LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 10 von insgesamt 10

Suchoptionen

  1. Artikel ; Online: Post_production. architectural design and the landscape of de-industrialisation

    Francesco Spanedda

    City, Territory and Architecture, Vol 10, Iss 1, Pp 1-

    2023  Band 10

    Abstract: Abstract Industrial facilities have been dispersed across the American and European landscapes since the early Nineteenth century. Also, their activity encouraged the growth of a vast global network of logistical, mining, and agricultural infrastructures. ...

    Abstract Abstract Industrial facilities have been dispersed across the American and European landscapes since the early Nineteenth century. Also, their activity encouraged the growth of a vast global network of logistical, mining, and agricultural infrastructures. Yet, since the late 1960s, a significant number of productive sectors have been gradually dismantled as a result of technical advancement, obsolescence, and changes in industrial regulations. The repurposing of “brownfields”, as abandoned industrial sites have been dubbed, became a topic of discussion in the architectural community. In the 1980s, this circumstance presented an amazing opportunity to modernise the layout of Western cities. Yet, contemporary critical views on the nature and effects of industrialism, societal transformations, and awareness of the environmental crisis at the turn of the Twentieth century call for refocusing the architectural discussion regarding brownfields. In this essay, case studies are examined and set against the backdrop of an expanding conversation in architecture regarding sustainability.
    Schlagwörter Architectural design ; Urban design ; Landscape design ; Brownfields regeneration ; Anthropocene ; Sustainable architecture ; Social Sciences ; H ; Communities. Classes. Races ; HT51-1595 ; Urban groups. The city. Urban sociology ; HT101-395
    Thema/Rubrik (Code) 720
    Sprache Englisch
    Erscheinungsdatum 2023-06-01T00:00:00Z
    Verlag SpringerOpen
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  2. Artikel ; Online: The flipped house and the bubble. Domestic space in the time of coronavirus

    Francesco Spanedda / Matteo Carmine Fusaro

    City, Territory and Architecture, Vol 9, Iss 1, Pp 1-

    2022  Band 13

    Abstract: Abstract The SARS-CoV-2 pandemic put the spatial layouts of contemporary housing to the test. During the strict lockdowns in the early phases of the outbreak and the limited, temporary restrictions of the later phases, the safeguarding of public health ... ...

    Abstract Abstract The SARS-CoV-2 pandemic put the spatial layouts of contemporary housing to the test. During the strict lockdowns in the early phases of the outbreak and the limited, temporary restrictions of the later phases, the safeguarding of public health was inevitably enforced by confining people at home, thus severing, by reasons of force majeure, the traditional relationship between the house and the city. As a result, every household had to contain within itself all aspects of public and private life, regardless of the spatial qualities and the extension of the dwelling. The unexpected new role of the last defence line against the virus showed all the advantages and limits of contemporary housing and the need for a rethinking of some of their typical features. The aim of this article is to investigate how the residential space, as a whole and in its constituent parts, has become a fundamental element in a difficult period, managing to incorporate unexpected functions and requirements but also revealing a series of congenital weaknesses.
    Schlagwörter Architectural design ; Housing ; Dwelling space ; Sharing economy ; Information capitalism ; Cognitive economy ; Social Sciences ; H ; Communities. Classes. Races ; HT51-1595 ; Urban groups. The city. Urban sociology ; HT101-395
    Thema/Rubrik (Code) 720
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag SpringerOpen
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  3. Artikel ; Online: New approaches to housing complexity

    Francesco Spanedda / Matteo Carmine Fusaro

    City, Territory and Architecture, Vol 7, Iss 1, Pp 1-

    designing dwellings in the age of cognitive economy

    2020  Band 8

    Abstract: Abstract Space is produced by a society in accordance with its habits, and habits, mostly in the Western society, have been heavily influenced by forms of production. Indeed, it is widely acknowledged that the Industrial Revolution definitely changed the ...

