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  1. Buch ; Online ; E-Book: Viruses, plagues, and history

    Oldstone, Michael B. A.

    past, present, and future

    2020  

    Verfasserangabe Michael B. A. Oldstone
    Schlagwörter Virus diseases/History
    Thema/Rubrik (Code) 614.57
    Sprache Englisch
    Umfang 1 Online-Ressource (xxii, 485 Seiten), Illustrationen, Diagramme
    Ausgabenhinweis Second edition
    Verlag Oxford University Press
    Erscheinungsort New York, NY
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020556721
    ISBN 978-0-19-005679-7 ; 978-0-19-005680-3 ; 9780190056780 ; 0-19-005679-7 ; 0-19-005680-0 ; 0190056789
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Buch ; Online ; E-Book: Ebola's curse

    Oldstone, Michael B. A. / Oldstone, Madeleine R.

    2013-2016 outbreak in West Africa : origin, spread and heroes

    2017  

    Verfasserangabe Michael B. A. Oldstone, Madeleine R. Oldstone
    Schlagwörter Ebola virus disease ; Africa, West ; Electronic books
    Sprache Englisch
    Umfang 1 Online-Ressource (xviii, 108 Seiten), Illustrationen
    Verlag Elsevier Academic Press
    Erscheinungsort London
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020404964
    ISBN 978-0-12-813889-2 ; 9780128138885 ; 0-12-813889-0 ; 0128138882
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  3. Artikel ; Online: History of Virology

    Oldstone, M.B.A.

    Encyclopedia of Microbiology

    Abstract: The history of virology can be traced as the personalities involved have described their concepts and published their experimental results. Although infections we now know as, e.g., rabies, yellow fever, smallpox, etc. were clinically evident in early ... ...

    Abstract The history of virology can be traced as the personalities involved have described their concepts and published their experimental results. Although infections we now know as, e.g., rabies, yellow fever, smallpox, etc. were clinically evident in early human history, the initial isolation of individual viruses and their assignment to specific diseases did not occur until about 1898, 120 years ago, a proverbial drop in the bucket of time. Just one lifetime ago, Peter Medawar, awarded the Nobel Prize in Medicine and Physiology in 1960, defined viruses as a piece of nucleic acid surrounded by bad news.
    Schlagwörter covid19
    Verlag Elsevier; PMC
    Dokumenttyp Artikel ; Online
    DOI 10.1016/b978-0-12-801238-3.00078-7
    Datenquelle COVID19

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  4. Artikel ; Online: The game's afoot: seeking viruses that cause chronic and degenerative neurologic and psychiatric disorder.

    Oldstone, M B A

    Molecular psychiatry

    2012  Band 17, Heft 5, Seite(n) 472–473

    Mesh-Begriff(e) Bipolar Disorder/virology ; Borna disease virus/immunology ; Depressive Disorder, Major/virology ; Female ; Humans ; Male ; Schizophrenia/virology
    Sprache Englisch
    Erscheinungsdatum 2012-05
    Erscheinungsland England
    Dokumenttyp Comment ; Journal Article
    ZDB-ID 1330655-8
    ISSN 1476-5578 ; 1359-4184
    ISSN (online) 1476-5578
    ISSN 1359-4184
    DOI 10.1038/mp.2012.5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4812: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Artikel ; Online: Chapter 5 ZMapp The Ethics of Decision Making

    Oldstone, Michael B.A. / Rose Oldstone, Madeleine

    Ebola's Curse

    Abstract: ... by Michael Oldstone and Madeleine Rose Oldstone, unlocks the mysteries of the largest outbreak of one ...

    Abstract Abstract Ebola’s Curse: 2013–2016 Outbreak in West Africa, a timely, needed and well-presented book by Michael Oldstone and Madeleine Rose Oldstone, unlocks the mysteries of the largest outbreak of one of the world’s most fearsome viruses. What is Ebola? Why did this happen? Here you will find the answers to these questions, while meeting fascinating people thrust into a situation as dramatic as any that could be imagined in a blockbuster novel or movie. By reading this book you will come to understand why the world was unprepared for the outbreak of such a deadly pathogen as Ebola virus and why it still is. You will gain intimate knowledge of a pathogen that spread like a tsunami over a region of the world that lacked the resources to fight it. You will meet a group of people that by chance were already there to fight another deadly virus. You will find out how in a matter of weeks this small group of doctors, nurses, and scientists were overwhelmed and why this matters. You will meet people that fought with limited resources at hand and became heroes that put the possibility of saving their patients ahead of their own lives. In the end you will gain insights into steps that must be taken to ensure that such a horrific virus outbreak never happens again anywhere in the world.
    Schlagwörter covid19
    Verlag Elsevier; PMC
    Dokumenttyp Artikel ; Online
    DOI 10.1016/b978-0-12-813888-5.00005-6
    Datenquelle COVID19

