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Buch ; Online: Nicholas of Cusa and the Kairos of Modernity: Cassirer, Gadamer, Blumenberg

Edward Moore, Michael

2013

Abstract: In this far-reaching essay, historian Michael Edward Moore examines modernity as an historical ... of the fifteenth-century master Nicholas of Cusa. Was Cusanus the last great medieval thinker, his ideas a summa ... to modern thought? Nicholas of Cusa lived during a time of historical and existential crisis, or kairos ...

Abstract	In this far-reaching essay, historian Michael Edward Moore examines modernity as an historical epoch following the end of the medieval period - and as a "messianic concept of time." In the early twentieth century, a debate over the meaning and origins of modernity unfolded among the philosophers Ernst Cassirer, Hans-Georg Gadamer and Hans Blumenberg. These thinkers tried to resolve the puzzle of the fifteenth-century master Nicholas of Cusa. Was Cusanus the last great medieval thinker, his ideas a summa of medieval tradition? Or was he a mysterious epochal figure, seated at one end of the bridge leading to modern thought? Nicholas of Cusa lived during a time of historical and existential crisis, or kairos, when medieval governments and cherished sources of unity were shaken. Likewise, the debate over his significance took place during a later phase of crisis for Europe, in the decades before and after the Second World War, when the collapse of European civilization was witnessed. Moore argues that modernity, so intently examined as an historical and spiritual problem, has significance for our contemporary sense of crisis
Schlagwörter	Philosophy (General)
Umfang	1 electronic resource (114 p.)
Verlag	punctum books
Erscheinungsort	Verlagsort nicht ermittelbar
Dokumenttyp	Buch ; Online
Anmerkung	English ; Open Access
HBZ-ID	HT020195658
ISBN	9780615840550 ; 0615840558
Datenquelle	ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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Artikel: Promoting the use of the PRECISE score for prostate MRI during active surveillance: results from the ESOR Nicholas Gourtsoyiannis teaching fellowship.

Insights into imaging

2022 Band 13, Heft 1, Seite(n) 111

Abstract: Objectives: The PRECISE criteria for serial multiparametric magnetic resonance imaging (MRI) of the prostate during active surveillance recommend the use of a dedicated scoring system (PRECISE score) to assess the likelihood of clinically significant ... ...

Abstract	Objectives: The PRECISE criteria for serial multiparametric magnetic resonance imaging (MRI) of the prostate during active surveillance recommend the use of a dedicated scoring system (PRECISE score) to assess the likelihood of clinically significant radiological change. This pilot study assesses the effect of an interactive teaching course on prostate MRI during active surveillance in assessing radiological change in serial imaging. Methods: Eleven radiology fellows and registrars with different experience in prostate MRI reading participated in a dedicated teaching course where they initially evaluated radiological change (based on their previous training in prostate MRI reading) independently in fifteen patients on active surveillance (baseline and follow-up scan), and then attended a lecture on the PRECISE score. The initial scans were reviewed for teaching purposes and afterwards the participants re-assessed the degree of radiological change in a new set of images (from fifteen different patients) applying the PRECISE score. Receiver operating characteristic analysis was performed. Confirmatory biopsies and PRECISE scores given in consensus by two radiologists (involved in the original draft of the PRECISE score) were the reference standard. Results: There was a significant improvement in the average area under the curve (AUC) for the assessment of radiological change from baseline (AUC: 0.60 [Confidence Intervals: 0.51-0.69] to post-teaching (AUC: 0.77 [0.70-0.84]). This was an improvement of 0.17 [0.016-0.28] (p = 0.004). Conclusions: A dedicated teaching course on the use of the PRECISE score improves the accuracy in the assessment of radiological change in serial MRI of the prostate.
Sprache	Englisch
Erscheinungsdatum	2022-07-07
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	2543323-4
ISSN	1869-4101
ISSN	1869-4101
DOI	10.1186/s13244-022-01252-1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Promoting the use of the PI-QUAL score for prostate MRI quality: results from the ESOR Nicholas Gourtsoyiannis teaching fellowship.

Giganti, Francesco / Cole, Alexander P / Fennessy, Fiona M / Clinton, Timothy / Moreira, Pedro Lopes Da Frota / Bernardes, Mariana Costa / Westin, Carl-Fredrik / Krishnaswamy, Deepa / Fedorov, Andriy / Wollin, Daniel A / Langbein, Bjoern / Frego, Nicola / Labban, Muhieddine / Badaoui, Joy S / Chang, Steven L / Briggs, Logan G / Tokuda, Junichi / Ambrosi, Alessandro / Kirkham, Alex /

Emberton, Mark / Kasivisvanathan, Veeru / Moore, Caroline M / Allen, Clare / Tempany, Clare M

European radiology

2022 Band 33, Heft 1, Seite(n) 461–471

Abstract: Objectives: The Prostate Imaging Quality (PI-QUAL) score is a new metric to evaluate the diagnostic quality of multiparametric magnetic resonance imaging (MRI) of the prostate. This study assesses the impact of an intervention, namely a prostate MRI ... ...

