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Artikel ; Online: Infratentorial Multinodular and Vacuolating Neuronal Tumor or Multinodular and Vacuolating Posterior Fossa Lesions of Unknown Significance? Clinico-Radiologic Findings from 2 Cases.

Morassi, Mauro / Bagatto, Daniele

2020 Band 136, Seite(n) 58–61

Abstract: Background: Infratentorial multinodular lesions resembling multinodular and vacuolating neuronal tumor of the cerebrum (MVNT) have been indicated in literature with 2 different names reflecting alternative perspectives: multinodular and vacuolating ... ...

Abstract	Background: Infratentorial multinodular lesions resembling multinodular and vacuolating neuronal tumor of the cerebrum (MVNT) have been indicated in literature with 2 different names reflecting alternative perspectives: multinodular and vacuolating posterior fossa lesions of unknown significance (MV-PLUS), suggesting that these lesions may belong to a new entity, and MVNT of the brain, assuming that they actually correspond to infratentorial MVNT. Because of the limited number of cases reported and the absence of histopathologic data, it is unclear which denomination should be used. Cases description: Two patients, a 41-year-old man (case 1) suffering headache and a 44-year-old man (case 2) with vertigo, underwent magnetic resonance imaging (MRI) examination. MRI showed, in both cases, multinodular lesions involving the vermis, broadly extending to the superior part of the right cerebellar hemisphere in case 1, and involving the superior paravermian part of the left cerebellar hemisphere in case 2. The follow-up period was 3 years in case 1 and 14 years in case 2. Conclusions: Infratentorial lesions show nodules with cystic or cyst-like signal intensity on MRI, a feature infrequently reported in supratentorial MVNT, and may involve the cortex. No variations were noted during a prolonged follow-up supporting the benign behavior of these lesions.
Mesh-Begriff(e)	Adult ; Cerebellar Neoplasms/complications ; Cerebellar Neoplasms/diagnostic imaging ; Cerebellar Neoplasms/physiopathology ; Headache/etiology ; Humans ; Infratentorial Neoplasms/complications ; Infratentorial Neoplasms/diagnostic imaging ; Infratentorial Neoplasms/physiopathology ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy ; Male ; Neoplasms, Neuroepithelial/complications ; Neoplasms, Neuroepithelial/diagnostic imaging ; Neoplasms, Neuroepithelial/physiopathology ; Perfusion Imaging ; Vertigo/etiology
Sprache	Englisch
Erscheinungsdatum	2020-01-07
Erscheinungsland	United States
Dokumenttyp	Case Reports
ZDB-ID	2534351-8
ISSN	1878-8769 ; 1878-8750
ISSN (online)	1878-8769
ISSN	1878-8750
DOI	10.1016/j.wneu.2019.12.166
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A multinodular and vacuolating neuronal tumor of the cerebrum (MVNT) with glioma-like appearance.

Bagatto, Daniele / Ius, Tamara / Pegolo, Enrico / Morassi, Mauro

Acta neurologica Belgica

2020 Band 121, Heft 6, Seite(n) 1851–1854

Mesh-Begriff(e)	Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/pathology ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/pathology ; Female ; Glioma/diagnostic imaging ; Glioma/pathology ; Humans ; Magnetic Resonance Imaging ; Middle Aged ; Seizures/diagnostic imaging ; Seizures/etiology
Sprache	Englisch
Erscheinungsdatum	2020-07-06
Erscheinungsland	Italy
Dokumenttyp	Case Reports ; Letter
ZDB-ID	127315-2
ISSN	2240-2993 ; 0300-9009
ISSN (online)	2240-2993
ISSN	0300-9009
DOI	10.1007/s13760-020-01426-y
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Dural Metastases of Advanced Prostate Cancer Detected by

Morassi, Mauro / Bonacina, Mattia / Bnà, Claudio / Zaniboni, Alberto / Savelli, Giordano

Diagnostics (Basel, Switzerland)

2020 Band 10, Heft 6

Abstract: Prostate cancer with extensive dural metastases is very rare, with only few cases described in the literature. We report one such case of a 74-year-old man with advanced prostate cancer, and in relatively good clinical condition. The patient returned ... ...

