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  1. Article ; Online: Prioritizing Maternal Mental Health in Addressing Morbidity and Mortality.

    Wisner, Katherine L / Murphy, Caitlin / Thomas, Megan M

    JAMA psychiatry

    2024  Volume 81, Issue 5, Page(s) 521–526

    Abstract: Importance: The rate of maternal mortality in the United States is 2-fold to 3-fold greater than that in other high-income countries. While many national initiatives have been developed to combat maternal mortality, these efforts often fail to include ... ...

    Abstract Importance: The rate of maternal mortality in the United States is 2-fold to 3-fold greater than that in other high-income countries. While many national initiatives have been developed to combat maternal mortality, these efforts often fail to include mental illness.
    Objective: To highlight the underrecognized contribution of mental illness to maternal mortality, which is nearly double that of postpartum hemorrhage.
    Evidence review: A topic outline was developed to include challenges in measuring perinatal mental conditions and mortality rates; contributions of social determinants of health to mental conditions and mortality; perinatal psychiatric disorder characterization; mechanisms by which maternal mental illness increases mortality, specifically, suicide and addictive disorders; access limitations and care "deserts"; prenatal stress and its impact on reproductive outcomes; increasing clinician expertise through cross-disciplinary education; intervention sites and models; and asserting that mental health is fundamental to maternal health. Publications in the last 3 years were prioritized, particularly those relating to policy. References were selected through consensus. Sources were PubMed, Ovid, direct data published on government websites, and health policy sources such as the Policy Center for Maternal Mental Health.
    Findings: Priority was given to recent sources. Citations from 2022-2023 numbered 26; within the last 5 years, 14; and historical references, 15. Recommendations to address each topic area serve as concluding statements for each section. To mitigate the contributions of mental illness to the maternal mortality risk, a coordinated effort is required across professional and governmental organizations.
    Conclusions and relevance: Concrete programmatic and policy changes are needed to reduce perinatal stress and address trauma, standardize the collection of social determinant of health data among perinatal patients, increase access to reproductive psychiatry curricula among prescribers, reduce perinatal mental health and obstetrical deserts, institute paid parental leave, and support seamless integration of perinatal and behavioral health care. Moreover, instead of focusing on a relatively minor portion of the contributors to health that current medical practice targets, fortifying the social foundation strengthens the prospects for the health of families for our current and future generations.
    MeSH term(s) Female ; Humans ; Pregnancy ; Health Priorities ; Maternal Health ; Maternal Mortality/trends ; Mental Disorders ; Mental Health ; Pregnancy Complications/mortality ; Social Determinants of Health ; United States/epidemiology
    Language English
    Publishing date 2024-02-21
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2023.5648
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Identifying rheological regimes within pyroclastic density currents.

    Jones, Thomas J / Shetty, Abhishek / Chalk, Caitlin / Dufek, Josef / Gonnermann, Helge M

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 4401

    Abstract: Pyroclastic density currents (PDCs) are the most lethal of all volcanic hazards. An ongoing challenge is to accurately forecast their run-out distance such that effective mitigation strategies can be implemented. Central to this goal is an understanding ... ...

    Abstract Pyroclastic density currents (PDCs) are the most lethal of all volcanic hazards. An ongoing challenge is to accurately forecast their run-out distance such that effective mitigation strategies can be implemented. Central to this goal is an understanding of the flow mobility-a quantitative rheological model detailing how the high temperature gas-pyroclast mixtures propagate. This is currently unknown, yet critical to accurately forecast the run-out distance. Here, we use a laboratory apparatus to perform rheological measurements on real gas-pyroclast mixtures at dynamic conditions found in concentrated to intermediate pumice-rich PDCs. We find their rheology to be non-Newtonian featuring (i) a yield stress where deposition occurs; (ii) shear-thinning behavior that promotes channel formation and local increases in velocity and (iii) shear-thickening behavior that promotes decoupling and potential co-PDC plume formation. We provide a universal regime diagram delineating these behaviors and illustrating how flow can transition between them during transport.
    Language English
    Publishing date 2024-05-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-48612-7
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  3. Article ; Online: Pharmacist-led review of empagliflozin and ertugliflozin following formulary update.

    Bateman, M Thomas / Nguyen, Ryan / Navathe, Ashwini B / McCarthy, Caitlin

    The American journal of managed care

    2023  Volume 29, Issue 8, Page(s) 424–428

    Abstract: Objectives: To evaluate the appropriateness of the medication management for anyone who might have been affected by the Horizon New Jersey Health Medicaid Health Maintenance Organization (HNJH Medicaid HMO) formulary update from empagliflozin to ... ...

