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  1. Artikel ; Online: Adenosine induces IL-31 secretion by T-helper 2 cells: Implication for the effect of adenosine on atopic dermatitis and its therapeutic strategy.

    Kawano, Masaaki / Takagi, Rie / Tokano, Mieko / Matsushita, Sho

    Biochemical and biophysical research communications

    2023  Band 645, Seite(n) 47–54

    Abstract: Interleukin (IL)-31 is a recently-identified cytokine with a well-defined role in the pathogenesis of pruritus. Previously, we reported that adenosine upregulates IL-17A secretion by T-helper (Th)17 cells; however, the effect of adenosine on T cell ... ...

    Abstract Interleukin (IL)-31 is a recently-identified cytokine with a well-defined role in the pathogenesis of pruritus. Previously, we reported that adenosine upregulates IL-17A secretion by T-helper (Th)17 cells; however, the effect of adenosine on T cell subsets other than Th17 remains unclear. In this report, we show that adenosine upregulated production of IL-31 by cluster of differentiation (CD)4
    Mesh-Begriff(e) Animals ; Mice ; Adenosine/metabolism ; Dermatitis, Atopic/metabolism ; Dermatitis, Atopic/pathology ; Pruritus ; Th2 Cells ; Interleukins/metabolism
    Chemische Substanzen Adenosine (K72T3FS567) ; Interleukins
    Sprache Englisch
    Erscheinungsdatum 2023-01-13
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 1090-2104 ; 0006-291X ; 0006-291X
    ISSN (online) 1090-2104 ; 0006-291X
    ISSN 0006-291X
    DOI 10.1016/j.bbrc.2023.01.038
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Istradefylline, an adenosine A2a receptor antagonist, inhibits the CD4

    Tokano, Mieko / Kawano, Masaaki / Takagi, Rie / Matsushita, Sho

    Immunological medicine

    2022  Band 45, Heft 4, Seite(n) 244–250

    Abstract: Extracellular adenosine produced from ATP plays a role in energy processes, neurotransmission, and inflammatory responses. Istradefylline is a selective adenosine A2a receptor (A2aR) antagonist used for the treatment of Parkinson's disease. We previously ...

    Abstract Extracellular adenosine produced from ATP plays a role in energy processes, neurotransmission, and inflammatory responses. Istradefylline is a selective adenosine A2a receptor (A2aR) antagonist used for the treatment of Parkinson's disease. We previously showed using mouse models that adenosine primes hypersecretion of interleukin (IL)-17A
    Mesh-Begriff(e) Animals ; Humans ; Mice ; Receptor, Adenosine A2A ; Adenosine A2 Receptor Antagonists/pharmacology ; Interleukin-17 ; Interleukin-8/pharmacology ; Purinergic P1 Receptor Antagonists/pharmacology ; Leukocytes, Mononuclear ; T-Lymphocytes ; Adenosine/pharmacology ; CD4-Positive T-Lymphocytes ; Inflammation
    Chemische Substanzen Receptor, Adenosine A2A ; Adenosine A2 Receptor Antagonists ; istradefylline (2GZ0LIK7T4) ; Interleukin-17 ; Interleukin-8 ; Purinergic P1 Receptor Antagonists ; Adenosine (K72T3FS567)
    Sprache Englisch
    Erscheinungsdatum 2022-07-05
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2578-5826
    ISSN (online) 2578-5826
    DOI 10.1080/25785826.2022.2094593
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Acute tenosynovitis following an accidental injection of Bacille Calmette-Guérin (BCG) in a health care worker

    Mieko Tokano / Norihito Tarumoto / Kazuo Imai / Takuya Sekine / Yasuto Omura / Kosuke Uehara / Shigefumi Maesaki

    Infection Prevention in Practice, Vol 6, Iss 1, Pp 100332- (2024)

    A case report

    2024  

    Abstract: Summary: Case: A 36-year-old female healthcare worker with no past medical history, accidentally injected her flexed right middle finger with live attenuated Mycobacterium bovis bacillus Calmette-Guérin (BCG). Swelling and erythema around the injured ... ...