Abstract	Prostate cancer with extensive dural metastases is very rare, with only few cases described in the literature. We report one such case of a 74-year-old man with advanced prostate cancer, and in relatively good clinical condition. The patient returned with complaints of headache and diplopia. Fluorocholine (
Sprache	Englisch
Erscheinungsdatum	2020-06-08
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics10060385
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Stroke in patients with COVID-19: Clinical and neuroimaging characteristics.

Vogrig, Alberto / Gigli, Gian Luigi / Bnà, Claudio / Morassi, Mauro

Neuroscience letters

2020 Band 743, Seite(n) 135564

Abstract: Acute cerebrovascular disease, particularly ischemic stroke, has emerged as a serious complication of infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of the Coronavirus disease-2019 (COVID-19). ... ...

Abstract	Acute cerebrovascular disease, particularly ischemic stroke, has emerged as a serious complication of infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of the Coronavirus disease-2019 (COVID-19). Accumulating data on patients with COVID-19-associated stroke have shed light on specificities concerning clinical presentation, neuroimaging findings, and outcome. Such specificities include a propensity towards large vessel occlusion, multi-territory stroke, and involvement of otherwise uncommonly affected vessels. Conversely, small-vessel brain disease, cerebral venous thrombosis, and intracerebral hemorrhage appear to be less frequent. Atypical neurovascular presentations were also described, ranging from bilateral carotid artery dissection to posterior reversible encephalopathy syndrome (PRES), and vasculitis. Cases presenting with encephalopathy or encephalitis with seizures heralding stroke were particularly challenging. The pathogenesis and optimal management of ischemic stroke associated with COVID-19 still remain uncertain, but emerging evidence suggest that cytokine storm-triggered coagulopathy and endotheliopathy represent possible targetable mechanisms. Some specific management issues in this population include the difficulty in identifying clinical signs of stroke in critically ill patients in the intensive care unit, as well as the need for a protected pathway for brain imaging, intravenous thrombolysis, and mechanical thrombectomy, keeping in mind that "time is brain" also for COVID-19 patients. In this review, we discuss the novel developments and challenges for the diagnosis and treatment of stroke in patients with COVID-19, and delineate the principles for a rational approach toward precision medicine in this emerging field.
Mesh-Begriff(e)	COVID-19/complications ; Humans ; SARS-CoV-2 ; Stroke/diagnostic imaging ; Stroke/pathology ; Stroke/virology
Sprache	Englisch
Erscheinungsdatum	2020-12-19
Erscheinungsland	Ireland
Dokumenttyp	Journal Article ; Review
ZDB-ID	194929-9
ISSN	1872-7972 ; 0304-3940
ISSN (online)	1872-7972
ISSN	0304-3940
DOI	10.1016/j.neulet.2020.135564
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Predictors of severe intracerebral hemorrhage expansion.

Morotti, Andrea / Li, Qi / Nawabi, Jawed / Busto, Giorgio / Mazzacane, Federico / Cavallini, Anna / Shoamanesh, Ashkan / Morassi, Mauro / Schlunk, Frieder / Piccolo, Laura / Urbinati, Giacomo / Pezzini, Debora / Paciaroni, Maurizio / Fainardi, Enrico / Casetta, Ilaria / Padovani, Alessandro / Zini, Andrea

European stroke journal

2024 , Seite(n) 23969873241247436

Abstract: Background: Severe hematoma expansion (sHE) has the strongest impact on intracerebral hemorrhage (ICH) outcome. We investigated the predictors of sHE.: Methods: Retrospective analysis of ICH patients admitted at nine sites in Italy, Germany, China, ... ...

