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  1. Artikel ; Online: Blood Magnesium levels in migraineurs within and between the headache attacks: a case control study.

    Samaie, Afshin / Asghari, Nabiollah / Ghorbani, Raheb / Arda, Jafar

    The Pan African medical journal

    2012  Band 11, Seite(n) 46

    Abstract: Introduction: Some probable mechanisms have been described to the relationship between magnesium (Mg) level and migraine headache attacks. In the study reported here, we sought to determine the total Mg serum status of patients with migraine within and ... ...

    Abstract Introduction: Some probable mechanisms have been described to the relationship between magnesium (Mg) level and migraine headache attacks. In the study reported here, we sought to determine the total Mg serum status of patients with migraine within and between the headache attacks and compare it with non-migraineurs.
    Methods: This study was performed on 50 migraineurs patients diagnosed according to the International Headache Society (IHS) criteria for acute migraine headache. Fifty healthy subjects without any family history or evidences of migraine were randomly selected from hospital personnel as the control group. Serum Mg level was measured by Xylidyl blue method.
    Results: In the group with migraine headache, no significant difference was found in the serum total Mg levels within and between migraine headache attacks (1.86 ± 0.41 mg/dl versus 1.95 ± 0.35 mg/dl, p = 0.224). But, serum total Mg level was notably lower in the group with these attacks compared to the control group (1.86 ± 0.41 mg/dl versus 2.10 ± 0.23 mg/dl, p < 0.001).
    Conclusion: Serum Mg level is on average significantly reduced in patients with migraine compared to the healthy group. However, the serum total Mg levels in migraineurs remained constant within and between migraine headache attacks.
    Mesh-Begriff(e) Adult ; Case-Control Studies ; Female ; Headache/blood ; Headache/epidemiology ; Humans ; Magnesium/analysis ; Magnesium/blood ; Male ; Middle Aged ; Migraine Disorders/blood ; Migraine Disorders/epidemiology ; Young Adult
    Chemische Substanzen Magnesium (I38ZP9992A)
    Sprache Englisch
    Erscheinungsdatum 2012-03-15
    Erscheinungsland Uganda
    Dokumenttyp Journal Article
    ZDB-ID 2514347-5
    ISSN 1937-8688 ; 1937-8688
    ISSN (online) 1937-8688
    ISSN 1937-8688
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Renal tubular dysfunction measured by N-acetyl-beta glucosaminidase/Creatinine activity index in children receiving antiepileptic drugs: a randomized controlled trial.

    Mazaheri, Mojgan / Samaie, Afshin / Semnani, Vahid

    Italian journal of pediatrics

    2011  Band 37, Seite(n) 21

    Abstract: To evaluate renal side-effects of anti-epileptic medication by valproate (VPA) and carbamazepine (CBZ), we performed a prospective study to assess renal tubular function by measuring N-acetyl-β glucosaminidase (NAG)/Cr activity index in epileptic ... ...

    Abstract To evaluate renal side-effects of anti-epileptic medication by valproate (VPA) and carbamazepine (CBZ), we performed a prospective study to assess renal tubular function by measuring N-acetyl-β glucosaminidase (NAG)/Cr activity index in epileptic children. The study was conducted on 112 children who were diagnosed with epilepsy (28 patients were observed before treatment with anti-epileptics, 28 children were administered VPA, 28 children were treated with CBZ, and 28 healthy children were selected age &sex matched for). An especial NAG assay kit was used for quantitative measuring of NAG in patient urine samples. The patients receiving VPA exhibited higher rate of NAG activity compared with the two groups which not receiving anti-epileptic drugs. Measurement of urinary NAG/Cr index in the children who received CBZ also, was significantly higher than those who were not administered anti-epileptic drugs. The measurement of NAG/Cr index in the VPA group was significantly higher than that in the CBZ group (NAG index: 2.75 versus 1.71). Children on anti-epileptic treatment with VPA or CBZ might demonstrate signs of renal tubular dysfunction, reflected by NAG/Cr activity index. This side effect can be potentially more occurred following VPA administration.
    Mesh-Begriff(e) Acetylglucosaminidase/metabolism ; Adolescent ; Anticonvulsants/adverse effects ; Anticonvulsants/therapeutic use ; Biomarkers/blood ; Biomarkers/urine ; Child ; Child, Preschool ; Creatinine/metabolism ; Diagnosis, Differential ; Epilepsy/drug therapy ; Female ; Follow-Up Studies ; Humans ; Kidney Tubules/drug effects ; Male ; Prognosis ; Prospective Studies ; Renal Tubular Transport, Inborn Errors/chemically induced ; Renal Tubular Transport, Inborn Errors/diagnosis ; Renal Tubular Transport, Inborn Errors/metabolism ; Risk Factors
    Chemische Substanzen Anticonvulsants ; Biomarkers ; Creatinine (AYI8EX34EU) ; Acetylglucosaminidase (EC 3.2.1.52)
    Sprache Englisch
    Erscheinungsdatum 2011-05-14
    Erscheinungsland England
    Dokumenttyp Comparative Study ; Journal Article ; Randomized Controlled Trial
    ZDB-ID 2088556-8
    ISSN 1824-7288 ; 1720-8424
    ISSN (online) 1824-7288
    ISSN 1720-8424
    DOI 10.1186/1824-7288-37-21
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Recent Progresses in Brain Gene Therapy

    Afsoun Seddighi / Amir Nikouei / Amir Saied Seddighi / Mohammad Asadpour / Noushin Masoudian / Afshin Samaie

    International Clinical Neuroscience Journal, Vol 3, Iss 4, Pp 177-

    2016  Band 181

    Abstract: Gene therapy consists of the introduction of genetic material into cells for a therapeutic purpose. The understanding of the basics of the molecular and cellular mechanisms in disease treatments has resulted in the development of high-tech gene transfer ... ...

