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  1. Artikel ; Online: Inferring the history of surname Ye based on Y chromosome high-resolution genotyping and sequencing data.

    Zeng, Zhen / Tian, Jiaoyang / Jiang, Chuangui / Ye, Weijian / Liu, Kaijun / Li, Yuchun

    Journal of human genetics

    2019  Band 64, Heft 8, Seite(n) 703–709

    Abstract: ... samples with surname Ye () in China were collected to unravel the history of this surname ... Ye. High-throughput sequencing of 131 unrelated male individuals covering all sub-haplogroups in O ... F492 was conducted to update the phylogeny of O-F492. Most of the Ye individuals (43/64, 67.19%) are ...

    Abstract Paternal inheritance of both Y chromosome and surnames makes it possible to trace the origin and migration histories of surnames based on high-resolution Y chromosome phylogeny. In this study, 292 male samples with surname Ye () in China were collected to unravel the history of this surname. Among these samples, O-F492 showed the highest frequency (26.71%). Analysis based on Y chromosome genotyping data of 52,798 males from virtually the whole China revealed a close correlation between O-F492 and surname Ye. High-throughput sequencing of 131 unrelated male individuals covering all sub-haplogroups in O-F492 was conducted to update the phylogeny of O-F492. Most of the Ye individuals (43/64, 67.19%) are embedded in three major branches, i.e., O-MF1461, O-MF15219, and O-FGC66159, deriving from the same node (O-FGC66168). These three clades restrictively distributed in different regions, likely attributed to independent differentiations. Coalescent ages of the three subclades are estimated ranging from 1,925 to 1,775 years ago, probably driven by the massive migration from north to south China after Yongjia riot in Jin Dynasty, consistent with the migration history of surname Ye. Our study thus shed important light on the history of the surname Ye from genetic perspective.
    Mesh-Begriff(e) China ; Chromosomes, Human, Y ; Genetic Markers ; Genetics, Population ; Genotype ; Haplotypes ; High-Throughput Nucleotide Sequencing ; Humans ; Male ; Paternal Inheritance ; Pedigree ; Phylogeny ; Phylogeography ; Polymorphism, Single Nucleotide
    Chemische Substanzen Genetic Markers
    Sprache Englisch
    Erscheinungsdatum 2019-05-15
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1425192-9
    ISSN 1435-232X ; 1434-5161
    ISSN (online) 1435-232X
    ISSN 1434-5161
    DOI 10.1038/s10038-019-0616-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Jie Du Tong Ye San Prevents N-Nitrosomethylbenzylamine-Induced Esophageal Carcinogenesis via Inhibition of Inflammation and Proliferation.

    Zhao, Simin / Jiang, Yanan / Tian, Tongde / Zhao, Jimin / Xie, Yifei / Chen, Xinhuan / Lu, Jing / Yang, Feng / Li, Honglin / Liu, Kangdong / Dong, Ziming

    Evidence-based complementary and alternative medicine : eCAM

    2019  Band 2019, Seite(n) 5752670

    Abstract: Jie du tong ye san (JDTYS), a traditional Chinese herbal formula, has been used for cancer adjuvant ...

    Abstract Jie du tong ye san (JDTYS), a traditional Chinese herbal formula, has been used for cancer adjuvant therapy in clinical use and has been shown to be effective in cancer patients. However, the mechanism of JDTYS is still unclear. Therefore, the aim of the present study is to investigate the chemopreventive effects of JDTYS for esophageal squamous cell carcinoma (ESCC) and to clarify the potential mechanism. N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal carcinogenesis was used to evaluate the effect of JDTYS
    Sprache Englisch
    Erscheinungsdatum 2019-05-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2019/5752670
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Jie Du Tong Ye San Prevents N-Nitrosomethylbenzylamine-Induced Esophageal Carcinogenesis via Inhibition of Inflammation and Proliferation

    Simin Zhao / Yanan Jiang / Tongde Tian / Jimin Zhao / Yifei Xie / Xinhuan Chen / Jing Lu / Feng Yang / Honglin Li / Kangdong Liu / Ziming Dong

    Evidence-Based Complementary and Alternative Medicine, Vol

    2019  Band 2019

    Abstract: Jie du tong ye san (JDTYS), a traditional Chinese herbal formula, has been used for cancer adjuvant ...

