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Article ; Online: The coronary capillary bed and its role in blood flow and oxygen delivery: A review.

Tomanek, Robert J

Anatomical record (Hoboken, N.J. : 2007)

2022 Volume 305, Issue 11, Page(s) 3199–3211

Abstract: The assumption that the coronary capillary blood flow is exclusively regulated by precapillary vessels is not supported by recent data. Rather, the complex coronary capillary bed has unique structural and geometric characteristics that invalidate many ... ...

Abstract	The assumption that the coronary capillary blood flow is exclusively regulated by precapillary vessels is not supported by recent data. Rather, the complex coronary capillary bed has unique structural and geometric characteristics that invalidate many assumptions regarding red blood cell (RBC) transport, for example, data based on a single capillary or that increases in flow are the result of capillary recruitment. It is now recognized that all coronary capillaries are open and that their variations in flow are due to structural differences, local O
MeSH term(s)	Adenosine ; Capillaries ; Erythrocytes/physiology ; Nitric Oxide ; Oxygen ; Phenylephrine
Chemical Substances	Phenylephrine (1WS297W6MV) ; Nitric Oxide (31C4KY9ESH) ; Adenosine (K72T3FS567) ; Oxygen (S88TT14065)
Language	English
Publishing date	2022-05-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2269667-2
ISSN	1932-8494 ; 1932-8486
ISSN (online)	1932-8494
ISSN	1932-8486
DOI	10.1002/ar.24951
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Book: Formation of the heart and its regulation

Tomanek, Robert J.

(Cardiovascular molecular morphogenesis)

2001

Author's details	ed. by Robert J. Tomanek
Series title	Cardiovascular molecular morphogenesis
Language	English
Size	XIV, 276 S. : Ill., graph. Darst.
Publisher	Birkhäuser
Publishing place	Boston
Publishing country	United States
Document type	Book
HBZ-ID	HT013093945
ISBN	0-8176-4216-1 ; 978-0-8176-4216-7
Database	Catalogue ZB MED Medicine, Health

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2001 A 4417	order for loan	Magazin

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Book: Assembly of the vasculature and its regulation

Tomanek, Robert J.

(Cardiovascular molecular morphogenesis)

2002

Author's details	Robert J. Tomanek, ed
Series title	Cardiovascular molecular morphogenesis
Keywords	Blood Vessels / embryology ; Blood Vessels / physiology ; Endothelium, Vascular / embryology ; Endothelium, Vascular / physiology ; Morphology ; Blutgefäßsystem ; Embryonalentwicklung ; Angiogenese ; Regulation ; Organogenese
Subject	Embryo ; Embryogenese ; Keimesentwicklung ; Gefäßentwicklung ; Organbildung ; Organentwicklung ; Gefäß-System
Language	English
Size	XVII, 279 S. : Ill., graph. Darst.
Publisher	Birkhäuser
Publishing place	Boston u.a.
Publishing country	United States
Document type	Book
Note	Literaturangaben
HBZ-ID	HT013368941
ISBN	3-7643-4229-3 ; 0-8176-4229-3 ; 978-3-7643-4229-6 ; 978-0-8176-4229-7
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Developmental Progression of the Coronary Vasculature in Human Embryos and Fetuses.

Tomanek, Robert J

Anatomical record (Hoboken, N.J. : 2007)

2016 Volume 299, Issue 1, Page(s) 25–41

Abstract: Although considerable advances in our understanding of mammalian and avian embryonic coronary development have occurred during the last decade, our current knowledge of this topic in humans is limited. Accordingly, the aim of this study was to determine ... ...

