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Artikel ; Online: The Medicinal Effects of Different Solvent Extracts of Pyracantha Coccinea Roem. Fruits

Neslihan Tekin KARACAER

Bezmiâlem Science, Vol 11, Iss 1, Pp 23-

Heavy Metal Content, Antioxidant, and Antimicrobial Properties

2023 Band 31

Abstract: Objective:The current investigation has been conducted to assess the total flavonoid content, total phenolic content, heavy metal composition, and antioxidant and antimicrobial activities of Pyracantha coccinea Roem. fruit extracts prepared with ... ...

Abstract	Objective:The current investigation has been conducted to assess the total flavonoid content, total phenolic content, heavy metal composition, and antioxidant and antimicrobial activities of Pyracantha coccinea Roem. fruit extracts prepared with different solvents.Methods:Ethanol, diethyl ether, and hot water extraction were used as solvents to prepare the extract of Pyracantha coccinea Roem. fruit. Total phenolic ingredient was assessed by Folin- Ciocalteu assay, and the total ingredient of flavonoids was measured spectrophotometrically via AlCl3 assay. The antioxidant activities of the extracts were investigated via free radical scavenging assays, DPPH, and ABTS. The fruits were analyzed by Inductively Coupled Plasma/Mass Spectrometer to determine heavy metal content. The antimicrobial activities of the extracts were investigated using agar well diffusion method against Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, and Candida albicans.Results:It was determined that the total flavonoid ingredient, total phenolic ingredient, ABTS and DPPH activities of the hot water extract were significantly higher than the other fractions. These parameters were found to be significantly higher in ethanol extract compared to ether extract. All extracts exhibited antimicrobial activity against Bacillus cereus and Pseudomonas aeruginosa while the hot water fraction exhibited the highest antibacterial effect against Pseudomonas aeruginosa. It was determined that Cr, Co, Ni, and Cu contents exceeded the toxicity thresholds that might be found in plants.Conclusion:These results suggest that Pyracantha coccinea Roem. fruit may be considered as a natural source of antioxidants and antimicrobial agents.
Schlagwörter	abts ; antimicrobial activity ; antioxidant activity ; dpph ; pyracantha coccinea roem ; Medicine (General) ; R5-920
Sprache	Englisch
Erscheinungsdatum	2023-01-01T00:00:00Z
Verlag	Galenos Publishing House
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel ; Online: In vitro AND in silico EVALUATION OF THYMOQUINONE AS POTENTIAL ANTICANCER AGENT IN HUMAN ACUTE MYELOID LEUKEMIA HL-60 CELLS

Neslihan Tekin Karacaer

Trakya University Journal of Natural Sciences, Vol 23, Iss 1, Pp 53-

2022 Band 63

Abstract: This study aims to explore the cytotoxic, apoptotic and autophagic effects of thymoquinone on human acute myeloid leukemia. The cytotoxic effects of thymoquinone were determined with 3-(4, 5-dimethylthiazol-2-yl)-2 and 5-diphenyltetrazolium bromide (MTT) ...

