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  1. Artikel: From Physiological Redox Signalling to Oxidant Stress.

    Ward, Jeremy P T

    Advances in experimental medicine and biology

    2017  Band 967, Seite(n) 335–342

    Abstract: Oxidant stress is strongly associated with cardiovascular disease, including pulmonary hypertension, but antioxidant therapies have so far proven ineffective. This is partly due to a lack of understanding of the key role played by reactive oxygen species ...

    Abstract Oxidant stress is strongly associated with cardiovascular disease, including pulmonary hypertension, but antioxidant therapies have so far proven ineffective. This is partly due to a lack of understanding of the key role played by reactive oxygen species (ROS) in physiological cell signalling, and partly to the complex interrelationships between generators of ROS (e.g. mitochondria and NADPH oxidases, NOX), cellular antioxidant systems and indeed Ca
    Sprache Englisch
    Erscheinungsdatum 2017
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-319-63245-2_21
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Physiological redox signalling and regulation of ion channels: implications for pulmonary hypertension.

    Ward, Jeremy P T

    Experimental physiology

    2017  Band 102, Heft 9, Seite(n) 1078–1082

    Abstract: New findings: What is the topic of this review? The review concerns the role of reactive oxygen species as physiological second messengers in potentiating G-protein-coupled receptor-mediated vasoconstriction and its potential dysregulation by oxidant ... ...

    Abstract New findings: What is the topic of this review? The review concerns the role of reactive oxygen species as physiological second messengers in potentiating G-protein-coupled receptor-mediated vasoconstriction and its potential dysregulation by oxidant stress in pulmonary hypertension. What advances does it highlight? The review highlights the concept that physiological signalling by reactive oxygen species must normally be highly compartmentalized to prevent self-regenerating oxidant stress and promiscuous and uncontrolled signalling, which contribute to the aetiology. Pulmonary hypertension is associated with oxidant stress and increased generation of reactive oxygen species (ROS) by NADPH oxidases (NOX), mitochondria and other sources. There is considerable evidence that these contribute to the aetiology via promotion of pulmonary vascular remodelling, endothelial dysfunction and enhanced vasoreactivity. However, it is now recognized that ROS act as important signalling mediators and second messengers in normal physiological conditions. Many ion channels and protein kinases crucial to pulmonary vascular function are directly or indirectly affected by redox/ROS, including K
    Mesh-Begriff(e) Humans ; Hypertension, Pulmonary/metabolism ; Hypertension, Pulmonary/physiopathology ; Ion Channels/metabolism ; Oxidation-Reduction ; Reactive Oxygen Species/metabolism ; Signal Transduction/physiology
    Chemische Substanzen Ion Channels ; Reactive Oxygen Species
    Sprache Englisch
    Erscheinungsdatum 2017-01-13
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/EP086040
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Society of Interventional Radiology-American College of Radiology Standardized Report-Based Data Registry: Early Observations and Reflections from 2017 to 2019 Biopsy Report Data of Select Sites.

    Charalel, Resmi A / Lewis, Paul B / Salei, Aliaksei / Cantos, Andrew / Dubel, Gregory / Baskin, Kevin M / Kassin, Michael T / Brook, Olga R / Al-Dulaimi, Ragheed / Kalva, Sanjeeva P / Ward, Thomas J / Durack, Jeremy C / Shah, Rajesh P

    Journal of vascular and interventional radiology : JVIR

    2023  Band 34, Heft 7, Seite(n) 1258–1260.e1

    Mesh-Begriff(e) Humans ; United States ; Radiology, Interventional ; Research Design
    Sprache Englisch
    Erscheinungsdatum 2023-03-25
    Erscheinungsland United States
    Dokumenttyp Letter
    ZDB-ID 1137756-2
    ISSN 1535-7732 ; 1051-0443
    ISSN (online) 1535-7732
    ISSN 1051-0443
    DOI 10.1016/j.jvir.2023.03.010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Topical therapy with negative allosteric modulators of the calcium-sensing receptor (calcilytics) for the management of asthma: the beginning of a new era?

    Riccardi, Daniela / Ward, Jeremy P T / Yarova, Polina L / Janssen, Luke J / Lee, Tak Hong / Ying, Sun / Corrigan, Chris J

    The European respiratory journal

    2022  Band 60, Heft 2

    Abstract: In this review article we present the evidence to date supporting the role of the calcium-sensing receptor (CaSR) as a key, pluripotential molecular trigger for asthma and speculate on the likely benefits of topical therapy of asthma with negative ... ...

