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Artikel ; Online: Assessment of health risk, genotoxicity, and thiol compounds in Trigonella foenum-graecum (Fenugreek) under arsenic stress.

Ahmad, Javed / Yasmeen, Rubina / Irfan, Mohammad / Al-Huqail, Asma A / Qureshi, Mohammad Irfan

Environmental science and pollution research international

2022

Abstract: Arsenic (As) traces have been reported worldwide in vegetables and crops cultivated in As-polluted soils. Being carcinogenic, the presence of As in edibles is of great concern as it ultimately reaches humans and animals through the food chain. Besides, ... ...

Abstract	Arsenic (As) traces have been reported worldwide in vegetables and crops cultivated in As-polluted soils. Being carcinogenic, the presence of As in edibles is of great concern as it ultimately reaches humans and animals through the food chain. Besides, As toxicity adversely affects the growth, physiology, metabolism, and productivity of crops. In the present study, Trigonella foenum-graecum (Fenugreek) was exposed to the As stress (0, 50, 100, and 150 μM sodium arsenate) for a week. Further, evaluation of As accumulation in roots and shoots, magnitude and visualization of oxyradicals, and thiol-based defence offered by Fenugreek was assessed. The root and leaf accumulated 258-453 μg g
Sprache	Englisch
Erscheinungsdatum	2022-07-30
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-22269-5
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Assessment of health risk, genotoxicity, and thiol compounds in Trigonella foenum-graecum (Fenugreek) under arsenic stress

Ahmad, Javed / Yasmeen, Rubina / Irfan, Mohammad / Al-Huqail, Asma A. / Qureshi, Mohammad Irfan

Environ Sci Pollut Res. 2023 Jan., v. 30, no. 1 p.884-898

2023

Abstract	Arsenic (As) traces have been reported worldwide in vegetables and crops cultivated in As-polluted soils. Being carcinogenic, the presence of As in edibles is of great concern as it ultimately reaches humans and animals through the food chain. Besides, As toxicity adversely affects the growth, physiology, metabolism, and productivity of crops. In the present study, Trigonella foenum-graecum (Fenugreek) was exposed to the As stress (0, 50, 100, and 150 μM sodium arsenate) for a week. Further, evaluation of As accumulation in roots and shoots, magnitude and visualization of oxyradicals, and thiol-based defence offered by Fenugreek was assessed. The root and leaf accumulated 258–453 μg g⁻¹ dry wt (DW) and 81.4–102.1 μg g⁻¹ DW of As, respectively. An arsenic-mediated decline in the growth index and increase in oxidative stress was noted. Arsenic stress modulated the content of thiol compounds; especially cysteine content increased from 0.36 to 0.43 µmole g⁻¹ FW protein was noted. Random Amplified Polymorphic DNA (RAPD)–based analysis showed DNA damage in As-treated plants. Health risk assessment parameters showed that As concentration in the consumable plant shoot was below the critical hazard level (hazard quotient < 1). Moreover, T. foenum-graecum showed varied responses to As-induced oxidative stress with applied concentrations (150 μM being more toxic than lower concentrations). In addition, the RAPD profile and level of thiol compounds were proved significant biomarkers to assess the As toxicity in plants. The conclusion of this study will help users of fenugreek to have a clue and create awareness regarding the consumption.
Schlagwörter	DNA damage ; Trigonella foenum-graecum ; arsenic ; biomarkers ; carcinogenicity ; cysteine ; decline ; fenugreek ; food chain ; genotoxicity ; health effects assessments ; leaves ; metabolism ; oxidative stress ; random amplified polymorphic DNA technique ; risk ; sodium arsenate ; thiols
Sprache	Englisch
Erscheinungsverlauf	2023-01
Umfang	p. 884-898.
Erscheinungsort	Springer Berlin Heidelberg
Dokumenttyp	Artikel ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-022-22269-5
Datenquelle	NAL Katalog (AGRICOLA)

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Artikel: Heartwood Extract of

Dar, Mohammad Irfan / Rafat, Sahar / Dev, Kapil / Abass, Sageer / Khan, Mohammad Umar / Abualsunun, Walaa A / Murshid, Samar S / Ahmad, Sayeed / Qureshi, Mohammad Irfan

Metabolites

2022 Band 12, Heft 10

Abstract: Diabetes mellitus leads to cellular damage and causes apoptosis by oxidative stress. Heartwood extract ... ...