Abstract	This study aims to explore the cytotoxic, apoptotic and autophagic effects of thymoquinone on human acute myeloid leukemia. The cytotoxic effects of thymoquinone were determined with 3-(4, 5-dimethylthiazol-2-yl)-2 and 5-diphenyltetrazolium bromide (MTT) tests. B-cell lymphoma 2 associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), caspase 3, mammalian target of rapamycin (mTOR), phosphatidylinositol-3-kinase (PI3K), and protein kinase B (AKT) gene expression analyzes were studied with quantitative real-time polymerase chain reaction (qRT-PCR). AutoDock Tools 4.2 software was applied to research the potential binding of thymoquinone in the active sites of Bax, Bcl-2, caspase 3, mTOR, PI3K, and AKT proteins. Thymoquinone caused a cytotoxic effect on HL-60 cells (Human leukemia cell line) with a value of 16.35 µM. Bcl-2 expression was decreased in all concentrations applied compared to the control. A decrease in caspase 3 expression level was detected in the cells treated with 10 µM, 15 µM, and 25 µM thymoquinone compared to the control. Thymoquinone induced an important decrease in mTOR and PI3K expressions compared to the control at all doses, while AKT decreased at a dose of 15 µM. The docking outcomes showed that thymoquinone interacts with the active site amino acids of apoptotic and autophagic proteins via hydrophobic interactions and hydrogen bonding. The present findings suggest that thymoquinone can stimulate autophagy by prevention of PI3K/AKT/mTOR pathway in HL-60 cells and may become a new target for the therapy of acute myeloid leukemia.
Schlagwörter	aml ; apoptosis ; autophagy ; molecular docking ; pi3k/akt/mtor ; thymoquinone ; Science (General) ; Q1-390
Thema/Rubrik (Code)	500
Sprache	Englisch
Erscheinungsdatum	2022-04-01T00:00:00Z
Verlag	Trakya University
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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Artikel: The Effects of Job Stress on Burnout and Turnover Intention: The Moderating Effects of Job Security and Financial Dependency.

Üngüren, Engin / Onur, Neslihan / Demirel, Hüsne / Tekin, Ömer Akgün

Behavioral sciences (Basel, Switzerland)

2024 Band 14, Heft 4

Abstract: 1) Background: The hospitality industry is known for exposing employees to work stress, which can lead to work-related burnout and high turnover rates. This study aims to examine the relationships between work stress, work-related burnout, and turnover ... ...

Abstract	(1) Background: The hospitality industry is known for exposing employees to work stress, which can lead to work-related burnout and high turnover rates. This study aims to examine the relationships between work stress, work-related burnout, and turnover intention. It also explores the mediating role of work-related burnout and the moderating role of job security and financial dependence. (2) Methods: A cross-sectional survey was conducted among 494 hotel employees working in five-star hotels in Belek and Manavgat, Türkiye, using a moderated mediation research model. The study found that work stress increases work-related burnout, which in turn increases turnover intention. Additionally, work-related burnout was found to mediate the relationship between work stress and turnover intention. Furthermore, it was found that perceived job security moderates the relationship between work stress levels and work-related burnout. Additionally, the variable of financial dependence was found to moderate the relationship between employees' levels of work-related burnout and their turnover intentions. Similarly, the study found that the financial dependence variable moderates the effect of work-related burnout on employees' turnover intention. Additionally, the study found that employees' perception of job security moderates the impact of work stress on work-related burnout. In conclusion, the study suggests that positive perceptions of job security can mitigate the impact of work stress on work-related burnout. Similarly, the impact of work-related burnout on turnover intention diminishes as the degree of financial dependence rises.
Sprache	Englisch
Erscheinungsdatum	2024-04-12
Erscheinungsland	Switzerland
Dokumenttyp	Journal Article
ZDB-ID	2651997-5
ISSN	2076-328X
ISSN	2076-328X
DOI	10.3390/bs14040322
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Evaluation of the Effect of Breast Milk Storage Conditions on the Viability of Cells in Breast Milk: A Pilot Study.

Surmeli Onay, Ozge / Tutal, Merve / Altug, Burcugul / Aydemir, Ozge / Barsan Kaya, Tugba / Eker Sarıboyacı, Ayla / Tekin, Ayse Neslihan

Indian journal of pediatrics

2024

Sprache	Englisch
Erscheinungsdatum	2024-05-02
Erscheinungsland	India
Dokumenttyp	Letter
ZDB-ID	218231-2
ISSN	0973-7693 ; 0019-5456
ISSN (online)	0973-7693
ISSN	0019-5456
DOI	10.1007/s12098-024-05143-9
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: A Tragic Consequence of Respiratory Syncytial Virus Infection.