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  6. Artikel ; Online: Chapter 9 Ebola’s Scorecard Failure of the WHO and the International Community

    Oldstone, Michael B.A. / Rose Oldstone, Madeleine

    Ebola's Curse

    Abstract: ... by Michael Oldstone and Madeleine Rose Oldstone, unlocks the mysteries of the largest outbreak of one ...

    Abstract Abstract Ebola’s Curse: 2013–2016 Outbreak in West Africa, a timely, needed and well-presented book by Michael Oldstone and Madeleine Rose Oldstone, unlocks the mysteries of the largest outbreak of one of the world’s most fearsome viruses. What is Ebola? Why did this happen? Here you will find the answers to these questions, while meeting fascinating people thrust into a situation as dramatic as any that could be imagined in a blockbuster novel or movie. By reading this book you will come to understand why the world was unprepared for the outbreak of such a deadly pathogen as Ebola virus and why it still is. You will gain intimate knowledge of a pathogen that spread like a tsunami over a region of the world that lacked the resources to fight it. You will meet a group of people that by chance were already there to fight another deadly virus. You will find out how in a matter of weeks this small group of doctors, nurses, and scientists were overwhelmed and why this matters. You will meet people that fought with limited resources at hand and became heroes that put the possibility of saving their patients ahead of their own lives. In the end you will gain insights into steps that must be taken to ensure that such a horrific virus outbreak never happens again anywhere in the world.
    Schlagwörter covid19
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    DOI 10.1016/b978-0-12-813888-5.00009-3
    Datenquelle COVID19

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  7. Artikel ; Online: ZMapp: The Ethics of Decision Making

    Oldstone, Michael B.A. / Rose Oldstone, Madeleine

    Ebola's Curse

    Abstract: ... by Michael Oldstone and Madeleine Rose Oldstone, unlocks the mysteries of the largest outbreak of one ...

    Abstract Ebola’s Curse: 2013–2016 Outbreak in West Africa, a timely, needed and well-presented book by Michael Oldstone and Madeleine Rose Oldstone, unlocks the mysteries of the largest outbreak of one of the world’s most fearsome viruses. What is Ebola? Why did this happen? Here you will find the answers to these questions, while meeting fascinating people thrust into a situation as dramatic as any that could be imagined in a blockbuster novel or movie. By reading this book you will come to understand why the world was unprepared for the outbreak of such a deadly pathogen as Ebola virus and why it still is. You will gain intimate knowledge of a pathogen that spread like a tsunami over a region of the world that lacked the resources to fight it. You will meet a group of people that by chance were already there to fight another deadly virus. You will find out how in a matter of weeks this small group of doctors, nurses, and scientists were overwhelmed and why this matters. You will meet people that fought with limited resources at hand and became heroes that put the possibility of saving their patients ahead of their own lives. In the end you will gain insights into steps that must be taken to ensure that such a horrific virus outbreak never happens again anywhere in the world.
    Schlagwörter covid19
    Verlag Elsevier; PMC
    Dokumenttyp Artikel ; Online
    DOI 10.1016/b978-0-12-813888-5.00005-6
    Datenquelle COVID19

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  8. Artikel ; Online: Ebola’s Scorecard: Failure of the WHO and the International Community

    Oldstone, Michael B.A. / Rose Oldstone, Madeleine

    Ebola's Curse

    Abstract: ... by Michael Oldstone and Madeleine Rose Oldstone, unlocks the mysteries of the largest outbreak of one ...

    Abstract Ebola’s Curse: 2013–2016 Outbreak in West Africa, a timely, needed and well-presented book by Michael Oldstone and Madeleine Rose Oldstone, unlocks the mysteries of the largest outbreak of one of the world’s most fearsome viruses. What is Ebola? Why did this happen? Here you will find the answers to these questions, while meeting fascinating people thrust into a situation as dramatic as any that could be imagined in a blockbuster novel or movie. By reading this book you will come to understand why the world was unprepared for the outbreak of such a deadly pathogen as Ebola virus and why it still is. You will gain intimate knowledge of a pathogen that spread like a tsunami over a region of the world that lacked the resources to fight it. You will meet a group of people that by chance were already there to fight another deadly virus. You will find out how in a matter of weeks this small group of doctors, nurses, and scientists were overwhelmed and why this matters. You will meet people that fought with limited resources at hand and became heroes that put the possibility of saving their patients ahead of their own lives. In the end you will gain insights into steps that must be taken to ensure that such a horrific virus outbreak never happens again anywhere in the world.
    Schlagwörter covid19
    Verlag PMC
    Dokumenttyp Artikel ; Online
    DOI 10.1016/b978-0-12-813888-5.00009-3
    Datenquelle COVID19

    Kategorien

    Fernleihe an ZB MED

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  9. Artikel ; Online: History of Virology

    Oldstone, M.B.A.

