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  1. AU=Schwartz Kevin L
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  1. Artikel ; Online: School-Based Mandatory Masking Policies and Absenteeism in Ottawa, Canada, in 2022.

    Thampi, Nisha / Schwartz, Kevin L / Science, Michelle / Brown, Kevin A

    JAMA network open

    2023  Band 6, Heft 7, Seite(n) e2325799

    Mesh-Begriff(e) Humans ; Absenteeism ; Canada ; Students ; Policy ; Schools
    Sprache Englisch
    Erscheinungsdatum 2023-07-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2574-3805
    ISSN (online) 2574-3805
    DOI 10.1001/jamanetworkopen.2023.25799
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Injuries From Legal Interventions Involving Conducted Energy Devices.

    Achola, Emma M / Griffith, Kevin N / Wrenn, Jesse O / Mitchell, Carmen R / Schwartz, Dawn / Roumie, Christianne L

    JAMA internal medicine

    2024  Band 184, Heft 4, Seite(n) 440–443

    Mesh-Begriff(e) Humans ; Law Enforcement ; Emergency Service, Hospital ; Black People
    Sprache Englisch
    Erscheinungsdatum 2024-02-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2023.8012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: The Effect of COVID-19 Vaccination on Outpatient Antibiotic Prescribing in Older Adults: A Self-Controlled Risk-Interval Study.

    Jorgensen, Sarah C J / Brown, Kevin / Clarke, Anna E / Schwartz, Kevin L / Maxwell, Colleen / Daneman, Nick / Kwong, Jeffrey C / MacFadden, Derek R

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2024  

    Abstract: Background: Coronavirus disease 2019 (COVID-19) vaccination has been associated with reduced outpatient antibiotic prescribing among older adults with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We assessed the ... ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) vaccination has been associated with reduced outpatient antibiotic prescribing among older adults with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We assessed the impact of COVID-19 vaccination on outpatient antibiotic prescribing in the broader population of older adults, regardless of SARS-CoV-2 infection status.
    Methods: We included adults aged ≥65 years who received their first, second, and/or third COVID-19 vaccine dose from December 2020 to December 2022. We used a self-controlled risk-interval design and included cases who received an antibiotic prescription 2-6 weeks before vaccination (pre-vaccination or control interval) or after vaccination (post-vaccination or risk interval). We used conditional logistic regression to estimate the odds of being prescribed (1) any antibiotic, (2) a typical "respiratory" infection antibiotic, or (3) a typical "urinary tract" infection antibiotic (negative control) in the post-vaccination interval versus the pre-vaccination interval. We accounted for temporal changes in antibiotic prescribing using background monthly antibiotic prescribing counts.
    Results: 469 923 vaccine doses met inclusion criteria. The odds of receiving any antibiotic or a respiratory antibiotic prescription were lower in the post-vaccination versus pre-vaccination interval (aOR, .973; 95% CI, .968-.978; aOR, .961; 95% CI, .953-.968, respectively). There was no association between vaccination and urinary antibiotic prescriptions (aOR, .996; 95% CI, .987-1.006). Periods with high (>10%) versus low (<5%) SARS-CoV-2 test positivity demonstrated greater reductions in antibiotic prescribing (aOR, .875; 95% CI, .845-.905; aOR, .996; 95% CI, .989-1.003, respectively).
    Conclusions: COVID-19 vaccination was associated with reduced outpatient antibiotic prescribing in older adults, especially during periods of high SARS-CoV-2 circulation.
    Sprache Englisch
    Erscheinungsdatum 2024-05-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciae182
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Case 16-2023: A 13-Year-Old Boy with Depression and Hypotension.

    Schwartz, Kevin R / Donovan, Abigail L / Hayes, Bryan D / Uchida, Mai / Rosen, Joy B

    The New England journal of medicine

    2023  Band 388, Heft 21, Seite(n) 1992–1999

    Mesh-Begriff(e) Adolescent ; Humans ; Male ; Depression/etiology ; Hypotension/etiology
    Sprache Englisch
    Erscheinungsdatum 2023-05-21
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMcpc2201237
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Variability in changes in physician outpatient antibiotic prescribing from 2019 to 2021 during the COVID-19 pandemic in Ontario, Canada.