Barsan Kaya, Tuğba / Öztunalı, Çiğdem / Aydemir, Özge / Sürmeli Onay, Özge / Tekin, Ayşe Neslihan

Clinical pediatrics

2023 Band 63, Heft 2, Seite(n) 171–175

Mesh-Begriff(e)	Humans ; Infant ; Respiratory Syncytial Virus Infections/complications ; Respiratory Syncytial Virus Infections/diagnosis
Sprache	Englisch
Erscheinungsdatum	2023-10-07
Erscheinungsland	United States
Dokumenttyp	Case Reports ; Journal Article
ZDB-ID	207678-0
ISSN	1938-2707 ; 0009-9228
ISSN (online)	1938-2707
ISSN	0009-9228
DOI	10.1177/00099228231204445
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel: Association Between Pandemic-Related Maternal Perinatal Anxiety and Early Postpartum Breastfeeding Success.

Bezirganoğlu Altuntaş, Neslihan / Baki Yıldırım, Sema / Güvey, Huri / Bayoglu Tekin, Yesim

Cureus

2024 Band 16, Heft 4, Seite(n) e57590

Abstract: Background and objectives: Prior studies have shown conflicting results on the impact of maternal anxiety on breastfeeding initiation and success. Furthermore, a substantial increase in maternal anxiety levels was shown in response to the COVID-19 ... ...

Abstract	Background and objectives: Prior studies have shown conflicting results on the impact of maternal anxiety on breastfeeding initiation and success. Furthermore, a substantial increase in maternal anxiety levels was shown in response to the COVID-19 pandemic. In this study, we aimed to investigate the relationship between maternal perinatal anxiety induced by the COVID-19 pandemic and early breastfeeding outcomes. Materials and methods: This cross-sectional study was conducted in two regional maternity hospitals, involving 220 first-time pregnant patients with a gestational age of ≥37 weeks. All patients had no current diagnosis of COVID-19 and no cases of COVID-19 in their close environment at the time of admission. At 24-48 hours postpartum or at the time of discharge, three following scoring systems were employed: the Coronavirus Anxiety Scale (CAS), the State-Trait Anxiety Inventory (STAI), and the LATCH (short for latch, audible swallowing, type of nipple, comfort, and hold) score. A LATCH score of ≥8 was chosen as the cutoff point for defining successful breastfeeding performance. Spearman's rank correlation was used to evaluate relationships between the CAS, STAI scores, maternal and infant factors, and LATCH scores. Results: There were no differences in baseline characteristics between groups categorized as successful and unsuccessful in breastfeeding initiation. The mean total STAI score was 86.3±13.2, the CAS score was 1.07±1.91, and the LATCH score was 8.42±1.7. Although there was an increase in State-Trait Anxiety Inventory-State Anxiety (STAI-S) scores compared to State-Trait Anxiety Inventory-Trait Anxiety (STAI-T) scores, and the STAI-S score and CAS score were higher in the unsuccessful group, these differences did not reach statistical significance (p = 0.22 and 0.16, respectively). When we evaluated the correlation of the LATCH score with STAI total, STAI-S and STAI-T scores, CAS score, and maternal and infant factors, only the type of delivery showed a significant correlation with the LATCH score (p = 0.008). Conclusions: Early postpartum breastfeeding efficiency, as measured by the LATCH score, was only correlated with the type of delivery. No significant correlation was found between pandemic-related maternal perinatal anxiety and early postpartum breastfeeding success.
Sprache	Englisch
Erscheinungsdatum	2024-04-04
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.57590
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Turkish validity and reliability of the lifestyle questionnaire related to cancer.

Öner, Neslihan / Borlu, Arda / Seyfeli, Mevlüde Yasemin Akşehirli / Tekin, Tuba

Revista da Associacao Medica Brasileira (1992)

2023 Band 69, Heft 2, Seite(n) 330–334

Abstract: Objective: The aim of this study was to adapt the lifestyle questionnaire related to cancer in Turkish and investigate its validity and reliability.: Methods: This methodological study was conducted on 1,196 participants. Cronbach's α was used to ... ...