    Abstract Objectives: To evaluate the appropriateness of the medication management for anyone who might have been affected by the Horizon New Jersey Health Medicaid Health Maintenance Organization (HNJH Medicaid HMO) formulary update from empagliflozin to ertugliflozin and to then optimize drug selection and monitoring.
    Study design: This is a single-center, 2-phase, pilot project led by 2 pharmacy students and the lead clinical pharmacist at a federally qualified health center in Trenton, New Jersey.
    Methods: The primary outcome of the study is the number and percentage of patients whose prescription was changed inappropriately from empagliflozin to ertugliflozin. Secondary outcomes include the number and percentage of patients whose prescription was changed inappropriately because of failure to consider cardiovascular history and/or missed renal function checks and whether pharmacists were able to optimize therapy. Data were generated from electronic health record reports and analyzed in Microsoft Excel.
    Results: A total of 126 unique patients were identified as receiving empagliflozin and/or ertugliflozin and 16 patients were switched from empagliflozin to ertugliflozin, all of whom had HNJH Medicaid HMO. Thirteen of the 16 (81.3%) patients were managed inappropriately based on their history of cardiovascular disease or inappropriate renal monitoring. Pharmacists recommended 22 interventions for patients who received empagliflozin and/or ertugliflozin, and all recommendations were accepted by providers.
    Conclusions: Following the HNJH Medicaid HMO's coverage update from empagliflozin to ertugliflozin, some patients received inappropriate therapy and providers accepted clinical pharmacists' recommendations to optimize therapy.
    MeSH term(s) United States ; Humans ; Pharmacists ; Pilot Projects ; Bridged Bicyclo Compounds, Heterocyclic
    Chemical Substances ertugliflozin (6C282481IP) ; empagliflozin (HDC1R2M35U) ; Bridged Bicyclo Compounds, Heterocyclic
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2035781-3
    ISSN 1936-2692 ; 1088-0224 ; 1096-1860
    ISSN (online) 1936-2692
    ISSN 1088-0224 ; 1096-1860
    DOI 10.37765/ajmc.2023.89408
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Collegiate student-athletes concussion knowledge and attitudes: what a difference a decade Makes.

    Buckley, Thomas A / Passalugo, Scott W / Gallo, Caitlin A / Bodt, Barry / Evans, Kelsey M / Munkasy, Barry A

    Brain injury

    2024  Volume 38, Issue 4, Page(s) 288–294

    Abstract: Objective: The purpose of this study was to assess changes in concussion knowledge and attitudes amongst incoming intercollegiate student-athletes over the course of a decade (2010-2012 vs 2021-2023).: Methods: There were 592 student-athletes from 2 ... ...

    Abstract Objective: The purpose of this study was to assess changes in concussion knowledge and attitudes amongst incoming intercollegiate student-athletes over the course of a decade (2010-2012 vs 2021-2023).
    Methods: There were 592 student-athletes from 2 cohorts (2010-2012, 2021-2023) who completed the Rosenbaum Concussion Knowledge and Attitudes Survey (ROCKaS) questionnaire which is comprised of a concussion knowledge index (CKI, 0-24) and attitude index (CAI, 15-75) with higher scores reflecting better performance. A three factor ANOVA (Group, Sex, Concussion History) compared performance on the CKI and CAI. Individual questions were compared between groups with a Chi-Square analysis.
    Results: For the CKI, there was a significant main effect for Group (2010-2012: 18.5 ± 2.6, 2021-2023: 19.4 ± 2.5,
    Conclusions: The results of this study show a modest increase in concussion knowledge; however, large improvements in concussion attitudes were observed between groups. These results suggest a continued improvement in student-athlete concussion awareness and provide specific areas to continue addressing persistent misconceptions.
    MeSH term(s) Humans ; Athletic Injuries ; Brain Concussion/diagnosis ; Surveys and Questionnaires ; Athletes ; Students ; Health Knowledge, Attitudes, Practice
    Language English
    Publishing date 2024-02-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639115-1
    ISSN 1362-301X ; 0269-9052
    ISSN (online) 1362-301X
    ISSN 0269-9052
    DOI 10.1080/02699052.2024.2314549
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Post hoc depression analysis from a pharmacist-led diabetes trial.

    Bateman, M Thomas / McCarthy, Caitlin / Prioli, Katherine M / Wagner, Mary L

    The mental health clinician

    2023  Volume 13, Issue 1, Page(s) 18–24

    Abstract: Introduction: Diabetes and depression may present concurrently, and clinical pharmacists are well equipped to manage these conditions. Clinical pharmacists were grant funded to implement a diabetes-focused randomized controlled trial in a Federally ... ...

