LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 10 von insgesamt 2313

Suchoptionen

  1. Artikel: Identification of T-cell-activating recombinant antigens shared among three candidate antileprosy vaccines, killed M. leprae, M. bovis BCG, and mycobacterium w.

    Mustafa, A S

    International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association

    1988  Band 56, Heft 2, Seite(n) 265–273

    Abstract: ... BCG, and Mycobacterium w, was studied using T-cell lines and clones raised from BCG- and killed-M ... kDa M. leprae and M. tuberculosis antigens are present in M. leprae, BCG, and Mycobacterium w; 18-kDa ... M. leprae antigen is shared between M. leprae and Mycobacterium w, 13B3 M. leprae antigen is ...

    Abstract Antigenic crossreactivity among three candidate antileprosy vaccines, killed Mycobacterium leprae, BCG, and Mycobacterium w, was studied using T-cell lines and clones raised from BCG- and killed-M. leprae-vaccinated subjects. To identify the crossreactive antigens, the T-cell lines and clones were tested against Escherichia coli lysates containing 65-, 36-, 28-, 18-, and 14-kilodalton (kDa) and 13B3 M. leprae antigens and 65-, 19-, and 12-kDa M. tuberculosis antigens. The short-term T-cell lines, which compared to T-cell clones are easy to raise and maintain, were equally effective in identifying the T-cell-activating recombinant antigens. The reactivity pattern of the T-cell lines and the clones suggested that 65-kDa M. leprae and M. tuberculosis antigens are present in M. leprae, BCG, and Mycobacterium w; 18-kDa M. leprae antigen is shared between M. leprae and Mycobacterium w, 13B3 M. leprae antigen is possessed by M. leprae and BCG. These and other unidentified T-cell-activating antigens shared among candidate leprosy vaccines may be the basis for induction of in vivo sensitization to M. leprae antigens after vaccination with BCG or Mycobacterium w.
    Mesh-Begriff(e) Antigens, Bacterial/analysis ; Antigens, Bacterial/immunology ; Bacterial Vaccines/immunology ; Cell Line ; Clone Cells ; Cross Reactions ; Humans ; Lymphocyte Activation ; Mycobacterium/immunology ; Mycobacterium bovis/immunology ; Mycobacterium leprae/immunology ; Recombinant Proteins/analysis ; Recombinant Proteins/immunology ; T-Lymphocytes/immunology ; Vaccines, Synthetic/immunology
    Chemische Substanzen Antigens, Bacterial ; Bacterial Vaccines ; Recombinant Proteins ; Vaccines, Synthetic
    Sprache Englisch
    Erscheinungsdatum 1988-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 982148-x
    ISSN 1544-581X ; 0148-916X
    ISSN (online) 1544-581X
    ISSN 0148-916X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Ui VI Zs.186: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel ; Online: Audiological profile of asymptomatic Covid-19 PCR-positive cases.

    Mustafa, M W M

    American journal of otolaryngology

    2020  Band 41, Heft 3, Seite(n) 102483

    Abstract: Objective: The current study compared the amplitude of transient evoked otoacoustic emissions (TEOAEs) and thresholds of pure-tone audiometry between asymptomatic COVID-19 PCR-positive cases and normal non-infected subjects.: Methods: Twenty cases ... ...

