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  1. Article: [Genetic Analysis of Thalassemia in 22 940 Pregnant Women in Xiangxi Tujia and Miao Autonomous Prefecture].

    Yu, Hui / Yang, Qing-Xiang / Liu, Chun / Peng, La-Ying / Zhou, Xiao-Bo / Shao, Lu / Huang, Nan

    Zhongguo shi yan xue ye xue za zhi

    2022  Volume 30, Issue 1, Page(s) 206–210

    Abstract: Objective: To investigate the incidence and types of thalassemia in Xiangxi Tujia and Miao ... ethnicity, 2 821 cases of Miao ethnicity, and 2 233 cases of Han ethnicity included, whose ethnicity were ...

    Abstract Objective: To investigate the incidence and types of thalassemia in Xiangxi Tujia and Miao Autonomous Prefecture.
    Methods: Automatic capillary electrophoresis was used to screen the thalassemia phenotypes of 22 940 blood samples of pregnant women and puerperants collected in our hospital and some other medical institutions in the prefecture during 2017-2019, among which there were 3 356 cases of Tujia ethnicity, 2 821 cases of Miao ethnicity, and 2 233 cases of Han ethnicity included, whose ethnicity were indicated. The samples with positive result would undergo further genetic testing.
    Results: There were 2 314 cases of suspicious thalassemia were screened from 22 940 cases by the electrophoresis, thus the positive rate was 10.1% (hematological phenotypes from some other institutions were not included). Specifically, there were 1 706 cases with HBA
    Conclusion: The positive rate of thalassemia screening in Xiangxi Autonomous Prefecture is roughly the same as that in other regions of Hunan. The positive predictive value of β-thalassemia screening is as high as 86%. Compared with the missed screening data, it is recommended to use hematology (MCV, MCH) method combined with capillary hemoglobin electrophoresis for thalassemia screening.
    MeSH term(s) Ethnicity ; Female ; Genetic Testing ; Hemoglobin A2/analysis ; Humans ; Pregnancy ; Pregnant Women ; alpha-Thalassemia/genetics ; beta-Thalassemia/genetics
    Chemical Substances Hemoglobin A2 (9034-53-1)
    Language Chinese
    Publishing date 2022-02-05
    Publishing country China
    Document type Journal Article
    ZDB-ID 2404306-0
    ISSN 1009-2137
    ISSN 1009-2137
    DOI 10.19746/j.cnki.issn.1009-2137.2022.01.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6603: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: 68Ga-DOTATATE PET/CT Detected Bone Metastasis Earlier Than 68Ga-FAPI PET/CT and 99mTc-MDP Bone Scintigraphy in a Patient With Nasopharyngeal Carcinoma.

    Zheng, Jieling / Zhu, Hongxu / Shao, Zezhong / Miao, Weibing

    Clinical nuclear medicine

    2024  

    Abstract: Abstract: A 53-year-old man with newly diagnosed nasopharyngeal carcinoma (NPC) underwent 99mTc-MDP bone scintigraphy for the potential bone metastases, and paired 68Ga-DOTATATE and 68Ga-FAPI PET/CT for initial staging. 68Ga-DOTATATE PET/CT identified 2 ...

    Abstract Abstract: A 53-year-old man with newly diagnosed nasopharyngeal carcinoma (NPC) underwent 99mTc-MDP bone scintigraphy for the potential bone metastases, and paired 68Ga-DOTATATE and 68Ga-FAPI PET/CT for initial staging. 68Ga-DOTATATE PET/CT identified 2 abnormal foci with increased tracer uptake in the cervical vertebra and the ilium, whereas 68Ga-FAPI PET/CT and bone scan detected only the ilium lesion. A subsequent biopsy confirmed NPC metastasis in the ilium. Furthermore, baseline and follow-up bone scintigraphy revealed that the positive lesion in the cervical vertebra, as indicated in 68Ga-DOTATATE PET/CT, was also a bone metastasis. This case highlighted the potential superiority of 68Ga-DOTATATE in NPC.
    Language English
    Publishing date 2024-05-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197628-x
    ISSN 1536-0229 ; 0363-9762
    ISSN (online) 1536-0229
    ISSN 0363-9762
    DOI 10.1097/RLU.0000000000005289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1276: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Book: T'u mien tseng wen chi tsai shu mu yū miao shang ti ying yung