Abstract	Objectives: The Prostate Imaging Quality (PI-QUAL) score is a new metric to evaluate the diagnostic quality of multiparametric magnetic resonance imaging (MRI) of the prostate. This study assesses the impact of an intervention, namely a prostate MRI quality training lecture, on the participant's ability to apply PI-QUAL. Methods: Sixteen participants (radiologists, urologists, physicists, and computer scientists) of varying experience in reviewing diagnostic prostate MRI all assessed the image quality of ten examinations from different vendors and machines. Then, they attended a dedicated lecture followed by a hands-on workshop on MRI quality assessment using the PI-QUAL score. Five scans assessed by the participants were evaluated in the workshop using the PI-QUAL score for teaching purposes. After the course, the same participants evaluated the image quality of a new set of ten scans applying the PI-QUAL score. Results were assessed using receiver operating characteristic analysis. The reference standard was the PI-QUAL score assessed by one of the developers of PI-QUAL. Results: There was a significant improvement in average area under the curve for the evaluation of image quality from baseline (0.59 [95 % confidence intervals: 0.50-0.66]) to post-teaching (0.96 [0.92-0.98]), an improvement of 0.37 [0.21-0.41] (p < 0.001). Conclusions: A teaching course (dedicated lecture + hands-on workshop) on PI-QUAL significantly improved the application of this scoring system to assess the quality of prostate MRI examinations. Key points: • A significant improvement in the application of PI-QUAL for the assessment of prostate MR image quality was observed after an educational intervention. • Appropriate training on image quality can be delivered to those involved in the acquisition and interpretation of prostate MRI. • Further investigation will be needed to understand the impact on improving the acquisition of high-quality diagnostic prostate MR examinations.
Mesh-Begriff(e)	Male ; Humans ; Prostate/diagnostic imaging ; Prostate/pathology ; Multiparametric Magnetic Resonance Imaging ; Fellowships and Scholarships ; Prostatic Neoplasms/pathology ; Magnetic Resonance Imaging/methods ; Retrospective Studies
Sprache	Englisch
Erscheinungsdatum	2022-06-30
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	1085366-2
ISSN	1432-1084 ; 0938-7994 ; 1613-3749
ISSN (online)	1432-1084
ISSN	0938-7994 ; 1613-3749
DOI	10.1007/s00330-022-08947-5
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online: Nicholas of Cusa and the Kairos of Modernity

Michael Edward Moore

Cassirer, Gadamer, Blumenberg

2013

Abstract	In this far-reaching essay, historian Michael Edward Moore examines modernity as an historical epoch following the end of the medieval period — and as a “messianic concept of time.” In the early twentieth century, a debate over the meaning and origins of modernity unfolded among the philosophers Ernst Cassirer, Hans-Georg Gadamer and Hans Blumenberg. These thinkers tried to resolve the puzzle of the fifteenth-century master Nicholas of Cusa. Was Cusanus the last great medieval thinker, his ideas a summa of medieval tradition? Or was he a mysterious epochal figure, seated at one end of the bridge leading to modern thought? Nicholas of Cusa lived during a time of historical and existential crisis, or kairos, when medieval governments and cherished sources of unity were shaken. Likewise, the debate over his significance took place during a later phase of crisis for Europe, in the decades before and after the Second World War, when the collapse of European civilization was witnessed. Moore argues that modernity, so intently examined as an historical and spiritual problem, has significance for our contemporary sense of crisis.
Schlagwörter	Middle Ages ; modernity ; Nicholas of Cusa ; intellectual history ; philosophy ; HPCB
Thema/Rubrik (Code)	940
Sprache	Englisch
Verlag	punctum books
Erscheinungsland	nl
Dokumenttyp	Buch ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: Robinson, Nicholas

Moore, Norman / Nutt, Claire L

Oxford dictionary of national biography v.47

2004

Verfasserangabe	Norman Moore, rev. Claire L. Nutt
Mesh-Begriff(e)	Physicians ; History, 18th Century ; History of Medicine
Schlagwörter	England
Sprache	Englisch
Umfang	p. 389-390.
Verlag	Oxford University Press
Erscheinungsort	Oxford ; New York
Dokumenttyp	Artikel
ISBN	019861411X ; 9780198614111
Datenquelle	Katalog der US National Library of Medicine (NLM)

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Artikel: La Crosse encephalitis virus habitat associations in Nicholas County, West Virginia.

