Artikel ; Online: Construction of a tubular scaffold that mimics J-shaped stress/strain mechanics using an innovative electrospinning technique.
Tissue engineering. Part C, Methods
2012 Band 18, Heft 8, Seite(n) 567–574
Abstract: ... characterized by a "J"-shaped curve on a stress-strain diagram with a low-stiffness highly elastic zone giving ... formation in tissues whose primary loading is pressure-based. "J"-shaped behavior arises ... of the corrugated laminae seen in blood vessels. In doing so, tubular scaffolds have been fabricated with complex "J ...
Abstract | Soft tissues such as blood vessel, lung, ureter, skin, etc., possess mechanical behavior characterized by a "J"-shaped curve on a stress-strain diagram with a low-stiffness highly elastic zone giving rise to a high-stiffness zone. This mechanical behavior may be adaptive and protective against aneurysm formation in tissues whose primary loading is pressure-based. "J"-shaped behavior arises from the synergistic interplay of two main structural proteins: collagen and elastin. An innovative electrospinning technique has been utilized to form tubular scaffold composites with structural features reminiscent of the corrugated laminae seen in blood vessels. In doing so, tubular scaffolds have been fabricated with complex "J"-shaped behavior through the use of elastic polyurethane and reinforcing poly-glycolic acid (PGA) woven mesh. In these studies, corrugated laminae were formed on the 175 μm and 1.5 mm scale. Initial moduli were 0.5±0.17 MPa (mean±standard deviation) giving rise to stiffer moduli of 36.09±6.72 MPa at a strain of 1.31±0.15. Burst pressures were physiologically relevant at 3095±1016 mmHg. The toughness of these prototypes was 6.3±1.9 MJ/m(3). The ability to employ different materials and different formation parameters utilizing this technique promises the ability to match complex stress-strain behaviors in soft tissues with a high degree of fidelity. |
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Mesh-Begriff(e) | Animals ; Elasticity ; Electrochemistry/methods ; Equipment Design ; Female ; Humans ; Male ; Materials Testing ; Polyglycolic Acid/chemistry ; Polyurethanes/chemistry ; Pressure ; Stress, Mechanical ; Tensile Strength ; Tissue Engineering/methods ; Tissue Scaffolds |
Chemische Substanzen | Polyurethanes ; Polyglycolic Acid (26009-03-0) |
Sprache | Englisch |
Erscheinungsdatum | 2012-08 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article |
ZDB-ID | 2420585-0 |
ISSN | 1937-3392 ; 1937-3384 |
ISSN (online) | 1937-3392 |
ISSN | 1937-3384 |
DOI | 10.1089/ten.TEC.2011.0286 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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