    Shao, Chen-sheng

    1989  

    Title translation Application of soil heating chemicals on tree seedlings.
    Author's details Shao Chen-sheng chu
    Keywords Plant-soil relationships. ; Soil heating.
    Language Chinese
    Size 31 p. :, ill. ;, 19 cm.
    Edition Ti 1 pan.
    Publisher Tung pei lin yeh ta hsuüeh ch'u pan she
    Publishing place Ha-erh-pin shih
    Document type Book
    ISBN 7810080482 ; 9787810080484
    Database NAL-Catalogue (AGRICOLA)

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  4. Book: Chung shu miao

    Shao, Chün

    (Kung nung sheng ch'an chi shu pien lan)

    1950  

    Title translation Growing saplings.
    Author's details Shao Chün chu. --
    Series title Kung nung sheng ch'an chi shu pien lan
    Keywords Trees/Seedlings. ; Seedlings.
    Language Chinese
    Size 16 p. ;, 17 cm. --
    Edition Ch'u pan. --
    Publisher Chung hua shu chü
    Publishing place Shang-hai
    Document type Book
    Note Cover title.
    Database NAL-Catalogue (AGRICOLA)

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  5. Book: Yang shu miao

    Shao, Chün

    (Kung nung sheng ch'an ch'i shu pien lan)

    1950  

    Title translation Growing saplings.
    Author's details Shao Chün pien chu. --
    Series title Kung nung sheng ch'an ch'i shu pien lan
    Keywords Trees/Seedlings. ; Tree farms.
    Language Chinese
    Size 56 p. :, ill. ;, 17 cm. --
    Edition Ch'u pan. --
    Publisher Chung-hua shu chü
    Publishing place Shang-hai
    Document type Book
    Note Cover title.
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Multi-functional integrated design of a copper foam-based cathode for high-performance lithium-oxygen batteries.

    Lan, Jing / Yu, Yuran / Miao, Fujun / Zhang, Peng / Shao, Guosheng

    Nanoscale

    2024  Volume 16, Issue 21, Page(s) 10283–10291

    Abstract: Lithium-oxygen batteries (LOBs) with extraordinarily high energy density are some of the most captivating energy storage devices. Designing an efficient catalyst system that can minimize the energy barriers and address the oxidant intermediate and side- ... ...

    Abstract Lithium-oxygen batteries (LOBs) with extraordinarily high energy density are some of the most captivating energy storage devices. Designing an efficient catalyst system that can minimize the energy barriers and address the oxidant intermediate and side-product issues is the major challenge regarding LOBs. Herein, we have developed a new type of integrated cathode of Cu foam-supported hierarchical nanowires decorated with highly catalytic Au nanoparticles which achieves a good combination of a gas diffusion electrode and a catalyst electrode, contributing to the synchronous multiphase transport of ions, oxygen, and electrons as well as improving the cathode reaction kinetics effectively. Benefiting from such a unique hierarchical architecture, the integrated cathode delivered superior electrochemical performance, including a high discharge capacity of up to 11.5 mA h cm
    Language English
    Publishing date 2024-05-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d4nr00263f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Machine learning to establish three sphingolipid metabolism genes signature to characterize the immune landscape and prognosis of patients with gastric cancer.

    Yan, Jianing / Yu, Xuan / Li, Qier / Miao, Min / Shao, Yongfu

    BMC genomics

    2024  Volume 25, Issue 1, Page(s) 319

    Abstract: Background: Gastric cancer (GC) is one of the most common malignant tumors worldwide. Nevertheless, GC still lacks effective diagnosed and monitoring method and treating targets. This study used multi omics data to explore novel biomarkers and immune ... ...