    Abstract Abstract Space is produced by a society in accordance with its habits, and habits, mostly in the Western society, have been heavily influenced by forms of production. Indeed, it is widely acknowledged that the Industrial Revolution definitely changed the space of modern landscapes, cities and dwellings life at all scales, and the way in which we perceive them. Cognitive capitalism is no exception. Since it fully established itself as one of the prevailing economic forces in the 21st century and in the Western world, it produced deep changes in the way in which people work, connect, and live. Starting from the assumption that changes in means of production generate new social relationships, this paper investigates how these changes might result in new ways of building architectural space. Without indulging in a deterministic attitude, it focuses on housing as one of the fundamental artefacts where a society expresses its approach to space. The house is a basic element of complex urban systems and is, therefore, the one calling for a more radical conceptual rethinking, marking an effective distance with the forms inherited from the previous centuries. Finally, the paper aims at understanding the repercussions of the digital paradigm on the space of dwelling, reasoning on some crucial questions to understand how housing might evolve, unfolding through its spatial configuration the new ways of life of the digital society.
    Schlagwörter Architectural design ; Housing ; Dwelling space ; Sharing economy ; Information capitalism ; Cognitive economy ; Social Sciences ; H ; Communities. Classes. Races ; HT51-1595 ; Urban groups. The city. Urban sociology ; HT101-395
    Thema/Rubrik (Code) 720
    Sprache Englisch
    Erscheinungsdatum 2020-11-01T00:00:00Z
    Verlag SpringerOpen
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  4. Artikel ; Online: Sustainable rehabilitation of neglected and marginal landscapes

    Paola Pittaluga / Francesco Spanedda

    City, Territory and Architecture, Vol 7, Iss 1, Pp 1-

    the San Lorenzo valley in Sardinia

    2020  Band 10

    Abstract: Abstract This paper describes a proposal for the sustainable rehabilitation of a neglected and marginal fluvial landscape. It situates the experience into a broader debate about sustainability and spatial design, and then draws from it some general ... ...

    Abstract Abstract This paper describes a proposal for the sustainable rehabilitation of a neglected and marginal fluvial landscape. It situates the experience into a broader debate about sustainability and spatial design, and then draws from it some general conclusion. The study subject is a fluvial valley characterised by thirty-six mills, which once served the agriculture of the surroundings. The decline of water as power source let to the decline of the valley. The mills became eventually farms, houses, or were left empty. The proposal envisions multiple forms of interaction with the different contextual issues related to the context, turning the design of the water course in a way to cope with erosion and floods, to produce clean energy, and finally as attractor for tourism. The result is a series of integrated actions that offers new opportunities to the community, designing a new sustainable landscape drawing from the specific natural and historical aspects of the site. Every action is linked with one of the anthropic and natural factors that characterise the valley, or that can be beneficially introduced, so that the proposal can be further adjusted in accordance with the relative importance of each factor over time.
    Schlagwörter Sustainability ; Rehabilitation ; Neglected and marginal landscape ; Collective management ; Social Sciences ; H ; Communities. Classes. Races ; HT51-1595 ; Urban groups. The city. Urban sociology ; HT101-395
    Thema/Rubrik (Code) 710
    Sprache Englisch
    Erscheinungsdatum 2020-10-01T00:00:00Z
    Verlag SpringerOpen
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  5. Artikel ; Online: New approaches to housing complexity: designing dwellings in the age of cognitive economy

    Spanedda, Francesco / Fusaro, Matteo Carmine

    City Territ Archit

    Abstract: Space is produced by a society in accordance with its habits, and habits, mostly in the Western society, have been heavily influenced by forms of production. Indeed, it is widely acknowledged that the Industrial Revolution definitely changed the space of ...

    Abstract Space is produced by a society in accordance with its habits, and habits, mostly in the Western society, have been heavily influenced by forms of production. Indeed, it is widely acknowledged that the Industrial Revolution definitely changed the space of modern landscapes, cities and dwellings life at all scales, and the way in which we perceive them. Cognitive capitalism is no exception. Since it fully established itself as one of the prevailing economic forces in the 21st century and in the Western world, it produced deep changes in the way in which people work, connect, and live. Starting from the assumption that changes in means of production generate new social relationships, this paper investigates how these changes might result in new ways of building architectural space. Without indulging in a deterministic attitude, it focuses on housing as one of the fundamental artefacts where a society expresses its approach to space. The house is a basic element of complex urban systems and is, therefore, the one calling for a more radical conceptual rethinking, marking an effective distance with the forms inherited from the previous centuries. Finally, the paper aims at understanding the repercussions of the digital paradigm on the space of dwelling, reasoning on some crucial questions to understand how housing might evolve, unfolding through its spatial configuration the new ways of life of the digital society.
    Schlagwörter covid19
    Verlag PMC
    Dokumenttyp Artikel ; Online
    DOI 10.1186/s40410-020-00128-5
    Datenquelle COVID19

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  6. Artikel ; Online: Molecularly Imprinted Microrods via Mesophase Polymerization.

    Parisi, Ortensia Ilaria / Scrivano, Luca / Candamano, Sebastiano / Ruffo, Mariarosa / Vattimo, Anna Francesca / Spanedda, Maria Vittoria / Puoci, Francesco

    Molecules (Basel, Switzerland)

    2017  Band 23, Heft 1

    Abstract: The aim of the present research work was the synthesis of molecularly imprinted polymers (MIPs) with a rod-like geometry via "mesophase polymerization". The ternary lyotropic system consisting of sodium dodecyl sulfate (SDS), water, and decanol was ... ...

