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  1. Buch: Molecular and cell biology of pain

    Price, Theodore J. / Dussor, Gregory

    (Progress in molecular biology and translational science ; 131)

    2015  

    Verfasserangabe ed. by Theodore J. Price ; Gregory Dussor
    Serientitel Progress in molecular biology and translational science ; 131
    Überordnung
    Schlagwörter Pain ; Pain/Treatment ; Schmerzforschung
    Schlagwörter Schmerz
    Thema/Rubrik (Code) 616.0472
    Sprache Englisch
    Umfang XVIII, 630, [7] Bl. : Ill., graph. Darst.
    Ausgabenhinweis 1. ed.
    Verlag Elsevier AP
    Erscheinungsort Amsterdam u.a.
    Erscheinungsland Niederlande
    Dokumenttyp Buch
    HBZ-ID HT018599802
    ISBN 978-0-12-801389-2 ; 9780128014325 ; 0-12-801389-3 ; 0128014326
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Artikel ; Online: A humanized focus on sickle cell pain.

    Sadler, Katelyn E / Price, Theodore J

    Blood

    2024  Band 143, Heft 20, Seite(n) 2016–2017

    Mesh-Begriff(e) Humans ; Anemia, Sickle Cell/complications ; Anemia, Sickle Cell/pathology ; Anemia, Sickle Cell/therapy ; Pain/etiology ; Pain/pathology ; Pain Management/methods
    Sprache Englisch
    Erscheinungsdatum 2024-05-16
    Erscheinungsland United States
    Dokumenttyp Editorial ; Journal Article
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2024024328
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Commentary on: Conserved transcriptional programming across sex and species after peripheral nerve injury predicts treatments for neuropathic pain.

    Lesnak, Joseph B / Price, Theodore J

    British journal of pharmacology

    2023  Band 180, Heft 20, Seite(n) 2603–2604

    Mesh-Begriff(e) Humans ; Peripheral Nerve Injuries/drug therapy ; Neuralgia/drug therapy ; Hyperalgesia
    Sprache Englisch
    Erscheinungsdatum 2023-07-25
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.16189
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Tiam1 creates a painful link between dendritic spine remodeling and NMDA receptors.

    Davis, Olivia C / Price, Theodore J

    Neuron

    2023  Band 111, Heft 13, Seite(n) 1993–1995

    Abstract: Dendritic spine remodeling in the dorsal horn is associated with many chronic pain models. Li et al. demonstrate that Tiam1 links Rac1-mediated spine changes to NMDA receptor activity to promote behavioral signs of chronic pain in rodents. ...

    Abstract Dendritic spine remodeling in the dorsal horn is associated with many chronic pain models. Li et al. demonstrate that Tiam1 links Rac1-mediated spine changes to NMDA receptor activity to promote behavioral signs of chronic pain in rodents.
    Mesh-Begriff(e) Humans ; Receptors, N-Methyl-D-Aspartate/metabolism ; Chronic Pain ; Dendritic Spines/metabolism ; Signal Transduction ; Neurons/metabolism ; rac1 GTP-Binding Protein/metabolism
    Chemische Substanzen Receptors, N-Methyl-D-Aspartate ; rac1 GTP-Binding Protein (EC 3.6.5.2)
    Sprache Englisch
    Erscheinungsdatum 2023-07-06
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 808167-0
    ISSN 1097-4199 ; 0896-6273
    ISSN (online) 1097-4199
    ISSN 0896-6273
    DOI 10.1016/j.neuron.2023.06.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: RNA isoform expression landscape of the human dorsal root ganglion generated from long-read sequencing.

    Arendt-Tranholm, Asta / Mwirigi, Juliet M / Price, Theodore J

    Pain

    2024  

    Abstract: Abstract: Splicing is a posttranscriptional RNA processing mechanism that enhances genomic complexity by creating multiple isoforms from the same gene. We aimed to characterize the isoforms expressed in the human peripheral nervous system, with the goal ...

    Abstract Abstract: Splicing is a posttranscriptional RNA processing mechanism that enhances genomic complexity by creating multiple isoforms from the same gene. We aimed to characterize the isoforms expressed in the human peripheral nervous system, with the goal of creating a resource to identify novel isoforms of functionally relevant genes associated with somatosensation and nociception. We used long-read sequencing to document isoform expression in the human dorsal root ganglia from 3 organ donors and validated in silico by confirming expression in short-read sequencing from 3 independent organ donors. Nineteen thousand five hundred forty-seven isoforms of protein-coding genes were detected and validated. We identified 763 isoforms with at least one previously undescribed splice junction. Previously unannotated isoforms of multiple pain-associated genes, including ASIC3, MRGPRX1, and HNRNPK, were identified. In the novel isoforms of ASIC3, a region comprising approximately 35% of the 5'UTR was excised. By contrast, a novel splice junction was used in isoforms of MRGPRX1 to include an additional exon upstream of the start codon, consequently adding a region to the 5'UTR. Novel isoforms of HNRNPK were identified, which used previously unannotated splice sites to both excise exon 14 and include a sequence in the 3' end of exon 13. This novel insertion is predicted to introduce a tyrosine phosphorylation site potentially phosphorylated by SRC. We also independently confirm a recently reported DRG-specific splicing event in WNK1 that gives insight into how painless peripheral neuropathy occurs when this gene is mutated. Our findings give a clear overview of mRNA isoform diversity in the human dorsal root ganglia obtained using long-read sequencing.
    Sprache Englisch
    Erscheinungsdatum 2024-05-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 193153-2
    ISSN 1872-6623 ; 0304-3959
    ISSN (online) 1872-6623
    ISSN 0304-3959
    DOI 10.1097/j.pain.0000000000003255
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: MNK1 and MNK2 expression in the human dorsal root and trigeminal ganglion.