    Abstract Background: Gastric cancer (GC) is one of the most common malignant tumors worldwide. Nevertheless, GC still lacks effective diagnosed and monitoring method and treating targets. This study used multi omics data to explore novel biomarkers and immune therapy targets around sphingolipids metabolism genes (SMGs).
    Method: LASSO regression analysis was performed to filter prognostic and differently expression SMGs among TCGA and GTEx data. Risk score model and Kaplan-Meier were built to validate the prognostic SMG signature and prognostic nomogram was further constructed. The biological functions of SMG signature were annotated via multi omics. The heterogeneity landscape of immune microenvironment in GC was explored. qRT-PCR was performed to validate the expression level of SMG signature. Competing endogenous RNA regulatory network was established to explore the molecular regulatory mechanisms.
    Result: 3-SMGs prognostic signature (GLA, LAMC1, TRAF2) and related nomogram were constructed combing several clinical characterizes. The expression difference and diagnostic value were validated by PCR data. Multi omics data reveals 3-SMG signature affects cell cycle and death via several signaling pathways to regulate GC progression. Overexpression of 3-SMG signature influenced various immune cell infiltration in GC microenvironment. RBP-SMGs-miRNA-mRNAs/lncRNAs regulatory network was built to annotate regulatory system.
    Conclusion: Upregulated 3-SMGs signature are excellent predictive diagnosed and prognostic biomarkers, providing a new perspective for future GC immunotherapy.
    MeSH term(s) Humans ; Stomach Neoplasms/genetics ; Prognosis ; Machine Learning ; Biomarkers ; Sphingolipids ; Tumor Microenvironment/genetics
    Chemical Substances Biomarkers ; Sphingolipids
    Language English
    Publishing date 2024-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041499-7
    ISSN 1471-2164 ; 1471-2164
    ISSN (online) 1471-2164
    ISSN 1471-2164
    DOI 10.1186/s12864-024-10243-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Unraveling the enigma of tumor-associated macrophages: challenges, innovations, and the path to therapeutic breakthroughs.

    Shao, Shengwen / Miao, Huilai / Ma, Wenxue

    Frontiers in immunology

    2023  Volume 14, Page(s) 1295684

    Abstract: Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME), influencing cancer progression significantly. Attracted by cancer cell signals, TAMs exhibit unparalleled adaptability, aligning with the dynamic tumor milieu. Their ... ...

    Abstract Tumor-associated macrophages (TAMs) are integral to the tumor microenvironment (TME), influencing cancer progression significantly. Attracted by cancer cell signals, TAMs exhibit unparalleled adaptability, aligning with the dynamic tumor milieu. Their roles span from promoting tumor growth and angiogenesis to modulating metastasis. While substantial research has explored the fundamentals of TAMs, comprehending their adaptive behavior, and leveraging it for novel treatments remains challenging. This review delves into TAM polarization, metabolic shifts, and the complex orchestration of cytokines and chemokines determining their functions. We highlight the complexities of TAM-targeted research focusing on their adaptability and potential variability in therapeutic outcomes. Moreover, we discuss the synergy of integrating TAM-focused strategies with established cancer treatments, such as chemotherapy, and immunotherapy. Emphasis is laid on pioneering methods like TAM reprogramming for cancer immunotherapy and the adoption of single-cell technologies for precision intervention. This synthesis seeks to shed light on TAMs' multifaceted roles in cancer, pinpointing prospective pathways for transformative research and enhancing therapeutic modalities in oncology.
    MeSH term(s) Humans ; Tumor-Associated Macrophages/pathology ; Prospective Studies ; Macrophages/metabolism ; Neoplasms/metabolism ; Immunotherapy ; Tumor Microenvironment
    Language English
    Publishing date 2023-11-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1295684
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Fangchinoline, an Extract of the

    Shao, Yanxiong / Li, Chaoran / Miao, Guojun / Xu, Yubo

    Current molecular pharmacology

    2023  Volume 17, Issue 1, Page(s) e100223213590

    Abstract: Background: Fangchinoline (Fan) is extracted from traditional Chinese medicine (called Fangji), or the root of Stephania tetrandra Moore. Fangji is well-known in Chinese medical literature for treating rheumatic diseases. Sjogren's syndrome (SS) is a ... ...

