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  1. Artikel ; Online: A beacon in the cytoplasm: Tracking translation of single mRNAs.

    Pingali, Hema V / Hilliker, Angela K

    The Journal of cell biology

    2016  Band 214, Heft 6, Seite(n) 649–652

    Abstract: Translation is carefully regulated to control protein levels and allow quick responses to changes in the environment. Certain questions about translation in vivo have been unattainable until now. In this issue, Pichon et al. (2016. J. Cell Biol http://dx. ...

    Abstract Translation is carefully regulated to control protein levels and allow quick responses to changes in the environment. Certain questions about translation in vivo have been unattainable until now. In this issue, Pichon et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201605024) describe a new technique to allow real-time monitoring of translation on single mRNAs.
    Mesh-Begriff(e) Cytoplasm ; RNA, Messenger
    Chemische Substanzen RNA, Messenger
    Sprache Englisch
    Erscheinungsdatum 2016--12
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 218154-x
    ISSN 1540-8140 ; 0021-9525
    ISSN (online) 1540-8140
    ISSN 0021-9525
    DOI 10.1083/jcb.201608075
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Haploidentical transplant with posttransplant cyclophosphamide vs matched unrelated donor transplant for acute myeloid leukemia.

    Ciurea, Stefan O / Zhang, Mei-Jie / Bacigalupo, Andrea A / Bashey, Asad / Appelbaum, Frederick R / Aljitawi, Omar S / Armand, Philippe / Antin, Joseph H / Chen, Junfang / Devine, Steven M / Fowler, Daniel H / Luznik, Leo / Nakamura, Ryotaro / O'Donnell, Paul V / Perales, Miguel-Angel / Pingali, Sai Ravi / Porter, David L / Riches, Marcie R / Ringdén, Olle T H /
    Rocha, Vanderson / Vij, Ravi / Weisdorf, Daniel J / Champlin, Richard E / Horowitz, Mary M / Fuchs, Ephraim J / Eapen, Mary

    Blood

    2015  Band 126, Heft 8, Seite(n) 1033–1040

    Abstract: We studied adults with acute myeloid leukemia (AML) after haploidentical (n = 192) and 8/8 HLA-matched unrelated donor (n = 1982) transplantation. Haploidentical recipients received calcineurin inhibitor (CNI), mycophenolate, and posttransplant ... ...

    Abstract We studied adults with acute myeloid leukemia (AML) after haploidentical (n = 192) and 8/8 HLA-matched unrelated donor (n = 1982) transplantation. Haploidentical recipients received calcineurin inhibitor (CNI), mycophenolate, and posttransplant cyclophosphamide for graft-versus-host disease (GVHD) prophylaxis; 104 patients received myeloablative and 88 received reduced intensity conditioning regimens. Matched unrelated donor transplant recipients received CNI with mycophenolate or methotrexate for GVHD prophylaxis; 1245 patients received myeloablative and 737 received reduced intensity conditioning regimens. In the myeloablative setting, day 30 neutrophil recovery was lower after haploidentical compared with matched unrelated donor transplants (90% vs 97%, P = .02). Corresponding rates after reduced intensity conditioning transplants were 93% and 96% (P = .25). In the myeloablative setting, 3-month acute grade 2-4 (16% vs 33%, P < .0001) and 3-year chronic GVHD (30% vs 53%, P < .0001) were lower after haploidentical compared with matched unrelated donor transplants. Similar differences were observed after reduced intensity conditioning transplants, 19% vs 28% (P = .05) and 34% vs 52% (P = .002). Among patients receiving myeloablative regimens, 3-year probabilities of overall survival were 45% (95% CI, 36-54) and 50% (95% CI, 47-53) after haploidentical and matched unrelated donor transplants (P = .38). Corresponding rates after reduced intensity conditioning transplants were 46% (95% CI, 35-56) and 44% (95% CI, 0.40-47) (P = .71). Although statistical power is limited, these data suggests that survival for patients with AML after haploidentical transplantation with posttransplant cyclophosphamide is comparable with matched unrelated donor transplantation.
    Mesh-Begriff(e) Adult ; Aged ; Cyclophosphamide/therapeutic use ; Female ; Graft vs Host Disease/prevention & control ; HLA Antigens/genetics ; Hematopoietic Stem Cell Transplantation/methods ; Histocompatibility Testing ; Humans ; Immunosuppressive Agents/therapeutic use ; Kaplan-Meier Estimate ; Leukemia, Myeloid, Acute/mortality ; Leukemia, Myeloid, Acute/surgery ; Male ; Middle Aged ; Proportional Hazards Models ; Tissue Donors ; Transplantation Conditioning/methods ; Young Adult
    Chemische Substanzen HLA Antigens ; Immunosuppressive Agents ; Cyclophosphamide (8N3DW7272P)
    Sprache Englisch
    Erscheinungsdatum 2015-06-30
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2015-04-639831
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 364: Hefte anzeigen

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