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  1. Artikel ; Online: Refractory Stage M Ganglioneuroblastoma With Bone Metastases and a Favorable, Chronic Course of Disease: Description of a Patient Cohort.

    Tas, Michelle L / Molenaar, Jan J / Peek, Annemarie M L / Lequin, Maarten H / Verdijk, Rob M / de Krijger, Ronald R / Tytgat, Godelieve A M / van Noesel, Max M

    Journal of pediatric hematology/oncology

    2021  Band 44, Heft 1, Seite(n) e5–e13

    Abstract: Refractory stage M neuroblastoma (NB) is associated with a poor prognosis and a progressive course ... who were diagnosed with stage M disease based on iodine-123-metaiodobenzylguanidine avid bone metastases ... a small minority of stage M patients. This GNB entity illustrates the clinical heterogeneity ...

    Abstract Refractory stage M neuroblastoma (NB) is associated with a poor prognosis and a progressive course of disease. Here, we describe a unique group of patients with a discrepant clinical course. Seven histologically confirmed ganglioneuroblastoma (GNB) (n=6) and differentiating NB (n=1) patients were identified who were diagnosed with stage M disease based on iodine-123-metaiodobenzylguanidine avid bone metastases. Six patients started on high-risk treatment, without tumor response (stable disease). Treatment was discontinued before the start of consolidation treatment because of refractory response in all patients. Unexpectedly, after cessation of treatment no progression of disease occurred. In 2 patients, the primary tumors expanded (>25%) very slowly during 1.5 and 3 years, and remained stable thereafter. Metabolically, a slow decrease of urinary homovanillic acid and vanillylmandelic acid levels and iodine-123-metaiodobenzylguanidine avidity was observed. All patients are alive with presence of metastatic disease after a median follow-up of 17 years (range: 6.7 to 27 y). Interestingly, at diagnosis, 6 patients were asymptomatic, 6 patients had GNB morphology, and 5 patients had meningeal metastases. These are all features seen in only a small minority of stage M patients. This GNB entity illustrates the clinical heterogeneity of neuroblastic tumors and can be used to further study the developmental origin of different NB subtypes.
    Mesh-Begriff(e) Bone Neoplasms/drug therapy ; Bone Neoplasms/secondary ; Bone Neoplasms/urine ; Child, Preschool ; Chronic Disease ; Consolidation Chemotherapy ; Female ; Ganglioneuroblastoma/drug therapy ; Ganglioneuroblastoma/urine ; Humans ; Infant ; Male ; Neoplasm Metastasis ; Neoplasm Staging ; Retrospective Studies
    Sprache Englisch
    Erscheinungsdatum 2021-04-17
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000002067
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Reply to A. Piccardo et al, E. Hindié et al, M.C. Kreissl et al, M. Doss, J. Buscombe, R. Fisher, M. Sollini et al, M. Lichtenstein, and M. Tulchinsky et al.

    Molenaar, Remco J / Sidana, Surbhi / Radivoyevitch, Tomas / Gerds, Aaron T / Carraway, Hetty E / Kalaycio, Matt / Nazha, Aziz / Adelstein, David J / Nasr, Christian / Maciejewski, Jaroslaw P / Majhail, Navneed S / Sekeres, Mikkael A / Mukherjee, Sudipto

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2018  Band 36, Heft 18, Seite(n) 1889–1892

    Mesh-Begriff(e) Adenocarcinoma ; Hematologic Neoplasms ; Humans ; Iodine Radioisotopes ; Thyroid Neoplasms
    Chemische Substanzen Iodine Radioisotopes
    Sprache Englisch
    Erscheinungsdatum 2018-05-03
    Erscheinungsland United States
    Dokumenttyp Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.2018.78.4074
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Subgrouping with Chain Graphical VAR Models.

    Park, Jonathan J / Chow, Sy-Miin / Epskamp, Sacha / Molenaar, Peter C M

    Multivariate behavioral research

    2024  , Seite(n) 1–23

    Abstract: Recent years have seen the emergence of an "idio-thetic" class of methods to bridge the gap between nomothetic and idiographic inference. These methods describe nomothetic trends in idiographic processes by pooling intraindividual information across ... ...

