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  1. Artikel ; Online: Effect of felodipine on indomethacin-induced gastric ulcers in rats.

    Akbaş, Nergis / Süleyman, Bahadır / Mammadov, Renad / Gülaboğlu, Mine / Akbaş, Emin Murat / Süleyman, Halis

    Experimental animals

    2023  Band 72, Heft 4, Seite(n) 505–512

    Abstract: Felodipine is a calcium channel blocker with antioxidant and anti-inflammatory properties. Researchers have stated that oxidative stress and inflammation also play a role in the pathophysiology of gastric ulcers caused by nonsteroidal anti-inflammatory ... ...

    Abstract Felodipine is a calcium channel blocker with antioxidant and anti-inflammatory properties. Researchers have stated that oxidative stress and inflammation also play a role in the pathophysiology of gastric ulcers caused by nonsteroidal anti-inflammatory drugs. The aim of this study was to investigate the antiulcer effect of felodipine on indomethacin-induced gastric ulcers in Wistar rats and compare it with that of famotidine. The antiulcer activities of felodipine (5 mg/kg) and famotidine were investigated biochemically and macroscopically in animals treated with felodipine (5 mg/kg) and famotidine in combination with indomethacin. The results were compared with those of the healthy control group and the group administered indomethacin alone. It was observed that felodipine suppressed the indomethacin-induced malondialdehyde increase (P<0.001); reduced the decrease in total glutathione amount (P<0.001), reduced the decrease superoxide dismutase (P<0.001), and catalase activities (P<0.001); and significantly inhibited ulcers (P<0.001) at the tested dose compared with indomethacin alone. Felodipine at a dose of 5 mg/kg reduced the indomethacin-induced decrease in cyclooxygenase-1 activity (P<0.001) but did not cause a significant reduction in the decrease in cyclooxygenase-2 activity. The antiulcer efficacy of felodipine was demonstrated in this experimental model. These data suggest that felodipine may be useful in the treatment of nonsteroidal anti-inflammatory drug-induced gastric injury.
    Mesh-Begriff(e) Rats ; Animals ; Indomethacin/adverse effects ; Stomach Ulcer/chemically induced ; Stomach Ulcer/drug therapy ; Stomach Ulcer/prevention & control ; Famotidine/adverse effects ; Felodipine/adverse effects ; Rats, Wistar ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Antioxidants/pharmacology
    Chemische Substanzen Indomethacin (XXE1CET956) ; Famotidine (5QZO15J2Z8) ; Felodipine (OL961R6O2C) ; Anti-Inflammatory Agents, Non-Steroidal ; Antioxidants
    Sprache Englisch
    Erscheinungsdatum 2023-06-13
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 2088228-2
    ISSN 1881-7122 ; 1341-1357 ; 0007-5124
    ISSN (online) 1881-7122
    ISSN 1341-1357 ; 0007-5124
    DOI 10.1538/expanim.23-0052
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: The Role of Adrenaline, Noradrenaline, and Cortisol in the Pathogenesis of the Analgesic Potency, Duration, and Neurotoxic Effect of Meperidine.

    Yilmaz, Mehmet / Suleyman, Bahadir / Mammadov, Renad / Altuner, Durdu / Bulut, Seval / Suleyman, Halis

    Medicina (Kaunas, Lithuania)

    2023  Band 59, Heft 10

    Abstract: Background and ... ...

    Abstract Background and Objectives
    Mesh-Begriff(e) Rats ; Animals ; Meperidine/adverse effects ; Epinephrine/therapeutic use ; Norepinephrine ; Hydrocortisone ; Metyrapone ; Caffeine/adverse effects ; Analgesics ; Epilepsy ; Seizures
    Chemische Substanzen Meperidine (9E338QE28F) ; Epinephrine (YKH834O4BH) ; Norepinephrine (X4W3ENH1CV) ; Hydrocortisone (WI4X0X7BPJ) ; Metyrapone (ZS9KD92H6V) ; Caffeine (3G6A5W338E) ; Analgesics
    Sprache Englisch
    Erscheinungsdatum 2023-10-09
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59101793
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Biochemical and histopathological evaluation of systemic and ocular toxicity of favipiravir in rats.

