF), and stromal cell-derived factor 1α (SDF-1α) plasma levels as potential biomarkers before and during ranibizumab (Lucentis(®)) treatment for neovascular age-related macular degeneration (nvAMD).
    Methods: Thirty-one patients with untreated nvAMD presenting for 3 consecutive intravitreal ranibizumab injections and a follow-up visit at 4 weeks intervals were enrolled. Peripheral blood was collected before each injection and at the follow-up visit and OEC clusters were cultured and evaluated according to previously published protocols. VEGF and SDF-1α plasma levels were measured by enzyme-linked immunosorbent assay and compared to values from healthy young and old control.
    Results: Patients with a high OEC count before treatment presented significantly more often with a short symptom duration and a smaller choroidal neovascularization size. VEGF plasma levels were significantly higher in nvAMD (282.4±195.2 pg/mL) compared to young (45.5±6.8 pg/mL) and old control (46.1±8.5 pg/mL). OEC levels decreased nonsignificantly during ranibizumab treatment, returning to baseline levels after the third injection. VEGF and SDF-1α plasma levels decreased significantly during treatment toward control values. Patients needing retreatment after 3 ranibizumab injections had significantly higher VEGF plasma levels at pretreatment compared to patients not needing further treatment.
    Conclusions: The results presented here suggest that VEGF plasma levels may warrant further evaluation regarding biological, therapeutical, and predictive implications in nvAMD.
    MeSH term(s) Aged ; Aged, 80 and over ; Angiogenesis Inhibitors/administration & dosage ; Angiogenesis Inhibitors/adverse effects ; Angiogenesis Inhibitors/therapeutic use ; Antibodies, Monoclonal, Humanized/administration & dosage ; Antibodies, Monoclonal, Humanized/adverse effects ; Antibodies, Monoclonal, Humanized/therapeutic use ; Biomarkers/blood ; Cell Count ; Chemokine CXCL12/blood ; Choroidal Neovascularization/blood ; Choroidal Neovascularization/complications ; Choroidal Neovascularization/drug therapy ; Drug Administration Schedule ; Endothelial Cells/drug effects ; Endothelial Cells/pathology ; Endothelium, Vascular/drug effects ; Endothelium, Vascular/pathology ; Female ; Humans ; Intravitreal Injections ; Macular Degeneration/blood ; Macular Degeneration/drug therapy ; Macular Degeneration/etiology ; Male ; Ranibizumab ; Treatment Outcome ; Vascular Endothelial Growth Factor A/blood
    Chemical Substances Angiogenesis Inhibitors ; Antibodies, Monoclonal, Humanized ; Biomarkers ; Chemokine CXCL12 ; Vascular Endothelial Growth Factor A ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2013-07
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1237021-6
    ISSN 1557-7732 ; 1080-7683
    ISSN (online) 1557-7732
    ISSN 1080-7683
    DOI 10.1089/jop.2012.0013
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  3. Article ; Online: Epidemic keratoconjunctivitis: the current situation and recommendations for prevention and treatment.

    Meyer-Rüsenberg, Birthe / Loderstädt, Ulrike / Richard, Gisbert / Kaulfers, Paul-Michael / Gesser, Caroline

    Deutsches Arzteblatt international

    2011  Volume 108, Issue 27, Page(s) 475–480

    Abstract: Background: Epidemic keratoconjunctivitis (EKC) is a highly contagious infection of the ocular surface. 316 cases were diagnosed in Germany in the first 8 months of 2010, corresponding to a 300% increase above the typical figures for recent years. This ... ...

    Abstract Background: Epidemic keratoconjunctivitis (EKC) is a highly contagious infection of the ocular surface. 316 cases were diagnosed in Germany in the first 8 months of 2010, corresponding to a 300% increase above the typical figures for recent years. This outbreak motivates us to present the current recommendations concerning EKC.
    Methods: Selective literature review.
    Results: EKC is an adenoviral infection that typically starts with a unilateral foreign body sensation and then develops, within a few hours or days, into bilateral keratoconjunctivitis with marked chemosis, epiphora, and photophobia. Visual impairment can persist for months because of subepithelial corneal infiltrates (nummuli) and irregular astigmatism. Randomized clinical trials have not shown any clear benefit in the acute phase from any of a variety of treatments, including steroids, calcineurin inhibitors, virostatic drugs and disinfecting agents. In the chronic phase, cyclosporin A eye drops can accelerate the regression of subepithelial infiltrates. Hygienic measures, including conscientious hand and surface disinfection, can lessen the spread of the disease.
    Conclusion: The first priority in the treatment of patients with definite or suspected EKC is the rigorous application of hygienic measures in medical facilities, particularly because there is still no effective drug treatment for this disease. No virostatic agent has yet been demonstrated to influence its course, either subjectively or objectively.
    MeSH term(s) Adenovirus Infections, Human/drug therapy ; Adenovirus Infections, Human/epidemiology ; Adenovirus Infections, Human/prevention & control ; Adenovirus Infections, Human/transmission ; Chronic Disease ; Cross-Sectional Studies ; Cyclosporine/administration & dosage ; Disease Notification ; Disinfection ; Epidemics/prevention & control ; Germany ; Hand Disinfection ; Humans ; Immunosuppressive Agents/administration & dosage ; Incidence ; Keratoconjunctivitis/drug therapy ; Keratoconjunctivitis/epidemiology ; Keratoconjunctivitis/prevention & control ; Ophthalmic Solutions ; Randomized Controlled Trials as Topic
    Chemical Substances Immunosuppressive Agents ; Ophthalmic Solutions ; Cyclosporine (83HN0GTJ6D)
    Language English
    Publishing date 2011-07-08
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 2406159-1
    ISSN 1866-0452 ; 1866-0452
    ISSN (online) 1866-0452
    ISSN 1866-0452
    DOI 10.3238/arztebl.2011.0475
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  4. Article: Pathological changes in human retinal ganglion cells associated with diabetic and hypertensive retinopathy.