    Abstract Objective: The current study compared the amplitude of transient evoked otoacoustic emissions (TEOAEs) and thresholds of pure-tone audiometry between asymptomatic COVID-19 PCR-positive cases and normal non-infected subjects.
    Methods: Twenty cases who were confirmed positive for COVID-19 and had none of the known symptoms for this viral infection formed the test group. Their age ranged between 20 and 50 years to avoid any age-related hearing affection. Patients who had definite symptoms of COVID-19 infection as well as those who had a history of hearing loss or a history of any known cause of hearing loss were excluded from the examined sample. TEOAEs amplitude was measured for all participants.
    Results: The high frequency pure-tone thresholds as well as the TEOAE amplitudes were significantly worse in the test group.
    Conclusions: COVID-19 infection could have deleterious effects on cochlear hair cell functions despite being asymptomatic. The mechanism of these effects requires further research.
    Mesh-Begriff(e) Acoustic Impedance Tests/methods ; Adult ; Asymptomatic Diseases ; Audiometry, Pure-Tone/methods ; Auditory Threshold/physiology ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Case-Control Studies ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/physiopathology ; Disease Outbreaks ; Female ; Follow-Up Studies ; Hearing Loss, Sensorineural/diagnosis ; Hearing Loss, Sensorineural/epidemiology ; Humans ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/physiopathology ; Reference Values ; Retrospective Studies ; Risk Assessment ; SARS-CoV-2 ; Young Adult
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-04-10
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 604541-8
    ISSN 1532-818X ; 0196-0709
    ISSN (online) 1532-818X
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2020.102483
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1637: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  3. Artikel: ACUTE TOXICITY OF COUMACINES: AN IN VIVO STUDY.

    Al-Shakarchi, W / Saber, Y / Merkhan, M / Mustafa, Y

    Georgian medical news

    2023  , Heft 338, Seite(n) 126–131

    Abstract: The design and synthesis of new drugs are increasingly challenging in chemistry settings. The synthesis is itself lured by the properties of the product after synthesis, including solubility, hygroscopicity, intensive adverse effects, and biological ... ...

    Abstract The design and synthesis of new drugs are increasingly challenging in chemistry settings. The synthesis is itself lured by the properties of the product after synthesis, including solubility, hygroscopicity, intensive adverse effects, and biological inefficacy; hence, the creation of a new drug should be considered in light of the avoidance of these downside features, if any. The present study is designed to investigate the acute toxicity of newly discovered heterocyclic frameworks derived from the coumarin backbone, namely coumacine I and coumacine II. To do so, a mouse model of 25 mice was subclassified into 5 groups (5 mice control, 5 mice coumacine I 1000 mg/kg, 5 mice coumacine II 1000 mg/kg, 5 mice coumacine I 2000 mg/kg, and 5 mice coumacine II 2000 mg/kg), a single dose was given, and mice were sacrificed after 4 hours post-dose. The blood sample and tissue were collected for biochemical and histopathological studies. Serums were analyzed for the measurement of renal function and liver enzyme activity using classical biochemical methods. A high dose of either compound caused deleterious changes, as evidenced by a significant (p<0.05) increase in creatinine, urea, GOT, and GPT, as well as disrupting tissue quasi-equilibrium at the cellular level in both kidney and liver. To sum up, coumacine I and coumacine II are relatively safe unless otherwise used in high doses, knowing that either dose in the present study is remarkably higher than the therapeutic dose of coumarins currently in use in clinical settings.
    Mesh-Begriff(e) Mice ; Animals ; Kidney/pathology ; Liver/pathology
    Sprache Englisch
    Erscheinungsdatum 2023-06-27
    Erscheinungsland Georgia (Republic)
    Dokumenttyp Journal Article
    ZDB-ID 2443648-3
    ISSN 1512-0112
    ISSN 1512-0112
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  4. Artikel ; Online: Audiological profile of asymptomatic Covid-19 PCR-positive cases

    Mustafa, M.W.M.

    American Journal of Otolaryngology

    2020  Band 41, Heft 3, Seite(n) 102483

    Schlagwörter Otorhinolaryngology ; covid19
    Sprache Englisch
    Verlag Elsevier BV
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 604541-8
    ISSN 0196-0709
    ISSN 0196-0709
    DOI 10.1016/j.amjoto.2020.102483
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1637: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel ; Online: Possible immuno-modulatory effects of tocilizumab in patients with refractory status epilepticus.

    El-Haggar, S M / Hegazy, S K / Mustafa, W / Khrieba, M O

    European review for medical and pharmacological sciences

    2023  Band 27, Heft 4, Seite(n) 1512–1521

    Abstract: Objective: Refractory Status Epilepticus (RSE) is a neurologic emergency that carries a high risk of mortality and morbidity. Every year, there are about 200,000 cases in the United States, affecting people of all ages. This study aimed to investigate ... ...