    Abstract The aim of the present research work was the synthesis of molecularly imprinted polymers (MIPs) with a rod-like geometry via "mesophase polymerization". The ternary lyotropic system consisting of sodium dodecyl sulfate (SDS), water, and decanol was chosen to prepare a hexagonal mesophase to direct the morphology of the synthesized imprinted polymers using theophylline, methacrylic acid, and ethylene glycol dimethacrylate as a drug model template, a functional monomer, and a crosslinker, respectively. The obtained molecularly imprinted microrods (MIMs) were assessed by performing binding experiments and in vitro release studies, and the obtained results highlighted good selective recognition abilities and sustained release properties. In conclusion, the adopted synthetic strategy involving a lyotropic mesophase system allows for the preparation of effective MIPs characterized by a rod-like morphology.
    Mesh-Begriff(e) Cross-Linking Reagents/chemistry ; Drug Carriers/chemistry ; Humans ; Methacrylates/chemistry ; Molecular Imprinting/methods ; Particle Size ; Polymerization ; Polymers/chemical synthesis ; Polymers/chemistry ; Sodium Dodecyl Sulfate/chemistry ; Solvents/chemistry ; Surface Properties ; Theophylline/chemistry ; Water/chemistry
    Chemische Substanzen Cross-Linking Reagents ; Drug Carriers ; Methacrylates ; Polymers ; Solvents ; Water (059QF0KO0R) ; methacrylic acid (1CS02G8656) ; Sodium Dodecyl Sulfate (368GB5141J) ; ethylene dimethacrylate (7BK5G69305) ; Theophylline (C137DTR5RG)
    Sprache Englisch
    Erscheinungsdatum 2017-12-28
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules23010063
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.MO 81: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  7. Artikel ; Online: Molecularly Imprinted Microrods via Mesophase Polymerization

    Ortensia Ilaria Parisi / Luca Scrivano / Sebastiano Candamano / Mariarosa Ruffo / Anna Francesca Vattimo / Maria Vittoria Spanedda / Francesco Puoci

    Molecules, Vol 23, Iss 1, p

    2017  Band 63

    Abstract: The aim of the present research work was the synthesis of molecularly imprinted polymers (MIPs) with a rod-like geometry via “mesophase polymerization”. The ternary lyotropic system consisting of sodium dodecyl sulfate (SDS), water, and decanol was ... ...

    Abstract The aim of the present research work was the synthesis of molecularly imprinted polymers (MIPs) with a rod-like geometry via “mesophase polymerization”. The ternary lyotropic system consisting of sodium dodecyl sulfate (SDS), water, and decanol was chosen to prepare a hexagonal mesophase to direct the morphology of the synthesized imprinted polymers using theophylline, methacrylic acid, and ethylene glycol dimethacrylate as a drug model template, a functional monomer, and a crosslinker, respectively. The obtained molecularly imprinted microrods (MIMs) were assessed by performing binding experiments and in vitro release studies, and the obtained results highlighted good selective recognition abilities and sustained release properties. In conclusion, the adopted synthetic strategy involving a lyotropic mesophase system allows for the preparation of effective MIPs characterized by a rod-like morphology.
    Schlagwörter molecularly imprinted polymers ; polymeric microrods ; mesophase polymerization ; theophylline ; Organic chemistry ; QD241-441
    Thema/Rubrik (Code) 540
    Sprache Englisch
    Erscheinungsdatum 2017-12-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  8. Artikel ; Online: Constitutive and herbivore-induced monoterpenes emitted by Populus x euroamericana leaves are key volatiles that orient Chrysomela populi beetles.

    Brilli, Federico / Ciccioli, Paolo / Frattoni, Massimiliano / Prestininzi, Marco / Spanedda, Antonio Franco / Loreto, Francesco

    Plant, cell & environment

    2009  Band 32, Heft 5, Seite(n) 542–552

    Abstract: Chrysomela populi beetles feed on poplar leaves and extensively damage plantations. We investigated whether olfactory cues orientate landing and feeding. Young, unexpanded leaves of hybrid poplar emit constitutively a blend of monoterpenes, primarily (E)- ...

