LIVIVO - Suchergebnisse -

Suchergebnis

Treffer 1 - 10 von insgesamt 4096

Suchoptionen

Artikel ; Online: The protective mechanism of Tao Hong Si Wu decoction against breast cancer through regulation of EGFR/ERK1/2 signaling.

Huang, Shi / Yao, Dan / Shan, Chun / Du, Xiuli / Pan, Linyu / Wang, Ni / Wang, Yongzhong / Duan, Xianchun / Peng, Daiyin

Journal of ethnopharmacology

2024 Band 332, Seite(n) 118339

Abstract: Ethnopharmacological relevance: Tao Hong Si Wu Decoction (THSWD), a traditional Chinese ...

Abstract	Ethnopharmacological relevance: Tao Hong Si Wu Decoction (THSWD), a traditional Chinese herbal medicine, is widely utilized in clinical settings, either alone or in combination with other medications, for the treatment of breast cancer. Aim of the study: The specific targeting molecule(s) of THSWD and its associated molecular mechanisms remain unclear. This research aims to elucidate the underlying molecular mechanisms of THSWD in the treatment of breast cancer. Materials and methods: The pharmacological properties of THSWD were investigated in breast cancer cells and tumor tissues using a range of methods including Acridine Orange/Ethidium Bromide (AO/EB) staining, Transwell assay, flow cytometry, immunofluorescence assay, and breast cancer mice models. Results: Our findings demonstrate that THSWD induces necrosis and/or apoptosis in breast cancer cells, while significantly inhibiting cell migration. Target proteins of THSWD in anticancer activity include EGFR, RAS, and others. THSWD treatment for breast cancer is associated with the EGFR/ERK1/2 signaling pathway. Conclusion: Our findings offer initial insights into the primary mechanism of action of THSWD in breast cancer treatment, indicating its potential as a complementary therapy deserving further investigation.
Sprache	Englisch
Erscheinungsdatum	2024-05-20
Erscheinungsland	Ireland
Dokumenttyp	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.118339
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Volltext online

Zugriff für angemeldete ZB MED Nutzerinnen und Nutzer

Zusatzmaterialien

Verfügbar in ZB MED Köln/Königswinter

Zs.A 1494: Hefte anzeigen

Standort:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Über subito bestellen

Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Details ▾

Artikel ; Online: Protective effect of Tao Hong Si Wu Decoction against inflammatory injury caused by intestinal flora disorders in an ischemic stroke mouse model.

Zhang, Lijuan / Xue, Sujun / Fei, Changyi / Yu, Chao / Li, Jingjing / Li, Yumeng / Wang, Ni / Chu, Furui / Pan, Lingyu / Duan, Xianchun / Peng, Daiyin

BMC complementary medicine and therapies

2024 Band 24, Heft 1, Seite(n) 124

Abstract: ... Tao Hong Si Wu Decoction (THSWD), against inflammatory injury after IS and its underlying mechanisms ...

