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  1. Article ; Online: Specialized pro-resolving mediators in vascular inflammation and atherosclerotic cardiovascular disease.

    Fredman, Gabrielle / Serhan, Charles N

    Nature reviews. Cardiology

    2024  

    Abstract: Timely resolution of the acute inflammatory response (or inflammation resolution) is an active, highly coordinated process that is essential to optimal health. Inflammation resolution is regulated by specific endogenous signalling molecules that function ...

    Abstract Timely resolution of the acute inflammatory response (or inflammation resolution) is an active, highly coordinated process that is essential to optimal health. Inflammation resolution is regulated by specific endogenous signalling molecules that function as 'stop signals' to terminate the inflammatory response when it is no longer needed; to actively promote healing, regeneration and tissue repair; and to limit pain. Specialized pro-resolving mediators are a superfamily of signalling molecules that initiate anti-inflammatory and pro-resolving actions. Without an effective and timely resolution response, inflammation can become chronic, a pathological state that is associated with many widely occurring human diseases, including atherosclerotic cardiovascular disease. Uncovering the mechanisms of inflammation resolution failure in cardiovascular diseases and identifying useful biomarkers for non-resolving inflammation are unmet needs. In this Review, we discuss the accumulating evidence that supports the role of non-resolving inflammation in atherosclerosis and the use of specialized pro-resolving mediators as therapeutic tools for the treatment of atherosclerotic cardiovascular disease. We highlight open questions about therapeutic strategies and mechanisms of disease to provide a framework for future studies on the prevention and treatment of atherosclerosis.
    Language English
    Publishing date 2024-01-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-023-00984-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Resolvins and cysteinyl-containing pro-resolving mediators activate resolution of infectious inflammation and tissue regeneration.

    Serhan, Charles N / Chiang, Nan

    Prostaglandins & other lipid mediators

    2023  Volume 166, Page(s) 106718

    Abstract: This review is a synopsis of the main points from the opening presentation by the authors in the Resolution of Inflammation session at the 8th European Workshop on Lipid Mediators held at the Karolinska Institute, Stockholm, Sweden, June 29th, 2022. ... ...

    Abstract This review is a synopsis of the main points from the opening presentation by the authors in the Resolution of Inflammation session at the 8th European Workshop on Lipid Mediators held at the Karolinska Institute, Stockholm, Sweden, June 29th, 2022. Specialized pro-resolving mediators (SPM) promote tissue regeneration, control infections and resolution of inflammation. These include resolvins, protectins, maresins and the newly identified conjugates in tissue regeneration (CTRs). We reported mechanisms of CTRs in activating primordial regeneration pathways in planaria using RNA-sequencing. Also, the 4S,5S-epoxy-resolvin intermediate in the biosynthesis of resolvin D3 and resolvin D4 was prepared by total organic synthesis. Human neutrophils convert this to resolvin D3 and resolvin D4, while human M2 macrophages transformed this labile epoxide intermediate to resolvin D4 and a novel cysteinyl-resolvin that is a potent isomer of RCTR1. The novel cysteinyl-resolvin significantly accelerates tissue regeneration with planaria and inhibits human granuloma formation.
    MeSH term(s) Humans ; Inflammation/drug therapy ; Inflammation/metabolism ; Macrophages/metabolism ; Docosahexaenoic Acids/pharmacology ; Docosahexaenoic Acids/metabolism ; Neutrophils/metabolism ; Inflammation Mediators/metabolism
    Chemical Substances Docosahexaenoic Acids (25167-62-8) ; Inflammation Mediators
    Language English
    Publishing date 2023-02-21
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1426962-4
    ISSN 2212-196X ; 1098-8823 ; 0090-6980
    ISSN (online) 2212-196X
    ISSN 1098-8823 ; 0090-6980
    DOI 10.1016/j.prostaglandins.2023.106718
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  3. Article ; Online: Resolution medicine in cancer, infection, pain and inflammation: are we on track to address the next Pandemic?

    Serhan, Charles N / Sulciner, Megan L

    Cancer metastasis reviews

    2023  Volume 42, Issue 1, Page(s) 13–17

    Abstract: Uncontrolled inflammation giving rise to excessive tissue inflammation can lead to chronic inflammation that enhances tissue destruction, amplifying many chronic human pathologies. Normally the acute inflammatory response is protective and should be self- ...