Abstract	Diabetes mellitus leads to cellular damage and causes apoptosis by oxidative stress. Heartwood extract of
Sprache	Englisch
Erscheinungsdatum	2022-10-05
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo12100947
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Impact of Some Toxic Metals on Important ABC Transporters in Soybean (

Naaz, Sheeba / Ahmad, Nadeem / Jameel, M Rizwan / Al-Huqail, Asma A / Khan, Faheema / Qureshi, M Irfan

ACS omega

2023 Band 8, Heft 30, Seite(n) 27597–27611

Abstract: In plants, ATP-binding cassette (ABC) transporters facilitate the movement of substrates across membranes using ATP for growth, development, and defense. Soils contaminated with toxic metals such as cadmium (Cd) and mercury (Hg) might adversely affect ... ...

Abstract	In plants, ATP-binding cassette (ABC) transporters facilitate the movement of substrates across membranes using ATP for growth, development, and defense. Soils contaminated with toxic metals such as cadmium (Cd) and mercury (Hg) might adversely affect the metabolism of plants and humans. In this study, a phylogenetic relationship among soybeans' (
Sprache	Englisch
Erscheinungsdatum	2023-07-19
Erscheinungsland	United States
Dokumenttyp	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c03325
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Testing of acute and sub-acute toxicity profile of novel naproxen sodium nanoformulation in male and female mice.

Qureshi, Irfan Zia / Razzaq, Ayesha / Naz, Syeda Sohaila

Regulatory toxicology and pharmacology : RTP

2024 Band 150, Seite(n) 105650

Abstract: Nanodrugs offer promising alternatives to conventionally used over the counter drugs. Compared to its free form, therapeutic benefits, and gastric tissue safety of naproxen sodium nanoformulation (NpNF) were recently demonstrated. Essential regulatory ... ...

Abstract	Nanodrugs offer promising alternatives to conventionally used over the counter drugs. Compared to its free form, therapeutic benefits, and gastric tissue safety of naproxen sodium nanoformulation (NpNF) were recently demonstrated. Essential regulatory safety data for this formulation are, however, not available. To address this, male and female BALB/c mice were subjected to acute and 14-day repeated-oral dose assessments. Our data indicate that NpNF was well tolerated up to 2000 mg/kg b.w. A 14-day subacute toxicity testing revealed that the oral administration of low dose (30 mg/kg) NpNF did not produce any adverse effects on blood profile and serum biochemical parameters. Levels of oxidative stress markers and antioxidant enzymes neared normal. Histology of selected tissues also showed no evidence of toxicity. In contrast, a ten-fold increase in NpNF dosage (300 mg/kg), demonstrated, irrespective of gender, mild to moderate toxicity (p < 0.05) in the brain, stomach, and heart tissues, while ROS, LPO, CAT, SOD, POD, and GSH levels remained unaffected in the liver, kidney, spleen, testis, and seminal vesicles. No effect on serum biochemical parameters, overall indicated a no-observed-adverse-effect level (NOAEL) is 300 mg/kg. Further increase in dosage (1000 mg/kg) significantly altered all parameters demonstrating that high dose is toxic.
Sprache	Englisch
Erscheinungsdatum	2024-05-21
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	604672-1
ISSN	1096-0295 ; 0273-2300
ISSN (online)	1096-0295
ISSN	0273-2300
DOI	10.1016/j.yrtph.2024.105650
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Impact of Ferrous Sulfate on Thylakoidal Multiprotein Complexes, Metabolism and Defence of

Ali, Arlene Asthana / Ahmad, Javed / Baig, Mohammad Affan / Ahmad, Altaf / A Al-Huqail, Asma / Qureshi, Mohammad Irfan

Plants (Basel, Switzerland)

2022 Band 11, Heft 12

Abstract: Forty-day- ... ...

Abstract	Forty-day-old
Sprache	Englisch
Erscheinungsdatum	2022-06-13
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2704341-1
ISSN	2223-7747
ISSN	2223-7747
DOI	10.3390/plants11121559
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Trigonella foenum-graecum (fenugreek) differentially regulates antioxidant potential, photosynthetic, and metabolic activities under arsenic stress.

Ahmad, Javed / Beg, Md Amjad / Ali, Arlene A / Al-Huqail, Asma A / Qureshi, M Irfan

Ecotoxicology and environmental safety

2022 Band 246, Seite(n) 114128

Abstract: Arsenic (As) contamination is continuously increasing in the groundwaters and soils around the world causing toxicity in the plants with a detrimental effect on physiology, growth, and yield. In a hydroponic system, thirty-day-old plants of Trigonella ... ...