Abstract	Background and aims: Recent studies have shown that intestinal flora are involved in the pathological process of ischemic stroke (IS). The potential protective effect of the traditional Chinese prescription, Tao Hong Si Wu Decoction (THSWD), against inflammatory injury after IS and its underlying mechanisms of action were investigated in the current study. Methods: Fifty SPF(Specefic pathogen Free) male C57 mice were randomly assigned to sham operation, model, THSWD low-dose (6.5 g/kg), medium-dose (13 g/kg) and high-dose (26 g/kg) groups (10 mice per group). Mouse models of transient middle cerebral artery occlusion were prepared via thread embolism. Neurological function score, hematoxylin-eosin (HE) staining, immunohistochemistry, enzyme-linked immunosorbent assay (ELISA), 16S ribosomal DNA (rDNA) sequencing, quantitative reverse transcription PCR (qRT-PCR) and other methods were employed to elucidate the underlying molecular mechanisms. Results: Notably, THSWD induced a reduction in the neurological function score (P < 0.01) and neuronal injury in brain tissue, increase in protein expression of Claudin-5 and zonula occludens-1 (ZO-1) in brain tissue(P < 0.01), and decrease in serum lipopolysaccharide (LPS)(P < 0.01), diamine oxidase (DAO)(P < 0.01) and D-lactic acid(P < 0.01, P < 0.05) levels to a significant extent. THSWD also inhibited the levels of tumor necrosis factor-α (TNF-α)(P < 0.01) and interleukin - 1β (IL-1β)(P < 0.01) in brain tissue, and increased alpha and beta diversity in ischemic stroke mice, along with a certain reversal effect on different microflora. Finally, THSWD inhibited the polarization of microglia cells(P < 0.01) and decreased the protein and gene expression of toll-like receptor-4 (TLR-4)(P < 0.01, P < 0.05) and nuclear factor kappa B (NF-κB)(P < 0.01) in brain tissue. Conclusion: Our data indicate that THSWD may interfere with inflammatory response in ischemic stroke by regulating intestinal flora and promoting intestinal barrier repair.
Mesh-Begriff(e)	Mice ; Male ; Animals ; Ischemic Stroke ; Gastrointestinal Microbiome ; Drugs, Chinese Herbal/pharmacology ; NF-kappa B/metabolism
Chemische Substanzen	Taohong Siwu decoction II ; Drugs, Chinese Herbal ; NF-kappa B
Sprache	Englisch
Erscheinungsdatum	2024-03-18
Erscheinungsland	England
Dokumenttyp	Journal Article
ISSN	2662-7671
ISSN (online)	2662-7671
DOI	10.1186/s12906-024-04417-1
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Details ▾
- Kostenpflichtig bestellen

Artikel: Exploration of the Potential Mechanism of Tao Hong Si Wu Decoction for the Treatment of Breast Cancer Based on Network Pharmacology and

Huang, Shi / Chen, Yan / Pan, Lingyu / Fei, Changyi / Wang, Ni / Chu, Furui / Peng, Daiyin / Duan, Xianchun / Wang, Yongzhong

Frontiers in oncology

2021 Band 11, Seite(n) 731522

Abstract: Background: Tao Hong Si Wu Decoction (THSWD) is a well-known traditional Chinese medicine used ...

Abstract	Background: Tao Hong Si Wu Decoction (THSWD) is a well-known traditional Chinese medicine used clinically alone or combined with drugs to treat breast cancer. However, there has been no study to date on the underlying mechanisms of its therapeutic effects. Objectives: To explore the potential mechanism of THSWD for the treatment of breast cancer using network pharmacology and experimental research. Methods: The active ingredients of THSWD were screened according to Lipinski's rule of five based on the 107 ingredients of THSWD identified by UPLC-Q-TOF-MS Results: In total, 27 active ingredients including 8 core components, were obtained from 107 ingredients and 218 THSWD target genes for the treatment of breast cancer were identified. THSWD is active in the treatment of breast cancer by targeting Ras, FoxO, PI3K-Akt and other signaling pathways. MCF-7 and MDA-MB-231 cell proliferation was inhibited by THSWD serum in a time and concentration dependent manner. THSWD could regulated the RNA and protein expression of core targets HRAS, MAPK1, AKT1, GRB2, and MAPK14 for treatment of breast cancer. Conclusion: The results of network pharmacology study showed that THSWD is active against breast cancer by intervening with multiple targets and pathways. Luteolin, kaempferol, senkyunolide E, and other 8 compounds may be the core active ingredients of THSWD in the treatment of breast cancer. THSWD treatment of breast cancer may be related to targeting Ras, FoxO, PI3K-Akt, and other signal pathways associated with the core targets HRAS, MAPK1, AKT1, GRB2, and MAPK14.
Sprache	Englisch
Erscheinungsdatum	2021-08-26
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.731522
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Details ▾
- Kostenpflichtig bestellen

Artikel: Metabolic Insight Into the Neuroprotective Effect of Tao-He-Cheng-Qi (THCQ) Decoction on ICH Rats Using Untargeted Metabolomics.

Yang, Rui-Pei / Cai, Da-Ke / Chen, Yu-Xing / Gang, Hai-Ning / Wei, Mei / Zhu, De-Quan / Li, Su-Mei / Yang, Jiu-Mei / Luo, Si-Ni / Bi, Xiao-Li / Sun, Dong-Mei

Frontiers in pharmacology

2021 Band 12, Seite(n) 636457

Abstract: Tao-He-Cheng-Qi decoction (THCQ) is an effective traditional Chinese medicine used to treat ...

