Artikel ; Online: PRELIMINARY REPORT ON THE PUTATIVE ASSOCIATION OF IL10 -3575 T/A GENETIC POLYMORPHISM WITH MALARIA SYMPTOMS.
Revista do Instituto de Medicina Tropical de Sao Paulo
2016 Band 58, Seite(n) 30
Abstract: ... However, regarding the IL10 -3575 T/A SNP, there were significantly more AA and AT subjects, carrying the polymorphic ... suggested the possibility that the IL10 - 3575 T/A SNP might be associated with the presence and maintenance ...
| Abstract | Only a small percentage of individuals living in endemic areas develop severe malaria suggesting that host genetic factors may play a key role. This study has determined the frequency of single nucleotide polymorphisms (SNPs) in some pro and anti-inflammatory cytokine gene sequences: IL6 (-174; rs1800795), IL12p40 (+1188; rs3212227), IL4 (+33; rs2070874), IL10 (-3575; rs1800890) and TGFb1 (+869; rs1800470), by means of PCR-RFLP. Blood samples were collected from 104 symptomatic and 37 asymptomatic subjects. Laboratory diagnosis was assessed by the thick blood smear test and nested-PCR. No association was found between IL6 (-174), IL12p40 (+1188), IL4 (+33), IL10 (- 3575), TGFb1 (+869) SNPs and malaria symptoms. However, regarding the IL10 -3575 T/A SNP, there were significantly more AA and AT subjects, carrying the polymorphic allele A, in the symptomatic group (c2 = 4.54, p = 0.01, OR = 0.40 [95% CI - 0.17- 0.94]). When the analysis was performed by allele, the frequency of the polymorphic allele A was also significantly higher in the symptomatic group (c2 = 4.50, p = 0.01, OR = 0.45 [95% CI - 0.21-0.95]). In conclusion, this study has suggested the possibility that the IL10 - 3575 T/A SNP might be associated with the presence and maintenance of malaria symptoms in individuals living in endemic areas. Taking into account that this polymorphism is related to decreased IL10 production, a possible role of this SNP in the pathophysiology of malaria is also suggested, but replication studies with a higher number of patients and evaluation of IL10 levels are needed for confirmation. |
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| Mesh-Begriff(e) | Adolescent ; Adult ; Aged ; Case-Control Studies ; Child ; Child, Preschool ; Female ; Genetic Predisposition to Disease ; Genotype ; Humans ; Interleukin-10/genetics ; Malaria/genetics ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Young Adult |
| Chemische Substanzen | Interleukin-10 (130068-27-8) |
| Sprache | Englisch |
| Erscheinungsdatum | 2016 |
| Erscheinungsland | Brazil |
| Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 128928-7 |
| ISSN | 1678-9946 ; 0036-4665 |
| ISSN (online) | 1678-9946 |
| ISSN | 0036-4665 |
| DOI | 10.1590/S1678-9946201658030 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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