Artikel ; Online: Mevalonate pathway, selenoproteins, redox balance, immune system, Covid-19: Reasoning about connections.
2020 Band 144, Seite(n) 110128
Abstract: It has been proposed that a degraded immune system is (one of) the condition(s) that predispose certain subjects to fatal consequences from infection by SARS-CoV-2. It is unknown whether therapeutic regimens to which these patients may have been ... ...
| Abstract | It has been proposed that a degraded immune system is (one of) the condition(s) that predispose certain subjects to fatal consequences from infection by SARS-CoV-2. It is unknown whether therapeutic regimens to which these patients may have been subjected to in the months/years preceding the infection could be immunocompromising. Statins are among the most widely prescribed cholesterol-lowering drugs. As competitive inhibitors of HMG-CoA-reductase, the key enzyme of the "mevalonate pathway" through which essential compounds, not only cholesterol, are synthesized, statins decrease the levels of cholesterol, and thus LDLs, as an innate defense mechanism, with controversial results in decreasing mortality from cardiovascular disease. Moreover, statins have pleiotropic, mostly deleterious effects on many cell types, including immune cells. In the attempt to decipher the enigma of SARS-CoV-2 infectivology, the hypothesis should be tested whether the population of subjects who succumbed to Covid-19 may have developed a compromised immunity at sub-clinical levels and have become more susceptible to fatal consequences from SARS-Cov-2 infection due to statin therapy. |
|---|---|
| Mesh-Begriff(e) | COVID-19/immunology ; Cholesterol/metabolism ; Cholesterol, LDL/metabolism ; Enzyme Inhibitors/pharmacology ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Immune System ; Immunity, Innate ; Inflammation ; Lipoproteins, LDL/metabolism ; Mevalonic Acid/chemistry ; Models, Theoretical ; Oxidation-Reduction ; Oxidative Stress ; Selenoproteins/chemistry ; COVID-19 Drug Treatment |
| Chemische Substanzen | Cholesterol, LDL ; Enzyme Inhibitors ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Lipoproteins, LDL ; Selenoproteins ; Cholesterol (97C5T2UQ7J) ; Mevalonic Acid (S5UOB36OCZ) |
| Schlagwörter | covid19 |
| Sprache | Englisch |
| Erscheinungsdatum | 2020-07-21 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article |
| ZDB-ID | 193145-3 |
| ISSN | 1532-2777 ; 0306-9877 |
| ISSN (online) | 1532-2777 |
| ISSN | 0306-9877 |
| DOI | 10.1016/j.mehy.2020.110128 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
| Zs.A 1132: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.