Artikel ; Online: Underuse of GLP-1 receptor agonists in the management of type 2 diabetes despite a favorable benefit-safety profile.
2024 , Seite(n) 1–14
Abstract: Introduction: Patients with type 2 diabetes (T2DM) are at high risk of atherosclerotic cardiovascular disease (ASCVD) and cardiovascular death. Cardiovascular protection is a key objective in T2DM.: Areas covered: Glucagon-like peptide-1 receptor ... ...
| Abstract | Introduction: Patients with type 2 diabetes (T2DM) are at high risk of atherosclerotic cardiovascular disease (ASCVD) and cardiovascular death. Cardiovascular protection is a key objective in T2DM. Areas covered: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have proven their efficacy in reducing major cardiovascular events in high-risk patients with T2DM in placebo-controlled trials, a finding confirmed in observational studies compared with other glucose-lowering agents. Overall, GLP-1RAs have a good safety profile associated with a favorable benefit/risk ratio for the management of T2DM, even if their cost-effectiveness might be questionable. International guidelines recommend GLP-1RAs as preferred glucose-lowering agents in patients with ASCVD and as a valuable alternative in overweight/obese patients with T2DM. However, real-life studies worldwide revealed that only a minority of patients receive a GLP-1RA, despite a positive trend for increased prescriptions in recent years. Surprisingly, however, fewer patients with established ASCVD are treated with these cardioprotective antihyperglycemic agents versus patients without ASCVD. Expert opinion: The reasons for GLP-1RA underuse in clinical practice are multiple. Multifaceted and coordinated interventions targeting all actors of the health-care system must be implemented to stimulate the adoption of GLP-1RAs as part of routine cardiovascular care among patients with T2DM, especially in those with ASCVD. |
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| Sprache | Englisch |
| Erscheinungsdatum | 2024-05-13 |
| Erscheinungsland | England |
| Dokumenttyp | Journal Article ; Review |
| ZDB-ID | 2088728-0 |
| ISSN | 1744-764X ; 1474-0338 |
| ISSN (online) | 1744-764X |
| ISSN | 1474-0338 |
| DOI | 10.1080/14740338.2024.2354885 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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