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  1. Buch ; Online: Phagocytosis: Molecular Mechanisms and Physiological Implications

    Lafuente, Esther M. / Niedergang, Florence / Rosales, Carlos

    2020  

    Schlagwörter Medicine ; Immunology ; phagocytosis ; phagosome ; CR3 ; necrotic debris ; efferocytosis ; macrophages ; microglia ; opsonins
    Umfang 1 electronic resource (251 pages)
    Verlag Frontiers Media SA
    Dokumenttyp Buch ; Online
    Anmerkung English ; Open Access
    HBZ-ID HT021230402
    ISBN 9782889661473 ; 2889661474
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  2. Buch ; Online: Integrative Approaches to the Molecular Physiology of Inflammation

    Hernández-Lemus, Enrique / Elena Soto, María / Rosales, Carlos

    2019  

    Schlagwörter Science: general issues ; Physiology ; Inflammation ; Molecular Physiology ; Integrative Approaches ; Complex Diseases
    Umfang 1 electronic resource (334 pages)
    Verlag Frontiers Media SA
    Dokumenttyp Buch ; Online
    Anmerkung English ; Open Access
    HBZ-ID HT021229859
    ISBN 9782889458004 ; 2889458008
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  3. Artikel ; Online: Reseña de "Guía general del Archivo Histórico Científico Manuel Sandoval Vallarta" de José Carlos Castañeda Reyes, Martha Ortega Soto y Federico Lazarín Miranda (eds.)

    ARMANDO ROJAS ROSALES

    Signos Históricos, Iss 19, Pp 192-

    2008  Band 200

    Schlagwörter History (General) ; D1-2009 ; History (General) and history of Europe ; D
    Sprache Spanisch
    Erscheinungsdatum 2008-01-01T00:00:00Z
    Verlag Universidad Autónoma Metropolitana Unidad Iztapalapa
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  4. Artikel: Neutrophils versus Protozoan Parasites:

    Uribe-Querol, Eileen / Rosales, Carlos

    Microorganisms

    2024  Band 12, Heft 4

    Abstract: Neutrophils are the most abundant polymorphonuclear granular leukocytes in human blood and are an essential part of the innate immune system. Neutrophils are efficient cells that eliminate pathogenic bacteria and fungi, but their role in dealing with ... ...

    Abstract Neutrophils are the most abundant polymorphonuclear granular leukocytes in human blood and are an essential part of the innate immune system. Neutrophils are efficient cells that eliminate pathogenic bacteria and fungi, but their role in dealing with protozoan parasitic infections remains controversial. At sites of protozoan parasite infections, a large number of infiltrating neutrophils is observed, suggesting that neutrophils are important cells for controlling the infection. Yet, in most cases, there is also a strong inflammatory response that can provoke tissue damage. Diseases like malaria, trichomoniasis, leishmaniasis, Chagas disease, and amoebiasis affect millions of people globally. In this review, we summarize these protozoan diseases and describe the novel view on how neutrophils are involved in protection from these parasites. Also, we present recent evidence that neutrophils play a double role in these infections participating both in control of the parasite and in the pathogenesis of the disease.
    Sprache Englisch
    Erscheinungsdatum 2024-04-19
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12040827
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Neutrophils vs. amoebas: Immunity against the protozoan parasite Entamoeba histolytica.

    Rosales, Carlos

    Journal of leukocyte biology

    2021  Band 110, Heft 6, Seite(n) 1241–1252

    Abstract: Entamoeba histolytica is a protozoan parasite with high prevalence in developing countries, and causes amoebiasis. This disease affects the intestine and the liver, and is the third leading cause of human deaths among parasite infections. E. histolytica ... ...