    Abstract In this review article we present the evidence to date supporting the role of the calcium-sensing receptor (CaSR) as a key, pluripotential molecular trigger for asthma and speculate on the likely benefits of topical therapy of asthma with negative allosteric modulators of the CaSR: calcilytics.
    Mesh-Begriff(e) Asthma/drug therapy ; Calcium ; Humans ; Receptors, Calcium-Sensing
    Chemische Substanzen Receptors, Calcium-Sensing ; Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2022-08-10
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02103-2021
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Buch: Physiology at a glance

    Ward, Jeremy P. T / Linden, R. W. A

    (At a glance series)

    2017  

    Verfasserangabe Jeremy P.T. Ward, Roger W.A. Linden
    Serientitel At a glance series
    Mesh-Begriff(e) Physiological Phenomena
    Sprache Englisch
    Umfang p. ;, cm.
    Ausgabenhinweis Fourth edition.
    Dokumenttyp Buch
    ISBN 9781119247272 ; 1119247276
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  6. Artikel ; Online: Development of a Highly Selective Ni(II) Chelator in Aqueous Solution.

    Gupta, Sayak / Ward, Cassandra L / Perera, S Sameera / Gowan, Conor T / Dittrich, Timothy M / Allen, Matthew J / McElmurry, Shawn P / Kodanko, Jeremy J

    Inorganic chemistry

    2022  Band 61, Heft 48, Seite(n) 19492–19501

    Abstract: The design, synthesis, and characterization of a novel Ni(II) ... ...

    Abstract The design, synthesis, and characterization of a novel Ni(II) chelator
    Mesh-Begriff(e) Chelating Agents ; Water ; Photoelectron Spectroscopy ; Spectrophotometry, Infrared ; Crystallography, X-Ray
    Chemische Substanzen Chelating Agents ; Water (059QF0KO0R)
    Sprache Englisch
    Erscheinungsdatum 2022-11-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.2c03441
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Buch: Physiology at a glance

    Ward, Jeremy P. T / Linden, R. W. A

    (At a glance)

    2013  

    Verfasserangabe Jeremy P.T. Ward, Roger W.A. Linden
    Serientitel At a glance
    Mesh-Begriff(e) Physiological Phenomena
    Sprache Englisch
    Umfang 165 p. :, ill.
    Ausgabenhinweis 3rd ed.
    Verlag John Wiley & Sons
    Erscheinungsort Chichester, West Sussex, UK
    Dokumenttyp Buch
    ISBN 9780470659786 ; 0470659785
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  8. Buch: The respiratory system at a glance

    Ward, Jeremy P. T / Ward, Jane / Leach, Richard M

    (At a glance series)

    2015  

    Verfasserangabe Jeremy P.T. Ward, Jane Ward, Richard M. Leach
    Serientitel At a glance series
    Mesh-Begriff(e) Respiratory Physiological Phenomena ; Respiratory Tract Diseases ; Respiratory System/physiopathology
    Sprache Englisch
    Umfang xiii, 103 pages :, illustrations
    Ausgabenhinweis Fourth edition.
    Dokumenttyp Buch
    Anmerkung Includes index.
    ISBN 9781118761076 ; 1118761073
    Datenquelle Katalog der US National Library of Medicine (NLM)

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  9. Artikel: A twist in the tail: synergism between mitochondria and NADPH oxidase in the hypoxia-induced elevation of reactive oxygen species in pulmonary artery.

    Ward, Jeremy P T

    Free radical biology & medicine

    2008  Band 45, Heft 9, Seite(n) 1220–1222

    Mesh-Begriff(e) Animals ; Calcium/metabolism ; Gene Expression Regulation, Enzymologic ; Humans ; Hypoxia ; Kinetics ; Mitochondria/metabolism ; Models, Biological ; NADPH Oxidases/metabolism ; Papillomaviridae/metabolism ; Protein Kinase C/metabolism ; Pulmonary Artery/metabolism ; Reactive Oxygen Species
    Chemische Substanzen Reactive Oxygen Species ; NADPH Oxidases (EC 1.6.3.-) ; Protein Kinase C (EC 2.7.11.13) ; Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2008-11-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 807032-5
    ISSN 1873-4596 ; 0891-5849
    ISSN (online) 1873-4596
    ISSN 0891-5849
    DOI 10.1016/j.freeradbiomed.2008.08.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Curiouser and curiouser: the perplexing conundrum of reactive oxygen species and hypoxic pulmonary vasoconstriction.

    Ward, Jeremy P T

    Experimental physiology

    2007  Band 92, Heft 5, Seite(n) 819–820

    Mesh-Begriff(e) Animals ; Humans ; Hypoxia/metabolism ; Hypoxia/physiopathology ; Pulmonary Circulation/physiology ; Reactive Oxygen Species/metabolism ; Vasoconstriction/physiology
    Chemische Substanzen Reactive Oxygen Species
    Sprache Englisch
    Erscheinungsdatum 2007-09
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Comment
    ZDB-ID 1016295-1
    ISSN 1469-445X ; 0958-0670
    ISSN (online) 1469-445X
    ISSN 0958-0670
    DOI 10.1113/expphysiol.2007.038414
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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