Abstract	Arsenic (As) contamination is continuously increasing in the groundwaters and soils around the world causing toxicity in the plants with a detrimental effect on physiology, growth, and yield. In a hydroponic system, thirty-day-old plants of Trigonella foenum-graecum were subjected to 0, 50, or 100 µM NaHAsO
Mesh-Begriff(e)	Trigonella ; Antioxidants/metabolism ; Arsenic/metabolism ; Plant Extracts/pharmacology ; Oxidative Stress ; Photosynthesis
Chemische Substanzen	Antioxidants ; Arsenic (N712M78A8G) ; Plant Extracts
Sprache	Englisch
Erscheinungsdatum	2022-09-30
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2022.114128
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Naproxen sodium nanoparticles are less toxic and gastroprotective agents than the conventional NSAID drug naproxen sodium in Balb/c mice.

Razzaq, Ayesha / Qureshi, Irfan Zia

Toxicology and applied pharmacology

2022 Band 452, Seite(n) 116192

Abstract: Use of non-steroidal anti-inflammatory drugs (NSAIDs) is one of the leading causes of gastric ulcers. Excellent therapeutic properties have made the use of NSAIDs widespread. Nano-drug delivery to reduce systemic toxicity through modulating drug ... ...

Abstract	Use of non-steroidal anti-inflammatory drugs (NSAIDs) is one of the leading causes of gastric ulcers. Excellent therapeutic properties have made the use of NSAIDs widespread. Nano-drug delivery to reduce systemic toxicity through modulating drug pharmacokinetics may be a better choice. Presently, we investigated if naproxen nanoformulation (PVA capped NPRS-MgO NPs) is less toxic to be used as an alternative drug. Groups of mice were assigned to control, NPRS-treated, CNF-treated, UNF-treated, and MgO NPs-treated groups. Analyses included gross examination of gastric mucosa, calculation of ulcer and inhibition indices, determination of tissue levels of reactive oxygen species (ROS), malondialdehyde (MDA), catalase (CAT), peroxidase (POD), superoxide dismutase (SOD), and reduced glutathione (GSH), histological and immunohistochemical assessment of i-NOS, COX-2, and caspase-3 of stomach mucosa, q-PCR for the detection of mRNA expression of IL-1β, IL-6, and TNF-α. Results were compared statistically at P < 0.05. Compared to NPRS-treated mice which developed multiple ulcers, had elevated MDA and ROS levels, and deceased CAT, POD, SOD, and GSH levels, significantly increased expression of IL-1β, IL-6, and TNF-α mRNA, damaged surface epithelium with disrupted glandular architecture and leucocyte infiltration of lamina propria with a marked increase in mucosal COX-2, i-NOS, and caspase-3 expression, oral administration of coated and uncoated naproxen nanoformulations prevented the gross mucosal damage by a restoration of all biochemical, histological, and immunohistochemical alterations to near control levels. The present study demonstrates that naproxen sodium nanoformulation has a gastroprotective action and in the clinical setting can be a better alternative to conventional naproxen.
Mesh-Begriff(e)	Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Caspase 3/genetics ; Caspase 3/metabolism ; Cyclooxygenase 2/genetics ; Cyclooxygenase 2/metabolism ; Gastric Mucosa/metabolism ; Gastric Mucosa/pathology ; Interleukin-6/metabolism ; Magnesium Oxide/metabolism ; Magnesium Oxide/therapeutic use ; Mice ; Mice, Inbred BALB C ; Nanoparticles/therapeutic use ; Naproxen/metabolism ; Naproxen/pharmacology ; Naproxen/therapeutic use ; Pharmaceutical Preparations/metabolism ; RNA, Messenger/metabolism ; Rats ; Rats, Wistar ; Reactive Oxygen Species/metabolism ; Stomach Ulcer/chemically induced ; Stomach Ulcer/drug therapy ; Stomach Ulcer/prevention & control ; Superoxide Dismutase/metabolism ; Tumor Necrosis Factor-alpha/metabolism
Chemische Substanzen	Anti-Inflammatory Agents, Non-Steroidal ; Interleukin-6 ; Pharmaceutical Preparations ; RNA, Messenger ; Reactive Oxygen Species ; Tumor Necrosis Factor-alpha ; Magnesium Oxide (3A3U0GI71G) ; Naproxen (57Y76R9ATQ) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Superoxide Dismutase (EC 1.15.1.1) ; Caspase 3 (EC 3.4.22.-)
Sprache	Englisch
Erscheinungsdatum	2022-08-08
Erscheinungsland	United States
Dokumenttyp	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	204477-8
ISSN	1096-0333 ; 0041-008X
ISSN (online)	1096-0333
ISSN	0041-008X
DOI	10.1016/j.taap.2022.116192
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Insights from the molecular docking analysis of gambogic acid with the Chikungunya spike glycoprotein E2.