    Abstract Jie du tong ye san (JDTYS), a traditional Chinese herbal formula, has been used for cancer adjuvant therapy in clinical use and has been shown to be effective in cancer patients. However, the mechanism of JDTYS is still unclear. Therefore, the aim of the present study is to investigate the chemopreventive effects of JDTYS for esophageal squamous cell carcinoma (ESCC) and to clarify the potential mechanism. N-nitrosomethylbenzylamine (NMBA)-induced rat esophageal carcinogenesis was used to evaluate the effect of JDTYS in vivo. Rats were treated with NMBA 3 times per week, for a total of 5 weeks. Rats in the treated groups were given JDTYS for 35 weeks. When rats were euthanized, esophageal tissue and blood were collected to evaluate the effects of JDTYS. The pathological grading of the rat esophageal preneoplastic lesions was classified and statistically analyzed. The protein levels of c-Jun and Ki67 were determined by immunohistochemistry. In addition, inflammation markers nuclear factor kappa B (NF-κB), cyclooxygenase-2 (COX-2), and the cluster of differentiation molecule 11B (CD11B) were also determined by immunohistochemistry. Moreover, the expression of COX-2 and Pentraxin 3 (PTX3) in rat serum was determined by enzyme-linked immunosorbent assay (ELISA). JDTYS could inhibit the formation of NMBA-induced esophageal preneoplastic lesions. JDTYS could downregulate the expression of proliferation related proteins Ki67 and c-Jun. Moreover, inflammation related proteins NF-κB, COX-2, and CD11B were inhibited and PTX3 was increased by JDTYS. In all, JDTYS is a promising chemopreventive formula against esophageal carcinogenesis by regulating inflammation and inhibiting cell proliferation.
    Schlagwörter Other systems of medicine ; RZ201-999
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2019-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Screening and identification of potential hypoglycemic components in Zeng Ye Tang by high-performance liquid chromatography coupled with tandem quadrupole time-of-flight mass spectrometry.

    Tian, Yu Shan / Du, Zhong Ying / Xiao, Ying / Yu, BoYang / Qi, Jin

    Journal of separation science

    2017  Band 40, Heft 24, Seite(n) 4709–4717

    Abstract: Zeng Ye Tang, a famous prescription consisting of Xuanshen, Maidong, and Shengdi (5:4:4), has been ... Although many studies have investigated the pharmacological effects of Zeng Ye Tang, the compounds responsible ... for its hypoglycemic effect have not been identified. In this study, 50 compounds in Zeng Ye Tang were identified by high ...

    Abstract Zeng Ye Tang, a famous prescription consisting of Xuanshen, Maidong, and Shengdi (5:4:4), has been used in China for a long time to treat diabetes caused by excessive heat with yin deficiency. Although many studies have investigated the pharmacological effects of Zeng Ye Tang, the compounds responsible for its hypoglycemic effect have not been identified. In this study, 50 compounds in Zeng Ye Tang were identified by high-performance liquid chromatography coupled with tandem quadrupole time-of-flight mass spectrometry. From these 50 compounds, nine cell-interacted compounds were identified by biospecific cell extraction using 3T3-L1 adipocytes. Moreover, nine potential active compounds that could be released into the blood were also acquired through serum pharmacochemical analysis in normal and diabetic rats after administration with Zeng Ye Tang. According to the established quantitative analytical method of nine constituents by high-performance liquid chromatography, six shared prototype constituents (catalpol/harpagide/p-coumaric acid/harpagoside/angoroside C/cinnamic acid (75.56:19.74:1.00:15.11:20.36:7.65), were screened and verified to exert remarkable hypoglycemic activity on type 2 diabetic mice. In conclusion, the six shared constituents may be responsible for the hypoglycemic activity of Zeng Ye Tang.
    Mesh-Begriff(e) Animals ; Chromatography, High Pressure Liquid ; Diabetes Mellitus, Experimental/blood ; Drugs, Chinese Herbal/chemistry ; Hypoglycemic Agents/blood ; Hypoglycemic Agents/isolation & purification ; Mice ; Rats ; Tandem Mass Spectrometry
    Chemische Substanzen Drugs, Chinese Herbal ; Hypoglycemic Agents
    Sprache Englisch
    Erscheinungsdatum 2017-12
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2047990-6
    ISSN 1615-9314 ; 1615-9306
    ISSN (online) 1615-9314
    ISSN 1615-9306
    DOI 10.1002/jssc.201700507
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Buch ; Online ; E-Book: Noncoding RNAs and bone