    Encyclopedia of Microbiology

    Abstract: Abstract The history of virology can be traced as the personalities involved have described their concepts and published their experimental results. Although infections we now know as, e.g., rabies, yellow fever, smallpox, etc. were clinically evident in ...

    Abstract Abstract The history of virology can be traced as the personalities involved have described their concepts and published their experimental results. Although infections we now know as, e.g., rabies, yellow fever, smallpox, etc. were clinically evident in early human history, the initial isolation of individual viruses and their assignment to specific diseases did not occur until about 1898, 120 years ago, a proverbial drop in the bucket of time. Just one lifetime ago, Peter Medawar, awarded the Nobel Prize in Medicine and Physiology in 1960, defined viruses as a piece of nucleic acid surrounded by bad news.
    Schlagwörter covid19
    Verlag Elsevier; PMC
    Dokumenttyp Artikel ; Online
    DOI 10.1016/b978-0-12-801238-3.00078-7
    Datenquelle COVID19

    Kategorien

    Fernleihe an ZB MED

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  10. Artikel ; Online: Expansion of CD8+ T cell population in Lassa virus survivors with low T cell precursor frequency reveals durable immune response in most survivors.

    LaVergne, Stephanie M / Sakabe, Saori / Momoh, Mambu / Kanneh, Lansana / Bond, Nell / Garry, Robert F / Grant, Donald S / de la Torre, Juan Carlos / Oldstone, Michael B A / Schieffelin, John S / Sullivan, Brian M

    PLoS neglected tropical diseases

    2022  Band 16, Heft 11, Seite(n) e0010882

    Abstract: Introduction: Lassa virus is a priority pathogen for vaccine research and development, however the duration of cellular immunity and protection in Lassa fever (LF) survivors remains unclear.: Methods: We investigated Lassa virus specific CD8+ T cell ... ...

    Abstract Introduction: Lassa virus is a priority pathogen for vaccine research and development, however the duration of cellular immunity and protection in Lassa fever (LF) survivors remains unclear.
    Methods: We investigated Lassa virus specific CD8+ T cell responses in 93 LF survivors. Peripheral blood mononuclear cells from these individuals were infected with recombinant vesicular stomatitis virus encoding Lassa virus antigens and virus specific T cell responses were measured after 18-hour incubation. Participants who had undetectable CD8+ T cell response underwent further analysis using a 10-day T cell proliferation assays to evaluate for low T cell precursor frequency.
    Results: Forty-five of the 93 LF survivors did not have a Lassa virus specific CD8+ T cell response. Of those with responses and a known date of onset of LF (N = 11), 9 had LF within the last ten years. Most participants without a measurable CD8+ T cell response were more than 10 years removed from a clinical history of LF (N = 14/16). Fourteen of 21 patients (67%) with undetectable CD8+ T cell response had a measurable Lassa virus specific CD8+ T cell response with the 10-day assay.
    Discussion: Despite reports of strong CD8+ T cell responses during acute Lassa virus infection, circulating Lassa virus-specific CD8+ T cells declined to undetectable levels in most Lassa fever survivors after ten years when evaluated with an 18-hour T cell stimulation. However, when Lassa virus-specific T cells were expanded prior to restimulation, a Lassa virus-specific CD8+ T cell response could be detected in many if the samples that were negative in the 18-hour stimulation assay, suggesting that prolonged cellular immunity does exist in Lassa fever survivors at low frequencies.
    Mesh-Begriff(e) Humans ; Lassa virus ; Lassa Fever ; Leukocytes, Mononuclear ; Precursor Cells, T-Lymphoid ; Immunity ; CD8-Positive T-Lymphocytes
    Sprache Englisch
    Erscheinungsdatum 2022-11-28
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2735
    ISSN (online) 1935-2735
    ISSN 1935-2735
    DOI 10.1371/journal.pntd.0010882
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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