Artikel ; Online: Thirst and drugs: A study in the World Health Organization's pharmacovigilance database.
British journal of clinical pharmacology
2024 Band 90, Heft 6, Seite(n) 1525–1528
Abstract: Thirst is a complex physiological compensatory mechanism but could also be associated with drugs. This association was poorly investigated previously. Using the WHO global pharmacovigilance database, Vigibase®, disproportionality analyses potential ... ...
| Abstract | Thirst is a complex physiological compensatory mechanism but could also be associated with drugs. This association was poorly investigated previously. Using the WHO global pharmacovigilance database, Vigibase®, disproportionality analyses potential associations between exposure to drugs and thirst reports were performed. All reports of thirst in adults between 01/01/2000 and 31/12/2023 were included. Results are expressed as reporting odds ratio (ROR). Analysis of the 3186 reports of thirst (978 'serious') allowed, first, to confirm the association between thirst and exposure to vasopressin antagonists (tolvaptan), lithium, gliflozins (dapagliflozin, empagliflozin), pregabalin and antimuscarinic drugs (glycopyronium, oxybutynin, tiotropium). Second, new safety signals were described with monoamine reuptake inhibitors (antidepressants: duloxetine, venlafaxine; anti-obesity agent: sibutramine), antipsychotic (olanzapine), glucocorticoid (prednisolone), diuretic (furosemide) drugs as well with ribavirin or sodium oxybate. This study is the first to offer a list of drugs associated with thirst in humans. |
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| Mesh-Begriff(e) | Humans ; Pharmacovigilance ; Databases, Factual/statistics & numerical data ; Adverse Drug Reaction Reporting Systems/statistics & numerical data ; Thirst/drug effects ; Male ; World Health Organization ; Female ; Adult ; Drug-Related Side Effects and Adverse Reactions/epidemiology ; Middle Aged ; Aged ; Young Adult |
| Sprache | Englisch |
| Erscheinungsdatum | 2024-04-16 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article |
| ZDB-ID | 188974-6 |
| ISSN | 1365-2125 ; 0306-5251 ; 0264-3774 |
| ISSN (online) | 1365-2125 |
| ISSN | 0306-5251 ; 0264-3774 |
| DOI | 10.1111/bcp.16080 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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