Abstract	Tao-He-Cheng-Qi decoction (THCQ) is an effective traditional Chinese medicine used to treat intracerebral hemorrhage (ICH). This study was performed to investigate the possible neuroprotective effect of THCQ decoction on secondary brain damage in rats with intracerebral hemorrhage and to elucidate the potential mechanism based on a metabolomics approach. Sprague-Dawley (SD) rats were randomly divided into five groups: the sham group, collagenase-induced ICH model group, THCQ low-dose (THCQ-L)-treated group, THCQ moderate-dose (THCQ-M)-treated group and THCQ high-dose (THCQ-H)-treated group. Following 3 days of treatment, behavioral changes and histopathological lesions in the brain were estimated. Untargeted metabolomics analysis with multivariate statistics was performed by using ultrahigh-performance liquid chromatography-mass spectrometry (UPLC-Q-Exactive Orbitrap MS). THCQ treatment at two dosages (5.64 and 11.27 g/kg·d) remarkably improved behavior (
Sprache	Englisch
Erscheinungsdatum	2021-05-03
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.636457
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

Zusatzmaterialien

Über subito bestellen

Details ▾
- Kostenpflichtig bestellen

Artikel ; Online: Metabolic Insight Into the Neuroprotective Effect of Tao-He-Cheng-Qi (THCQ) Decoction on ICH Rats Using Untargeted Metabolomics

Rui-Pei Yang / Da-Ke Cai / Yu-Xing Chen / Hai-Ning Gang / Mei Wei / De-Quan Zhu / Su-Mei Li / Jiu-Mei Yang / Si-Ni Luo / Xiao-Li Bi / Dong-Mei Sun

Frontiers in Pharmacology, Vol

2021 Band 12

Abstract: Tao-He-Cheng-Qi decoction (THCQ) is an effective traditional Chinese medicine used to treat ...

Abstract	Tao-He-Cheng-Qi decoction (THCQ) is an effective traditional Chinese medicine used to treat intracerebral hemorrhage (ICH). This study was performed to investigate the possible neuroprotective effect of THCQ decoction on secondary brain damage in rats with intracerebral hemorrhage and to elucidate the potential mechanism based on a metabolomics approach. Sprague-Dawley (SD) rats were randomly divided into five groups: the sham group, collagenase-induced ICH model group, THCQ low-dose (THCQ-L)-treated group, THCQ moderate-dose (THCQ-M)-treated group and THCQ high-dose (THCQ-H)-treated group. Following 3 days of treatment, behavioral changes and histopathological lesions in the brain were estimated. Untargeted metabolomics analysis with multivariate statistics was performed by using ultrahigh-performance liquid chromatography–mass spectrometry (UPLC-Q-Exactive Orbitrap MS). THCQ treatment at two dosages (5.64 and 11.27 g/kg·d) remarkably improved behavior (p < 0.05), brain water content (BMC) and hemorheology (p < 0.05) and improved brain nerve tissue pathology and inflammatory infiltration in ICH rats. Moreover, a metabolomic analysis demonstrated that the serum metabolic profiles of ICH patients were significantly different between the sham group and the ICH-induced model group. Twenty-seven biomarkers were identified that potentially predict the clinical benefits of THCQ decoction. Of these, 4 biomarkers were found to be THCQ-H group-specific, while others were shared between two clusters. These metabolites are mainly involved in amino acid metabolism and glutamate-mediated cell excitotoxicity, lipid metabolism-mediated oxidative stress, and mitochondrial dysfunction caused by energy metabolism disorders. In addition, a correlation analysis showed that the behavioral scores, brain water content and hemorheology were correlated with levels of serum metabolites derived from amino acid and lipid metabolism. In conclusion, the results indicate that THCQ decoction significantly attenuates ICH-induced secondary ...
Schlagwörter	intracerebral hemorrhage ; traditional Chinese medicine ; Tao-He-Cheng-Qi decoction ; metabolomics ; secondary brain injury ; Therapeutics. Pharmacology ; RM1-950
Thema/Rubrik (Code)	616
Sprache	Englisch
Erscheinungsdatum	2021-05-01T00:00:00Z
Verlag	Frontiers Media S.A.
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