    Abstract Introduction: Diabetes and depression may present concurrently, and clinical pharmacists are well equipped to manage these conditions. Clinical pharmacists were grant funded to implement a diabetes-focused randomized controlled trial in a Federally Qualified Health Center. The objective of this analysis is to evaluate if glycemic control and depressive symptoms improve for patients with diabetes and depression with additional management from clinical pharmacists compared with those receiving the standard of care.
    Methods: This is a post hoc subgroup analysis of a diabetes-focused randomized controlled trial. Pharmacists enrolled patients with type 2 diabetes mellitus (T2DM) and a glycated hemoglobin (A1C) greater than 8% and randomly assigned them to 1 of 2 cohorts, one managed by the primary care provider alone and one with additional care from the pharmacist. Pharmacists completed encounters with patients who have T2DM with or without depression to comprehensively optimize pharmacotherapy while tracking glycemic and depressive outcomes throughout the study.
    Results: A1C improved from baseline to 6 months in patients with depressive symptoms who received additional care from pharmacists by -2.4 percentage points (SD, 2.41) compared with a -0.1 percentage point (SD, 1.78) reduction in the control arm (
    Discussion: Patients with T2DM and depressive symptoms experienced better diabetes outcomes with additional pharmacist management compared with a similar cohort of patients with depressive symptoms, managed independently by primary care providers. These patients with diabetes and comorbid depression received a higher level of engagement and care from the pharmacists, which led to more therapeutic interventions.
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Journal Article
    ISSN 2168-9709
    ISSN (online) 2168-9709
    DOI 10.9740/mhc.2023.02.018
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  6. Article ; Online: Adolescents' adherence to Centers for Disease Control and Prevention guidelines during the COVID-19 pandemic.

    Clough, Isabelle M / Drozdova, Anna D / Cavanagh, Caitlin / Gile Thomas, April

    Child: care, health and development

    2022  Volume 48, Issue 6, Page(s) 1052–1061

    Abstract: Background: The outbreak of the coronavirus (COVID-19) pandemic in the United States resulted in safety guidelines from the Centers for Disease Control and Prevention (CDC) intended to curb the spread of the virus. Adolescents are potentially at risk ... ...

    Abstract Background: The outbreak of the coronavirus (COVID-19) pandemic in the United States resulted in safety guidelines from the Centers for Disease Control and Prevention (CDC) intended to curb the spread of the virus. Adolescents are potentially at risk for disregarding these guidelines due to their reduced psychosocial maturity compared with adults. The current study examined the relationship between adolescents' psychosocial maturity, perceived importance of the CDC guidelines and adherence to the CDC guidelines within some of the highest risk groups for contracting COVID-19 in a county particularly impacted by the pandemic (i.e., Hispanic and low-SES youth in El Paso, Texas).
    Methods: Participants completed a phone interview with a research assistant regarding their thoughts and behaviours in the initial months of the COVID-19 pandemic. Adolescents (N = 68) were 15.38 years old on average (SD = 1.05, range = 13, 17), predominantly male (60.3%) and nearly exclusively Hispanic/Latino (94.1%).
    Results: Results indicated that although more psychosocially mature adolescents reported greater adherence to the CDC guidelines than less psychosocially mature adolescents, the association between psychosocial maturity and adherence was fully mediated by how important adolescents felt it was to follow the guidelines. Specifically, greater perceived importance was associated with greater adherence to the guidelines.
    Conclusions: The current study found that more psychosocially mature adolescents adhere to CDC's safety guidelines better than less psychosocially mature adolescents because they are more likely to view the guidelines as important. Information that attempts to increase adolescent adherence to the guidelines should therefore emphasize not only that following the guidelines is important, but why following the guidelines is so important. Less psychosocially mature adolescents may benefit most from interventions efforts and targeted messages regarding the importance of following the CDC's guidelines, as more psychosocially mature adolescents already recognize this importance.
    MeSH term(s) Adolescent ; Adult ; COVID-19/epidemiology ; COVID-19/prevention & control ; Centers for Disease Control and Prevention, U.S. ; Female ; Humans ; Male ; Pandemics/prevention & control ; United States/epidemiology
    Language English
    Publishing date 2022-04-21
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 223039-2
    ISSN 1365-2214 ; 0305-1862
    ISSN (online) 1365-2214
    ISSN 0305-1862
    DOI 10.1111/cch.13012
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  7. Article ; Online: Standardization of Videorecorded Speech Samples for Children with Cleft Palate: Methods to Facilitate High-Quality Speech Outcomes Data Collection.