    Abstract Recent years have seen the emergence of an "idio-thetic" class of methods to bridge the gap between nomothetic and idiographic inference. These methods describe nomothetic trends in idiographic processes by pooling intraindividual information across individuals to inform group-level inference or vice versa. The current work introduces a novel "idio-thetic" model: the subgrouped chain graphical vector autoregression (scGVAR). The scGVAR is unique in its ability to identify subgroups of individuals who share common dynamic network structures in both lag(1) and contemporaneous effects. Results from Monte Carlo simulations indicate that the scGVAR shows promise over similar approaches when clusters of individuals differ in their contemporaneous dynamics and in showing increased sensitivity in detecting nuanced group differences while keeping Type-I error rates low. In contrast, a competing approach-the Alternating Least Squares VAR (ALS VAR) performs well when groups were separated by larger distances. Further considerations are provided regarding applications of the ALS VAR and scGVAR on real data and the strengths and limitations of both methods.
    Sprache Englisch
    Erscheinungsdatum 2024-02-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1532-7906
    ISSN (online) 1532-7906
    DOI 10.1080/00273171.2023.2289058
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Management of Lithium Dosing Around Delivery: An Observational Study.

    Molenaar, Nina M / Poels, Eline M P / Robakis, Thalia / Wesseloo, Richard / Bergink, Veerle

    Focus (American Psychiatric Publishing)

    2024  Band 22, Heft 1, Seite(n) 120–125

    Abstract: Objectives: Recommendations on lithium dosing around delivery vary, with several guidelines suggesting that lithium should be discontinued prior to delivery. We aimed to evaluate the validity of these recommendations by investigating 1) maternal lithium ...

    Abstract Objectives: Recommendations on lithium dosing around delivery vary, with several guidelines suggesting that lithium should be discontinued prior to delivery. We aimed to evaluate the validity of these recommendations by investigating 1) maternal lithium blood level changes following delivery, and 2) the association between neonatal lithium blood levels at delivery and neonatal outcomes.
    Methods: In this retrospective observational cohort study, we included women with at least one lithium blood level measurement during the final week of pregnancy and the first postpartum week. For aim 2, we included a subcohort of women with neonates for whom neonatal lithium blood levels (obtained from the umbilical cord or a neonatal vein puncture within 24 hours of delivery) were available.
    Results: There were a total of 233 maternal lithium blood level measurements; 55 (23.6%) in the week before delivery and 178 (76.4%) in the week after. There was no association between time and lithium blood level/dose ratio (Pearson correlation coefficient -0.03,
    Conclusion: Based on our findings, we do not recommend lowering the dosage or discontinuation of lithium prior to delivery. Stable dosing can prevent subtherapeutic lithium serum levels, which is especially important in the postpartum period when relapse risks are highest.Appeared originally in
    Sprache Englisch
    Erscheinungsdatum 2024-01-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1541-4094
    ISSN 1541-4094
    DOI 10.1176/appi.focus.23021031
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: On Subgrouping Continuous Processes in Discrete Time.

    Park, Jonathan J / Fisher, Zachary / Chow, Sy-Miin / Molenaar, Peter C M

    Multivariate behavioral research

    2023  Band 58, Heft 1, Seite(n) 154–155

    Sprache Englisch
    Erscheinungsdatum 2023-02-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1532-7906
    ISSN (online) 1532-7906
    DOI 10.1080/00273171.2022.2160957
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Research Note: Comparing methods to assess Valgus-Varus deformity in broiler chickens.

    van den Brand, H / Molenaar, R / Klaasen, M

    Poultry science

    2022  Band 101, Heft 7, Seite(n) 101907

    Abstract: Valgus-varus deformity (VVD) is one of the leg disorders affecting health and welfare of broiler chickens. In research, several protocols are used to determine the prevalence and/or severity of VVD. This study aimed to investigate effects of five ... ...