    Abstract Objective: Refractory Status Epilepticus (RSE) is a neurologic emergency that carries a high risk of mortality and morbidity. Every year, there are about 200,000 cases in the United States, affecting people of all ages. This study aimed to investigate the possible immuno-modulatory effect of tocilizumab in RSE patients receiving conventional anti-epileptic drugs.
    Patients and methods: 50 outpatients who fulfilled the inclusion requirements for RSE were recruited in this randomized, controlled, and prospective study. The patients were divided into two groups randomly (n=25); the control group received standard RSE treatment, consisting of propofol, pentobarbital, and midazolam, and the tocilizumab group received standard RSE treatment plus tocilizumab. A neurologist evaluated each patient at the beginning of the therapy and after 3 months. Before and after treatment, serum nuclear factor kappa B (NF-κB), interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β) and serum electrolytes were assessed.
    Results: The tocilizumab group showed a statistically significant reduction in the level of assessed parameters in comparison with the control group.
    Conclusions: Tocilizumab might be a novel adjuvant anti-inflammatory medication in managing RSE.
    Mesh-Begriff(e) Humans ; Prospective Studies ; Status Epilepticus ; Antibodies, Monoclonal, Humanized ; Outpatients
    Chemische Substanzen tocilizumab (I031V2H011) ; Antibodies, Monoclonal, Humanized
    Sprache Englisch
    Erscheinungsdatum 2023-03-05
    Erscheinungsland Italy
    Dokumenttyp Randomized Controlled Trial ; Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202302_31392
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1887: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  6. Artikel: Audiological profile of asymptomatic Covid-19 PCR-positive cases

    Mustafa, M W M

    Am J Otolaryngol

    Abstract: OBJECTIVE: The current study compared the amplitude of transient evoked otoacoustic emissions (TEOAEs) and thresholds of pure-tone audiometry between asymptomatic COVID-19 PCR-positive cases and normal non-infected subjects. METHODS: Twenty cases who ... ...

    Abstract OBJECTIVE: The current study compared the amplitude of transient evoked otoacoustic emissions (TEOAEs) and thresholds of pure-tone audiometry between asymptomatic COVID-19 PCR-positive cases and normal non-infected subjects. METHODS: Twenty cases who were confirmed positive for COVID-19 and had none of the known symptoms for this viral infection formed the test group. Their age ranged between 20 and 50 years to avoid any age-related hearing affection. Patients who had definite symptoms of COVID-19 infection as well as those who had a history of hearing loss or a history of any known cause of hearing loss were excluded from the examined sample. TEOAEs amplitude was measured for all participants. RESULTS: The high frequency pure-tone thresholds as well as the TEOAE amplitudes were significantly worse in the test group. CONCLUSIONS: COVID-19 infection could have deleterious effects on cochlear hair cell functions despite being asymptomatic. The mechanism of these effects requires further research.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #46506
    Datenquelle COVID19

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  7. Artikel ; Online: Food sensitization and cardiovascular mortality: An intriguing association in need of further study.

    Shaker, Marcus / Abrams, Elissa M / Oppenheimer, John / Anagnostou, Aikaterini / Codispoti, Christopher D / Golden, David B K / Greenhawt, Matthew / Stukus, David / Moore-Clingenpeel, Melissa / Hughes, Sarah W / Mack, Douglas P / Mustafa, S Shahzad / Lang, David M

    The Journal of allergy and clinical immunology

    2024  Band 153, Heft 4, Seite(n) 1163–1165

    Mesh-Begriff(e) Humans ; Food/adverse effects ; Allergens ; Lung ; Cardiovascular Diseases ; Food Hypersensitivity
    Chemische Substanzen Allergens
    Sprache Englisch
    Erscheinungsdatum 2024-01-22
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2023.12.018
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Uh III Zs.92: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  8. Artikel: Acquisition and Transmission of '

    Cooper, W Rodney / Swisher Grimm, Kylie D / Angelella, Gina M / Mustafa, Tariq

    Plant disease

    2023  Band 107, Heft 8, Seite(n) 2440–2445

    Abstract: ...