Nasci, R S / Moore, C G / Biggerstaff, B J / Panella, N A / Liu, H Q / Karabatsos, N / Davis, B S / Brannon, E S

Journal of medical entomology

2000 Band 37, Heft 4, Seite(n) 559–570

Abstract: ... landing collections were used in a La Crosse virus-enzootic area in Nicholas County, WV. Study sites were ... in Nicholas County, WV, are contrasted with those studied in other geographic regions where La Crosse virus is ...

Abstract	Aedes triseriatus (Say) population density patterns and La Crosse encephalitis virus infection rates were evaluated in relation to a variety of habitat parameters over a 14-wk period. Ovitraps and landing collections were used in a La Crosse virus-enzootic area in Nicholas County, WV. Study sites were divided into categories by habitat type and by proximity to the residences of known La Crosse encephalitis cases. Results demonstrated that Ae. triseriatus population densities were higher in sugar maple/red maple habitats than in hemlock/mixed hardwood habitats or in a site characterized by a large number of small red maple trees. Sites containing artificial containers had higher population densities than those without. La Crosse virus minimum infection rates in mosquitoes collected as eggs ranged from 0.4/1,000 to 7.5/1,000 in the 12 study sites, but did not differ significantly among sites regardless of habitat type or proximity to human case residences. La Crosse virus infection rates in landing Ae. triseriatus mosquitoes ranged from 0.0/1,000 to 27.0/1,000. La Crosse virus was also isolated from host-seeking Ae. canadensis (Theobald) in two study sites, at rates similar to those found in the Ae. triseriatus populations. The Ae. triseriatus oviposition patterns and La Crosse virus infection rates suggest that this mosquito species disperses readily in the large woodlands of central West Virginia. The La Crosse enzootic habitats in Nicholas County, WV, are contrasted with those studied in other geographic regions where La Crosse virus is found.
Mesh-Begriff(e)	Aedes/virology ; Animals ; Behavior, Animal ; Female ; Humans ; Insect Vectors/virology ; La Crosse virus/isolation & purification ; Weather ; West Virginia
Sprache	Englisch
Erscheinungsdatum	2000-07
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	410635-0
ISSN	0022-2585
ISSN	0022-2585
DOI	10.1603/0022-2585-37.4.559
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Illustrations from the Wellcome Institute Library. Nicholas Gainsford: his book.

Moore, K

Medical history

1993 Band 37, Heft 4, Seite(n) 442–447

Mesh-Begriff(e)	Academies and Institutes/history ; History, 17th Century ; History, 18th Century ; History, 19th Century ; History, 20th Century ; Manuscripts as Topic/history ; United Kingdom
Sprache	Englisch
Erscheinungsdatum	1993-10
Erscheinungsland	England
Dokumenttyp	Biography ; Historical Article ; Journal Article
ZDB-ID	214353-7
ISSN	2048-8343 ; 0025-7273
ISSN (online)	2048-8343
ISSN	0025-7273
DOI	10.1017/s0025727300058774
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: La crosse encephalitis virus habitat associations in Nicholas County, West Virginia

Nasci, R.S / Moore, C.G / Biggerstaff, B.J / Panella, N.A / Liu, H.Q / Karabatsos, N / Davis, B.S / Brannon, E.S

Journal of medical entomology. July 2000. v. 37 (4)

2000

Schlagwörter	infection ; Aedes triseriatus ; Aedes canadensis ; disease vectors ; population density ; tree cavities ; deciduous forests ; botanical composition ; forest trees ; containers ; ova ; breeding sites ; West Virginia
Sprache	Englisch
Erscheinungsverlauf	2000-07
Umfang	p. 559-570.
Dokumenttyp	Artikel
ZDB-ID	410635-0
ISSN	0022-2585
ISSN	0022-2585
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel ; Online: A Computational Framework for the Administration of 5-Aminovulinic Acid Before Glioblastoma Surgery.

Zeng, Jia / Moore, Nicholas J

Bulletin of mathematical biology

2024 Band 86, Heft 7, Seite(n) 83

Abstract: 5-Aminolevulinic Acid (5-ALA) is the only fluorophore approved by the FDA as an intraoperative optical imaging agent for fluorescence-guided surgery in patients with glioblastoma. The dosing regimen is based on rodent tests where a maximum signal occurs ... ...

