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Artikel: An outreach activity to enhance biochemistry pedagogy.

Roth, Karl S / Bannerman, Tammy / Gopalan, Venkat

2023 Band 48, Heft 5, Seite(n) 410–413

Abstract: Students are self-motivated to learn when provided opportunities that connect theory and real-world applications. Here, we describe for biochemistry majors a newborn screening-focused outreach activity that seeks to develop students' mastery of ... ...

Abstract	Students are self-motivated to learn when provided opportunities that connect theory and real-world applications. Here, we describe for biochemistry majors a newborn screening-focused outreach activity that seeks to develop students' mastery of disciplinary content and soft skills (e.g., critical thinking, teamwork, effective communication, community engagement) and to enhance student engagement.
Mesh-Begriff(e)	Humans ; Biochemistry/education ; Students
Sprache	Englisch
Erscheinungsdatum	2023-03-14
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	194216-5
ISSN	1362-4326 ; 0968-0004 ; 0376-5067
ISSN (online)	1362-4326
ISSN	0968-0004 ; 0376-5067
DOI	10.1016/j.tibs.2023.02.003
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Liver-targeted polymeric prodrugs delivered subcutaneously improve tafenoquine therapeutic window for malaria radical cure.

Science advances

2024 Band 10, Heft 16, Seite(n) eadk4492

Abstract: Approximately 3.3 billion people live with the threat ... ...

Abstract	Approximately 3.3 billion people live with the threat of
Mesh-Begriff(e)	Humans ; Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Aminoquinolines/adverse effects ; Malaria/drug therapy ; Malaria, Vivax/drug therapy ; Malaria, Vivax/chemically induced ; Liver
Chemische Substanzen	tafenoquine (262P8GS9L9) ; Antimalarials ; Aminoquinolines
Sprache	Englisch
Erscheinungsdatum	2024-04-19
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adk4492
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Diabetes insipidus and Guillain-Barré-like syndrome following CAR-T cell therapy: a case report.

Koch, Christian / Fleischer, Juliane / Popov, Todor / Frontzek, Karl / Schreiner, Bettina / Roth, Patrick / Manz, Markus G / Unseld, Simone / Müller, Antonia M S / Russkamp, Norman F

Journal for immunotherapy of cancer

2023 Band 11, Heft 1

Abstract: Background: Immune effector cell-associated neurotoxicity syndrome (ICANS) is a common adverse event of CD19-directed chimeric antigen receptor (CAR) T cell therapy. Other neurological adverse events, however, have not methodically been described and ... ...

Abstract	Background: Immune effector cell-associated neurotoxicity syndrome (ICANS) is a common adverse event of CD19-directed chimeric antigen receptor (CAR) T cell therapy. Other neurological adverse events, however, have not methodically been described and studied. Furthermore, safety data on CAR-T cell therapy in patients with central nervous system (CNS) lymphoma remain limited. Main body: We here report occurrence of a Guillain-Barré-like syndrome (GBS) and central diabetes insipidus (cDI) following tisagenlecleucel therapy for relapsed high-grade lymphoma with CNS involvement. Both complications were refractory to standard treatment of ICANS. Weakness of respiratory muscles required mechanical ventilation and tracheostomy while cDI was treated with desmopressin substitution for several weeks. Muscle-nerve biopsy and nerve conduction studies confirmed an axonal pattern of nerve damage. T cell-rich infiltrates and detection of the CAR transgene in muscle-nerve sections imply a direct or indirect role of CAR-T cell-mediated inflammation. In line with current treatment guidelines for GBS, intravenous immunoglobulin was administered and gradual but incomplete recovery was observed over the course of several months. Conclusions: This case report highlights the risk of rare but severe neurological adverse events, such as acute GBS or cDI, in patients treated with CAR-T cells. It further underlines the importance of appropriate patient surveillance and systematic reporting of rare complications to eventually improve treatment.
Mesh-Begriff(e)	Humans ; Receptors, Chimeric Antigen ; Immunotherapy, Adoptive/adverse effects ; Lymphoma, Non-Hodgkin ; Central Nervous System Neoplasms ; Diabetes Insipidus/etiology ; Cell- and Tissue-Based Therapy ; Diabetes Mellitus
Chemische Substanzen	Receptors, Chimeric Antigen ; cell-associated neurotoxicity
Sprache	Englisch
Erscheinungsdatum	2023-01-23
Erscheinungsland	England
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2022-006059
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch: Biochemistry and disease

Cohn, Robert M. / Roth, Karl S.

bridging basic science and clinical practice

1996

Verfasserangabe	Robert M. Cohn ; Karl S. Roth
Schlagwörter	Medicine ; Biochemistry ; Metabolic Diseases
Sprache	Englisch
Umfang	XIV, 587 S. : graph. Darst.
Verlag	Williams & Wilkins
Erscheinungsort	Baltimore u.a.
Erscheinungsland	Vereinigte Staaten
Dokumenttyp	Buch
HBZ-ID	HT007558033
ISBN	0-683-02049-8 ; 978-0-683-02049-6
Datenquelle	Katalog ZB MED Medizin, Gesundheit