    Abstract Summary: Case: A 36-year-old female healthcare worker with no past medical history, accidentally injected her flexed right middle finger with live attenuated Mycobacterium bovis bacillus Calmette-Guérin (BCG). Swelling and erythema around the injured area appeared two days after the needlestick injury. She was referred to the hospital and presented approximately nine days after self-inoculation. Surgical debridement was immediately performed. After 38 days, colonies were observed on cultures of the removed tissue on Ogawa's medium. This isolate was identified as M. bovis BCG by polymerase chain reaction (PCR) based on RD1 gene deletion. She had a history of BCG vaccination and her skin lesion appeared immediately after the accidental injection of M. bovis BCG. Therefore, in the differential diagnosis, the possibility that the lesion was an allergic reaction to BCG was considered. The subsequent culture results came back positive for M. bovis BCG and acute tenosynovitis caused by M. bovis BCG was diagnosed. The skin lesion was treated with anti-mycobacterial drugs and resolved. Discussion: The allergic reactions to BCG should be considered in the differential diagnosis of skin lesions following BCG vaccination. It is important to promptly submit a specimen for culture as delayed initiation of appropriate treatment can lead to a poor prognosis. In patients with accidental injection of M. bovis BCG, it is important to consider timely surgical excision and appropriate antimycobacterial therapy.
    Schlagwörter Tenosynovitis ; Mycobacterial infection ; Mycobacterium bovis bacillus Calmette-Guérin (BCG) ; Mycobacterium tuberculosis ; Accidental injection ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2024-03-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel ; Online: Acute tenosynovitis following an accidental injection of Bacille Calmette-Guérin (BCG) in a health care worker: A case report.

    Tokano, Mieko / Tarumoto, Norihito / Imai, Kazuo / Sekine, Takuya / Omura, Yasuto / Uehara, Kosuke / Maesaki, Shigefumi

    Infection prevention in practice

    2023  Band 6, Heft 1, Seite(n) 100332

    Abstract: Case: A 36-year-old female healthcare worker with no past medical history, accidentally injected her flexed right middle finger with live attenuated : Discussion: The allergic reactions to BCG should be considered in the differential diagnosis of ... ...

    Abstract Case: A 36-year-old female healthcare worker with no past medical history, accidentally injected her flexed right middle finger with live attenuated
    Discussion: The allergic reactions to BCG should be considered in the differential diagnosis of skin lesions following BCG vaccination. It is important to promptly submit a specimen for culture as delayed initiation of appropriate treatment can lead to a poor prognosis. In patients with accidental injection of
    Sprache Englisch
    Erscheinungsdatum 2023-12-12
    Erscheinungsland England
    Dokumenttyp Case Reports
    ISSN 2590-0889
    ISSN (online) 2590-0889
    DOI 10.1016/j.infpip.2023.100332
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Extracellular adenosine induces hypersecretion of IL-17A by T-helper 17 cells through the adenosine A2a receptor.

    Tokano, Mieko / Matsushita, Sho / Takagi, Rie / Yamamoto, Toshimasa / Kawano, Masaaki

    Brain, behavior, & immunity - health

    2022  Band 26, Seite(n) 100544

    Abstract: Extracellular adenosine, produced from ATP secreted by neuronal or immune cells, may play a role in endogenous regulation of inflammatory responses. Studies show that adenosine induces hypersecretion of IL-17A by ... ...

    Abstract Extracellular adenosine, produced from ATP secreted by neuronal or immune cells, may play a role in endogenous regulation of inflammatory responses. Studies show that adenosine induces hypersecretion of IL-17A by CD4
    Sprache Englisch
    Erscheinungsdatum 2022-10-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2666-3546
    ISSN (online) 2666-3546
    DOI 10.1016/j.bbih.2022.100544
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Malignant syphilis requiring differentiation from Kaposi's sarcoma.