    Shiers, Stephanie / Sahn, James J / Price, Theodore J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Mitogen activated protein kinase interacting kinases (MNK) 1 and 2 are serine/threonine protein kinases that play an important role in translation of mRNAs through their phosphorylation of the RNA 5’-cap binding protein, eukaryotic translation ... ...

    Abstract Mitogen activated protein kinase interacting kinases (MNK) 1 and 2 are serine/threonine protein kinases that play an important role in translation of mRNAs through their phosphorylation of the RNA 5’-cap binding protein, eukaryotic translation initiation factor (eIF) 4E. These kinases are downstream targets for mitogen activated protein kinases (MAPKs), extracellular activity regulated protein kinase (ERK) and p38. MNKs have been implicated in the sensitization of peripheral nociceptors of the dorsal root and trigeminal ganglion (DRG and TG) using transgenic mouse lines and through the use of specific inhibitors of MNK1 and MNK2. While specific knockout of the
    Sprache Englisch
    Erscheinungsdatum 2023-01-04
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.01.04.522773
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: RNA isoform expression landscape of the human dorsal root ganglion (DRG) generated from long read sequencing.

    Arendt-Tranholm, Asta / Mwirigi, Juliet M / Price, Theodore J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Splicing is a post-transcriptional RNA processing mechanism that enhances genomic complexity by creating multiple isoforms from the same gene. Diversity in splicing in the mammalian nervous system is associated with neuronal development, synaptic ... ...

    Abstract Splicing is a post-transcriptional RNA processing mechanism that enhances genomic complexity by creating multiple isoforms from the same gene. Diversity in splicing in the mammalian nervous system is associated with neuronal development, synaptic function and plasticity, and is also associated with diseases of the nervous system ranging from neurodegeneration to chronic pain. We aimed to characterize the isoforms expressed in the human peripheral nervous system, with the goal of creating a resource to identify novel isoforms of functionally relevant genes associated with somatosensation and nociception. We used long read sequencing (LRS) to document isoform expression in the human dorsal root ganglia (hDRG) from 3 organ donors. Isoforms were validated
    Sprache Englisch
    Erscheinungsdatum 2023-11-01
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.10.28.564535
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Translation regulation and pain special issue editorial for neurobiology of pain.

    Price, Theodore J

    Neurobiology of pain (Cambridge, Mass.)

    2018  Band 4, Seite(n) 1

    Sprache Englisch
    Erscheinungsdatum 2018-05-30
    Erscheinungsland United States
    Dokumenttyp Editorial
    ISSN 2452-073X
    ISSN 2452-073X
    DOI 10.1016/j.ynpai.2018.05.001
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Nerve Detection and Visualization Using Hyperspectral Imaging for Surgical Guidance.

    Tran, Minh Ha / Bryarly, Michelle / Ma, Ling / Yousuf, Muhammad Saad / Price, Theodore J / Fei, Baowei

    Proceedings of SPIE--the International Society for Optical Engineering

    2024  Band 12930

    Abstract: During surgery of delicate regions, differentiation between nerve and surrounding tissue is crucial. Hyperspectral imaging (HSI) techniques can enhance the contrast between types of tissue beyond what the human eye can differentiate. Whereas an RGB image ...

    Abstract During surgery of delicate regions, differentiation between nerve and surrounding tissue is crucial. Hyperspectral imaging (HSI) techniques can enhance the contrast between types of tissue beyond what the human eye can differentiate. Whereas an RGB image captures 3 bands within the visible light range (
    Sprache Englisch
    Erscheinungsdatum 2024-04-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 0277-786X
    ISSN 0277-786X
    DOI 10.1117/12.3008470
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Neuroimmune Mechanisms Underlying Post-acute Sequelae of SARS-CoV-2 (PASC) Pain, Predictions from a Ligand-Receptor Interactome.

    Lesnak, Joseph B / Mazhar, Khadijah / Price, Theodore J

    Current rheumatology reports

    2023  Band 25, Heft 9, Seite(n) 169–181

    Abstract: Purpose of review: Individuals with post-acute sequelae of SARS-CoV-2 (PASC) complain of persistent musculoskeletal pain. Determining how COVID-19 infection produces persistent pain would be valuable for the development of therapeutics aimed at ... ...

    Abstract Purpose of review: Individuals with post-acute sequelae of SARS-CoV-2 (PASC) complain of persistent musculoskeletal pain. Determining how COVID-19 infection produces persistent pain would be valuable for the development of therapeutics aimed at alleviating these symptoms.
    Recent findings: To generate hypotheses regarding neuroimmune interactions in PASC, we used a ligand-receptor interactome to make predictions about how ligands from PBMCs in individuals with COVID-19 communicate with dorsal root ganglia (DRG) neurons to induce persistent pain. In a structured literature review of -omics COVID-19 studies, we identified ligands capable of binding to receptors on DRG neurons, which stimulate signaling pathways including immune cell activation and chemotaxis, the complement system, and type I interferon signaling. The most consistent finding across immune cell types was an upregulation of genes encoding the alarmins S100A8/9 and MHC-I. This ligand-receptor interactome, from our hypothesis-generating literature review, can be used to guide future research surrounding mechanisms of PASC-induced pain.
    Mesh-Begriff(e) Humans ; SARS-CoV-2 ; Neuroimmunomodulation ; COVID-19/complications ; Ligands ; Disease Progression ; Musculoskeletal Pain
    Chemische Substanzen Ligands
    Sprache Englisch
    Erscheinungsdatum 2023-06-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2057357-1
    ISSN 1534-6307 ; 1523-3774
    ISSN (online) 1534-6307
    ISSN 1523-3774
    DOI 10.1007/s11926-023-01107-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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