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  1. Artikel ; Online: Molecular therapy for polyQ disorders: from bench to clinical trials.

    de Sousa-Lourenço, João / Silva, Ana C / Pereira de Almeida, Luís / Nobre, Rui J

    Trends in molecular medicine

    2024  

    Abstract: Polyglutamine (polyQ) disorders are monogenic neurodegenerative disorders. Currently, no therapies are available for this complex group of disorders. Here, we aim to provide an overview of recent promising preclinical studies and the ongoing clinical ... ...

    Abstract Polyglutamine (polyQ) disorders are monogenic neurodegenerative disorders. Currently, no therapies are available for this complex group of disorders. Here, we aim to provide an overview of recent promising preclinical studies and the ongoing clinical trials focusing on molecular therapies for polyQ disorders.
    Sprache Englisch
    Erscheinungsdatum 2024-06-04
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2036490-8
    ISSN 1471-499X ; 1471-4914
    ISSN (online) 1471-499X
    ISSN 1471-4914
    DOI 10.1016/j.molmed.2024.05.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Photosynthetic Pigment and Carbohydrate Profiling of

    Resende, Ana C R / Pereira, Rui / Nunes, Cláudia / Cruz, Sónia / Calado, Ricardo / Cartaxana, Paulo

    Plants (Basel, Switzerland)

    2023  Band 12, Heft 6

    Abstract: ... Fucus ... ...

    Abstract Fucus vesiculosus
    Sprache Englisch
    Erscheinungsdatum 2023-03-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12061324
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Napping behaviour, daytime sleepiness, and arousal in high performance athletes and non-athlete controls.

    Pereira, Rui / Hartescu, Iuliana / Jackson, Robin C / Morgan, Kevin

    Journal of sports sciences

    2023  Band 41, Heft 16, Seite(n) 1530–1537

    Abstract: Napping offers a strategy to manage sleep, aid recovery and enhance performance in elite sport. However, relatively little research attention has focussed on the natural history of athlete napping or tested the widely held assumption that athlete napping ...

    Abstract Napping offers a strategy to manage sleep, aid recovery and enhance performance in elite sport. However, relatively little research attention has focussed on the natural history of athlete napping or tested the widely held assumption that athlete napping is mainly a consequence of degraded night-time sleep. Within a sample of 158 team (
    Mesh-Begriff(e) Humans ; Sleep ; Arousal ; Attention ; Disorders of Excessive Somnolence ; Athletes
    Sprache Englisch
    Erscheinungsdatum 2023-12-11
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 995528-8
    ISSN 1466-447X ; 0264-0414
    ISSN (online) 1466-447X
    ISSN 0264-0414
    DOI 10.1080/02640414.2023.2281158
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Exposure to suicide in the family and suicidal ideation in Portugal during the Covid-19 pandemic: The mediating role of unbearable psychache.

    Pereira, Alexandra Medina / Campos, Rui C

    The British journal of clinical psychology

    2021  Band 61, Heft 3, Seite(n) 598–612

    Abstract: Objectives: This study tested the mediation effects of two facets of psychache - bearable and unbearable - in the relationship between exposure to suicide in the family and suicidal ideation in Portugal during the Covid-19 pandemic.: Methods: Two ... ...

    Abstract Objectives: This study tested the mediation effects of two facets of psychache - bearable and unbearable - in the relationship between exposure to suicide in the family and suicidal ideation in Portugal during the Covid-19 pandemic.
    Methods: Two hundred and forty-four adults aged between 19 and 64 participated. Two groups were defined: one exposed to suicide in the family (n = 42) and a control group (n = 192).
    Results: Path analysis using structural equation modelling tested a mediation model. Results demonstrated that unbearable psychache fully mediated the relationship between exposure to suicide and suicidal ideation, even when controlling for the mediation effects of depressive symptoms, the presence of a psychiatric diagnosis, and years of education.
    Conclusions: These results suggest that rather than considering just the global experience of psychache in individuals exposed to suicide, researchers and clinicians should look to the presence of unbearable psychache given its contribution to suicidal ideation.
    Practitioner points: Unbearable psychache fully mediated the relationship between exposure to suicide in the family and suicidal ideation It is not the global experience of psychache that contributes to suicide ideation in individuals exposed to suicide in the family rather the presence of unbearable psychache.
    Mesh-Begriff(e) Adult ; COVID-19 ; Humans ; Mental Disorders ; Middle Aged ; Pandemics ; Portugal/epidemiology ; Suicidal Ideation ; Young Adult
    Sprache Englisch
    Erscheinungsdatum 2021-08-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 625324-6
    ISSN 2044-8260 ; 0144-6657
    ISSN (online) 2044-8260
    ISSN 0144-6657
    DOI 10.1111/bjc.12325
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  5. Artikel: Zieve's Syndrome: An Underdiagnosed Cause of Non-immune Hemolytic Anemia.