    Abstract Entamoeba histolytica is a protozoan parasite with high prevalence in developing countries, and causes amoebiasis. This disease affects the intestine and the liver, and is the third leading cause of human deaths among parasite infections. E. histolytica infection of the intestine or liver is associated with a strong inflammation characterized by a large number of infiltrating neutrophils. Consequently, several reports suggest that neutrophils play a protective role in amoebiasis. However, other reports indicate that amoebas making direct contact with neutrophils provoke lysis of these leukocytes, resulting in the release of their lytic enzymes, which in turn provoke tissue damage. Therefore, the role of neutrophils in this parasitic infection remains controversial. Neutrophils migrate from the circulation to sites of infection, where they display several antimicrobial functions, including phagocytosis, degranulation, and formation of neutrophil extracellular traps (NET). Recently, it was found that E. histolytica trophozoites are capable of inducing NET formation. Neutrophils in touch with amoebas launched NET in an explosive manner around the amoebas and completely covered them in nebulous DNA and cell aggregates where parasites got immobilized and killed. In addition, the phenotype of neutrophils can be modified by the microbiome resulting in protection against amoebas. This review describes the mechanisms of E. histolytica infection and discusses the novel view of how neutrophils are involved in innate immunity defense against amoebiasis. Also, the mechanisms on how the microbiome modulates neutrophil function are described.
    Mesh-Begriff(e) Animals ; Entamoeba histolytica/immunology ; Entamoebiasis/immunology ; Humans ; Neutrophils/immunology
    Sprache Englisch
    Erscheinungsdatum 2021-06-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.4MR0521-849RR
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Neutrophils at the crossroads of innate and adaptive immunity.

    Rosales, Carlos

    Journal of leukocyte biology

    2020  Band 108, Heft 1, Seite(n) 377–396

    Abstract: Neutrophils are the most abundant leukocytes in blood. From the circulation, they are quickly mobilized to sites of inflammation and/or infection. At the affected tissues, neutrophils display an impressive array of antimicrobial functions, including ... ...

    Abstract Neutrophils are the most abundant leukocytes in blood. From the circulation, they are quickly mobilized to sites of inflammation and/or infection. At the affected tissues, neutrophils display an impressive array of antimicrobial functions, including degranulation, production of reactive oxygen species (ROS), phagocytosis, and formation of neutrophil extracellular traps (NET). Because neutrophils are the first type of leukocytes to arrive at affected tissues and display potent microbicidal functions, they have been classically viewed as the first line of defense. In this view, neutrophils only destroy invading pathogens and then quietly die at the site of infection. However, in the last decade it has become increasingly evident that neutrophils are much more complex cells having not only effector functions in the innate immune response, but also the capacity of modulating the adaptive immune response, via direct interaction with, or by producing cytokines that affect dendritic cells and lymphocytes. In addition, neutrophil heterogeneity with clear different functional phenotypes has been recently described particularly in cancer and inflammation. This review provides an overview on the life of a neutrophil describing its beginnings, lifespan, and their principal functions in innate and adaptive immunity. Also, neutrophil heterogeneity and our current understanding of neutrophil contributions to health and disease are discussed.
    Mesh-Begriff(e) Adaptive Immunity ; Animals ; Anti-Infective Agents/metabolism ; Cell Adhesion ; Homeostasis ; Humans ; Immunity, Innate/immunology ; Neutrophils/immunology
    Chemische Substanzen Anti-Infective Agents
    Sprache Englisch
    Erscheinungsdatum 2020-03-23
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1002/JLB.4MIR0220-574RR
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Human neutrophil Fc gamma receptors: different buttons for different responses.

    Alemán, Omar Rafael / Rosales, Carlos

    Journal of leukocyte biology

    2023  Band 114, Heft 6, Seite(n) 571–584

    Abstract: Neutrophils are fundamental cells in host defense. These leukocytes are quickly recruited from the blood to sites of infection or tissue damage. At these sites, neutrophils initiate several innate immune responses, including phagocytosis, production of ... ...

    Abstract Neutrophils are fundamental cells in host defense. These leukocytes are quickly recruited from the blood to sites of infection or tissue damage. At these sites, neutrophils initiate several innate immune responses, including phagocytosis, production of reactive oxygen species, degranulation to release proteases and other antimicrobial compounds, production of inflammatory mediators, and formation of neutrophil extracellular traps. In addition to their role in innate immunity, neutrophils are now recognized as cells that also regulate adaptive immunity, via interaction with dendritic cells and lymphocytes. Neutrophils also respond to adaptive immunity by interacting with antibody molecules. Indeed, antibody molecules allow neutrophils to have antigen-specific responses. Neutrophils express different receptors for antibodies. The receptors for immunoglobulin G molecules are known as Fcγ receptors. Upon Fcγ receptor aggregation on the cell membrane, these receptors trigger distinct signal transduction cascades that activate particular cellular responses. In this review, we describe the major Fcγ receptors expressed on human neutrophils and discuss how each Fcγ receptor activates a choice of signaling pathways to stimulate particular neutrophil responses.
    Mesh-Begriff(e) Humans ; Neutrophils ; Receptors, IgG/metabolism ; Phagocytosis ; Immunity, Innate ; Signal Transduction ; Extracellular Traps/metabolism
    Chemische Substanzen Receptors, IgG
    Sprache Englisch
    Erscheinungsdatum 2023-07-12
    Erscheinungsland England
    Dokumenttyp Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1093/jleuko/qiad080
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Vitamin supplements that positively influence COVID-19 treatment.