    Qian, Airong / Tian, Ye

    2021  

    Verfasserangabe Airong Qian, Ye Tian, editors
    Schlagwörter Bones/Diseases/Genetic aspects ; Non-coding RNA. ; RNA ; Teixit ossi
    Thema/Rubrik (Code) 616.71042
    Sprache Englisch
    Umfang 1 online resource (186 pages)
    Verlag Springer
    Erscheinungsort Singapore
    Dokumenttyp Buch ; Online ; E-Book
    Bemerkung Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 981-16-2402-X ; 981-16-2401-1 ; 978-981-16-2402-5 ; 978-981-16-2401-8
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  6. Artikel: Screening and identification of potential hypoglycemic components in Zeng Ye Tang by high‐performance liquid chromatography coupled with tandem quadrupole time‐of‐flight mass spectrometry

    Tian, Yu Shan / Zhong Ying Du / Ying Xiao / BoYang Yu / Jin Qi

    Journal of separation science. 2017 Dec., v. 40, no. 24

    2017  

    Abstract: Zeng Ye Tang, a famous prescription consisting of Xuanshen, Maidong, and Shengdi (5:4:4), has been ... Although many studies have investigated the pharmacological effects of Zeng Ye Tang, the compounds responsible ... for its hypoglycemic effect have not been identified. In this study, 50 compounds in Zeng Ye Tang were identified by highâ ...

    Abstract Zeng Ye Tang, a famous prescription consisting of Xuanshen, Maidong, and Shengdi (5:4:4), has been used in China for a long time to treat diabetes caused by excessive heat with yin deficiency. Although many studies have investigated the pharmacological effects of Zeng Ye Tang, the compounds responsible for its hypoglycemic effect have not been identified. In this study, 50 compounds in Zeng Ye Tang were identified by high‐performance liquid chromatography coupled with tandem quadrupole time‐of‐flight mass spectrometry. From these 50 compounds, nine cell‐interacted compounds were identified by biospecific cell extraction using 3T3‐L1 adipocytes. Moreover, nine potential active compounds that could be released into the blood were also acquired through serum pharmacochemical analysis in normal and diabetic rats after administration with Zeng Ye Tang. According to the established quantitative analytical method of nine constituents by high‐performance liquid chromatography, six shared prototype constituents (catalpol/harpagide/p‐coumaric acid/harpagoside/angoroside C/cinnamic acid (75.56:19.74:1.00:15.11:20.36:7.65), were screened and verified to exert remarkable hypoglycemic activity on type 2 diabetic mice. In conclusion, the six shared constituents may be responsible for the hypoglycemic activity of Zeng Ye Tang.
    Schlagwörter active ingredients ; adipocytes ; animal disease models ; blood serum ; catalpol ; cinnamic acid ; glycemic effect ; heat ; high performance liquid chromatography ; mass spectrometry ; mice ; noninsulin-dependent diabetes mellitus ; prototypes ; rats ; screening ; China
    Sprache Englisch
    Erscheinungsverlauf 2017-12
    Umfang p. 4709-4717.
    Erscheinungsort John Wiley & Sons, Ltd
    Dokumenttyp Artikel
    Anmerkung JOURNAL ARTICLE
    ZDB-ID 2047990-6
    ISSN 1615-9314 ; 1615-9306
    ISSN (online) 1615-9314
    ISSN 1615-9306
    DOI 10.1002/jssc.201700507
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Buch: Zhongguo nong ye he nong cun de gai ge yu fa zhan

    Tian, Jiyun

    1999  

    Verfasserangabe Tian Jiyun zhu
    Schlagwörter Agriculture and state ; Agriculture/Economic aspects ; Rural development ; China
    Sprache Chinesisch
    Umfang 7, 8, 809 p. [1] leaf of plates :, 1 col. ill. ;, 21 cm.
    Ausgabenhinweis Di 2 ban.
    Verlag Zhongguo nong ye chu ban she
    Erscheinungsort Beijing shi
    Dokumenttyp Buch
    ISBN 7109061078 ; 9787109061071
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Buch: Zhong Ri Han nong ye xian dai hua bi jiao yan jiu