    Ribeiro, Rui / Ferreira, Marli / Coelho, Rui / Pereira, Cláudia

    Cureus

    2024  Band 16, Heft 1, Seite(n) e52034

    Abstract: Zieve's syndrome is an underdiagnosed condition characterized by the triad of jaundice, hemolytic anemia, and hyperlipidemia in the setting of chronic alcohol use. It may be accompanied by acute alcoholic hepatitis. The distinction between the ... ...

    Abstract Zieve's syndrome is an underdiagnosed condition characterized by the triad of jaundice, hemolytic anemia, and hyperlipidemia in the setting of chronic alcohol use. It may be accompanied by acute alcoholic hepatitis. The distinction between the coexistence of acute alcoholic hepatitis with Zieve's syndrome and Zieve's syndrome in isolation is crucial, given the different treatments and prognoses in these situations. A 35-year-old woman presented with complaints of abdominal discomfort, nausea, and vomiting in the previous week. She was a heavy drinker with resultant cirrhosis, splenomegaly, and esophageal varices. An ancillary test showed hemolytic anemia, moderately elevated transaminases, hyperbilirubinemia, and coagulopathy. A negative direct Coombs test established the anemia as non-immune, supporting the diagnosis of Zieve's syndrome despite the absence of hyperlipidemia. Maddrey's discriminant function score was 92 points, so she was treated with supportive measures, as well as corticosteroids in the setting of acute alcoholic hepatitis. The patient showed a favorable clinical and analytical evolution and was discharged home one month following admission with her hemoglobin levels stabilized. Previous literature focused on the distinction between Zieve's syndrome and acute alcoholic hepatitis but they may coexist.
    Sprache Englisch
    Erscheinungsdatum 2024-01-10
    Erscheinungsland United States
    Dokumenttyp Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52034
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Synthesis and characterization of fluorescent poly(α-cyclodextrin)/carbon quantum dots composite for efficient removal and detection of toluene and xylene from aqueous media.

    Silva, Emilly C / Pina, João / Pereira, Rui F P / Murtinho, Dina / Valente, Artur J M / Fajardo, André R

    Environmental pollution (Barking, Essex : 1987)

    2024  Band 347, Seite(n) 123778

    Abstract: ... reveal that the accessible Stern-Volmer quenching constants for toluene and xylene are K ...

    Abstract This study reports the synthesis and characterization of a supramolecular composite comprised of carbon dots (CDots) embedded within net-poly[(α-cyclodextrin)-ν-(citric acid)] (α-CD/CA/CDots) for the removal and detection of toluene and xylene from aqueous media. The remarkable stability of CDots within the composite enables the preservation of photoluminescence properties for prolonged storage and extended UV-light irradiation. As demonstrated, following the adsorption of both organic compounds, the composite detected them in the aqueous medium due to a fluorescence quenching mechanism. Spectroscopic analyses reveal that the accessible Stern-Volmer quenching constants for toluene and xylene are K
    Mesh-Begriff(e) Toluene ; Xylenes/chemistry ; Carbon/chemistry ; Quantum Dots ; alpha-Cyclodextrins ; Water ; Coloring Agents
    Chemische Substanzen Toluene (3FPU23BG52) ; Xylenes ; Carbon (7440-44-0) ; alpha-Cyclodextrins ; Water (059QF0KO0R) ; Coloring Agents
    Sprache Englisch
    Erscheinungsdatum 2024-03-16
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2024.123778
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Risk Assessment of Nine Coccidiostats in Commercial and Home-Raised Eggs.

    Martins, Rui R / Pereira, André M P T / Silva, Liliana J G / Esteves, Alexandra / Duarte, Sofia C / Freitas, Andreia / Pena, Angelina

    Foods (Basel, Switzerland)

    2023  Band 12, Heft 6

    Abstract: The poultry industry, in order to prevent and control coccidiosis caused ... ...