Abstract	Objective: The aim of this study was to adapt the lifestyle questionnaire related to cancer in Turkish and investigate its validity and reliability. Methods: This methodological study was conducted on 1,196 participants. Cronbach's α was used to assess validity and reliability. The internal consistency was evaluated using item-total correlation. Results: The normed chi-square in this study was 5.87. The root mean square error of approximation was calculated as 0.051. The comparative fit index and the Tucker-Lewis Index were 0.83 and 0.81, respectively. The split-half method was used to test the reliability of the scale (Part 1 Cronbach's α: 0.826, Part 2 Cronbach's α: 0.812, and Adjusted Cronbach's α: 0.881). Conclusion: The Turkish version of lifestyle questionnaire related to cancer (8 subscales, 41 items) is a reliable and valid measure to evaluate lifestyle behaviors related to cancer in adults.
Mesh-Begriff(e)	Adult ; Humans ; Reproducibility of Results ; Psychometrics ; Life Style ; Surveys and Questionnaires ; Neoplasms
Sprache	Englisch
Erscheinungsdatum	2023-03-03
Erscheinungsland	Brazil
Dokumenttyp	Journal Article
ZDB-ID	731969-1
ISSN	1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
ISSN (online)	1806-9282
ISSN	0104-4230 ; 0004-5241 ; 0102-843X
DOI	10.1590/1806-9282.20221292
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Ten-year Single Center Experience With Colistin Therapy in NICU.

Kaya, Tuğba Barsan / Sürmeli Onay, Özge / Aydemir, Özge / Tekin, Ayşe Neslihan

The Pediatric infectious disease journal

2023

Abstract: Background: Colistin, a cationic polypeptide antibiotic of the polymyxin class has come back into use due to its potent antimicrobial activity against multidrug-resistant gram-negative bacteria and the lack of new antibiotics. The purpose of this study ... ...

Abstract	Background: Colistin, a cationic polypeptide antibiotic of the polymyxin class has come back into use due to its potent antimicrobial activity against multidrug-resistant gram-negative bacteria and the lack of new antibiotics. The purpose of this study was to assess the critically ill infants treated with colistin in our neonatal intensive care unit and to identify predisposing factors for the emergence of acute kidney injury (AKI) following colistin treatment. Methods: This was a retrospective case-control study that included infants with proven or suspected nosocomial infections in the neonatal intensive care unit of a University Hospital between January 2012 and March 2022. Over the same time period, the clinical and laboratory characteristics and outcomes of patients who received antibiotic combination with colistin were compared to patients who received antibiotic combination without colistin. Results: A total of 77 patients were in the colistin group (ColG) and 77 patients were in the control group. The demographic and clinical characteristics of the study groups were similar. In the ColG compared to the control group, hyponatremia, hypokalemia, hypophosphatemia, hypomagnesia and AKI were all more prevalent (P < 0.05). The most important finding in our study was the higher incidence of AKI and mortality in ColG, as well as the increasing nephrotoxic effect of other medications when used in conjunction with colistin. Conclusion: During colistin therapy, newborn infants must be closely monitored for AKI. Clinicians should be aware of an increased incidence of hyponatremia, hypokalemia, hypophosphatemia, hypomagnesia, AKI and its consequences in infants given colistin. As awareness increases, harmful effects will decrease.
Sprache	Englisch
Erscheinungsdatum	2023-10-05
Erscheinungsland	United States
Dokumenttyp	Journal Article
ZDB-ID	392481-6
ISSN	1532-0987 ; 0891-3668
ISSN (online)	1532-0987
ISSN	0891-3668
DOI	10.1097/INF.0000000000004130
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Assessment of foetal ventriculomegaly from prenatal to early postnatal period: a single-centre retrospective cohort study.

