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  1. Artikel: Iron overload.

    Siah, Chiang W / Trinder, Debbie / Olynyk, John K

    Clinica chimica acta; international journal of clinical chemistry

    2005  Band 358, Heft 1-2, Seite(n) 24–36

    Abstract: Iron overload disorders represent a heterogenous group of conditions resulting from inherited and acquired causes. With the discovery of new proteins and genetic defects we have gained greater insight into their causation at the molecular level and the ... ...

    Abstract Iron overload disorders represent a heterogenous group of conditions resulting from inherited and acquired causes. With the discovery of new proteins and genetic defects we have gained greater insight into their causation at the molecular level and the complex mechanisms of normal and disordered iron homeostasis. Here we review the normal mechanisms and regulation of gastrointestinal iron absorption and liver iron transport and their dysregulation in iron overload states. Advances in the understanding of the natural history of iron overload disorders and new methods for clinical detection and management of hereditary hemochromatosis are also reviewed.
    Mesh-Begriff(e) Ceruloplasmin/deficiency ; Ceruloplasmin/metabolism ; Hemochromatosis/metabolism ; Hemochromatosis/pathology ; Humans ; Iron/metabolism ; Iron Overload/etiology ; Iron Overload/metabolism ; Iron Overload/pathology ; Liver Diseases/metabolism ; Liver Diseases/pathology ; Models, Biological ; Transferrin/deficiency ; Transferrin/metabolism
    Chemische Substanzen Transferrin ; Iron (E1UOL152H7) ; Ceruloplasmin (EC 1.16.3.1)
    Sprache Englisch
    Erscheinungsdatum 2005-08
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cccn.2005.02.022
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Normal iron metabolism and the pathophysiology of iron overload disorders.

    Siah, Chiang W / Ombiga, John / Adams, Leon A / Trinder, Debbie / Olynyk, John K

    The Clinical biochemist. Reviews

    2006  Band 27, Heft 1, Seite(n) 5–16

    Abstract: Iron overload disorders represent a heterogenous group of conditions resulting from inherited and acquired causes. If undiagnosed they can be progressive and fatal. Early detection and phlebotomy prior to the onset of cirrhosis can reduce morbidity and ... ...

    Abstract Iron overload disorders represent a heterogenous group of conditions resulting from inherited and acquired causes. If undiagnosed they can be progressive and fatal. Early detection and phlebotomy prior to the onset of cirrhosis can reduce morbidity and normalise life expectancy. We now have greater insight into the complex mechanisms of normal and disordered iron homeostasis following the discovery of new proteins and genetic defects. Here we review the normal mechanisms and regulation of gastrointestinal iron absorption and liver iron transport and their dysregulation in iron overload states. Advances in the understanding of the natural history of iron overload disorders and new methods for clinical detection and management of hereditary haemochromatosis are also reviewed. The current screening strategies target high-risk groups such as first-degree relatives of affected individuals and those with clinical features suggestive of iron loading. Potential ethical, legal and psychosocial issues arising through application of genetic screening programs need to be resolved prior to implementation of general population screening programs.
    Sprache Englisch
    Erscheinungsdatum 2006-08-02
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 1018054-0
    ISSN 1838-0212 ; 0159-8090
    ISSN (online) 1838-0212
    ISSN 0159-8090
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 2815: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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