    Abstract Uncontrolled inflammation giving rise to excessive tissue inflammation can lead to chronic inflammation that enhances tissue destruction, amplifying many chronic human pathologies. Normally the acute inflammatory response is protective and should be self-limited returning tissues to functional homeostasis with endogenous programmed resolution via leukocyte vasculature cell-cell interactions and crosstalk that biosynthesize pro-resolving mediators. When failed resolution takes place, as with the use of NSAIDs, tissues undergo chronic inflammation and fibrosis. Herein, we discuss these mechanisms and the role of specialized proresolving mediators, the resolvins, protectins and maresins produced from essential omega-3 fatty acids EPA and DHA, and their contributions via their cognate cell surface receptors, to the resolution response. Harnessing these pathways and their cellular mechanisms can help in providing new therapeutic approaches to many human diseases, infections, organ protection and trauma via resolution medicine to enhance the body's own resilience to challenge.
    MeSH term(s) Humans ; Docosahexaenoic Acids/therapeutic use ; Docosahexaenoic Acids/metabolism ; Pandemics ; Inflammation/metabolism ; Pain ; Neoplasms
    Chemical Substances Docosahexaenoic Acids (25167-62-8)
    Language English
    Publishing date 2023-02-13
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 604857-2
    ISSN 1573-7233 ; 0167-7659
    ISSN (online) 1573-7233
    ISSN 0167-7659
    DOI 10.1007/s10555-023-10091-5
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  4. Book: Fundamentals of inflammation

    Serhan, Charles N. / Ward, Peter A. / Gilroy, Derek W.

    2010  

    Author's details ed. by Charles N. Serhan ; Peter A. Ward ; Derek W. Gilroy
    Keywords Inflammation / immunology ; Immunity, Cellular / physiology
    Language English
    Size XIV, 473 S. : Ill., graph. Darst., 28 cm
    Publisher Cambridge Univ. Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT016443043
    ISBN 978-0-521-88729-8 ; 0-521-88729-1
    Database Catalogue ZB MED Medicine, Health

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    2010 A 3662 order for loan Magazin

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  5. Book ; Conference proceedings: Advances in eicosanoid research

    Serhan, Charles N.

    12 tables ; [text of the main lectures presented at the Workshop Advances in Eicosanoid Research held in San Francisco, California, from July 28 to July 30, 1999]

    (Ernst Schering Research Foundation workshop ; 31)

    2000  

    Event/congress Workshop Advances in Eicosanoid Research (1999, SanFranciscoCalif.)
    Author's details C. N. Serhan ... ed
    Series title Ernst Schering Research Foundation workshop ; 31
    Collection
    Keywords Eicosanoide
    Subject Eikosanoide ; Icosanoide
    Language English
    Size XII, 221 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT012754202
    ISBN 3-540-66747-4 ; 978-3-540-66747-6
    Database Catalogue ZB MED Medicine, Health

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  6. Article ; Online: Stereocontrolled total synthesis of Resolvin D4 and 17(

    Nshimiyimana, Robert / Glynn, Stephen J / Serhan, Charles N / Petasis, Nicos A

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 8, Page(s) 1667–1673

    Abstract: The total synthesis of Resolvin D4 and its 17( ...

    Abstract The total synthesis of Resolvin D4 and its 17(
    MeSH term(s) Humans ; Fatty Acids, Unsaturated/chemistry ; Docosahexaenoic Acids ; Inflammation ; Stereoisomerism
    Chemical Substances resolvin D4 ; Fatty Acids, Unsaturated ; Docosahexaenoic Acids (25167-62-8)
    Language English
    Publishing date 2023-02-22
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d2ob01697d
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  7. Book ; Conference proceedings: Eicosanoids & other bioactive lipids in cancer, inflammation and related diseases

    Serhan, Charles N.