Abstract	Although considerable advances in our understanding of mammalian and avian embryonic coronary development have occurred during the last decade, our current knowledge of this topic in humans is limited. Accordingly, the aim of this study was to determine if the development of the human coronary vasculature in humans is like that of other mammals and avians. The data document a progression of events involving mesenchymal cell-containing villi from the proepicardium, establishment of blood islands and a capillary network. The major finding of the study is direct evidence that the capillary plexus associated with spindle cells and erythroblasts invades the base of the aorta to form coronary ostia. A role for the dorsal mesocardium is also indicated by the finding that cells from this region are continuous with the aorta and pulmonary artery. The development of the tunica media of the coronary arteries follows the same base-apex progression as in other species, with the development of branches occurring late in the embryonic period. The fetal period is characterized by 1) growth and a numerical increase in the smallest arterial branches, veins, and venules, 2) innervation of arteries, and 3) inclusion of elastic fibers in the tunica media of the coronary arteries and development of the tunica adventitia. In conclusion, the data demonstrate that the development of the coronary system in humans is similar to that of other mammalian and avian species, and for the first time documents that the formation of the ostia and coronary stems in humans occurs by ingrowth of a vascular plexus and associated cells from the epicardium.
MeSH term(s)	Coronary Vessels/embryology ; Endothelium, Vascular/embryology ; Fetus/embryology ; Heart/embryology ; Humans ; Image Processing, Computer-Assisted ; Microscopy
Language	English
Publishing date	2016-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2269667-2
ISSN	1932-8494 ; 1932-8486
ISSN (online)	1932-8494
ISSN	1932-8486
DOI	10.1002/ar.23283
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Book: Coronary vasculature

Tomanek, Robert J

development, structure-function, and adaptations

2013

Author's details	Robert J. Tomanek
MeSH term(s)	Coronary Vessels/physiology ; Coronary Vessels/anatomy & histology ; Cardiovascular Diseases ; Adaptation, Physiological
Language	English
Size	xviii, 276 p. :, ill.
Publisher	Springer
Publishing place	New York
Document type	Book
ISBN	9781461448860 ; 9781461448877 ; 1461448867 ; 1461448875
Database	Catalogue of the US National Library of Medicine (NLM)

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Book ; Online: Coronary Vasculature

Tomanek, Robert J

Development, Structure-Function, and Adaptations

2013

Abstract: ... myocardial perfusion was written by Dr. Robert J. Tomanek, Emeritus Professor of Anatomy and Cell Biology ...

Author's details	by Robert J. Tomanek
Abstract	Ischemic heart disease is the leading cause of morbidity and mortality in the developed world. The high metabolism and oxygen demand of the cardiac myocardium depends on both a high blood flow and a rich capillary density. For this reason, the growth of the coronary vasculature is vital, not only in early development, but also in the adult faced with various stresses. Novel technologies have enabled the discovery of the molecular mechanisms underlying the growth and assembly coronary vessels, and this volume covers the hierarchy of the coronary vasculature from its embryonic origins through its postnatal growth, adulthood, and senescence. Chapters address normal coronary development, coronary anomalies and their possible underlying developmental errors, coronary vessel adaptations to exercise training, aging, hypoxia, myocardial ischemia, and cardiac hypertrophy.This comprehensive overview of current research in coronary vessels and myocardial perfusion was written by Dr. Robert J. Tomanek, Emeritus Professor of Anatomy and Cell Biology at the University of Iowa. The book reviews, discusses, and integrates findings from various areas of coronary vasculature research, and as a result, will be a valuable reference source for cardiovascular scientists and physicians for many years to come.
MeSH term(s)	Adaptation, Physiological ; Cardiovascular Diseases ; Coronary Vessels/anatomy & histology ; Coronary Vessels/physiology
Keywords	Cardiology ; Medicine ; Technik / Wissen # Biologie
Language	English
Size	Online-Ressource (XVIII, 276 p. 74 illus., 59 illus. in color), digital
Publisher	Springer
Publishing place	Boston, MA
Document type	Book ; Online
Note	Description based upon print version of record
ISBN	9781461448860 ; 9781461448877 ; 1461448867 ; 1461448875
DOI	10.1007/978-1-4614-4887-7
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Coronary anomalies in mice with congenital heart defects.

Tomanek, Robert J / Yu, Qing / Lo, Cecilia W

Anatomical record (Hoboken, N.J. : 2007)

2015 Volume 298, Issue 2, Page(s) 408–417

Abstract: Background: Coronary anomalies are frequently associated with congenital cardiac defects. Accordingly, we tested the hypothesis that the development of the tunica media of coronary arteries/arterioles is compromised in mice with cardiac defects of the ... ...