    Tandon, Pranav / Brown, Kevin A / Daneman, Nick / Langford, Bradley J / Leung, Valerie / Friedman, Lindsay / Schwartz, Kevin L

    Antimicrobial stewardship & healthcare epidemiology : ASHE

    2023  Band 3, Heft 1, Seite(n) e171

    Abstract: Objective: To evaluate inter-physician variability and predictors of changes in antibiotic prescribing before (2019) and during (2020/2021) the coronavirus disease 2019 (COVID-19) pandemic.: Methods: We conducted a retrospective cohort analysis of ... ...

    Abstract Objective: To evaluate inter-physician variability and predictors of changes in antibiotic prescribing before (2019) and during (2020/2021) the coronavirus disease 2019 (COVID-19) pandemic.
    Methods: We conducted a retrospective cohort analysis of physicians in Ontario, Canada prescribing oral antibiotics in the outpatient setting between January 1, 2019 and December 31, 2021 using the IQVIA Xponent data set. The primary outcome was the change in the number of antibiotic prescriptions between the prepandemic and pandemic period. Secondary outcomes were changes in the selection of broad-spectrum agents and long-duration (>7 d) antibiotic use. We used multivariable linear regression models to evaluate predictors of change.
    Results: There were 17,288 physicians included in the study with substantial inter-physician variability in changes in antibiotic prescribing (median change of -43.5 antibiotics per physician, interquartile range -136.5 to -5.0). In the multivariable model, later career stage (adjusted mean difference [aMD] -45.3, 95% confidence interval [CI] -52.9 to -37.8,
    Conclusions: Antibiotic prescribing changed throughout the COVID-19 pandemic with overall decreases in antibiotic initiation, broad-spectrum agents, and prolonged antibiotic courses with inter-physician variability. These findings present opportunities for community antibiotic stewardship interventions.
    Sprache Englisch
    Erscheinungsdatum 2023-10-19
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2732-494X
    ISSN (online) 2732-494X
    DOI 10.1017/ash.2023.433
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Author Correction: Effectiveness of mRNA COVID-19 vaccine booster doses against Omicron severe outcomes.

    Grewal, Ramandip / Nguyen, Lena / Buchan, Sarah A / Wilson, Sarah E / Nasreen, Sharifa / Austin, Peter C / Brown, Kevin A / Fell, Deshayne B / Gubbay, Jonathan B / Schwartz, Kevin L / Tadrous, Mina / Wilson, Kumanan / Kwong, Jeffrey C

    Nature communications

    2023  Band 14, Heft 1, Seite(n) 2031

    Sprache Englisch
    Erscheinungsdatum 2023-04-11
    Erscheinungsland England
    Dokumenttyp Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-37906-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Variability in changes in physician outpatient antibiotic prescribing from 2019 to 2021 during the COVID-19 pandemic in Ontario, Canada

    Pranav Tandon / Kevin A. Brown / Nick Daneman / Bradley J. Langford / Valerie Leung / Lindsay Friedman / Kevin L. Schwartz

    Antimicrobial Stewardship & Healthcare Epidemiology, Vol

    2023  Band 3

    Abstract: Abstract Objective: To evaluate inter-physician variability and predictors of changes in antibiotic prescribing before (2019) and during (2020/2021) the coronavirus disease 2019 (COVID-19) pandemic. Methods: We conducted a retrospective cohort analysis ... ...

    Abstract Abstract Objective: To evaluate inter-physician variability and predictors of changes in antibiotic prescribing before (2019) and during (2020/2021) the coronavirus disease 2019 (COVID-19) pandemic. Methods: We conducted a retrospective cohort analysis of physicians in Ontario, Canada prescribing oral antibiotics in the outpatient setting between January 1, 2019 and December 31, 2021 using the IQVIA Xponent data set. The primary outcome was the change in the number of antibiotic prescriptions between the prepandemic and pandemic period. Secondary outcomes were changes in the selection of broad-spectrum agents and long-duration (>7 d) antibiotic use. We used multivariable linear regression models to evaluate predictors of change. Results: There were 17,288 physicians included in the study with substantial inter-physician variability in changes in antibiotic prescribing (median change of −43.5 antibiotics per physician, interquartile range −136.5 to −5.0). In the multivariable model, later career stage (adjusted mean difference [aMD] −45.3, 95% confidence interval [CI] −52.9 to −37.8, p < .001), family medicine (aMD −46.0, 95% CI −62.5 to −29.4, p < .001), male patient sex (aMD −52.4, 95% CI −71.1 to −33.7, p < .001), low patient comorbidity (aMD −42.5, 95% CI −50.3 to −34.8, p < .001), and high prescribing to new patients (aMD −216.5, 95% CI −223.5 to −209.5, p < .001) were associated with decreases in antibiotic initiation. Family medicine and high prescribing to new patients were associated with a decrease in selection of broad-spectrum agents and prolonged antibiotic use. Conclusions: Antibiotic prescribing changed throughout the COVID-19 pandemic with overall decreases in antibiotic initiation, broad-spectrum agents, and prolonged antibiotic courses with inter-physician variability. These findings present opportunities for community antibiotic stewardship interventions.
    Schlagwörter Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-01-01T00:00:00Z
    Verlag Cambridge University Press
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Follow-up blood cultures do not reduce mortality in hospitalized patients with Gram-negative bloodstream infection: a retrospective population-wide cohort study.