    Abstract Background: Fangchinoline (Fan) is extracted from traditional Chinese medicine (called Fangji), or the root of Stephania tetrandra Moore. Fangji is well-known in Chinese medical literature for treating rheumatic diseases. Sjogren's syndrome (SS) is a rheumatic disease whose progression can be mediated via CD4+ T cell infiltration.
    Objective: This study identifies the potential role of Fan in inducing apoptosis in Jurkat T cells.
    Methods: First, we explored the biological process (BP) associated with SS development by performing a gene ontology analysis of SS salivary gland-related mRNA microarray data. The effect of Fan on Jurkat cells was investigated by analyzing the viability, proliferation, apoptosis, reactive oxygen species (ROS) production, and DNA damage.
    Results: Biological process analysis showed that T cells played a role in salivary gland lesions in patients with SS, indicating the significance of T cell inhibition in SS treatment. Viability assays revealed that the half-maximal inhibitory concentration of Fan was 2.49 μM in Jurkat T cells, while the proliferation assay revealed that Fan had an inhibitory effect on the proliferation of Jurkat T cells. The results of the apoptotic, ROS, agarose gel electrophoresis, and immunofluorescence assays showed that Fan induced oxidative stress-induced apoptosis and DNA damage in a dosedependent manner.
    Conclusion: These results indicate that Fan could significantly induce oxidative stress-induced apoptosis and DNA damage and inhibit the proliferation of Jurkat T cells. Moreover, Fan further enhanced the inhibitory effect on DNA damage and apoptosis by inhibiting the pro-survival Akt signal.
    MeSH term(s) Humans ; Jurkat Cells ; Reactive Oxygen Species ; Proto-Oncogene Proteins c-akt ; Stephania tetrandra ; Oxidative Stress ; Apoptosis ; DNA Damage
    Chemical Substances fangchinoline (953592C3ZB) ; Reactive Oxygen Species ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2023-02-20
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1874-4702
    ISSN (online) 1874-4702
    DOI 10.2174/1874467216666230210152454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Porous polymer magnetic adsorbents for dye wastewater treatment.

    Xue, Tao / Shao, Feifei / Miao, Han / Li, Xinxin

    Environmental science and pollution research international

    2023  Volume 30, Issue 43, Page(s) 97147–97159

    Abstract: Dye wastewater discharged from industries has caused serious environmental problems. The recent decade has witnessed adsorption technology emerging as an advanced dye wastewater treatment method with great potential Therefore, we fabricated two kinds of ... ...

    Abstract Dye wastewater discharged from industries has caused serious environmental problems. The recent decade has witnessed adsorption technology emerging as an advanced dye wastewater treatment method with great potential Therefore, we fabricated two kinds of magnetic porous adsorbents (HSF and HSVF) with different specific surface areas and activity sites. Both of which exhibit excellent performance with remarkable dye adsorption capacities, especially HSVF. We further investigated their adsorption kinetic and isotherm in detail. Therein, HSVF showed a nice desorption capacity, and it could be recycled rapidly by magnetism, which exhibited the advantages of effective, easy operation, and low cost. In addition, their adsorption kinetic and isotherm were further studied and compared in detail. The results revealed that introducing strong active sites could improve both the adsorption capacity and rate effectively even though sacrificing part of specific surface areas, indicating that active sites might play a dominant role during the dye adsorption process.
    MeSH term(s) Polymers ; Porosity ; Wastewater ; Adsorption ; Magnetic Phenomena ; Water Purification/methods ; Water Pollutants, Chemical/analysis ; Kinetics
    Chemical Substances Polymers ; Wastewater ; Water Pollutants, Chemical
    Language English
    Publishing date 2023-08-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-29102-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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