    Abstract Valgus-varus deformity (VVD) is one of the leg disorders affecting health and welfare of broiler chickens. In research, several protocols are used to determine the prevalence and/or severity of VVD. This study aimed to investigate effects of five different protocols on the angulation of the tibiotarsal-tarsometatarsal joint. Angulation was determined (1) in living chickens with fixation at the femorotibiotarsal joint; (2) in dead chickens without fixation; (3) in dead chickens with fixation; (4) in dissected legs, including muscles, but without skin; (5) in dissected legs, without muscles, but with intact joints. Fixation of the leg at the femorotibiotarsal joint largely reduced the angulation of the tibiotarsal-tarsometatarsal joint. When fixation was used, no differences in angulation were found when broilers were live, dead or legs were dissected, but when no fixation was used, angulation was considerably higher, due to a large lateral deviation of the leg. It can be concluded that in intact chickens, fixation of the femorotibiotarsal joint is essential to determine VVD angulation in an appropriate way.
    Mesh-Begriff(e) Animals ; Chickens/abnormalities ; Joints/abnormalities ; Joints/pathology ; Lower Extremity/anatomy & histology ; Lower Extremity Deformities, Congenital/pathology ; Lower Extremity Deformities, Congenital/veterinary
    Sprache Englisch
    Erscheinungsdatum 2022-04-06
    Erscheinungsland England
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 242586-5
    ISSN 1525-3171 ; 0032-5791
    ISSN (online) 1525-3171
    ISSN 0032-5791
    DOI 10.1016/j.psj.2022.101907
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: SETD2: from chromatin modifier to multipronged regulator of the genome and beyond

    Molenaar, Thom M. / van Leeuwen, Fred

    Cellular and molecular life sciences. 2022 June, v. 79, no. 6

    2022  

    Abstract: Histone modifying enzymes play critical roles in many key cellular processes and are appealing proteins for targeting by small molecules in disease. However, while the functions of histone modifying enzymes are often linked to epigenetic regulation of ... ...

    Abstract Histone modifying enzymes play critical roles in many key cellular processes and are appealing proteins for targeting by small molecules in disease. However, while the functions of histone modifying enzymes are often linked to epigenetic regulation of the genome, an emerging theme is that these enzymes often also act by non-catalytic and/or non-epigenetic mechanisms. SETD2 (Set2 in yeast) is best known for associating with the transcription machinery and methylating histone H3 on lysine 36 (H3K36) during transcription. This well-characterized molecular function of SETD2 plays a role in fine-tuning transcription, maintaining chromatin integrity, and mRNA processing. Here we give an overview of the various molecular functions and mechanisms of regulation of H3K36 methylation by Set2/SETD2. These fundamental insights are important to understand SETD2’s role in disease, most notably in cancer in which SETD2 is frequently inactivated. SETD2 also methylates non-histone substrates such as α-tubulin which may promote genome stability and contribute to the tumor-suppressor function of SETD2. Thus, to understand its role in disease, it is important to understand and dissect the multiple roles of SETD2 within the cell. In this review we discuss how histone methylation by Set2/SETD2 has led the way in connecting histone modifications in active regions of the genome to chromatin functions and how SETD2 is leading the way to showing that we also have to look beyond histones to truly understand the physiological role of an ‘epigenetic’ writer enzyme in normal cells and in disease.
    Schlagwörter chromatin ; enzymes ; epigenetics ; genome ; histones ; lysine ; methylation ; yeasts
    Sprache Englisch
    Erscheinungsverlauf 2022-06
    Umfang p. 346.
    Erscheinungsort Springer International Publishing
    Dokumenttyp Artikel
    Anmerkung Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04352-9
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Artikel: Galgangatresie en de operatie volgens Kasai: ervaringen gedurende de periode 1972 t.m. 1981.

