Artikel ; Online: New structural insights into the multifunctional influenza A matrix protein 1.
2021 Band 595, Heft 20, Seite(n) 2535–2543
Abstract: Influenza A virus matrix protein 1 (M1) is the most abundant protein within virions and functions at multiple steps of the virus life cycle, including nuclear RNA export, virus particle assembly, and virus disassembly. Two recent publications have ... ...
| Abstract | Influenza A virus matrix protein 1 (M1) is the most abundant protein within virions and functions at multiple steps of the virus life cycle, including nuclear RNA export, virus particle assembly, and virus disassembly. Two recent publications have presented the first structures of full-length M1 and show that it assembles filaments in vitro via an interface between the N- and C-terminal domains of adjacent monomers. These filaments were found to be similar to those that form the endoskeleton of assembled virions. The structures provide a molecular basis to understand the functions of M1 during the virus life cycle. Here, we compare and discuss the two structures, and explore their implications for the mechanisms by which the multifunctional M1 protein can mediate virus assembly, interact with viral ribonucleoproteins and act during infection of a new cell. |
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| Mesh-Begriff(e) | Humans ; Influenza A virus/chemistry ; Protein Conformation ; Viral Matrix Proteins/chemistry |
| Chemische Substanzen | M1 protein, Influenza A virus ; Viral Matrix Proteins |
| Sprache | Englisch |
| Erscheinungsdatum | 2021-10-02 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 212746-5 |
| ISSN | 1873-3468 ; 0014-5793 |
| ISSN (online) | 1873-3468 |
| ISSN | 0014-5793 |
| DOI | 10.1002/1873-3468.14194 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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