Sohret, Nurullah Cihan / Tekin, Ayse Neslihan / Surmeli Onay, Ozge / Suman, Kamuran / Aydemir, Ozge / Velipasaoglu, Melih

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

2022 , Seite(n) 1–8

Abstract: The aim of this study was to evaluate the early neonatal outcomes of cases with foetal ventriculomegaly (VM) and to investigate the aetiological and prognostic factors according to the degree of VM in a single tertiary referring centre. The medical ... ...

Abstract	The aim of this study was to evaluate the early neonatal outcomes of cases with foetal ventriculomegaly (VM) and to investigate the aetiological and prognostic factors according to the degree of VM in a single tertiary referring centre. The medical records of 87 foetuses diagnosed with VM (≥10 mm) within 6 years were evaluated. Postnatal evaluation and early neonatal prognosis were determined in 39 cases divided into two groups as mild (10-15 mm, 30 cases) and severe (>15 mm, 9 cases) according to the ventricular size. The mean gestational age at which foetal VM was detected was 22 + 3 weeks. In terms of severity, severe cases of VM were more frequent in terminated pregnancies. There was no difference in gestational age, birth weight, fifth minute Apgar scores, or cord blood gases between mild and severe cases at delivery. Isolated VM was detected in 63% of mild and 22% of severe cases. In severe cases, the need for intensive care and surgery was higher than in mild cases. Antenatal VM regressed in 50% of mild cases and 22% of severe cases. Increasing knowledge about neonatal prognosis, the factors involved in aetiology, and the degree of VM will guide the management of foetal VM.IMPACT STATEMENT
Sprache	Englisch
Erscheinungsdatum	2022-09-23
Erscheinungsland	England
Dokumenttyp	Journal Article
ZDB-ID	604639-3
ISSN	1364-6893 ; 0144-3615
ISSN (online)	1364-6893
ISSN	0144-3615
DOI	10.1080/01443615.2022.2125295
Datenquelle	MEDical Literature Analysis and Retrieval System OnLINE

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Artikel ; Online: Apoptotic Effect of Bortezomib on Pancreatic Islet Cells in STZ-induced Diabetic Rats

Çiğdem Ekin / Neslihan Tekin Karacaer / Mehtap Tarhan Karaoğlan / İbrahim Örün / Kamile Öztürk

Makara Journal of Health Research, Vol 26, Iss 3, Pp 197-

2022 Band 203

Abstract: Background: This study aimed to investigate the possible apoptotic role of bortezomib (BMZ) on pancreatic islets of streptozotocin (STZ)-induced diabetic rats. Methods: Sprague-Dawley rats were divided into groups that were administered BMZ alone or in ... ...

Abstract	Background: This study aimed to investigate the possible apoptotic role of bortezomib (BMZ) on pancreatic islets of streptozotocin (STZ)-induced diabetic rats. Methods: Sprague-Dawley rats were divided into groups that were administered BMZ alone or in combination with STZ. To evaluate the effect of BMZ on the development of diabetes, blood glucose levels were measured regularly in the animals. Islet cell viability was determined by staining the islets with fluorescein diacetate and propidium iodide. Expression of the Bcl-2 and bax genes was determined in islet cells by quantitative real-time polymerase chain reaction. Results: Administering STZ-induced hyperglycemia in the rats reduced the viability of islet cells and the bcl-2/bax ratio. In the group administered BMZ alone, the bcl-2/bax gene expression rate in islets increased significantly compared to the control group. BMZ co-administered with STZ significantly increased islet cell viability and the bcl-2/bax ratio compared to the diabetic group. Conclusions: This study demonstrates that BMZ may protect pancreatic islet cells from apoptosis by increasing islet viability and upregulating the bcl-2/bax gene expression ratio, even though it failed to protect against the destructive effect of STZ.
Schlagwörter	apoptosis ; bortezomib ; pancreatic islets ; rats ; type 1 diabetes ; Medicine ; R
Thema/Rubrik (Code)	610
Sprache	Englisch
Erscheinungsdatum	2022-12-01T00:00:00Z
Verlag	Universitas Indonesia
Dokumenttyp	Artikel ; Online
Datenquelle	BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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