    Özcan, Delil / Özçelik, Fatih / Mammadov, Renad / Aktaş, Mehmet / Altındağ, Fikret / Alkan, Abdurrahman Alpaslan / Karapapak, Murat / Altuner, Durdu / Süleyman, Halis

    Cutaneous and ocular toxicology

    2024  Band 43, Heft 2, Seite(n) 105–112

    Abstract: Purpose: ...

    Abstract Purpose:
    Mesh-Begriff(e) Animals ; Male ; Pyrazines/toxicity ; Pyrazines/administration & dosage ; Amides/toxicity ; Rats, Wistar ; Rats ; Antiviral Agents/toxicity ; Glutathione/metabolism ; Malondialdehyde/metabolism ; Superoxide Dismutase/metabolism ; Eye/drug effects ; Eye/pathology ; Oxidative Stress/drug effects ; Tumor Necrosis Factor-alpha/blood ; Interleukin-1beta/blood ; Conjunctiva/pathology ; Conjunctiva/drug effects
    Chemische Substanzen favipiravir (EW5GL2X7E0) ; Pyrazines ; Amides ; Antiviral Agents ; Glutathione (GAN16C9B8O) ; Malondialdehyde (4Y8F71G49Q) ; Superoxide Dismutase (EC 1.15.1.1) ; Tumor Necrosis Factor-alpha ; Interleukin-1beta
    Sprache Englisch
    Erscheinungsdatum 2024-01-12
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 605635-0
    ISSN 1556-9535 ; 1556-9527 ; 0731-3829
    ISSN (online) 1556-9535
    ISSN 1556-9527 ; 0731-3829
    DOI 10.1080/15569527.2023.2300788
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Protective effect of cinnamon extract against cobalt-induced multiple organ damage in rats.

    Isik, Bahar / Suleyman, Bahadir / Mammadov, Renad / Bulut, Seval / Yavuzer, Bulent / Altuner, Durdu / Coban, Taha Abdulkadir / Suleyman, Halis

    Frontiers in pharmacology

    2024  Band 15, Seite(n) 1384181

    Abstract: Background: The role of oxidative stress and inflammation in cobalt (Co) toxicity has been the focus of previous studies. Cinnamon and its main components have been reported to have protective effects in various tissues with antioxidant and anti- ... ...

    Abstract Background: The role of oxidative stress and inflammation in cobalt (Co) toxicity has been the focus of previous studies. Cinnamon and its main components have been reported to have protective effects in various tissues with antioxidant and anti-inflammatory effects.
    Aims: In this study, the protective effect of cinnamon extract (CE) against possible Co-induced heart, kidney, and liver damage in rats was investigated biochemically.
    Methods: Eighteen
    Results: CoCL
    Conclusion: Co induced the production of oxidants and proinflammatory parameters and antioxidant depletion in heart, kidney, and liver tissues of rats. Our experimental results show that CE protects heart, kidney, and liver tissues against oxidative and inflammatory changes induced by CoCLl
    Sprache Englisch
    Erscheinungsdatum 2024-05-09
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2024.1384181
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Lacidipine, thiamine pyrophosphate and their combination on the ocular ischemic syndrome induced by bilateral common carotid artery ligation.

    Cicek, Ibrahim / Somuncu, Ahmet Mehmet / Altuner, Durdu / Suleyman, Bahadir / Mammadov, Renad / Bulut, Seval / Coban, Taha Abdulkadir / Bal Tastan, Tugba / Suleyman, Halis

    International journal of ophthalmology

    2024  Band 17, Heft 5, Seite(n) 815–821

    Abstract: Aim: To investigate the effect of lacidipine, thiamine pyrophosphate (TPP) and the combination of lacidipine and TPP against oxidative and inflammatory eye damage induced by bilateral common carotid artery ligation in rats.: Methods: Male albino ... ...

    Abstract Aim: To investigate the effect of lacidipine, thiamine pyrophosphate (TPP) and the combination of lacidipine and TPP against oxidative and inflammatory eye damage induced by bilateral common carotid artery ligation in rats.
    Methods: Male albino Wistar rats were categorized as those who underwent sham surgery (SG), right and left common carotid cross-clamping and unclamping procedure (CCU), lacidipine+CCU (LCCU), TPP+CCU (TCCU), and combination of lacidipine and TPP (LTC)+CCU (LTCCU). One hour before anesthesia, the LCCU (
    Results: Lacidipine, TPP, and LTC significantly prevent the increase in malondialdehyde, tumor necrosis factor-alpha, interleukin-1β (IL-1β), and IL-6 levels, decrease in total glutathione levels, superoxide dismutase and catalase activities and histopathological retinal damage in eye tissue induced by bilateral common carotid artery ligation in rats. The impact of these drugs on protection is determined to be LTC>lacidipine>TPP.
    Conclusion: As a result of the study, it is concluded that LTC may be more effective than lacidipine and TPP alone in treating ocular ischemic syndrome.
    Sprache Englisch
    Erscheinungsdatum 2024-05-18
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 2663246-9
    ISSN 2227-4898 ; 2222-3959
    ISSN (online) 2227-4898
    ISSN 2222-3959
    DOI 10.18240/ijo.2024.05.04
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Carvacrol prevents acrylamide-induced oxidative and inflammatory liver damage and dysfunction in rats.

    Cerrah, Serkan / Ozcicek, Fatih / Gundogdu, Betul / Cicek, Betul / Coban, Taha Abdulkadir / Suleyman, Bahadir / Altuner, Durdu / Bulut, Seval / Suleyman, Halis

    Frontiers in pharmacology

    2023  Band 14, Seite(n) 1161448

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2023-04-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1161448
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Effects of benidipine, paracetamol, and their combination on postoperative and normal tissue pain thresholds.

    Bedir, Zehra / Ozkaloglu Erdem, Kezban Tuna / Doymus, Omer / Suleyman, Halis / Yavuzer, Bulent / Cicek, Betul / Altuner, Durdu / Mammadov, Renad / Yilmaz, Mehmet / Coban, Taha Abdulkadir / Suleyman, Bahadir / Bulut, Seval

    Frontiers in pharmacology

    2024  Band 14, Seite(n) 1326128

    Abstract: Introduction: ...

    Abstract Introduction:
    Sprache Englisch
    Erscheinungsdatum 2024-01-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1326128
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Effect of adenosine triphosphate on ribociclib-induced skin toxicity in rats.

    Akbaş, Nergis / Akbaş, Emin Murat / Süleyman, Zeynep / Çiçek, Betül / Ağgül, Ahmet Gökhan / Mokhtare, Behzad / Süleyman, Halis

    Cutaneous and ocular toxicology

    2023  Band 42, Heft 1, Seite(n) 32–37

    Abstract: Purpose: Ribociclib is a CDK4/6 inhibitor approved for the treatment of breast cancer; it inhibits the activity of CDK4/6 by competitively binding to adenosine 5'-triphosphate (ATP) binding sites. Although generally well-tolerated, ribociclib has been ... ...

    Abstract Purpose: Ribociclib is a CDK4/6 inhibitor approved for the treatment of breast cancer; it inhibits the activity of CDK4/6 by competitively binding to adenosine 5'-triphosphate (ATP) binding sites. Although generally well-tolerated, ribociclib has been connected to a number of serious dermatologic complications. This study explored the effects of ATP on ribociclib-induced skin damage.
    Materials and methods: Using a rat model, ATP 25 mg/kg was injected intraperitoneally in the ATP + Ribociclib (ATR) group (
    Results: In the histopathological evaluation of the RCB group, dermal necrosis, degeneration in hair follicles, and pycnosis in keratinocytes were observed. Only mild degeneration was observed in the ATR group; the HC group had a normal histological appearance. The malondialdehyde (MDA) values were significantly higher and the superoxide dismutase (SOD), catalase (CAT), and total glutathione (tGSH) levels were significantly lower in the RCB group in comparison to the HC group (
    Conclusion: ATP may be useful in the treatment of ribociclib-induced skin damage.
    Mesh-Begriff(e) Rats ; Animals ; Rats, Wistar ; Glutathione/metabolism ; Superoxide Dismutase ; Solvents ; Water
    Chemische Substanzen ribociclib (TK8ERE8P56) ; Glutathione (GAN16C9B8O) ; Superoxide Dismutase (EC 1.15.1.1) ; Solvents ; Water (059QF0KO0R)
    Sprache Englisch
    Erscheinungsdatum 2023-01-19
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 605635-0
    ISSN 1556-9535 ; 1556-9527 ; 0731-3829
    ISSN (online) 1556-9535
    ISSN 1556-9527 ; 0731-3829
    DOI 10.1080/15569527.2023.2166524
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: The Role of Alpha-2 Adrenergic Receptors in Anti-ulcer Activity.

    Suleyman, Halis

    The Eurasian journal of medicine

    2015  Band 44, Heft 1, Seite(n) 43–45

    Abstract: Although peptic ulcer disease has long been recognized, the proposed mechanisms of its etiopathogenesis change every year. This review shows that gastric ulcers have a significant relationship with alpha-2 adrenergic receptors. The aggravating factors of ...

    Abstract Although peptic ulcer disease has long been recognized, the proposed mechanisms of its etiopathogenesis change every year. This review shows that gastric ulcers have a significant relationship with alpha-2 adrenergic receptors. The aggravating factors of gastric ulcer formation have been reported to act by blocking alpha-2 adrenergic receptors, whereas drugs possessing anti-ulcer activity have been shown to ensure gastric protection by stimulating the alpha-2 adrenergic receptors. The data derived from the literature indicate the likelihood that any drug or substance selectively stimulating the alpha-2 adrenergic receptors may possess anti-ulcer activity.
    Sprache Englisch
    Erscheinungsdatum 2015-01-06
    Erscheinungsland Turkey
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2577670-8
    ISSN 1308-8742 ; 1308-8734
    ISSN (online) 1308-8742
    ISSN 1308-8734
    DOI 10.5152/eajm.2012.09
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  10. Artikel: The role of Hippophae rhamnoides L. on 5-fluorouracil-ınduced oral mucositis in rats.

    Dilber, Muhammet / Suleyman, Bahadir / Mammadov, Renad / Suleyman, Zeynep / Yavuzer, Bulent / Gulaboglu, Mine / Erhan, Ertugrul / Salcan, Ismail / Suleyman, Halis

    Pakistan journal of pharmaceutical sciences

    2023  Band 36, Heft 5, Seite(n) 1443–1449

    Abstract: Current study aimed to research the effect of Hippophae rhamnoides (HRE) on potantial oral oxidative and inflammatory damage of 5-FU in rats. The rats were assigned to three groups; healthy (HG), 5-FU 100mg/kg (FUG) and HRE 50mg/kg +5-FU 100mg/kg (HRFU). ...

    Abstract Current study aimed to research the effect of Hippophae rhamnoides (HRE) on potantial oral oxidative and inflammatory damage of 5-FU in rats. The rats were assigned to three groups; healthy (HG), 5-FU 100mg/kg (FUG) and HRE 50mg/kg +5-FU 100mg/kg (HRFU). The 5-FU was injected in the FUG group intraperitoneally. The HRFU was injected 5-FU at 100mg/kg IP one hour after the 50mg/kg HRE was given orally. Olive oil was used as a solvent for the HG. HRE was given to the rats three times a day for ten days. 5-FU was given one dose on the 1st, 3rd and 5th days. On the 10th day, the tissues removed from the animals were euthanized with high-dose anaesthesia and were macroscopically examined. The levels of the oxidant, antioxidant and proinflammatory cytokines were investigated.It was seen that HRE alleviated the symptoms of severe mucositis by antagonizing the effects of 5-FU on oxidant, antioxidant and proinflammatory cytokines such as malondialdehyde, total glutathione, superoxide dismutase, catalase, nuclear factor kappa-B and interleukin-6 in inner cheek and tongue tissue. These results recommend that HRE may be benefical in the cure of 5-FU-associated oral mucositis.
    Mesh-Begriff(e) Rats ; Animals ; Fluorouracil/toxicity ; Antioxidants/pharmacology ; Hippophae ; Stomatitis/chemically induced ; Stomatitis/drug therapy ; Interleukin-6 ; Oxidants/pharmacology ; Intestinal Mucosa
    Chemische Substanzen Fluorouracil (U3P01618RT) ; Antioxidants ; Interleukin-6 ; Oxidants
    Sprache Englisch
    Erscheinungsdatum 2023-10-23
    Erscheinungsland Pakistan
    Dokumenttyp Journal Article
    ZDB-ID 885131-1
    ISSN 1011-601X
    ISSN 1011-601X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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