Abstract	Background: Coronary anomalies are frequently associated with congenital cardiac defects. Accordingly, we tested the hypothesis that the development of the tunica media of coronary arteries/arterioles is compromised in mice with cardiac defects of the outflow tract (persistent truncus arteriosus, double outlet right ventricle and transposition of the great arteries) by studying hearts of G7-9 generation mice bred from mutagenized mice caused by N-ethyl-N-nitrosourea. Mice were studied at embryonic days E16.5, E17.5, and postnatal days 1 and 11. Data were based on immunohistochemistry of serial sections. Results: In 21 of 24 mice with outflow tract defects, the development of smooth muscle in arteries and arterioles was retarded; most commonly arterioles had an incomplete layer of smooth muscle or in a few instances, lacked a tunica media. In this model, an absence of a coronary ostium occurred in only 2 mice, indicating that the mechanisms underlying the formation of coronary ostia and the recruitment and differentiation of vascular smooth muscle differ. Coronary fistulas were present in 20% and dilated vessels in 30% of the hearts with cardiac defects. Conclusions: The data suggest that vascular smooth muscle recruitment and differentiation are not necessarily linked to other coronary anomalies, such as absence of a main coronary artery or branching patterns.
MeSH term(s)	Animals ; Animals, Newborn ; Coronary Vessel Anomalies/pathology ; Heart Defects, Congenital/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Muscle, Smooth, Vascular/pathology ; Tunica Media/pathology
Language	English
Publishing date	2015-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2269667-2
ISSN	1932-8494 ; 1932-8486
ISSN (online)	1932-8494
ISSN	1932-8486
DOI	10.1002/ar.23056
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Article: Formation of the coronary vasculature during development.

Tomanek, Robert J

Angiogenesis

2005 Volume 8, Issue 3, Page(s) 273–284

Abstract: The formation of the coronary vasculature involves a series of carefully regulated temporal events that include vasculogenesis, angiogenesis, arteriogenesis and remodeling. This review explores these events, which begin with the migration of ... ...

Abstract	The formation of the coronary vasculature involves a series of carefully regulated temporal events that include vasculogenesis, angiogenesis, arteriogenesis and remodeling. This review explores these events, which begin with the migration of proepicardial cells to form the epicardium and end with postnatal growth and remodeling. Coronary endothelial, smooth muscle and fibroblast cells differentiate via epithelial-mesenchymal transformation; these cells delaminate from the epicardium. Following the formation of a tubular network by endothelial cells, an aortic ring of endothelial cells penetrates the aorta at the left and right aortic cusps to form the two ostia. Smooth muscle cell recruitment occurs rapidly and the coronary artery network begins forming as blood flow is established. Recent studies have identified a number of regulatory molecules that play key roles in epicardial formation and the transformation of its component cells into mesenchyme. Moreover, we are finally gaining some understanding regarding the interplay of angiogenic growth factors in the complex process of establishing the coronary vascular tree. Understanding coronary embryogenesis is important for interventions regarding adult cardiovascular diseases as well as those necessary to correct congenital defects.
MeSH term(s)	Cell Differentiation/physiology ; Coronary Vessels/embryology ; Coronary Vessels/growth & development ; Endothelial Cells/physiology ; Endothelial Growth Factors/metabolism ; Humans ; Models, Biological ; Muscle, Smooth/physiology ; Neovascularization, Physiologic/physiology
Chemical Substances	Endothelial Growth Factors
Language	English
Publishing date	2005
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1484717-6
ISSN	0969-6970
ISSN	0969-6970
DOI	10.1007/s10456-005-9014-9
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Article ; Online: The antioxidant and anti-inflammatory activities of avasopasem manganese in age-associated, cisplatin-induced renal injury.

Mapuskar, Kranti A / Pulliam, Casey F / Tomanek-Chalkley, Ann / Rastogi, Prerna / Wen, Hsiang / Dayal, Sanjana / Griffin, Benjamin R / Zepeda-Orozco, Diana / Sindler, Amy L / Anderson, Carryn M / Beardsley, Robert / Kennedy, Eugene P / Spitz, Douglas R / Allen, Bryan G

Redox biology

2024 Volume 70, Page(s) 103022

Abstract: ... Experimental design: Young and old C57BL/6 J murine models of cisplatin-induced AKI and CKD were treated with the SOD ...