    Tokano, Mieko / Tarumoto, Norihito / Imai, Kazuo / Yamaguchi, Hiroshi / Takeji, Masaaki / Inayoshi, Fumito / Okamoto, Keita / Okumura, Nobuhito / Maesaki, Shigefumi

    IDCases

    2024  Band 36, Seite(n) e01943

    Abstract: Malignant syphilis (MS) is a rare variant of secondary syphilis. Also known as rupioid syphilis, MS is characterized by the presence of multiple papules, papulopustules, black lamellate crust that may resemble an oyster shell, or nodules with ulceration ... ...

    Abstract Malignant syphilis (MS) is a rare variant of secondary syphilis. Also known as rupioid syphilis, MS is characterized by the presence of multiple papules, papulopustules, black lamellate crust that may resemble an oyster shell, or nodules with ulceration lacking central clearing. MS is often associated with immunodeficiency and frequently co-occurs with HIV infection. We here report a case of MS in a patient with HIV infection. HIV infection can cause atypical clinical symptoms of syphilis. In this case, unlike previous cases, cutaneous lesions of MS were limited to the face, making the diagnosis challenging based on clinical findings alone. However, his laboratory findings, appearance of the Jarisch-Herxheimer reaction, and a dramatic response to antibiotic therapy are characteristic of MS, making the diagnosis even more certain. Our case suggests the importance of physicians considering the possibility of MS when observing black-crusted lesions.
    Sprache Englisch
    Erscheinungsdatum 2024-04-16
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2024.e01943
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: A case of

    Tokano, Mieko / Tarumoto, Norihito / Imai, Kazuo / Sakai, Jun / Kodana, Masahiro / Naito, Erika / Uchida, Yoshitaka / Nagata, Makoto / Maesaki, Shigefumi

    IDCases

    2022  Band 31, Seite(n) e01654

    Abstract: We report a case ... ...

    Abstract We report a case of
    Sprache Englisch
    Erscheinungsdatum 2022-12-01
    Erscheinungsland Netherlands
    Dokumenttyp Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2022.e01654
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Vancomycin-resistant

    Tokano, Mieko / Tarumoto, Norihito / Sakai, Jun / Imai, Kazuo / Kodana, Masahiro / Kawamura, Toru / Maeda, Takuya / Maesaki, Shigefumi

    Microbiology spectrum

    2023  Band 12, Heft 1, Seite(n) e0244423

    Abstract: Importance: Our study emphasizes the efficacy of whole-genome sequencing (WGS) in addressing outbreaks of vancomycin-resistant enterococci. WGS enables the identification and tracking of resistant bacterial strains, early detection and management of ... ...

    Abstract Importance: Our study emphasizes the efficacy of whole-genome sequencing (WGS) in addressing outbreaks of vancomycin-resistant enterococci. WGS enables the identification and tracking of resistant bacterial strains, early detection and management of novel infectious disease outbreaks, and the appropriate selection and use of antibiotics. Furthermore, our approach deepens our understanding of how resistant bacteria transfer genes and adapt to their environments or hosts. For modern medicine, these insights have significant implications for controlling infections and effectively managing antibiotic use in the current era, where antibiotic resistance is progressing.
    Mesh-Begriff(e) Humans ; Vancomycin-Resistant Enterococci/genetics ; Molecular Epidemiology ; Vancomycin/pharmacology ; Vancomycin/therapeutic use ; Enterococcus faecium/genetics ; Japan/epidemiology ; Multilocus Sequence Typing ; Anti-Bacterial Agents/pharmacology ; Gram-Positive Bacterial Infections/epidemiology ; Gram-Positive Bacterial Infections/microbiology ; Bacterial Proteins/genetics
    Chemische Substanzen Vancomycin (6Q205EH1VU) ; Anti-Bacterial Agents ; Bacterial Proteins
    Sprache Englisch
    Erscheinungsdatum 2023-12-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02444-23
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Multicenter Study of the Effectiveness of Antifungal Stewardship Team Intervention for Candidemia in Japan in 2008-2021.