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Signatur	Leihstatus	Standort
1997 A 4717	bestellbar zur Ausleihe	Magazin

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Artikel: Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2

Eastman, Richard T / Rusinova, Radda / Herold, Karl F / Huang, Xi-Ping / Dranchak, Patricia / Voss, Ty C / Rana, Sandeep / Shrimp, Jonathan H / White, Alex D / Hemmings, Hugh C / Roth, Bryan L / Inglese, James / Andersen, Olaf S / Dahlin, Jayme L

bioRxiv : the preprint server for biology

2023

Abstract: Since it was proposed as a potential host-directed antiviral agent for SARS-CoV-2, the antiparasitic drug ivermectin has been investigated thoroughly in clinical trials, which have provided insufficient support for its clinical efficacy. To examine the ... ...

Abstract	Since it was proposed as a potential host-directed antiviral agent for SARS-CoV-2, the antiparasitic drug ivermectin has been investigated thoroughly in clinical trials, which have provided insufficient support for its clinical efficacy. To examine the potential for ivermectin to be repurposed as an antiviral agent, we therefore undertook a series of preclinical studies. Consistent with early reports, ivermectin decreased SARS-CoV-2 viral burden in
Sprache	Englisch
Erscheinungsdatum	2023-10-24
Erscheinungsland	United States
Dokumenttyp	Preprint
DOI	10.1101/2023.10.23.563088
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Buch: Pediatric endocrinology and inborn errors of metabolism

Sarafoglou, Kyriakie / Hoffmann, Georg F / Roth, Karl S

2017

Verfasserangabe	editor, Kyriakie Sarafoglou ; associate editors, Georg F. Hoffmann, Karl S. Roth
Mesh-Begriff(e)	Endocrine System Diseases ; Child ; Metabolism, Inborn Errors ; Infant
Sprache	Englisch
Umfang	p. ;, cm.
Ausgabenhinweis	Second edition.
Dokumenttyp	Buch
ISBN	9780071773140 ; 0071773142
Datenquelle	Katalog der US National Library of Medicine (NLM)

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Artikel ; Online: Concurrent isolation of hepatic stem cells and hepatocytes from the human liver.

Lee, Serene M L / Bertinetti-Lapatki, Cristina / Schiergens, Tobias S / Jauch, Karl-Walter / Roth, Adrian B / Thasler, Wolfgang E

In vitro cellular & developmental biology. Animal

2020 Band 56, Heft 3, Seite(n) 253–260

Abstract: Hepatocytes differentiated from induced pluripotent stem cells or stem cells have the potential to be representative in vitro models of the human liver for research as well as early safety assessment programs. However, up until now, there has been no ... ...

Abstract	Hepatocytes differentiated from induced pluripotent stem cells or stem cells have the potential to be representative in vitro models of the human liver for research as well as early safety assessment programs. However, up until now, there has been no definitive proof that differentiated hepatocytes recapitulate the phenotype and functional characteristics of primary hepatocytes from the same individual. Thus, a method for the concurrent isolation of hepatocytes and hepatic stem cells is presented here to provide the cells necessary for the evaluation of the required benchmarking. The method presented here generated high-quality hepatocytes with a purity of 94 ± 1% and a high percentage viability of 79 ± 2%. Furthermore, the hepatic stem cells isolated were found to be actively proliferating and have a purity of 98 ± 1%. Thus, these isolated cells can be used as a powerful tool for the validation of differentiated hepatocyte in vitro models.
Mesh-Begriff(e)	Cell Separation/methods ; Epithelial Cell Adhesion Molecule/metabolism ; Hepatocytes/cytology ; Humans ; Keratin-19/metabolism ; Liver/cytology ; Liver Cirrhosis/pathology ; Stem Cells/cytology ; Stem Cells/metabolism
Chemische Substanzen	Epithelial Cell Adhesion Molecule ; Keratin-19
Sprache	Englisch
Erscheinungsdatum	2020-03-27
Erscheinungsland	Germany
Dokumenttyp	Journal Article
ZDB-ID	1077810-x
ISSN	1543-706X ; 0883-8364 ; 1071-2690
ISSN (online)	1543-706X
ISSN	0883-8364 ; 1071-2690
DOI	10.1007/s11626-020-00433-w
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: The immune response to a Coxiella burnetii vaccine in sheep varies according to their natural pre-exposure.

Böttcher, Jens / Bauer, Benjamin U / Ambros, Christina / Alex, Michaela / Domes, Ursula / Roth, Sabine / Boll, Kerstin / Korneli, Martin / Bogner, Karl-Heinz / Randt, Andreas / Janowetz, Britta

Vaccine

2024 Band 42, Heft 8, Seite(n) 1993–2003

Abstract: Q fever in humans is caused by Coxiella (C.) burnetii. In 2008 and 2012, cases of Q fever in humans were linked to an infected flock of approximately 650 ewes. Since 2013 gimmers (G'13, G'14, G'15 etc.) were primary vaccinated (two doses) with an ... ...