Qamar, Sadia / Syeda, Amna / Amjad Beg, M / Irfan Qureshi, M

Bioinformation

2023 Band 19, Heft 5, Seite(n) 525–530

Abstract: Chikungunya fever is a mosquito-borne disease caused by the chikungunya virus (CHIKV) and has drawn substantial attention in recent years. So far, no effective treatment is available in the form of drugs or vaccines. In this study, we aimed to screen ... ...

Abstract	Chikungunya fever is a mosquito-borne disease caused by the chikungunya virus (CHIKV) and has drawn substantial attention in recent years. So far, no effective treatment is available in the form of drugs or vaccines. In this study, we aimed to screen some drugs against the pathogenic Chikungunya virus through a molecular docking approach. As a fact, the spike E2 protein plays an important role in viral attachment to the human host cell, binding to a cell receptor MXRA8. The molecules screened for in-silico interaction against MXRA8 were selected with top hit based on binding affinity. The existing intermolecular bonds were investigated further in the active site of the protein that interacts with the top-hit ligands. Gambogic acid (guttic acid) was depicted as the furthermost potential inhibitor when compared to the others it had the lowest binding affinity (-10.9 kcal/mol). Gambogic acid, as a potential antiviral agent against the spike E2 protein, could be a promising candidate.
Sprache	Englisch
Erscheinungsdatum	2023-05-31
Erscheinungsland	Singapore
Dokumenttyp	Journal Article
ZDB-ID	2203786-X
ISSN	0973-2063
ISSN	0973-2063
DOI	10.6026/97320630019525
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: CRISPR/Cas9-Mediated Genome Editing of Soluble Starch Synthesis Enzyme in Rice for Low Glycemic Index

Jameel, Mohd Rizwan / Ansari, Zubaida / Al-Huqail, Asma A. / Naaz, Sheeba / Qureshi, Mohammad Irfan

Agronomy. 2022 Sept. 16, v. 12, no. 9

2022

Abstract: In the present study, the selected rice (Oryza sativa cv. indica) was genetically modified to increase the amylose content in the seeds. The ‘CRISPR-Cas9’ genome-editing tool was used to knock out three isoforms of soluble starch synthase (SSS) viz. ... ...

Abstract	In the present study, the selected rice (Oryza sativa cv. indica) was genetically modified to increase the amylose content in the seeds. The ‘CRISPR-Cas9’ genome-editing tool was used to knock out three isoforms of soluble starch synthase (SSS) viz. SSSII-1, SSSII-2 and SSSII-3. A genetic transformation vector designed with appropriate gRNAs, Cas9, and antibiotic resistance was used to create SSS knockout mutants to enrich the content of amylose. Putative rice mutants were developed with high amylose content in the seeds of up to 63% as compared to 23% in the wild types (control). Rice with a low Glycemic Index (GI) value and high amylose content rice is preferred to avoid a sudden rise in glucose in the bloodstream. The frequencies of bi-allelic or homozygous transgenic lines of SSSII-1, SSSII-2, and SSSII-3 in the first generation were tested via the Mendelian fashion of segregated bi-allelic lines in the T₁ generation of the putative rice mutants. The T₁ generation segregation showed a frame-shift mutation. A molecular characterization of the putative mutants successfully demonstrated the development of a Cas9-free rice mutant with a higher amount of amylose in the rice.
Schlagwörter	CRISPR-Cas systems ; Oryza sativa ; agronomy ; amylose ; antibiotic resistance ; blood flow ; gene editing ; genetic transformation ; genetically modified organisms ; genome ; glucose ; glycemic index ; homozygosity ; mutants ; mutation ; rice ; starch synthase
Sprache	Englisch
Erscheinungsverlauf	2022-0916
Erscheinungsort	Multidisciplinary Digital Publishing Institute
Dokumenttyp	Artikel
ZDB-ID	2607043-1
ISSN	2073-4395
ISSN	2073-4395
DOI	10.3390/agronomy12092206
Datenquelle	NAL Katalog (AGRICOLA)

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