    Ong, Sean W X / Luo, Jin / Fridman, Daniel J / Lee, Samantha M / Johnstone, Jennie / Schwartz, Kevin L / Diong, Christina / Patel, Samir N / MacFadden, Derek / Langford, Bradley / Tong, Steven Y C / Brown, Kevin A / Daneman, Nick

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2024  

    Abstract: Objectives: The utility of follow-up blood cultures (FUBCs) in patients with Gram-negative bloodstream infection (GN-BSI) is controversial. Observational studies have suggested significant mortality benefit but may be limited by single-centre designs, ... ...

    Abstract Objectives: The utility of follow-up blood cultures (FUBCs) in patients with Gram-negative bloodstream infection (GN-BSI) is controversial. Observational studies have suggested significant mortality benefit but may be limited by single-centre designs, immortal time bias, and residual confounding. We examined the impact of FUBCs on mortality in patients with GN-BSI in a retrospective population-wide cohort study in Ontario, Canada.
    Methods: Adult patients with GN-BSI hospitalized between April 2017 and December 2021 were included. Primary outcome was all-cause mortality within 30 days. FUBC was treated as a time-varying exposure. Secondary outcomes were 90-day mortality, length of stay, and number of days alive and out of hospital at 30 and 90 days.
    Results: Thirty-four thousand one hundred patients were included; 8807 (25.8%) patients received FUBC, of which 966 (11.0%) were positive. Median proportion of patients receiving FUBC was 18.8% (interquartile range, 10.0-29.7%; range, 0-66.1%) across 101 hospitals; this correlated with positivity and contamination rate. Eight hundred ninety (10.1%) patients in the FUBC group and 2263 (8.9%) patients in the no FUBC group died within 30 days. In the fully adjusted model, there was no association between FUBC and mortality (hazard ratio, 0.97; 95% CI, 0.90-1.04). Patients with FUBC had significantly longer length of stay (median, 11 vs. 7 days; adjusted risk ratio, 1.18; 95% CI, 1.16-1.21) and fewer number of days alive and out of hospital at 30 and 90 days.
    Discussion: FUBC collection in patients with GN-BSI varies widely across hospitals and may be associated with prolonged hospitalization without clear survival benefit. Residual confounding may be present given the observational design. Clear benefit should be demonstrated in a randomized trial before widespread adoption of routine FUBC.
    Sprache Englisch
    Erscheinungsdatum 2024-03-27
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2024.03.025
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: [Titelangabe fehlt]

    Schwartz, Kevin L / McGeer, Allison J / Bogoch, Isaac I

    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

    2021  Band 193, Heft 23, Seite(n) E888–E891

    Titelübersetzung Le dépistage des personnes asymptomatiques au moyen de tests antigéniques rapides: un outil de santé publique pour lutter contre la COVID-19.
    Sprache Französisch
    Erscheinungsdatum 2021-06-07
    Erscheinungsland Canada
    Dokumenttyp Journal Article
    ZDB-ID 215506-0
    ISSN 1488-2329 ; 0008-4409 ; 0820-3946
    ISSN (online) 1488-2329
    ISSN 0008-4409 ; 0820-3946
    DOI 10.1503/cmaj.210100-f
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Corrigendum to "Highly versus less bioavailable oral antibiotics in the treatment of gram-negative bloodstream infections: a propensity-matched cohort analysis" [Clin Microbiol Infect 29(4) (2023 April) 490-497].

    Mponponsuo, Kwadwo / Brown, Kevin A / Fridman, Daniel J / Johnstone, Jennie / Langford, Bradley J / Lee, Samantha M / MacFadden, Derek R / Patel, Samir N / Schwartz, Kevin L / Daneman, Nick

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Band 29, Heft 12, Seite(n) 1617

    Sprache Englisch
    Erscheinungsdatum 2023-08-16
    Erscheinungsland England
    Dokumenttyp Published Erratum
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.08.011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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