    Abstract '
    Mesh-Begriff(e) Animals ; Liberibacter ; Haplotypes ; Plant Diseases/microbiology ; Solanum tuberosum/microbiology ; Hemiptera/microbiology
    Sprache Englisch
    Erscheinungsdatum 2023-08-17
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 754182-x
    ISSN 0191-2917
    ISSN 0191-2917
    DOI 10.1094/PDIS-11-22-2701-RE
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Bonn

    Z 2043: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  9. Artikel: Priapism as an Unusual Symptom of T-cell Acute Lymphoblastic Leukemia in a Pediatric Case.

    Mustafa, Mohammedalamin / Hanafy, Ehab / Riyad, Shaima / Altoonisi, Mustafa M / Aboulela, Waseem

    Cureus

    2024  Band 16, Heft 2, Seite(n) e54331

    Abstract: Acute lymphoblastic leukemia (ALL) in pediatric patients typically presents with recognizable symptoms such as fever, pallor, and bone pain. However, atypical manifestations can complicate the diagnostic landscape. We present a unique case of a seven- ... ...

    Abstract Acute lymphoblastic leukemia (ALL) in pediatric patients typically presents with recognizable symptoms such as fever, pallor, and bone pain. However, atypical manifestations can complicate the diagnostic landscape. We present a unique case of a seven-year-old male with T-cell ALL whose presenting symptom was priapism. This case underscores the need for heightened awareness among healthcare professionals regarding the diverse clinical presentations of leukemia, emphasizing the importance of a multidisciplinary team approach for comprehensive evaluation and management. Our seven-year-old patient presented with priapism. A comprehensive diagnostic workup, including complete blood counts and subsequent bone marrow examination, led to the diagnosis of T-cell ALL. Given the rare presentation, a multidisciplinary team consisting of pediatric oncologists/hematologists, urologists, and other relevant specialists collaborated to formulate a tailored treatment plan. The patient received an intensified chemotherapy regimen, resulting in the resolution of priapism and hematologic improvement. Priapism as an initial presentation of T-cell ALL in a pediatric patient is an exceptional occurrence, necessitating a specialized and collaborative approach to diagnosis and management. This case report highlights the importance of interdisciplinary coordination involving pediatric oncologists and urologists in addressing the unique challenges posed by atypical leukemia presentations. The rarity of this manifestation emphasizes the need for further research to elucidate the underlying mechanisms and establish optimal management strategies for similar cases.
    Sprache Englisch
    Erscheinungsdatum 2024-02-16
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.54331
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  10. Artikel: Central serous chorioretinopathy secondary to intramuscular testosterone therapy.

    Lockhart, M / Ali, E / Mustafa, M / Tormey, W / Sreenan, S / Saaed, A / McDermott, J H

    Endocrinology, diabetes & metabolism case reports

    2023  Band 2023, Heft 2

    Abstract: Summary: A patient treated with intramuscular testosterone replacement therapy for primary hypogonadism developed blurred vision shortly after receiving his testosterone injection. The symptom resolved over subsequent weeks and recurred after his next ... ...

    Abstract Summary: A patient treated with intramuscular testosterone replacement therapy for primary hypogonadism developed blurred vision shortly after receiving his testosterone injection. The symptom resolved over subsequent weeks and recurred after his next injection. A diagnosis of central serous chorioretinopathy (CSR) was confirmed following ophthalmology review. A decision was made to change the patient's testosterone regime from this 12-weekly intramuscular injection to a daily topical testosterone gel, given the possibility that peak blood levels of testosterone following intramuscular injection were causing his ocular complaint. His CSR did not recur after this change in treatment. CSR secondary to testosterone therapy is a rare finding but has been reported previously in the literature.
    Learning points: Blurred vision in patients treated with testosterone replacement therapy (TRT) should prompt an ophthalmology review. The potential for reduced risk of central serous chorioretinopathy (CSR) with daily transdermal testosterone remains a matter of conjecture. CSR is a rare potential side effect of TRT.
    Sprache Englisch
    Erscheinungsdatum 2023-05-22
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2785530-2
    ISSN 2052-0573
    ISSN 2052-0573
    DOI 10.1530/EDM-22-0348
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang