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  1. Artikel ; Online: The regulation mechanism of transition metal doping on Hg

    Zhang, Guomeng / Jiang, Ye / Yang, Zhengda / Sun, Xin / Xu, Yichao / Cheng, Siyuan / Zhang, Xiang / Song, Jiayao

    The Science of the total environment

    2024  Band 927, Seite(n) 172334

    Abstract: The mercury oxidation performance of Ce/ ... ...

    Abstract The mercury oxidation performance of Ce/TiO
    Sprache Englisch
    Erscheinungsdatum 2024-04-10
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.172334
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  2. Artikel ; Online: Inadvertently enriched cyanobacteria prompted bacterial phosphorus uptake without aeration in a conventional anaerobic/oxic reactor.

    Nie, Jiaxiang / Wang, Xiaoxia / Sun, Peng / Yu, Deshuang / Yu, Zhengda / Qiu, Yanling / Zhao, Ji

    The Science of the total environment

    2024  Band 927, Seite(n) 172313

    Abstract: The enhanced biological phosphorus removal (EBPR) process requires alternate anaerobic and aerobic conditions, which are regulated respectively by aeration off and on. Recently, in an ordinary EBPR reactor, an abnormal orthophosphate concentration ( ... ...

    Abstract The enhanced biological phosphorus removal (EBPR) process requires alternate anaerobic and aerobic conditions, which are regulated respectively by aeration off and on. Recently, in an ordinary EBPR reactor, an abnormal orthophosphate concentration (PO
    Mesh-Begriff(e) Phosphorus/metabolism ; Cyanobacteria/metabolism ; Cyanobacteria/physiology ; Bioreactors/microbiology ; Anaerobiosis ; Waste Disposal, Fluid/methods ; Biofilms ; Aerobiosis
    Chemische Substanzen Phosphorus (27YLU75U4W)
    Sprache Englisch
    Erscheinungsdatum 2024-04-07
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.172313
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  3. Artikel ; Online: Ce-based three-dimensional mesoporous microspheres with Mn homogeneous incorporation for toluene oxidation.

    Jiang, Yinsheng / Jiang, Ye / Xu, Yichao / Sun, Xin / Cheng, Siyuan / Liu, Yanan / Dou, Xiao / Yang, Zhengda

    Journal of colloid and interface science

    2024  

    Abstract: Ce-based three-dimensional (3D) mesoporous microspheres with Mn homogeneous incorporation were synthesized. The CeMn-0.4, characterized by a Ce/Mn molar ratio of 6:4, demonstrated exceptional catalytic activity and stability. The formation of CeMn solid ... ...

    Abstract Ce-based three-dimensional (3D) mesoporous microspheres with Mn homogeneous incorporation were synthesized. The CeMn-0.4, characterized by a Ce/Mn molar ratio of 6:4, demonstrated exceptional catalytic activity and stability. The formation of CeMn solid solution strengthened the Ce-Mn interaction, yielding higher concentrations of Ce
    Sprache Englisch
    Erscheinungsdatum 2024-04-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 241597-5
    ISSN 1095-7103 ; 0021-9797
    ISSN (online) 1095-7103
    ISSN 0021-9797
    DOI 10.1016/j.jcis.2024.04.128
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  4. Artikel ; Online: Comprehensive Parameter Space Mapping of Cell Cycle Dynamics under Network Perturbations.

    Li, Zhengda / Wang, Shiyuan / Sun, Meng / Jin, Minjun / Khain, Daniel / Yang, Qiong

    ACS synthetic biology

    2024  Band 13, Heft 3, Seite(n) 804–815

    Abstract: Studies of quantitative systems and synthetic biology have extensively utilized models to interpret data, make predictions, and guide experimental designs. However, models often simplify complex biological systems and lack experimentally validated ... ...

    Abstract Studies of quantitative systems and synthetic biology have extensively utilized models to interpret data, make predictions, and guide experimental designs. However, models often simplify complex biological systems and lack experimentally validated parameters, making their reliability in perturbed systems unclear. Here, we developed a droplet-based synthetic cell system to continuously tune parameters at the single-cell level in multiple dimensions with full dynamic ranges, providing an experimental framework for global parameter space scans. We systematically perturbed a cell-cycle oscillator centered on cyclin-dependent kinase (Cdk1), enabling comprehensive mapping of period landscapes in response to network perturbations. The data allowed us to challenge existing models and refine a new model that matches the observed response. Our analysis demonstrated that Cdk1 positive feedback inhibition restricts the cell cycle frequency range, confirming model predictions; furthermore, it revealed new cellular responses to the inhibition of the Cdk1-counteracting phosphatase PP2A: monomodal or bimodal distributions across varying inhibition levels, underscoring the complex nature of cell cycle regulation that can be explained by our model. This comprehensive perturbation platform may be generalizable to exploring other complex dynamic systems.
    Mesh-Begriff(e) Reproducibility of Results ; Cell Cycle ; Cell Division
    Sprache Englisch
    Erscheinungsdatum 2024-02-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2161-5063
    ISSN (online) 2161-5063
    DOI 10.1021/acssynbio.3c00631
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  5. Artikel ; Online: The Rehabilitation Training Simulation of High Difficulty Movement and Sports Strain Site Based on Big Data

    Xiaojie Zhang / Zhengda Ma / Yongming Sun / Yanle Hu

    Journal of Healthcare Engineering, Vol

    2021  Band 2021

    Abstract: We study the rehabilitation training of damaged parts of ice and snow sports clock and ensure the physical safety of athletes. The results show that the RBF neural network updates the center, weight, and width of the radial basis function, and the ... ...

    Abstract We study the rehabilitation training of damaged parts of ice and snow sports clock and ensure the physical safety of athletes. The results show that the RBF neural network updates the center, weight, and width of the radial basis function, and the predicted maximum compliance is 99%, and the minimum compliance is 93%. After many analysis times, the prediction results show that the difference between the predicted degree of conformity and the actual results is less than 8%. The RBF neural network is trained according to the risk database of sports injury, and the RBF neural network will output corresponding values to realize sports injury estimation. The experimental results show that the designed model has high precision and efficiency.
    Schlagwörter Medicine (General) ; R5-920 ; Medical technology ; R855-855.5
    Sprache Englisch
    Erscheinungsdatum 2021-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel ; Online: Recombinant human erythropoietin protects against immature brain damage induced by hypoxic/ischemia insult.

    Sun, Zhengda / Song, Jiqing / Song, Qijun / Li, Lin / Tian, Xinxin / Wang, Lijun

    Neuroreport

    2023  Band 34, Heft 17, Seite(n) 801–810

    Abstract: To investigate the neuroprotection of recombinant human erythropoietin (rhEPO) against hypoxic/ischemic (HI) insult in three-day-old rats. Postnatal day 3 (PD3) rats were randomly divided into three groups: Sham group, HI group and HI+rhEPO group. ... ...

    Abstract To investigate the neuroprotection of recombinant human erythropoietin (rhEPO) against hypoxic/ischemic (HI) insult in three-day-old rats. Postnatal day 3 (PD3) rats were randomly divided into three groups: Sham group, HI group and HI+rhEPO group. Ligation of the right common carotid artery and hypoxia to induce HI brain injury. After HI insult, the rats received intraperitoneal injection of rhEPO (5000 IU/Kg, qod) in HI+rhEPO group or equal saline in other groups. On PD10, damage of brain tissue was examined by hematoxylin-eosin (HE) staining, observation of neuronal apoptosis in the hippocampus and cortex using immunofluorescence assay (marker: TUNEL). Immunohistochemical staining or western blotting was performed to detect the expression of cyclooxygenase-2 (COX-2), Caspase-3 and phosphorylated Akt (p-Akt) protein. On PD28, cognitive ability of rats was assessed by Morris water maze test. HI injury causes brain pathological morphology and cognitive function damage in PD3 rats, which can be alleviated by rhEPO intervention. Compared with the HI group, the HI+rhEPO group showed an increase in platform discovery rate and cross platform frequency, while the search platform time was shortened (P < 0.05). The proportion of TUNEL positive neurons and the expression of COX-2 and Caspase-3 proteins in brain tissue in the hippocampus and cortex was decreased, while the expression of p-Akt protein was upregulated (P < 0.05). RhEPO could protect against the pathological and cognitive impairment of immature brain induced by HI insult. This neuroprotective activity may involve in inhibiting inflammatory and apoptosis by activation of PI3K/Akt signaling pathway.
    Mesh-Begriff(e) Humans ; Rats ; Animals ; Caspase 3/metabolism ; Rats, Sprague-Dawley ; Proto-Oncogene Proteins c-akt/metabolism ; Cyclooxygenase 2/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Brain/metabolism ; Hypoxia/metabolism ; Hypoxia-Ischemia, Brain/complications ; Hypoxia-Ischemia, Brain/drug therapy ; Hypoxia-Ischemia, Brain/metabolism ; Erythropoietin/pharmacology ; Erythropoietin/therapeutic use ; Ischemia/metabolism ; Animals, Newborn ; Neuroprotective Agents/pharmacology
    Chemische Substanzen Caspase 3 (EC 3.4.22.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Erythropoietin (11096-26-7) ; Neuroprotective Agents
    Sprache Englisch
    Erscheinungsdatum 2023-10-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1049746-8
    ISSN 1473-558X ; 0959-4965
    ISSN (online) 1473-558X
    ISSN 0959-4965
    DOI 10.1097/WNR.0000000000001957
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  7. Artikel ; Online: The Rehabilitation Training Simulation of High Difficulty Movement and Sports Strain Site Based on Big Data.

