Artikel ; Online: Viral vaccines and CTL response.
Journal of biomedicine & biotechnology
2010 Band 2010, Seite(n) 141657
Abstract: Immune induction by successful vaccine formulations seems to involve stimulation of both humoral and cellular arms of immunity. Nevertheless, CD8+ CTLs are of critical relevance in the context of intracellular infection and tumor for many reasons. The ... ...
Abstract | Immune induction by successful vaccine formulations seems to involve stimulation of both humoral and cellular arms of immunity. Nevertheless, CD8+ CTLs are of critical relevance in the context of intracellular infection and tumor for many reasons. The task of exerting antipathogen activity by CD8+ T cells, which principally function to control and eradicate intracellular pathogens, is enabled by constitutive expression of MHC class-I molecules on all tissue types. CTL induction offers hope for vaccines against pathogens that are resistant to neutralizing activity. This review discusses the mechanism of immune induction by some successful vaccines and based on the accrued evidence suggests ideas for improved design of CTL-inducing vaccines. |
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Mesh-Begriff(e) | Acute Disease ; Animals ; B-Lymphocytes/immunology ; Chronic Disease ; Humans ; Lymphocyte Activation/immunology ; T-Lymphocytes, Cytotoxic/immunology ; Viral Vaccines/immunology |
Chemische Substanzen | Viral Vaccines |
Sprache | Englisch |
Erscheinungsdatum | 2010-03-31 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article ; Review |
ZDB-ID | 2052552-7 |
ISSN | 1110-7251 ; 1110-7243 |
ISSN (online) | 1110-7251 |
ISSN | 1110-7243 |
DOI | 10.1155/2010/141657 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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