    Baylis, Adriane L / Cummings, Caitlin E / Lien, Kari M / Sitzman, Thomas J / Kirschner, Richard E / Chapman, Kathy L

    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association

    2023  , Page(s) 10556656231217645

    Abstract: Background: Collection of high-quality videorecorded speech samples is essential for speech outcomes research.: Solution: Cleft palate team SLPs were trained to collect standard videorecorded speech samples in the clinic setting across 20 sites in ... ...

    Abstract Background: Collection of high-quality videorecorded speech samples is essential for speech outcomes research.
    Solution: Cleft palate team SLPs were trained to collect standard videorecorded speech samples in the clinic setting across 20 sites in North America. Standard training and equipment was provided.
    What we did that is new: Quality management procedures were developed and utilized to verify video quality and protocol adherence. Over 97% of speech samples collected by trained SLPs met defined quality standards.
    Language English
    Publishing date 2023-11-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1069409-2
    ISSN 1545-1569 ; 0009-8701 ; 1055-6656
    ISSN (online) 1545-1569
    ISSN 0009-8701 ; 1055-6656
    DOI 10.1177/10556656231217645
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  8. Article ; Online: Self-Reported Mental Health Measures of Incoming Collegiate Student-Athletes With a History of COVID-19.

    Anderson, Melissa N / Gallo, Caitlin A / Passalugo, Scott W / Nimeh, Jake M / Buckley, Thomas A

    Journal of athletic training

    2023  Volume 58, Issue 10, Page(s) 895–901

    Abstract: Background: People with a history of COVID-19 may experience persistent neuropsychological disruptions such as lower satisfaction with life, depression, and anxiety. Although student-athletes are at low risk for severe COVID-19 complications, the effect ...

    Abstract Background: People with a history of COVID-19 may experience persistent neuropsychological disruptions such as lower satisfaction with life, depression, and anxiety. Although student-athletes are at low risk for severe COVID-19 complications, the effect of COVID-19 on mental health has not been elucidated.
    Objective: To compare patient-reported mental health outcomes for incoming collegiate athletes with (COVID+) or without (COVID-) a history of COVID-19.
    Design: Case-control study.
    Setting: Laboratory.
    Patients or other participants: A total of 178 student-athletes, consisting of 79 in the COVID+ group (44.3%; age = 18.90 ± 0.16 years) and 99 in the COVID- group (55.6%; age = 18.95 ± 0.16 years).
    Main outcome measure(s): Participants completed the Satisfaction With Life Scale (SWLS), the Hospital Anxiety and Depression Scale (HADS), and the State-Trait Anxiety Inventory (STAI). Unadjusted 1-way analyses of variance were conducted across all patient-reported outcomes. Analyses of covariance were calculated to determine the interaction of COVID-19 group, sex, and race and ethnicity on outcomes. Post hoc Bonferroni testing was performed to identify specific differences between groups. A χ2 analysis was computed to compare the number of athletes in each group who met the standard clinical cut points.
    Results: We observed a between-groups difference for HADS depression (P = .047), whereby athletes in the COVID+ group had higher ratings (2.86 ± 0.26). We found group differences for the SWLS (P = .02), HADS anxiety (P = .003), and STAI state anxiety (P = .01) such that all scores were higher for the COVID+ group in the adjusted model. Post hoc testing revealed that female student-athletes in the COVID+ group had worse HADS anxiety (P = .01) and STAI trait anxiety (P = .002) scores than individuals in all other groups. We did not demonstrate differences between groups in the percentage of responses below established diagnostic thresholds.
    Conclusions: Incoming collegiate student-athletes who reported a previous COVID-19 diagnosis displayed higher depression scores, suggesting that clinicians may need to provide appropriate identification and referral for mental health conditions. However, we were encouraged that most participants, regardless of a history of COVID-19 diagnosis, had mental health scores that did not exceed established diagnostic threshold values.
    MeSH term(s) Humans ; Female ; Adolescent ; Young Adult ; Adult ; Athletic Injuries/diagnosis ; Self Report ; Mental Health ; COVID-19 Testing ; Case-Control Studies ; COVID-19/epidemiology ; Athletes/psychology ; Students/psychology
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2070051-9
    ISSN 1938-162X ; 1062-6050
    ISSN (online) 1938-162X
    ISSN 1062-6050
    DOI 10.4085/1062-6050-0554.22
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  9. Article ; Online: Clinical factors associated with ultrashort length of stay in patients undergoing lower extremity bypass for peripheral arterial disease.