Volltext online

Volltext online

Zusatzmaterialien

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Artikel ; Online: Exploration of the Potential Mechanism of Tao Hong Si Wu Decoction for the Treatment of Breast Cancer Based on Network Pharmacology and In Vitro Experimental Verification

Shi Huang / Yan Chen / Lingyu Pan / Changyi Fei / Ni Wang / Furui Chu / Daiyin Peng / Xianchun Duan / Yongzhong Wang

Frontiers in Oncology, Vol

2021 Band 11

Abstract: BackgroundTao Hong Si Wu Decoction (THSWD) is a well-known traditional Chinese medicine used ...

Abstract	BackgroundTao Hong Si Wu Decoction (THSWD) is a well-known traditional Chinese medicine used clinically alone or combined with drugs to treat breast cancer. However, there has been no study to date on the underlying mechanisms of its therapeutic effects.ObjectivesTo explore the potential mechanism of THSWD for the treatment of breast cancer using network pharmacology and experimental research.MethodsThe active ingredients of THSWD were screened according to Lipinski’s rule of five based on the 107 ingredients of THSWD identified by UPLC-Q-TOF-MSE. The targets of THSWD and breast cancer from multiple databases were collected, and a Compound-Target-Pathway network based on protein-protein interaction (PPI) was constructed. Gene ontology (GO) analysis and KEGG pathway analysis were performed via the DAVID server. Molecular docking studies verified the selected key ingredients and key targets. The results of network pharmacology were verified by in vitro experiments. Including the effects of THSWD drug-containing rat serum (THSWD serum) on cell proliferation, and on the targets HRAS, MAPK1, AKT1, GRB2, and MAPK14 were assayed by RT-qPCR and Western blot assays.ResultsIn total, 27 active ingredients including 8 core components, were obtained from 107 ingredients and 218 THSWD target genes for the treatment of breast cancer were identified. THSWD is active in the treatment of breast cancer by targeting Ras, FoxO, PI3K-Akt and other signaling pathways. MCF-7 and MDA-MB-231 cell proliferation was inhibited by THSWD serum in a time and concentration dependent manner. THSWD could regulated the RNA and protein expression of core targets HRAS, MAPK1, AKT1, GRB2, and MAPK14 for treatment of breast cancer.ConclusionThe results of network pharmacology study showed that THSWD is active against breast cancer by intervening with multiple targets and pathways. Luteolin, kaempferol, senkyunolide E, and other 8 compounds may be the core active ingredients of THSWD in the treatment of breast cancer. THSWD treatment of breast cancer ...
Schlagwörter	Taohong Siwu Decoction (THSWD) ; network pharmacology ; breast cancer ; traditional Chinese medicine ; target identification ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
Thema/Rubrik (Code)	616
Sprache	Englisch
Erscheinungsdatum	2021-08-01T00:00:00Z
Verlag	Frontiers Media S.A.
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

Volltext online

Volltext online

Zusatzmaterialien

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Artikel: CuO/Ta₂O₅ core/shell nanoparticles produced by arc-discharge in water

Delaportas, D / Svarnas, P / Alexandrou, I / Georga, S.N / Krontiras, C.A / Xanthopoulos, N.I / Siokou, A / Chalker, P.R

Materials letters. 2011 Aug., v. 65, no. 15-16

2011

Abstract: The formation of novel nanoparticles, i.e. CuO/Ta₂O₅ core/shell, via anodic arc-discharge in water ...