Abstract	Background: Severe hematoma expansion (sHE) has the strongest impact on intracerebral hemorrhage (ICH) outcome. We investigated the predictors of sHE. Methods: Retrospective analysis of ICH patients admitted at nine sites in Italy, Germany, China, and Canada. The following imaging features were analyzed: non-contrast CT (NCCT) hypodensities, heterogeneous density, blend sign, irregular shape, and CT angiography (CTA) spot sign. The outcome of interest was sHE, defined as volume increase >66% and/or >12.5 from baseline to follow-up NCCT. Predictors of sHE were explored with logistic regression. Results: A total of 1472 patients were included (median age 73, 56.6% males) of whom 223 (15.2%) had sHE. Age (odds ratio (OR) per year, 95% confidence interval (CI), 1.02 (1.01-1.04)), Anticoagulant treatment (OR 3.00, 95% CI 2.09-4.31), Glasgow Coma Scale (OR 0.93, 95% CI 0.89-0.98), time from onset/last known well to imaging, (OR per h 0.96, 95% CI 0.93-0.99), and baseline ICH volume, (OR per mL 1.02, 95% CI 1.02-1.03) were independently associated with sHE. Ultra-early hematoma growth (baseline volume/baseline imaging time) was also a predictor of sHE (OR per mL/h 1.01, 95% CI 1.00-1.02). All NCCT and CTA imaging markers were also predictors of sHE. Amongst imaging features NCCT hypodensities had the highest sensitivity (0.79) whereas the CTA spot sign had the highest positive predictive value (0.51). Conclusions: sHE is common in the natural history of ICH and can be predicted with few clinical and imaging variables. These findings might inform clinical practice and future trials targeting active bleeding in ICH.
Sprache	Englisch
Erscheinungsdatum	2024-04-16
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2851287-X
ISSN	2396-9881 ; 2396-9873
ISSN (online)	2396-9881
ISSN	2396-9873
DOI	10.1177/23969873241247436
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A hybrid machine learning/deep learning COVID-19 severity predictive model from CT images and clinical data.

Chieregato, Matteo / Frangiamore, Fabio / Morassi, Mauro / Baresi, Claudia / Nici, Stefania / Bassetti, Chiara / Bnà, Claudio / Galelli, Marco

Scientific reports

2022 Band 12, Heft 1, Seite(n) 4329

Abstract: COVID-19 clinical presentation and prognosis are highly variable, ranging from asymptomatic and paucisymptomatic cases to acute respiratory distress syndrome and multi-organ involvement. We developed a hybrid machine learning/deep learning model to ... ...

Abstract	COVID-19 clinical presentation and prognosis are highly variable, ranging from asymptomatic and paucisymptomatic cases to acute respiratory distress syndrome and multi-organ involvement. We developed a hybrid machine learning/deep learning model to classify patients in two outcome categories, non-ICU and ICU (intensive care admission or death), using 558 patients admitted in a northern Italy hospital in February/May of 2020. A fully 3D patient-level CNN classifier on baseline CT images is used as feature extractor. Features extracted, alongside with laboratory and clinical data, are fed for selection in a Boruta algorithm with SHAP game theoretical values. A classifier is built on the reduced feature space using CatBoost gradient boosting algorithm and reaching a probabilistic AUC of 0.949 on holdout test set. The model aims to provide clinical decision support to medical doctors, with the probability score of belonging to an outcome class and with case-based SHAP interpretation of features importance.
Mesh-Begriff(e)	Algorithms ; COVID-19/diagnostic imaging ; Deep Learning ; Humans ; Machine Learning ; Tomography, X-Ray Computed/methods
Sprache	Englisch
Erscheinungsdatum	2022-03-14
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-07890-1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Bilateral carotid artery dissection in a SARS-CoV-2 infected patient: causality or coincidence?

Morassi, Mauro / Bigni, Barbara / Cobelli, Milena / Giudice, Lodoviga / Bnà, Claudio / Vogrig, Alberto

Journal of neurology

2020 Band 267, Heft 10, Seite(n) 2812–2814

Mesh-Begriff(e)	Betacoronavirus ; Brain Neoplasms/complications ; COVID-19 ; Carotid Artery, Internal, Dissection/complications ; Coronavirus Infections/complications ; Humans ; Male ; Middle Aged ; Oligodendroglioma/complications ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2020-06-12
Erscheinungsland	Germany
Dokumenttyp	Case Reports ; Letter
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-020-09984-0
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: 18F-Fluorocholine Uptake by a Head and Neck Meningeal Inflammatory Pseudotumor.

Savelli, Giordano / Morassi, Mauro / Cobelli, Milena / Stefanelli, Antonella / Zaniboni, Alberto

Clinical nuclear medicine

2019 Band 44, Heft 8, Seite(n) 657–659

Abstract: F-Fluoro-ethyl-choline (F-FCH) PET/CT is widely used to study patients affected by prostate cancer. However, F-FCH may be taken-up by other neoplastic diseases, infections, and non-infective inflammatory processes. While this behavior may be an ... ...