    Houwen, R H / Molenaar, J C / Sinaasappel, M

    Nederlands tijdschrift voor geneeskunde

    1983  Band 127, Heft 35, Seite(n) 1565–1568

    Titelübersetzung Biliary atresia and Kasai's operation: experiences during the period 1972 through 1981.
    Mesh-Begriff(e) Bile Ducts/abnormalities ; Bile Ducts/surgery ; Child ; Child, Preschool ; Female ; Hepatic Duct, Common/surgery ; Humans ; Infant ; Jejunum/surgery ; Male ; Methods ; Prognosis ; Retrospective Studies
    Sprache Niederländisch
    Erscheinungsdatum 1983-08-27
    Erscheinungsland Netherlands
    Dokumenttyp English Abstract ; Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: SETD2: from chromatin modifier to multipronged regulator of the genome and beyond.

    Molenaar, Thom M / van Leeuwen, Fred

    Cellular and molecular life sciences : CMLS

    2022  Band 79, Heft 6, Seite(n) 346

    Abstract: Histone modifying enzymes play critical roles in many key cellular processes and are appealing proteins for targeting by small molecules in disease. However, while the functions of histone modifying enzymes are often linked to epigenetic regulation of ... ...

    Abstract Histone modifying enzymes play critical roles in many key cellular processes and are appealing proteins for targeting by small molecules in disease. However, while the functions of histone modifying enzymes are often linked to epigenetic regulation of the genome, an emerging theme is that these enzymes often also act by non-catalytic and/or non-epigenetic mechanisms. SETD2 (Set2 in yeast) is best known for associating with the transcription machinery and methylating histone H3 on lysine 36 (H3K36) during transcription. This well-characterized molecular function of SETD2 plays a role in fine-tuning transcription, maintaining chromatin integrity, and mRNA processing. Here we give an overview of the various molecular functions and mechanisms of regulation of H3K36 methylation by Set2/SETD2. These fundamental insights are important to understand SETD2's role in disease, most notably in cancer in which SETD2 is frequently inactivated. SETD2 also methylates non-histone substrates such as α-tubulin which may promote genome stability and contribute to the tumor-suppressor function of SETD2. Thus, to understand its role in disease, it is important to understand and dissect the multiple roles of SETD2 within the cell. In this review we discuss how histone methylation by Set2/SETD2 has led the way in connecting histone modifications in active regions of the genome to chromatin functions and how SETD2 is leading the way to showing that we also have to look beyond histones to truly understand the physiological role of an 'epigenetic' writer enzyme in normal cells and in disease.
    Mesh-Begriff(e) Chromatin/genetics ; Chromatin/metabolism ; Epigenesis, Genetic ; Histones/genetics ; Histones/metabolism ; Methylation ; Protein Processing, Post-Translational/genetics ; Saccharomyces cerevisiae/metabolism
    Chemische Substanzen Chromatin ; Histones
    Sprache Englisch
    Erscheinungsdatum 2022-06-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04352-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Granger Causality Testing with Intensive Longitudinal Data.

    Molenaar, Peter C M

    Prevention science : the official journal of the Society for Prevention Research

    2018  Band 20, Heft 3, Seite(n) 442–451

    Abstract: The availability of intensive longitudinal data obtained by means of ambulatory assessment opens up new prospects for prevention research in that it allows the derivation of subject-specific dynamic networks of interacting variables by means of vector ... ...

    Abstract The availability of intensive longitudinal data obtained by means of ambulatory assessment opens up new prospects for prevention research in that it allows the derivation of subject-specific dynamic networks of interacting variables by means of vector autoregressive (VAR) modeling. The dynamic networks thus obtained can be subjected to Granger causality testing in order to identify causal relations among the observed time-dependent variables. VARs have two equivalent representations: standard and structural. Results obtained with Granger causality testing depend upon which representation is chosen, yet no criteria exist on which this important choice can be based. A new equivalent representation is introduced called hybrid VARs with which the best representation can be chosen in a data-driven way. Partial directed coherence, a frequency-domain statistic for Granger causality testing, is shown to perform optimally when based on hybrid VARs. An application to real data is provided.
    Mesh-Begriff(e) Causality ; Longitudinal Studies ; Models, Theoretical
    Sprache Englisch
    Erscheinungsdatum 2018-05-30
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2251270-6
    ISSN 1573-6695 ; 1389-4986
    ISSN (online) 1573-6695
    ISSN 1389-4986
    DOI 10.1007/s11121-018-0919-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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