    Carlos-Gutiérrez, Liliana R / Rosales-León, Tomás F / Salazar-Deza, Carmen A / Carlos-Reyes, Melecio B

    Gaceta medica de Mexico

    2023  Band 159, Heft 3, Seite(n) 273–274

    Titelübersetzung Suplementos vitamínicos que influyen positivamente en el tratamiento de COVID-19.
    Mesh-Begriff(e) Humans ; Vitamins/therapeutic use ; COVID-19 ; COVID-19 Drug Treatment ; Dietary Supplements ; Vitamin D
    Chemische Substanzen Vitamins ; Vitamin D (1406-16-2)
    Sprache Englisch
    Erscheinungsdatum 2023-07-25
    Erscheinungsland Mexico
    Dokumenttyp Letter ; Comment
    ZDB-ID 425456-9
    ISSN 0016-3813
    ISSN 0016-3813
    DOI 10.24875/GMM.M23000779
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Nonsurgical Management of Shoulder Pain in Rotator Cuff Tears: Ultrasound-Guided Biceps Tenotomy Combined With Corticosteroid Injection.

    García, Nicolás / Droppelmann, Guillermo / Oliver, Nicolás / Jorquera, Carlos / Rosales, Julio

    Arthroscopy techniques

    2024  Band 13, Heft 2, Seite(n) 102847

    Abstract: Traditionally, the management of rotator cuff tears in elderly individuals has involved surgical intervention, specifically biceps tenotomy. However, surgical procedures come with inherent medical risks and significant financial costs. As an alternative, ...

    Abstract Traditionally, the management of rotator cuff tears in elderly individuals has involved surgical intervention, specifically biceps tenotomy. However, surgical procedures come with inherent medical risks and significant financial costs. As an alternative, ultrasound-guided biceps tenotomy combined with corticosteroid has emerged as a highly effective, well-tolerated, and cost-efficient option. This article aims to describe the procedural technique of nonsurgical management using ultrasound-guided biceps tenotomy combined with corticosteroid injection.
    Sprache Englisch
    Erscheinungsdatum 2024-01-01
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2653101-X
    ISSN 2212-6287
    ISSN 2212-6287
    DOI 10.1016/j.eats.2023.09.022
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?

    Rosales, Carlos

    Frontiers in physiology

    2018  Band 9, Seite(n) 113

    Abstract: Neutrophils are the most abundant leukocytes in the circulation, and have been regarded as first line of defense in the innate arm of the immune system. They capture and destroy invading microorganisms, through phagocytosis and intracellular degradation, ...

    Abstract Neutrophils are the most abundant leukocytes in the circulation, and have been regarded as first line of defense in the innate arm of the immune system. They capture and destroy invading microorganisms, through phagocytosis and intracellular degradation, release of granules, and formation of neutrophil extracellular traps after detecting pathogens. Neutrophils also participate as mediators of inflammation. The classical view for these leukocytes is that neutrophils constitute a homogenous population of terminally differentiated cells with a unique function. However, evidence accumulated in recent years, has revealed that neutrophils present a large phenotypic heterogeneity and functional versatility, which place neutrophils as important modulators of both inflammation and immune responses. Indeed, the roles played by neutrophils in homeostatic conditions as well as in pathological inflammation and immune processes are the focus of a renovated interest in neutrophil biology. In this review, I present the concept of neutrophil phenotypic and functional heterogeneity and describe several neutrophil subpopulations reported to date. I also discuss the role these subpopulations seem to play in homeostasis and disease.
    Sprache Englisch
    Erscheinungsdatum 2018-02-20
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2018.00113
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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