    Abstract Gene therapy consists of the introduction of genetic material into cells for a therapeutic purpose. The understanding of the basics of the molecular and cellular mechanisms in disease treatments has resulted in the development of high-tech gene transfer materials with improved therapeutic efficacy. Based on the results of more than 2000 clinical trials to date, gene therapy is going to be included in standard treatment approaches in some specific diseases. Also, gene therapy has been highly improved in central and peripheral nervous system diseases. This review tried to focus on techniques and approaches in brain tumors and nervous system’s gene therapy strategies and will discuss about associated problems and potential future in management of inherited or acquired neurological disorders.
    Schlagwörter Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2016-10-01T00:00:00Z
    Verlag Shahid Beheshti University of Medical Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Blood Magnesium levels in migraineurs within and between the headache attacks

    Afshin Samaie / Nabiollah Asghari / Raheb Ghorbani / Jafar Arda

    The Pan African Medical Journal, Vol 11, Iss

    a case control study

    2012  Band 46

    Abstract: INTRODUCTION: Some probable mechanisms have been described to the relationship between magnesium (Mg) level and migraine headache attacks. In the study reported here, we sought to determine the total Mg serum status of patients with migraine within and ... ...

    Abstract INTRODUCTION: Some probable mechanisms have been described to the relationship between magnesium (Mg) level and migraine headache attacks. In the study reported here, we sought to determine the total Mg serum status of patients with migraine within and between the headache attacks and compare it with non-migraineurs. METHODS: This study was performed on 50 migraineurs patients diagnosed according to the International Headache Society (IHS) criteria for acute migraine headache. Fifty healthy subjects without any family history or evidences of migraine were randomly selected from hospital personnel as the control group. Serum Mg level was measured by Xylidyl blue method. RESULTS: In the group with migraine headache, no significant difference was found in the serum total Mg levels within and between migraine headache attacks (1.86 ± 0.41 mg/dl versus 1.95 ± 0.35 mg/dl, p = 0.224). But, serum total Mg level was notably lower in the group with these attacks compared to the control group (1.86 ± 0.41 mg/dl versus 2.10 ± 0.23 mg/dl, p less than 0.001). CONCLUSION: Serum Mg level is on average significantly reduced in patients with migraine compared to the healthy group. However, the serum total Mg levels in migraineurs remained constant within and between migraine headache attacks.
    Schlagwörter migraine ; magnesium ; blood ; headache ; Medicine ; R
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2012-03-01T00:00:00Z
    Verlag The Pan African Medical Journal
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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  5. Artikel ; Online: Renal tubular dysfunction measured by N-acetyl-beta glucosaminidase/Creatinine activity index in children receiving antiepileptic drugs

    Samaie Afshin / Mazaheri Mojgan / Semnani Vahid

    The Italian Journal of Pediatrics, Vol 37, Iss 1, p

    a randomized controlled trial

    2011  Band 21

    Abstract: Abstract To evaluate renal side-effects of anti-epileptic medication by valproate (VPA) and carbamazepine (CBZ), we performed a prospective study to assess renal tubular function by measuring N -acetyl-β glucosaminidase (NAG)/Cr activity index in ... ...

    Abstract Abstract To evaluate renal side-effects of anti-epileptic medication by valproate (VPA) and carbamazepine (CBZ), we performed a prospective study to assess renal tubular function by measuring N -acetyl-β glucosaminidase (NAG)/Cr activity index in epileptic children. The study was conducted on 112 children who were diagnosed with epilepsy (28 patients were observed before treatment with anti-epileptics, 28 children were administered VPA, 28 children were treated with CBZ, and 28 healthy children were selected age &sex matched for). An especial NAG assay kit was used for quantitative measuring of NAG in patient urine samples. The patients receiving VPA exhibited higher rate of NAG activity compared with the two groups which not receiving anti-epileptic drugs. Measurement of urinary NAG/Cr index in the children who received CBZ also, was significantly higher than those who were not administered anti-epileptic drugs. The measurement of NAG/Cr index in the VPA group was significantly higher than that in the CBZ group (NAG index: 2.75 versus 1.71). Children on anti-epileptic treatment with VPA or CBZ might demonstrate signs of renal tubular dysfunction, reflected by NAG/Cr activity index. This side effect can be potentially more occurred following VPA administration.
    Schlagwörter Pediatrics ; RJ1-570 ; Medicine ; R ; DOAJ:Pediatrics ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2011-05-01T00:00:00Z
    Verlag BioMed Central
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

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