    Abstract Chrysomela populi beetles feed on poplar leaves and extensively damage plantations. We investigated whether olfactory cues orientate landing and feeding. Young, unexpanded leaves of hybrid poplar emit constitutively a blend of monoterpenes, primarily (E)-beta-ocimene and linalool. This blend attracts inexperienced adults of C. populi that were not previously fed with poplar leaves. In mature leaves constitutively emitting isoprene, insect attack induces biosynthesis and emission of the same blend of monoterpenes, but in larger amount than in young leaves. The olfactometric test indicates that inexperienced beetles are more attracted by adult than by young attacked leaves, suggesting that attraction by induced monoterpenes is dose dependent. The blend does not attract adults that previously fed on poplar leaves. Insect-induced emission of monoterpenes peaks 4 d after the attack, and is also detected in non-attacked leaves. Induced monoterpene emission is associated in mature leaves with a larger decrease of isoprene emission. The reduction of isoprene emission is faster than photosynthesis reduction in attacked leaves, and also occurs in non-attacked leaves. Insect-induced monoterpenes are quickly and completely labelled by 13C. It is speculated that photosynthetic carbon preferentially allocated to constitutive isoprene in healthy leaves is in part diverted to induced monoterpenes after the insect attack.
    Mesh-Begriff(e) Animals ; Butadienes ; Coleoptera/physiology ; Feeding Behavior ; Hemiterpenes/biosynthesis ; Monoterpenes/metabolism ; Pentanes ; Photosynthesis ; Plant Leaves/metabolism ; Populus/metabolism ; Volatile Organic Compounds/metabolism
    Chemische Substanzen Butadienes ; Hemiterpenes ; Monoterpenes ; Pentanes ; Volatile Organic Compounds ; isoprene (0A62964IBU)
    Sprache Englisch
    Erscheinungsdatum 2009-05
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 391893-2
    ISSN 1365-3040 ; 0140-7791
    ISSN (online) 1365-3040
    ISSN 0140-7791
    DOI 10.1111/j.1365-3040.2009.01948.x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Bonn

    Z 80/729: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  9. Artikel: Constitutive and herbivore-induced monoterpenes emitted by Populus x euroamericana leaves are key volatiles that orient Chrysomela populi beetles

    BRILLI, FEDERICO / CICCIOLI, PAOLO / FRATTONI, MASSIMILIANO / PRESTININZI, MARCO / SPANEDDA, ANTONIO FRANCO / LORETO, FRANCESCO

    Plant, cell & environment. 2009 May, v. 32, no. 5

    2009  

    Abstract: Chrysomela populi beetles feed on poplar leaves and extensively damage plantations. We investigated whether olfactory cues orientate landing and feeding. Young, unexpanded leaves of hybrid poplar emit constitutively a blend of monoterpenes, primarily (E)- ...

    Abstract Chrysomela populi beetles feed on poplar leaves and extensively damage plantations. We investigated whether olfactory cues orientate landing and feeding. Young, unexpanded leaves of hybrid poplar emit constitutively a blend of monoterpenes, primarily (E)-β-ocimene and linalool. This blend attracts inexperienced adults of C. populi that were not previously fed with poplar leaves. In mature leaves constitutively emitting isoprene, insect attack induces biosynthesis and emission of the same blend of monoterpenes, but in larger amount than in young leaves. The olfactometric test indicates that inexperienced beetles are more attracted by adult than by young attacked leaves, suggesting that attraction by induced monoterpenes is dose dependent. The blend does not attract adults that previously fed on poplar leaves. Insect-induced emission of monoterpenes peaks 4 d after the attack, and is also detected in non-attacked leaves. Induced monoterpene emission is associated in mature leaves with a larger decrease of isoprene emission. The reduction of isoprene emission is faster than photosynthesis reduction in attacked leaves, and also occurs in non-attacked leaves. Insect-induced monoterpenes are quickly and completely labelled by ¹³C. It is speculated that photosynthetic carbon preferentially allocated to constitutive isoprene in healthy leaves is in part diverted to induced monoterpenes after the insect attack.
    Schlagwörter Chrysomela ; Populus ; biosynthesis ; carbon ; emissions ; feeds ; hybrids ; insects ; leaves ; linalool ; olfactometry ; photosynthesis ; plantations ; young adults
    Sprache Englisch
    Erscheinungsverlauf 2009-05
    Umfang p. 542-552.
    Verlag Blackwell Publishing Ltd
    Erscheinungsort Oxford, UK
    Dokumenttyp Artikel
    ZDB-ID 391893-2
    ISSN 1365-3040 ; 0140-7791
    ISSN (online) 1365-3040
    ISSN 0140-7791
    DOI 10.1111/j.1365-3040.2009.01948.x
    Datenquelle NAL Katalog (AGRICOLA)

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Bonn

    Z 80/729: Hefte anzeigen

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  10. Artikel: CXCR-4 expression on bone marrow CD34+ cells prior to mobilization can predict mobilization adequacy in patients with hematologic malignancies.