Abstract	Purpose: Cisplatin contributes to acute kidney injury (AKI) and chronic kidney disease (CKD) that occurs with greater frequency and severity in older patients. Age-associated cisplatin sensitivity in human fibroblasts involves increased mitochondrial superoxide produced by older donor cells. Experimental design: Young and old C57BL/6 J murine models of cisplatin-induced AKI and CKD were treated with the SOD mimetic avasopasem manganese to investigate the potential antioxidant and anti-inflammatory effects. Adverse event reporting from a phase 2 and a phase 3 randomized clinical trial (NCT02508389 and NCT03689712) conducted in patients treated with cisplatin and AVA was determined to have established the incidence and severity of AKI. Results: Cisplatin-induced AKI and CKD occurred in all mice, however, was more pronounced in older mice. AVA reduced cisplatin-induced mortality, AKI, and CKD, in older animals. AVA also alleviated cisplatin-induced alterations in mitochondrial electron transport chain (ETC) complex activities and NADPH Oxidase 4 (NOX4) and inhibited the increased levels of the inflammation markers, TNFα, IL1, ICAM-1, and VCAM-1. Analysis of age-stratified subjects treated with cisplatin from clinical trials (NCT02508389, NCT03689712) also supported that the incidence of AKI increased with age and AVA reduced age-associated therapy-induced adverse events (AE), including hypomagnesemia, increased creatinine, and AKI. Conclusions: Older mice and humans are more susceptible to cisplatin-induced kidney injury, and treatment with AVA mitigates age-associated damage. Mitochondrial ETC and NOX4 activities represent sources of superoxide production contributing to cisplatin-induced kidney injury, and pro-inflammatory cytokine production and endothelial dysfunction may also be increased by superoxide formation.
MeSH term(s)	Humans ; Mice ; Animals ; Aged ; Cisplatin/pharmacology ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Superoxides ; Mice, Inbred C57BL ; Kidney ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/drug therapy ; Renal Insufficiency, Chronic ; Anti-Inflammatory Agents/pharmacology ; Organometallic Compounds
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Antioxidants ; avasopasem manganese (EY1WA413UL) ; Superoxides (11062-77-4) ; Anti-Inflammatory Agents ; Organometallic Compounds
Language	English
Publishing date	2024-01-01
Publishing country	Netherlands
Document type	Randomized Controlled Trial ; Clinical Trial, Phase II ; Clinical Trial, Phase III ; Journal Article
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2023.103022
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Article ; Online: Structural composition of myocardial infarction scar in middle-aged male and female rats: does sex matter?

Bogatyryov, Yevgen / Tomanek, Robert J / Dedkov, Eduard I

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society

2013 Volume 61, Issue 11, Page(s) 833–848

Abstract: The present study was designed to determine whether the structural composition of the scar in middle-aged post-myocardial infraction (MI) rats is affected by the biological sex of the animals. A large MI was induced in 12-month-old male (M-MI) and female ...

Abstract	The present study was designed to determine whether the structural composition of the scar in middle-aged post-myocardial infraction (MI) rats is affected by the biological sex of the animals. A large MI was induced in 12-month-old male (M-MI) and female (F-MI) Sprague-Dawley rats by ligation of the left coronary artery. Four weeks after the MI, rats with transmural infarctions, greater than 50% of the left ventricular (LV) free wall, were evaluated. The extent of LV remodeling and fractional volumes of fibrillar collagen (FC), myofibroblasts, vascular smooth muscle (SM) cells, and surviving cardiac myocytes (CM) in the scars were compared between the two sexes. The left ventricle of post-MI male and female rats underwent a similar degree of remodeling as evidenced by the analogous scar thinning ratio (0.46 ± 0.02 vs. 0.42 ± 0.05) and infarct expansion index (1.06 ± 0.07 vs. 1.12 ± 0.08), respectively. Most important, the contents of major structural components of the scar revealed no evident difference between M-MI and F-MI rats (interstitial FC, 80.74 ± 2.08 vs. 82.57 ± 4.53; myofibroblasts, 9.59 ± 1.68 vs.9.56 ± 1.15; vascular SM cells, 2.27 ± 0.51 vs. 3.38 ± 0.47; and surviving CM, 3.26 ± 0.39 vs. 3.05 ± 0.38, respectively). Our data are the first to demonstrate that biological sex does not influence the structural composition of a mature scar in middle-aged post-MI rats.
MeSH term(s)	Age Factors ; Animals ; Cicatrix/pathology ; Female ; Immunohistochemistry ; Male ; Myocardial Infarction/pathology ; Myocardium/pathology ; Rats ; Rats, Sprague-Dawley ; Sex Factors ; Ventricular Remodeling
Language	English
Publishing date	2013-07-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	218208-7
ISSN	1551-5044 ; 0022-1554
ISSN (online)	1551-5044
ISSN	0022-1554
DOI	10.1369/0022155413499794
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