    Zhang, Xiaojie / Ma, Zhengda / Sun, Yongming / Hu, Yanle

    Publikation ZURÜCKGEZOGEN

    Journal of healthcare engineering

    2021  Band 2021, Seite(n) 2911025

    Abstract: We study the rehabilitation training of damaged parts of ice and snow sports clock and ensure the physical safety of athletes. The results show that the RBF neural network updates the center, weight, and width of the radial basis function, and the ... ...

    Abstract We study the rehabilitation training of damaged parts of ice and snow sports clock and ensure the physical safety of athletes. The results show that the RBF neural network updates the center, weight, and width of the radial basis function, and the predicted maximum compliance is 99%, and the minimum compliance is 93%. After many analysis times, the prediction results show that the difference between the predicted degree of conformity and the actual results is less than 8%. The RBF neural network is trained according to the risk database of sports injury, and the RBF neural network will output corresponding values to realize sports injury estimation. The experimental results show that the designed model has high precision and efficiency.
    Mesh-Begriff(e) Athletes ; Big Data ; Computer Simulation ; Humans ; Neural Networks, Computer ; Sports
    Sprache Englisch
    Erscheinungsdatum 2021-09-29
    Erscheinungsland England
    Dokumenttyp Journal Article ; Retracted Publication
    ZDB-ID 2545054-2
    ISSN 2040-2309 ; 2040-2295
    ISSN (online) 2040-2309
    ISSN 2040-2295
    DOI 10.1155/2021/2911025
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Peroxymonosulfate activation by walnut shell activated carbon supported nano zero-valent iron for the degradation of tetracycline: Performance, degradation pathway and mechanism.

    Duan, Pingping / Kong, Fanlong / Fu, Xiuzheng / Han, Zhijie / Sun, Guangwei / Yu, Zhengda / Wang, Sen / Cui, Yuqian

    Environmental research

    2023  Band 245, Seite(n) 117971

    Abstract: In this study, activated carbon (WS-AC) was prepared from walnut shell. Nano-zero-valent iron (nZVI) was loaded on walnut shell activated carbon by liquid phase reduction method and used as catalyst (WS-AC/nZVI) to activate peroxymonosulfate (PMS) to ... ...

    Abstract In this study, activated carbon (WS-AC) was prepared from walnut shell. Nano-zero-valent iron (nZVI) was loaded on walnut shell activated carbon by liquid phase reduction method and used as catalyst (WS-AC/nZVI) to activate peroxymonosulfate (PMS) to efficiently degrade tetracycline (TC) in solution. The composite material with a mass ratio of WS-AC to nZVI of 1:1 has the highest catalytic performance for activating PMS to degrade TC. The results showed that under the conditions of TC concentration of 100 ppm, PMS dosage of 0.2 mM and WS-AC/nZVI dosage of 0.1 g/L, the removal efficiency of TC could reach 81%. Based on quenching experiments and electron spin resonance (EPR), it was verified that •OH, SO
    Mesh-Begriff(e) Charcoal ; Juglans ; Iron/chemistry ; Water Pollutants, Chemical/chemistry ; Anti-Bacterial Agents ; Tetracycline/chemistry ; Peroxides
    Chemische Substanzen peroxymonosulfate (22047-43-4) ; Charcoal (16291-96-6) ; Iron (E1UOL152H7) ; Water Pollutants, Chemical ; Anti-Bacterial Agents ; Tetracycline (F8VB5M810T) ; Peroxides
    Sprache Englisch
    Erscheinungsdatum 2023-12-23
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2023.117971
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  9. Artikel ; Online: Integrated bioinformatics approaches to investigate alterations in transcriptomic profiles of monkeypox infected human cell line model