    Radomski, Shannon N / Sorber, Rebecca / Canner, Joseph K / Holscher, Courtenay M / Weaver, M Libby / Hicks, Caitlin W / Reifsnyder, Thomas

    Journal of vascular surgery

    2024  

    Abstract: Introduction: Length of stay (LOS) is a major driver of cost and resource utilization following lower extremity bypass (LEB). However, the variable comorbidity burden and mobility status of LEB patients makes implementing enhanced recovery after surgery ...

    Abstract Introduction: Length of stay (LOS) is a major driver of cost and resource utilization following lower extremity bypass (LEB). However, the variable comorbidity burden and mobility status of LEB patients makes implementing enhanced recovery after surgery (ERAS) pathways challenging. The aim of this study was to utilize a large national database to identify patient factors associated with ultrashort LOS among patients undergoing LEB for peripheral artery disease (PAD).
    Methods: All patients undergoing LEB for PAD in the National Surgical Quality Improvement Project database from 2011-2018 were included. Patients were divided into two groups based on the length of postoperative stay: ultrashort (<=2 days) and standard (>2 days). Thirty-day outcomes were compared using descriptive statistics, and multivariable logistic regression was used to identify patient factors associated with ultrashort LOS.
    Results: Overall, 17,510 patients were identified who underwent LEB, of which 2,678 (15.3%) patients had an ultrashort postoperative LOS (mean 1.8 days) and 14,832 (84.7%) patients had a standard LOS (mean 7.1 days). When compared to patients with standard LOS, patients with an ultrashort LOS were more likely to be admitted from home (95.9% vs 88.0%, p<0.001), undergo elective surgery (86.1% vs. 59.1%, p<0.001) and to be active smokers (52.1% vs. 40.4%, p<0.001). Ultrashort LOS patients were also more likely to have claudication as the indication for LEB (53.1% vs. 22.5%, p<0.001), have a popliteal revascularization target rather than a tibial/pedal target (76.7% vs 55.3%, p<0.001) and had a prosthetic conduit (40.0% vs. 29.9%, p<0.001). There was no significant difference in mortality between the two groups (1.4% vs 1.8%, p=0.21); however ultrashort LOS patients had a lower frequency of unplanned readmission (10.7% vs. 18.8%, p<0.001) and need for major reintervention (1.9% vs. 5.6%, p<0.001). On multivariable analysis, elective status (OR:2.66, 95%CI:2.33-3.04), active smoking (OR:1.18, 95%CI:1.07-1.30) and lack of vein harvest (OR:1.55, 95%CI:1.41-1.70) were associated with ultrashort LOS. Presence of rest pain (OR:0.57, 95%CI:0.51-0.63), tissue loss (OR:0.30, 95%CI:0.27-0.34) and totally dependent functional status (OR:0.54, 95%CI:0.35-0.84) were negatively associated with ultrashort LOS. When examining the subgroup of patients who underwent vein harvest, totally dependent (OR:0.38 95%CI:0.19-0.75) and partially dependent (OR:0.53, 95%CI:0.32-0.88) functional status were persistently negatively associated with ultrashort LOS.
    Conclusions: Ultrashort LOS (<= 2 days) following LEB is uncommon but feasible in select patients. Preoperative functional status and mobility are important factors to consider when identifying LEB patients who may be candidates for early discharge.
    Language English
    Publishing date 2024-05-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605700-7
    ISSN 1097-6809 ; 0741-5214
    ISSN (online) 1097-6809
    ISSN 0741-5214
    DOI 10.1016/j.jvs.2024.04.073
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  10. Article ; Online: Guideline for the management of

    Patel, Priya / Robinson, Paula D / Fisher, Brian T / Phillips, Robert / Morgan, Jessica E / Lehrnbecher, Thomas / Kuczynski, Susan / Koenig, Christa / Haeusler, Gabrielle M / Esbenshade, Adam / Elgarten, Caitlin / Duong, Nathan / Diorio, Caroline / Castagnola, Elio / Beauchemin, Melissa P / Ammann, Roland A / Dupuis, L Lee / Sung, Lillian

    EClinicalMedicine

    2024  Volume 72, Page(s) 102604

    Abstract: Our objective was to update a clinical practice guideline for the prevention and treatment ... ...

    Abstract Our objective was to update a clinical practice guideline for the prevention and treatment of
    Language English
    Publishing date 2024-04-20
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2024.102604
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