    Abstract The poultry industry, in order to prevent and control coccidiosis caused by
    Sprache Englisch
    Erscheinungsdatum 2023-03-13
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12061225
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Nutritive Value and Bioactivities of a Halophyte Edible Plant:

    Correia, Iris / Antunes, Madalena / Tecelão, Carla / Neves, Marta / Pires, Cristiana L / Cruz, Pedro F / Rodrigues, Maria / Peralta, Claúdia C / Pereira, Cidália D / Reboredo, Fernando / Moreno, Maria João / Brito, Rui M M / Ribeiro, Vânia S / Vaz, Daniela C / Campos, Maria Jorge

    Plants (Basel, Switzerland)

    2024  Band 13, Heft 3

    Abstract: ... Crithmum ... ...

    Abstract Crithmum maritimum
    Sprache Englisch
    Erscheinungsdatum 2024-01-31
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13030427
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  9. Artikel ; Online: A metatranscriptomics strategy for efficient characterization of the microbiome in human tissues with low microbial biomass.

    Pereira-Marques, Joana / Ferreira, Rui M / Figueiredo, Ceu

    Gut microbes

    2024  Band 16, Heft 1, Seite(n) 2323235

    Abstract: The high background of host RNA poses a major challenge to metatranscriptome analysis of human samples. Hence, metatranscriptomics has been mainly applied to microbe-rich samples, while its application in human tissues with low ratio of microbial to host ...

    Abstract The high background of host RNA poses a major challenge to metatranscriptome analysis of human samples. Hence, metatranscriptomics has been mainly applied to microbe-rich samples, while its application in human tissues with low ratio of microbial to host cells has yet to be explored. Since there is no computational workflow specifically designed for the taxonomic and functional analysis of this type of samples, we propose an effective metatranscriptomics strategy to accurately characterize the microbiome in human tissues with a low ratio of microbial to host content. We experimentally generated synthetic samples with well-characterized bacterial and host cell compositions, and mimicking human samples with high and low microbial loads. These synthetic samples were used for optimizing and establishing the workflow in a controlled setting. Our results show that the integration of the taxonomic analysis of optimized Kraken 2/Bracken with the functional analysis of HUMAnN 3 in samples with low microbial content, enables the accurate identification of a large number of microbial species with a low false-positive rate, while improving the detection of microbial functions. The effectiveness of our metatranscriptomics workflow was demonstrated in synthetic samples, simulated datasets, and most importantly, human gastric tissue specimens, thus providing a proof of concept for its applicability on mucosal tissues of the gastrointestinal tract. The use of an accurate and reliable metatranscriptomics approach for human tissues with low microbial content will expand our understanding of the functional activity of the mucosal microbiome, uncovering critical interactions between the microbiome and the host in health and disease.
    Mesh-Begriff(e) Humans ; Biomass ; Gastrointestinal Microbiome/genetics ; Metagenomics/methods ; Microbiota/genetics ; Bacteria/genetics
    Sprache Englisch
    Erscheinungsdatum 2024-02-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2575755-6
    ISSN 1949-0984 ; 1949-0984
    ISSN (online) 1949-0984
    ISSN 1949-0984
    DOI 10.1080/19490976.2024.2323235
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: A critical look at the Portuguese public-private partnerships in healthcare.

    Pereira, Miguel A / Ferreira, Diogo C / Marques, Rui C

    The International journal of health planning and management

    2020  Band 36, Heft 2, Seite(n) 302–315

    Abstract: The pre-conceived idea that contracts in a public-private partnership (PPP) regime, in healthcare or in any other economic sector, are, as a rule, ruinous and appealing for only a share of the stakeholders, lacks a solid basis that confirms it. This idea, ...

    Abstract The pre-conceived idea that contracts in a public-private partnership (PPP) regime, in healthcare or in any other economic sector, are, as a rule, ruinous and appealing for only a share of the stakeholders, lacks a solid basis that confirms it. This idea, outset and nurtured by the media, has been instigating the distrust of the users who, in turn, demand a more rigorous and efficient utilisation of public resources. Being Portugal in the top of countries that resort to PPPs, it is urgent to inquire if its respective contracts originated an inefficient and ineffective management of resources. It is precisely this discussion that we address in this paper, focusing our efforts in the Portuguese healthcare sector.
    Mesh-Begriff(e) Contracts ; Delivery of Health Care ; Health Facilities ; Portugal ; Public-Private Sector Partnerships
    Sprache Englisch
    Erscheinungsdatum 2020-10-04
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 632786-2
    ISSN 1099-1751 ; 0749-6753
    ISSN (online) 1099-1751
    ISSN 0749-6753
    DOI 10.1002/hpm.3084
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