    Gangga Anuraga / Jilu Lang / Do Thi Minh Xuan / Hoang Dang Khoa Ta / Jia-Zhen Jiang / Zhengda Sun / Sanskriti Dey / Sachin Kumar / Ayushi Singh / Gagan Kajla / Wei-Jan Wang / Chih-Yang Wang

    Journal of Infection and Public Health, Vol 17, Iss 1, Pp 60-

    2024  Band 69

    Abstract: Background: The recent re-emergence of the monkeypox (mpox) epidemic in nonendemic regions has raised concerns regarding a potential global outbreak. The mpox virus (MPV) is a smallpox-like virus belonging to the genus Orthopoxvirus (family: Poxviridae). ...

    Abstract Background: The recent re-emergence of the monkeypox (mpox) epidemic in nonendemic regions has raised concerns regarding a potential global outbreak. The mpox virus (MPV) is a smallpox-like virus belonging to the genus Orthopoxvirus (family: Poxviridae). Although studies suggest that MPV infection suppresses the Toll-like receptor-3- and tumor necrosis factor-α-related signaling pathways, whether MPV regulates other immune-related pathways remains unclear. Methods: In this study, two distinct temporal patterns were used for establishing an MPV-infected human immortal epithelial cancer cell line (HeLa). These two durations 2 and 12 h of incubation were selected to identify the coregulated genes and pathways affected by MPV infection. Results: The use of the Gene Ontology framework, Kyoto Encyclopedia of Genes and Genome database, and MetaCore software yielded valuable insights. Specifically, various pathways were found to be enriched in HeLa cells infected with MPV for 2 and 12 h. These pathways included Notch, CD40, CD95, hypoxia-inducible factor-1-α, interleukin (IL)− 1, IL-6, phosphoinositide 3-kinase, nuclear factor-κB, mitogen-activated protein kinase, and oxidative stress–induced signalling pathways. Clusters and pathways of metabolism and viral replication cycles were significantly associated with the 2-hour infection group. This association was identified based on the regulation of genes such as HSPG2, RHPN2, MYL1, ASPHD2, CA9, VIPR1, SNX12, MGC2752, SLC25A1, PEX19, and AREG. Furthermore, clusters and pathways related to immunity and cell movement were found to be associated with the 12-hour infection group. This association was identified based on the regulation of genes such as C1orf21, C19orf48, HRK, IL8, GULP1, SCAND2, ATP5C1, FEZ1, SGSH, TACC2, CYP4X1, MMP1, CPB1, P2RY13, WDR27, PRPF4, and ENDOD1. Conclusions: This study can improve our understanding of the mechanisms underlying the pathophysiology and post-infection sequelae of mpox. Our findings provide valuable insights into the various modes of ...
    Schlagwörter Monkeypox (mpox) ; Viral replication ; Cellular metabolism ; Cell movement ; Immune response ; Bioinformatics ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 570
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
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  10. Artikel ; Online: Detection system of the lobster eye telescope with large field of view.

    Chen, Yifan / Sun, Xiaojin / Li, Zhengda / Wang, Chengbin / Zhang, Chen / Sun, Shengli

    Applied optics

    2022  Band 61, Heft 29, Seite(n) 8813–8818

    Abstract: The lobster eye telescope is promising for large-field x ray imaging in astronomy. The special structure of the lobster eye system makes the focal plane a sphere, resulting in detector defocus when the field is large. In this study, we established a ... ...

    Abstract The lobster eye telescope is promising for large-field x ray imaging in astronomy. The special structure of the lobster eye system makes the focal plane a sphere, resulting in detector defocus when the field is large. In this study, we established a model based on the principle of lobster eye imaging and simulated the imaging at different image distances. The results reveal the relationship between the defocus and position accuracy and angular resolution. To ensure the optical performance of the large field lobster eye telescope, we propose a detection system design method using multiple detectors stitched together to form a spherical-like surface and apply it to the development of the Einstein Probe/wide-field x ray telescope (EP/WXT) submodule. About 70% of the detection area is out of focus within 0.5 mm. The scanning image of the integrated WXT submodule shows good uniformity of the point spread function (PSF) for various incident angles, and the effect of defocus on imaging is acceptable.
    Mesh-Begriff(e) Animals ; Telescopes ; Nephropidae ; X-Rays ; Astronomy ; Vision, Ocular
    Sprache Englisch
    Erscheinungsdatum 2022-10-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1539-4522
    ISSN (online) 1539-4522
    DOI 10.1364/AO.469433
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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