Abstract	5-Aminolevulinic Acid (5-ALA) is the only fluorophore approved by the FDA as an intraoperative optical imaging agent for fluorescence-guided surgery in patients with glioblastoma. The dosing regimen is based on rodent tests where a maximum signal occurs around 6 h after drug administration. Here, we construct a computational framework to simulate the transport of 5-ALA through the stomach, blood, and brain, and the subsequent conversion to the fluorescent agent protoporphyrin IX at the tumor site. The framework combines compartmental models with spatially-resolved partial differential equations, enabling one to address questions regarding quantity and timing of 5-ALA administration before surgery. Numerical tests in two spatial dimensions indicate that, for tumors exceeding the detection threshold, the time to peak fluorescent concentration is 2-7 h, broadly consistent with the current surgical guidelines. Moreover, the framework enables one to examine the specific effects of tumor size and location on the required dose and timing of 5-ALA administration before glioblastoma surgery.
Mesh-Begriff(e)	Glioblastoma/surgery ; Glioblastoma/drug therapy ; Glioblastoma/pathology ; Glioblastoma/diagnostic imaging ; Aminolevulinic Acid/administration & dosage ; Humans ; Brain Neoplasms/surgery ; Computer Simulation ; Protoporphyrins/administration & dosage ; Protoporphyrins/metabolism ; Models, Biological ; Surgery, Computer-Assisted/methods ; Mathematical Concepts ; Animals ; Photosensitizing Agents/administration & dosage ; Optical Imaging/methods ; Fluorescent Dyes/administration & dosage
Chemische Substanzen	Aminolevulinic Acid (88755TAZ87) ; Protoporphyrins ; protoporphyrin IX (C2K325S808) ; Photosensitizing Agents ; Fluorescent Dyes
Sprache	Englisch
Erscheinungsdatum	2024-06-06
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	184905-0
ISSN	1522-9602 ; 0007-4985 ; 0092-8240
ISSN (online)	1522-9602
ISSN	0007-4985 ; 0092-8240
DOI	10.1007/s11538-024-01312-1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch ; Online: Radiolarian events in the eastern Equatorial Pacific, supplementary data to: Moore, Theodore C; Shackleton, Nicholas J; Pisias, Nicklas G (1993): Paleoceanography and the diachrony of radiolarian events in the eastern equatorial Pacific. Paleoceanography, 8(5), 567-586

Moore, Theodore C / Pisias, Nicklas G / Shackleton, Nicholas J

1993

Abstract: The development of an orbitally tuned time scale for the ODP leg 138 sites provides biostratigraphers a very high resolution chronostratigraphic framework. With this framework we are better able to define which of the first and last appearances of ... ...

Abstract	The development of an orbitally tuned time scale for the ODP leg 138 sites provides biostratigraphers a very high resolution chronostratigraphic framework. With this framework we are better able to define which of the first and last appearances of species appear to be synchronous. In addition, the geographic distribution of sites provides the means with which the detailed spatial patterns of invasion of new species and the extinction of older species can be mapped. These maps not only provide information on the process of evolution, migration, and extinction, they can also be related to water mass distributions and near-surface circulation of the ocean. Of 39 radiolarian events studied at 11 sites in the eastern equatorial Pacific, 28 were found to have a minimum range in their estimated age that exceeded 0.15 m.y. The temporal pattern of first and last appearances of these diachronous events have coherent spatial patterns that indicate shifts in the areas of high oceanographic gradients over the past 10 Ma. These changes in the locations of high gradient regions suggest that the South Equatorial Current (SEC) was north of its present position prior to approximately 7 Ma. There was a southward shift in the northern boundary of this current between approximately 6 and 7 Ma, and the development of a relatively strong gradient between the northeastern and northwestern sites. Between approximately 3.7 and 3.4 Ma, there was a very slight northward shift in the northern boundary of the SEC and the steep gradients between the northeastern and northwestern sites may have disappeared. This change is thought to be associated with the closing of the Isthmus of Panama. The temporal-spatial patterns of diachronous events younger than 3.4 Ma are consistent with patterns of circulation in the modern ocean.
Sprache	Englisch
Erscheinungsverlauf	1993-9999
Umfang	Online-Ressource
Verlag	PANGAEA - Data Publisher for Earth & Environmental Science
Erscheinungsort	Bremen/Bremerhaven
Dokumenttyp	Buch ; Online
Anmerkung	This dataset is supplement to doi:10.1029/93PA01328
DOI	10.1594/PANGAEA.730419
Datenquelle	Katalog der Technische Informationsbibliothek Hannover

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