    Zhang, Zhonggen / Tian, Wanhuo

    2002  

    Verfasserangabe Zhang Zhonggen, Tian Wanhuo zhu
    Schlagwörter Agriculture and state ; Agriculture/Economic aspects ; Agricultural innovations
    Sprache Chinesisch
    Umfang 6, 3, 224 p. :, ill. ;, 21 cm.
    Ausgabenhinweis Di 1 ban.
    Verlag Zhongguo nong ye chu ban she ; Xin hua shu dian Beijing fa xing suo fa xing
    Erscheinungsort Beijing shi
    Dokumenttyp Buch
    ISBN 7109078558 ; 9787109078550
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  9. Artikel ; Online: Toward Reproducible, Generalizable, and Clinically Useful Neurophysiological Subtypes of Major Depressive Disorder.

    Tian, Ye Ella

    Biological psychiatry

    2023  Band 94, Heft 12, Seite(n) e45–e47

    Mesh-Begriff(e) Humans ; Depressive Disorder, Major/classification
    Sprache Englisch
    Erscheinungsdatum 2023-11-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 209434-4
    ISSN 1873-2402 ; 0006-3223
    ISSN (online) 1873-2402
    ISSN 0006-3223
    DOI 10.1016/j.biopsych.2023.09.016
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  10. Artikel ; Online: A novel linear B cell epitope of the canine coronavirus nucleocapsid protein identified by a monoclonal antibody.

    Tian, Xiaoyan / Tang, Ye / Gan, Junji / Ye, Jianqiang

    Veterinary microbiology

    2024  Band 293, Seite(n) 110098

    Abstract: The infection of canine coronavirus (CCoV) causes a highly contagious disease in dogs with acute gastroenteritis. The efficient serological diagnostics is critical for controlling the disease caused by CCoV. Nucleocapsid (N) protein of CCoV is an ... ...

    Abstract The infection of canine coronavirus (CCoV) causes a highly contagious disease in dogs with acute gastroenteritis. The efficient serological diagnostics is critical for controlling the disease caused by CCoV. Nucleocapsid (N) protein of CCoV is an important target for developing serological approaches. However, little is known about the antigenic sites in the N protein of CCoV. In this study, we generated a monoclonal antibody (mAb) against the N protein of CCoV, designated as 13E8, through the fusion of the sp2/0 cells with the spleen cells from a mouse immunized with the purified recombinant GST-N protein. Epitope mapping revealed that mAb 13E8 recognized a novel linear B cell epitope in N protein at 294-314aa (named as EP-13E8) by using a serial of truncated N protein through Western blot and ELISA. Sequence analysis showed that the sequence of EP-13E8 was highly conserved (100 %) among different CCoV strains analyzed, but exhibited a low similarity (31.8-63.6 %) with the responding sequence in other coronaviruses of the same genus such as FCoV, PEDV and HCoV except for TGEV (95.5 % identity). Structural assay suggested that the epitope of EP-13E8 were located in the close proximity on the surface of the N protein. Overall, the mAb 13E8 against N protein generated and its epitope EP-13E8 identified here paid the way for further developing epitope-based serological diagnostics for CCoV.
    Mesh-Begriff(e) Animals ; Antibodies, Monoclonal/immunology ; Epitopes, B-Lymphocyte/immunology ; Dogs ; Mice ; Nucleocapsid Proteins/immunology ; Coronavirus, Canine/immunology ; Epitope Mapping ; Antibodies, Viral/immunology ; Antibodies, Viral/blood ; Mice, Inbred BALB C ; Coronavirus Nucleocapsid Proteins/immunology ; Dog Diseases/virology ; Dog Diseases/immunology ; Coronavirus Infections/veterinary ; Coronavirus Infections/immunology ; Coronavirus Infections/virology ; Coronavirus Infections/diagnosis ; Amino Acid Sequence
    Chemische Substanzen Antibodies, Monoclonal ; Epitopes, B-Lymphocyte ; Nucleocapsid Proteins ; Antibodies, Viral ; Coronavirus Nucleocapsid Proteins
    Sprache Englisch
    Erscheinungsdatum 2024-04-25
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 753154-0
    ISSN 1873-2542 ; 0378-1135
    ISSN (online) 1873-2542
    ISSN 0378-1135
    DOI 10.1016/j.vetmic.2024.110098
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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