Abstract	The formation of novel nanoparticles, i.e. CuO/Ta₂O₅ core/shell, via anodic arc-discharge in water is reported. Typical core diameters and shell thicknesses are about 20 and 5nm, respectively. Both core and shell are crystalline. The resulting core/shell-structured nanopowder exhibits dielectric behavior.
Schlagwörter	copper ; nanoparticles ; tantalum ; water
Sprache	Englisch
Erscheinungsverlauf	2011-08
Umfang	p. 2337-2340.
Erscheinungsort	Elsevier B.V.
Dokumenttyp	Artikel
ZDB-ID	1491964-3
ISSN	1873-4979 ; 0167-577X
ISSN (online)	1873-4979
ISSN	0167-577X
DOI	10.1016/j.matlet.2011.05.044
Datenquelle	NAL Katalog (AGRICOLA)

Volltext online

Zugriff für angemeldete ZB MED Nutzerinnen und Nutzer

Zusatzmaterialien

Über subito bestellen

Details ▾
- Volltext online
- Kostenpflichtig bestellen

Buch: You zhi tao xin pin zhong feng chan zai pei

Wang, Guoping / Hong, Ni

2000

Titelvarianten	Youzhili xinpinzhong fengchan zaipei
Verfasserangabe	Wang Guoping, Hong Ni bian zhu
Schlagwörter	Peach/Varieties
Sprache	Chinesisch
Umfang	5, 180 p., 20 p. of plates :, ill. ;, 19 cm.
Ausgabenhinweis	Di 1 ban.
Verlag	Jin dun chu ban she
Erscheinungsort	Beijing
Dokumenttyp	Buch
ISBN	7508211014 ; 9787508211015
Datenquelle	NAL Katalog (AGRICOLA)

Zusatzmaterialien

Über subito bestellen

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Details ▾
- Kostenpflichtig bestellen

Buch: Tao ku yü ta mi ti ch'u ts'ang

Ni, Chao-chen / Wan, Mu-lin

1981

Titelübersetzung	Storage of rice.
Verfasserangabe	Ni Chao-chen, Wan Mu-lin pien [hsieh]. --
Schlagwörter	Rice/Storage.
Sprache	Chinesisch
Umfang	102 p. :, ill. ;, 19 cm.
Ausgabenhinweis	Ti 1 pan. --
Verlag	Chung-kuo ts'ai cheng ching chi ch'u pan she ; Hsin hua shu tien Pei-ching fa hsing so fa hsing
Erscheinungsort	Pei-ching
Dokumenttyp	Buch
Anmerkung	Errata slip inserted.
Datenquelle	NAL Katalog (AGRICOLA)

Zusatzmaterialien

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Details ▾

Buch: Tsʻan chung hsüeh shih yen shih hsi chih tao

Tsʻai, Yen-chang / Ni, Hung-tʻung

tsʻan sang chuan yeh yung

1984

Körperschaft	Che-chiang sheng shao hsing ti chʻü nung yeh hsüeh hsiao
Verfasserangabe	Che-chiang sheng shao hsing ti chʻü nung yeh hsüeh hsiao pien ; [pien che Tsʻai Yen-chang, Ni Hung-tʻung]
Schlagwörter	Silkworms/Study and teaching
Sprache	Chinesisch
Umfang	2, 44 p. :, ill. ;, 19 cm.
Ausgabenhinweis	Ti 1 pan.
Verlag	Nung yeh chʻu pan she ; Hsin hua shu tien Pei-ching fa hsing so fa hsing
Erscheinungsort	Pei-ching
Dokumenttyp	Buch
Anmerkung	"Chʻüan kuo chung teng nung yeh hsüeh hsiao shih yung chiao tsʻai." ; "Tsʻan sang chuan yeh yung."
Datenquelle	NAL Katalog (AGRICOLA)

Zusatzmaterialien

Fernleihe an ZB MED

Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Details ▾

Zum Seitenanfang

Volltext online

Zusatzmaterialien

Kategorien

Verfügbar in ZB MED Köln/Königswinter

Über subito bestellen

Zusatzmaterialien

Kategorien

Über subito bestellen

Fernleihe an ZB MED

Zusatzmaterialien

Kategorien

Über subito bestellen

Zusatzmaterialien

Kategorien

Über subito bestellen

Volltext online

Zusatzmaterialien

Kategorien

Fernleihe an ZB MED

Volltext online

Zusatzmaterialien

Kategorien

Fernleihe an ZB MED

Volltext online

Zusatzmaterialien

Kategorien

Über subito bestellen

Zusatzmaterialien

Kategorien

Über subito bestellen

Fernleihe an ZB MED

Zusatzmaterialien

Kategorien

Fernleihe an ZB MED

Zusatzmaterialien

Kategorien

Fernleihe an ZB MED