Abstract	F-Fluoro-ethyl-choline (F-FCH) PET/CT is widely used to study patients affected by prostate cancer. However, F-FCH may be taken-up by other neoplastic diseases, infections, and non-infective inflammatory processes. While this behavior may be an opportunity to study different diseases, on the other hand, this condition brings with it the source of error in the evaluation of the images. Here we present the case of a meningeal inflammatory pseudotumor evidenced by F-FCH.
Mesh-Begriff(e)	Choline/analogs & derivatives ; Granuloma, Plasma Cell/diagnostic imaging ; Humans ; Male ; Meninges/diagnostic imaging ; Meninges/pathology ; Middle Aged ; Neck/diagnostic imaging ; Neck/pathology ; Positron Emission Tomography Computed Tomography ; Prostatic Neoplasms/diagnostic imaging ; Radiopharmaceuticals
Chemische Substanzen	Radiopharmaceuticals ; fluorocholine (6029HGL0QP) ; Choline (N91BDP6H0X)
Sprache	Englisch
Erscheinungsdatum	2019-07-05
Erscheinungsland	United States
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	197628-x
ISSN	1536-0229 ; 0363-9762
ISSN (online)	1536-0229
ISSN	0363-9762
DOI	10.1097/RLU.0000000000002635
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: New Indo-Pacific species of the genus Teretia Norman, 1888 (Gastropoda: Raphitomidae).

Morassi, Mauro / Bonfitto, Antonio

Zootaxa

2015 Band 3911, Heft 4, Seite(n) 560–570

Abstract: Four new species are assigned to the genus Teretia Norman, 1888 in the family Raphitomidae Bellardi, 1875 and herein described: Teretia neocaledonica sp. nov., T. sysoevi sp. nov., T. tongaensis sp. nov. from the southeastern Pacific and Teretia tavianii ...

Abstract	Four new species are assigned to the genus Teretia Norman, 1888 in the family Raphitomidae Bellardi, 1875 and herein described: Teretia neocaledonica sp. nov., T. sysoevi sp. nov., T. tongaensis sp. nov. from the southeastern Pacific and Teretia tavianii sp. nov. from the Gulf of Aden. The new species represent the first Indo-Pacific record of a genus previously known in the recent molluscan fauna by only two species from the Atlantic Ocean-Mediterranean Sea and Southern Africa. A possible Tethyan origin for the genus Teretia is suggested.
Mesh-Begriff(e)	Animal Distribution ; Animal Structures/anatomy & histology ; Animal Structures/growth & development ; Animals ; Atlantic Ocean ; Body Size ; Gastropoda/anatomy & histology ; Gastropoda/classification ; Gastropoda/growth & development ; Indian Ocean ; Organ Size
Sprache	Englisch
Erscheinungsdatum	2015-01-21
Erscheinungsland	New Zealand
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.3911.4.5
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Four new African turriform gastropods (Mollusca: Conoidea).

Morassi, Mauro / Bonfitto, Antonio

Zootaxa

2015 Band 3710, Seite(n) 271–280

Abstract: Four new species, belonging to four distinct conoidean families, are described from east Africa and Mozambique Channel. Iredalea adenensis sp. nov. (Drilliidae Olsson, 1964), from Gulf of Aden, and Buchema shearmani sp. nov. (Horaiclavidae Bouchet et al., ...

Abstract	Four new species, belonging to four distinct conoidean families, are described from east Africa and Mozambique Channel. Iredalea adenensis sp. nov. (Drilliidae Olsson, 1964), from Gulf of Aden, and Buchema shearmani sp. nov. (Horaiclavidae Bouchet et al., 2011), from off Mogadishu (Somalia), both trawled by local fishermen, represent the first record of their respective genera in eastern Africa. Crassispira somalica sp. nov. (Pseudomelatomidae Morrison, 1965), also collected offshore from Modagishu (Somalia), represents the first eastern Africa species bearing "typical" Crassispira features. Tropidoturris vizcondei sp. nov. (Borsoniidae Bellardi, 1875), from the Mozambique Channel, increases the knowledge of a genus considered endemic to southeastern Africa.
Mesh-Begriff(e)	Africa, Eastern ; Animals ; Biodiversity ; Gastropoda/anatomy & histology ; Gastropoda/classification
Sprache	Englisch
Erscheinungsdatum	2015-06-02
Erscheinungsland	New Zealand
Dokumenttyp	Journal Article
ISSN	1175-5326
ISSN	1175-5326
DOI	10.11646/zootaxa.3710.3.5
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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