Abstract	Q fever in humans is caused by Coxiella (C.) burnetii. In 2008 and 2012, cases of Q fever in humans were linked to an infected flock of approximately 650 ewes. Since 2013 gimmers (G'13, G'14, G'15 etc.) were primary vaccinated (two doses) with an inactivated C.burnetii vaccine without any revaccination. In 2013, 30 ewes were primary vaccinated (A'13). Shedding was annually monitored by qPCR-testing of vaginal and nasal swabs collected at lambing. Animals were tested for Phase I- (PhI) and PhII-antibodies (Ab) and for PhII-specific-interferon-γ (IFN-γ) before and after vaccination. The effect of a revaccination was determined in 2018 and 2023. Groups of randomly selected gimmers primary vaccinated in 2015, 2016 and 2017 and a mixed group of older animals (A'13, G'13 and G'14) were revaccinated once in 2018. The trial was repeated in 2023 on groups primary vaccinated in 2019-2023. Major shedding after the outbreak in 2012 ceased in 2014. Thereafter C.burnetii was only sporadically detected at low-level in 2018, 2021 and 2023. Sheep naturally exposed to C.burnetii during the outbreak in 2012 (A'13, G'13) mounted a strong and complete (PhI, PhII, IFN-γ) recall immune response after vaccination. A serological PhI
Mesh-Begriff(e)	Humans ; Sheep ; Animals ; Female ; Coxiella burnetii ; Q Fever/prevention & control ; Q Fever/veterinary ; Q Fever/epidemiology ; Antibodies ; Bacterial Vaccines ; Immunity
Chemische Substanzen	Antibodies ; Bacterial Vaccines
Sprache	Englisch
Erscheinungsdatum	2024-02-21
Erscheinungsland	Netherlands
Dokumenttyp	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2024.02.048
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.MO 458: Hefte anzeigen

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Artikel ; Online: Nonspecific membrane bilayer perturbations by ivermectin underlie SARS-CoV-2 in vitro activity

bioRxiv

Abstract	Since it was proposed as a potential host-directed antiviral agent for SARS-CoV-2, the antiparasitic drug ivermectin has been investigated thoroughly in clinical trials, which have provided insufficient support for its clinical efficacy. To examine the potential for ivermectin to be repurposed as an antiviral agent, we therefore undertook a series of preclinical studies. Consistent with early reports, ivermectin decreased SARS-CoV-2 viral burden in in vitro models at low micromolar concentrations, five- to ten-fold higher than the reported toxic clinical concentration. At similar concentrations, ivermectin also decreased cell viability and increased biomarkers of cytotoxicity and apoptosis. Further mechanistic and profiling studies revealed that ivermectin nonspecifically perturbs membrane bilayers at the same concentrations where it decreases the SARS-CoV-2 viral burden, resulting in nonspecific modulation of membrane-based targets such as G-protein coupled receptors and ion channels. These results suggest that a primary molecular mechanism for the in vitro antiviral activity of ivermectin may be nonspecific membrane perturbation, indicating that ivermectin is unlikely to be translatable into a safe and effective antiviral agent. These results and experimental workflow provide a useful paradigm for performing preclinical studies on (pandemic-related) drug repurposing candidates.
Schlagwörter	covid19
Sprache	Englisch
Erscheinungsdatum	2023-10-24
Verlag	Cold Spring Harbor Laboratory
Dokumenttyp	Artikel ; Online
DOI	10.1101/2023.10.23.563088
Datenquelle	COVID19

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Artikel: Concurrent isolation of hepatic stem cells and hepatocytes from the human liver

Lee, Serene M. L / Bertinetti-Lapatki, Cristina / Schiergens, Tobias S / Jauch, Karl-Walter / Roth, Adrian B / Thasler, Wolfgang E

In vitro cellular & developmental biology. 2020 Mar., v. 56, no. 3

2020

Abstract	Hepatocytes differentiated from induced pluripotent stem cells or stem cells have the potential to be representative in vitro models of the human liver for research as well as early safety assessment programs. However, up until now, there has been no definitive proof that differentiated hepatocytes recapitulate the phenotype and functional characteristics of primary hepatocytes from the same individual. Thus, a method for the concurrent isolation of hepatocytes and hepatic stem cells is presented here to provide the cells necessary for the evaluation of the required benchmarking. The method presented here generated high-quality hepatocytes with a purity of 94 ± 1% and a high percentage viability of 79 ± 2%. Furthermore, the hepatic stem cells isolated were found to be actively proliferating and have a purity of 98 ± 1%. Thus, these isolated cells can be used as a powerful tool for the validation of differentiated hepatocyte in vitro models.
Schlagwörter	functional properties ; hepatocytes ; humans ; induced pluripotent stem cells ; liver ; models ; phenotype ; safety assessment ; viability
Sprache	Englisch
Erscheinungsverlauf	2020-03
Umfang	p. 253-260.
Erscheinungsort	Springer US
Dokumenttyp	Artikel
ISSN	1071-2690
DOI	10.1007/s11626-020-00433-w
Datenquelle	NAL Katalog (AGRICOLA)

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