    Dabusti, Melissa / Lanza, Francesco / Campioni, Diana / Castagnari, Barbara / Tieghi, Alessia / Moretti, Sabrina / Punturieri, Marina / De Angeli, Cristiano / Spanedda, Romedio / Ferrazzi, Eros / Castoldi, Gianluigi

    Journal of hematotherapy & stem cell research

    2003  Band 12, Heft 4, Seite(n) 425–434

    Abstract: To investigate the mechanisms of mobilization and of the factors implicated in the homing of progenitors and possibly understand the reasons for unpredicted mobilization failure, we analyzed CXCR-4 (CD184) expression on bone marrow (BM) CD34+ cells prior ...

    Abstract To investigate the mechanisms of mobilization and of the factors implicated in the homing of progenitors and possibly understand the reasons for unpredicted mobilization failure, we analyzed CXCR-4 (CD184) expression on bone marrow (BM) CD34+ cells prior to peripheral blood stem cell (PBSC) mobilization in 24 patients affected by hematologic malignancies (non-Hodgkin lymphoma, multiple myeloma, and acute myeloid leukemia). We wanted to determine whether the level of CXCR-4 expressed by hematopoietic stem cells could influence mobilization process and therefore could be considered a predictive factor for mobilization adequacy. These data were also compared with stromal cell function as assessed by colony forming unit-fibroblast (CFU-F) and CFU endothelial cells (CFU-En) assays and stromal layer confluence capacity exhibited by patients' BM cells. In this study, we also compared CXCR-4 expression on CD34+ cells from different sources and at different migration stages specifically bone marrow (BM), steady state peripheral blood (SSPB), fetal cord blood (FCB), cord blood (CB), and mobilized PBSC. Seven (29%) of the 24 patients undergoing mobilization failed to achieve an adequate number of CD34+ stem cells (5 x 10(6)/kg CD34+ cells) and showed a very high expression frequency of CXCR-4 on BM CD34(+) stem cells (mean number of positive cells, 97%) investigated before the mobilization regimen. We also found that high expression intensity per cell for CXCR-4 was associated with lower amounts of mobilized CD34+ cells whereas those patients (17 out of 24 patients, 71%) with lower expression intensity per cell of CD184 on BM CD34+ cells prior to mobilization harvested at least 5 x 10(6)/kg CD34+ cells. Setting a cut off of 5 x 10(6)/kg CD34+ cells harvested, patients mobilizing less had a mean value of 97% CD34+ cells expressing CXCR-4 with a relative mean channel fluorescence of 458 whereas patients mobilizing more than 5 x 10(6)/kg CD34+ progenitors showed a mean value of 59.8% CD34+/CXCR4+ cells with a relative mean channel fluorescence value of 305. Interestingly, in the poor mobilizers group, the marrow stromal microenvironment was found to be more severely damaged in comparison with that of good mobilizers. The comparative analysis of CXCR-4 expression showed no difference in percentage values between steady-state PB (87.4%) and BM (85.1%) stem cells whereas mobilized CD34+ stem cells have a lower expression frequency of CXCR-4 (71.6%) compared to that of progenitors from other sources. Fetal blood CD34+ stem cells had the lowest mean expression frequency of CD184 antigen (36.3%), while CB cells had the highest (94.8%). In conclusion, this study provides evidence that monitoring CXCR-4 CD34 double positive cells before mobilization can be regarded as a predictive factor for mobilization outcome, giving us directional cues for the choice of the best stem cell mobilization regimens.
    Mesh-Begriff(e) Antigens, CD34/biosynthesis ; Bone Marrow Cells/cytology ; Bone Marrow Cells/metabolism ; Cell Movement ; Erythroid Precursor Cells ; Fetal Blood/cytology ; Fibroblasts/metabolism ; Flow Cytometry ; Hematologic Neoplasms/blood ; Hematologic Neoplasms/therapy ; Hematopoietic Stem Cells/cytology ; Humans ; Leukapheresis ; Middle Aged ; Peripheral Blood Stem Cell Transplantation/methods ; Receptors, CXCR4/biosynthesis ; Stem Cells ; Time Factors
    Chemische Substanzen Antigens, CD34 ; Receptors, CXCR4
    Sprache Englisch
    Erscheinungsdatum 2003-08
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1494547-2
    ISSN 1525-8165
    ISSN 1525-8165
    DOI 10.1089/152581603322286051
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 3616: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

Zum Seitenanfang