    6th International Conference [on Eicosanoids & Other Bioactive Lipids in Cancer Inflammation Related Diseases] ; Boston, Mass., USA, September 2 - 15, 1999 ; program and abstracts

    (Prostaglandins & other lipid mediators ; 59,1/6)

    1999  

    Event/congress International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Related Diseases (6, 1999, BostonMass.)
    Author's details [guest ed.: C. N. Serhan]
    Series title Prostaglandins & other lipid mediators ; 59,1/6
    Collection
    Language English
    Size S. 1 - 235
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book ; Conference proceedings
    HBZ-ID HT011179842
    Database Catalogue ZB MED Medicine, Health

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  8. Book: Molecular and cellular basis of inflammation

    Serhan, Charles N.

    (Current inflammation research)

    1999  

    Author's details ed. by Charles N. Serhan
    Series title Current inflammation research
    Keywords Inflammation / immunology ; Immunity, Cellular / physiology ; Entzündung ; Cytologie ; Molekularbiologie
    Subject Inflammatio ; Entzündungsreaktion ; Molekulare Biologie ; Zellbiologie ; Zellenlehre ; Zellforschung ; Zellkunde ; Zelluologie ; Zytologie ; Zelle
    Language English
    Size XII, 338 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT010294477
    ISBN 0-89603-595-6 ; 978-0-89603-595-9
    Database Catalogue ZB MED Medicine, Health

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  9. Article ; Online: Macrophage Specific Lipoxygenase Deletion Amplify Cardiac Repair Activating Tregs in Chronic Heart Failure.

    Kain, Vasundhara / Grilo, Gabriel Araujo / Upadhyay, Gunjan / Nadler, Jerry L / Serhan, Charles N / Halade, Ganesh V

    Journal of leukocyte biology

    2024  

    Abstract: Splenic leukocytes, particularly macrophage-expressed lipoxygenases, facilitate the biosynthesis of resolution mediators essential for cardiac repair. Next, we asked whether deletion of 12/15 lipoxygenase (12/15LOX) in macrophages impedes the resolution ... ...

    Abstract Splenic leukocytes, particularly macrophage-expressed lipoxygenases, facilitate the biosynthesis of resolution mediators essential for cardiac repair. Next, we asked whether deletion of 12/15 lipoxygenase (12/15LOX) in macrophages impedes the resolution of inflammation following myocardial infarction (MI). Using 12/15flox/flox and LysMcre scheme, we generated macrophage-specific 12/15LOX (Mɸ-12/15LOX-/-) mice. Young C57BL/6J wild-type and Mɸ-12/15LOX-/- male mice were subjected to permanent coronary ligation micro-surgery. Mice were monitored at day (d)1-d5 (as acute HF; AHF) and to d56 (chronic HF; CHF) post-MI, maintaining no-MI as d0 naïve controls. Post-ligation, Mɸ-12/15LOX-/- mice showed increased survival (88%vs56%) and limited heart dysfunction compared with WT. In AHF, Mɸ-12/15LOX-/- mice have increased biosynthesis of epoxyeicosatrienoic acid (EETs) by 30%, with the decrease in D-series resolvins, protectin, and maresin by 70% in the infarcted heart. Overall, myeloid cell profiling from the heart and spleen indicated that Mɸ-12/15LOX-/- mice showed higher immune cells with reparative Ly6Clow macrophages during AHF. In addition, the detailed immune profiling revealed reparative macrophage phenotype (Ly6Clow) in Mɸ-12/15LOX-/- mice in a splenocardiac manner post-MI. Mɸ-12/15LOX-/- mice showed an increase in myeloid population that coordinated increase of Tregs (CD4+/Foxp3+) in the spleen and injured heart at CHF compared with WT. Thus, macrophage-specific deletion of 12/15LOX directs reparative macrophage phenotype to facilitate cardiac repair. The presented study outlines the complex role of 12/15LOX in macrophage plasticity, and Treg signaling that indicates resolution mediators are viable targets to facilitate cardiac repair in heart failure post-MI.
    Language English
    Publishing date 2024-05-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1093/jleuko/qiae113
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  10. Article ; Online: Bang and Dyerberg's omega-3 discovery turns fifty.

    Harris, William S / Calder, Philip C / Mozaffarian, Dariush / Serhan, Charles N

    Nature food

    2022  Volume 2, Issue 5, Page(s) 303–305

    Language English
    Publishing date 2022-11-15
    Publishing country England
    Document type Letter
    ISSN 2662-1355
    ISSN (online) 2662-1355
    DOI 10.1038/s43016-021-00289-7
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