    Tokano, Mieko / Tarumoto, Norihito / Sakai, Jun / Imai, Kazuo / Koizumi, Sakaru / Karaushi, Haruka / Hatanaka, Tamotsu / Kishi, Etsuko / Seki, Masafumi / Mitsutake, Koutaro / Maesaki, Shigefumi

    Infectious disease reports

    2024  Band 16, Heft 2, Seite(n) 356–366

    Abstract: Candidemia, linked to high mortality rates, requires prompt antifungal therapy for better outcomes. Treatment is structured as an action bundle, which is beneficial when followed closely. However, the Japanese action bundle lacks detailed guidance on ... ...

    Abstract Candidemia, linked to high mortality rates, requires prompt antifungal therapy for better outcomes. Treatment is structured as an action bundle, which is beneficial when followed closely. However, the Japanese action bundle lacks detailed guidance on severe complications like endocarditis or ocular issues. To address this, we adjusted the action bundle and assessed outcomes with and without AFT intervention. We strengthened protocols for blood cultures and organ assessments, and the AFT contacted the primary physician when yeast-like fungi were detected in the patient's blood culture bottles. Analyzing 204 candidemia cases from 2008-2021, we observed increased adherence and reduced mortality post-AFT intervention. Ophthalmology consultations rose significantly, but many patients had only one visit, suggesting inadequate follow-up. If endophthalmitis is diagnosed, a change in the treatment approach may be necessary. There is a possibility that abnormal ocular findings will be detected during subsequent visits, which highlights the need for improvement in ophthalmology follow-up rates as a future challenge for our AFT activities.
    Sprache Englisch
    Erscheinungsdatum 2024-04-15
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ISSN 2036-7430
    ISSN 2036-7430
    DOI 10.3390/idr16020027
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Signaling via dopamine and adenosine receptors modulate viral peptide-specific and T-cell IL-8 response in COVID-19.

    Tokano, Mieko / Takagi, Rie / Kawano, Masaaki / Maesaki, Shigefumi / Tarumoto, Norihito / Matsushita, Sho

    Immunological medicine

    2022  Band 45, Heft 3, Seite(n) 162–167

    Abstract: B-cell but not T-cell responses have been extensively studied using peripheral blood mononuclear cells (PBMCs) obtained from patients with coronavirus disease 2019 (COVID-19). Our recent study showed that not only T-helper (Th) 17 but also Th1 cells ... ...

    Abstract B-cell but not T-cell responses have been extensively studied using peripheral blood mononuclear cells (PBMCs) obtained from patients with coronavirus disease 2019 (COVID-19). Our recent study showed that not only T-helper (Th) 17 but also Th1 cells directly produce interleukin (IL)-8, a major source of neutrophilic inflammation, which is also known to induce disseminated intravascular coagulation (DIC) in COVID-19 patients. Neutrophilic inflammation caused by IL-17A or IL-8 can be fatal; thus, therapeutic intervention is highly expected. The present study aimed to investigate the T-cell responses in the Japanese patients. We synthesized spike protein-derived 15-mer peptides that are expected to bind to HLA class II allelic products frequently observed in the Japanese population, and checked the T-cell responses in Japanese patients with COVID-19. We have found that (i) patients show marked IL-8 but not IL-17A responses; (ii) these responses are restricted by HLA-DR; and (iii) IL-8 responses are abrogated by a dopamine D2 like receptor (D2R) agonist, ropinirole, and an adenosine A2a receptor (A2aR) antagonist, istradefylline. Compounds used for the treatment of Parkinson's disease may ease DIC in COVID-19. (183 words).
    Mesh-Begriff(e) Dopamine ; Dopamine Agonists/pharmacology ; Humans ; Inflammation ; Interleukin-8 ; Leukocytes, Mononuclear/metabolism ; Purinergic P1 Receptor Antagonists ; Receptor, Adenosine A2A/metabolism ; T-Lymphocytes/immunology ; COVID-19 Drug Treatment
    Chemische Substanzen Dopamine Agonists ; Interleukin-8 ; Purinergic P1 Receptor Antagonists ; Receptor, Adenosine A2A ; Dopamine (VTD58H1Z2X)
    Sprache Englisch
    Erscheinungsdatum 2022-05-27
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2578-5826
    ISSN (online) 2578-5826
    DOI 10.1080/25785826.2022.2079369
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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