    Meyer-Rüsenberg, Birthe / Pavlidis, Mitrofanis / Stupp, Tobias / Thanos, Solon

    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

    2006  Volume 245, Issue 7, Page(s) 1009–1018

    Abstract: Background: To examine whether systemic diseases like diabetes and arterial hypertension, which frequently cause retinopathies leading to blindness effect the morphology of retinal ganglion cells (RGC).: Methods: Histological retina material with a ... ...

    Abstract Background: To examine whether systemic diseases like diabetes and arterial hypertension, which frequently cause retinopathies leading to blindness effect the morphology of retinal ganglion cells (RGC).
    Methods: Histological retina material with a history of being untreated, or laser-coagulated (LC) diabetic retinopathy (DR), or arterial hypertensive retinopathy (AHR) was used. The RGC were labeled by introducing crystals of the fluorescent carbocyanine dye DiI into the nerve fiber layer, which contains ganglion cell axons.
    Results: The typical silhouettes of both major types of RGC, parasol and midget cells, were identified. The axons in DR and AHR retinas showed morphology changes such as irregular swelling and beading. Dendritic field sizes were significantly reduced in RGC of both the hypertonic and diabetic retinas. A significant reduction in branching frequency was evident in both the diabetic and hypertonic retinas, in both the midget and the parasol cells. In LC retinas, both parasol and midget RGC were observed within the LC spots, although their numbers were dramatically decreased compared with normal retinas.
    Conclusions: The data suggest that diabetes and arterial hypertonia have similar effects on the morphology of RGC, in addition to causing microvascular alterations and bleeding. Therefore, therapeutic measures and prognostic outcomes in diabetic and hypertensive retinopathy should also consider regressive changes in retinal neurons.
    MeSH term(s) Adult ; Aged ; Axons/pathology ; Carbocyanines ; Diabetic Retinopathy/complications ; Diabetic Retinopathy/surgery ; Fluorescent Dyes ; Humans ; Hypertension/complications ; Laser Coagulation ; Microscopy, Fluorescence ; Middle Aged ; Nerve Fibers/pathology ; Retinal Diseases/etiology ; Retinal Ganglion Cells/pathology
    Chemical Substances 3,3'-dihexadecylindocarbocyanine ; Carbocyanines ; Fluorescent Dyes
    Language English
    Publishing date 2006-12-21
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8435-9
    ISSN 1435-702X ; 0721-832X
    ISSN (online) 1435-702X
    ISSN 0721-832X
    DOI 10.1007/s00417-006-0489-x
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  5. Article: Übersichtsarbeit. Keratokonjunktivitis epidemica. Infektionslage und aktuelle Hinweise zu Prophylaxe und Therapie. Epidemie Keratoconjunctivitis - The Current Situation and Recommendations for Prevention and Treatment

    Meyer-Rüsenberg, Birthe / Loderstädt, Ulrike / Richard, Gisbert / Kaulfers, Paul-Michael / Gesser, Caroline

    Deutsches Ärzteblatt : Ausgabe A, Praxis-Ausgabe : niedergelassene Ärzte

    2011  Volume 108, Issue 27, Page(s) 475

    Language German
    Document type Article
    ZDB-ID 1453475-7
    ISSN 0012-1207
    Database Current Contents Medicine

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  6. Conference proceedings: Systemische VEGF-Werte vor und während intravitrealer Ranibizumab (Lucentis®)-Therapie

    Meyer-Rüsenberg, Birthe / Kunst, F. / Grierson, R. / Richard, G. / Berna-Thill, M.

    2010  , Page(s) 10rg20

    Title translation Systemic VEGF levels before and during intravitreal Ranibizumab (Lucentis®) treatment
    Event/congress 23rd Annual Conference of the German Retina Society; Freiburg i. Br.; ; German Retina Society; 2010
    Keywords Medizin, Gesundheit
    Publishing date 2010-09-21
    Publisher German Medical Science GMS Publishing House; Düsseldorf
    Document type Conference proceedings
    DOI 10.3205/10rg20
    Database German Medical Science

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