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  1. Artikel ; Online: Comparative chemical characters of

    Sha, Miao / Li, Xiaohuan / Liu, Yu / Tian, Hongyue / Liang, Xu / Li, Xia / Gao, Wenyuan

    Chinese herbal medicines

    2023  Band 15, Heft 3, Seite(n) 439–446

    Abstract: Objective: Pseudostellaria heterophylla: Methods: In this study, the content of polysaccharide in 28 batches of : Results: The polysaccharide content in Guizhou and Jiangsu was higher than that of other production areas, which varied significant ... ...

    Abstract Objective: Pseudostellaria heterophylla
    Methods: In this study, the content of polysaccharide in 28 batches of
    Results: The polysaccharide content in Guizhou and Jiangsu was higher than that of other production areas, which varied significant from different origins. While the content of heterophyllin B in Anhui and Jiangsu was high. The correlation coefficients of HPLC fingerprints for 28 batches samples ranged from 0.877 to 0.990, and the characteristic map can be used to identify and evaluate the quality of
    Conclusion: HPLC fingerprint was established to evaluate the quality and authenticity of
    Sprache Englisch
    Erscheinungsdatum 2023-03-21
    Erscheinungsland Singapore
    Dokumenttyp Journal Article
    ISSN 2589-3610
    ISSN (online) 2589-3610
    DOI 10.1016/j.chmed.2022.10.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Mesenchymal Stem Cell Therapy in Kidney Diseases

    Fukun Chen / NaNa Chen / Chunjuan Xia / Hongyue Wang / Lishi Shao / Chen Zhou / Jiaping Wang

    Cell Transplantation, Vol

    Potential and Challenges

    2023  Band 32

    Abstract: Kidney disease (KD) is a life-threatening disease characterized by high morbidity and mortality in clinical settings, which can be caused by many reasons, and the incidence increases with age. However, supportive therapy and kidney transplantation still ... ...

    Abstract Kidney disease (KD) is a life-threatening disease characterized by high morbidity and mortality in clinical settings, which can be caused by many reasons, and the incidence increases with age. However, supportive therapy and kidney transplantation still have limitations in alleviating KD progression. Recently, mesenchymal stem cells (MSCs) have shown great potential in repairing injury through their multidirectional differentiation and self-renewal ability. Of note, MSCs serve as a safe and effective therapeutic strategy for treating KD in preclinical and clinical trials. Functionally, MSCs ameliorate KD progression by regulating the immune response, renal tubular cell apoptosis, tubular epithelial–mesenchymal transition, oxidative stress, angiogenesis, and so on. In addition, MSCs exhibit remarkable efficacy in both acute kidney injury (AKI) and chronic kidney disease (CKD) through paracrine mechanisms. In this review, we outline the biological characteristics of MSCs, discuss the efficacy and mechanisms of MSCs-based therapy for KD, summarize the completed and ongoing clinical trials, as well as analyze limitations and new strategies, aiming to provide new ideas and approaches for the preclinical experiments and clinical trials of MSCs transplantation for KD.
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-04-01T00:00:00Z
    Verlag SAGE Publishing
    Dokumenttyp Artikel ; Online
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  3. Artikel ; Online: Mesenchymal Stem Cell Therapy in Kidney Diseases: Potential and Challenges.

    Chen, Fukun / Chen, NaNa / Xia, Chunjuan / Wang, Hongyue / Shao, Lishi / Zhou, Chen / Wang, Jiaping

    Cell transplantation

    2023  Band 32, Seite(n) 9636897231164251

    Abstract: Kidney disease (KD) is a life-threatening disease characterized by high morbidity and mortality in clinical settings, which can be caused by many reasons, and the incidence increases with age. However, supportive therapy and kidney transplantation still ... ...

    Abstract Kidney disease (KD) is a life-threatening disease characterized by high morbidity and mortality in clinical settings, which can be caused by many reasons, and the incidence increases with age. However, supportive therapy and kidney transplantation still have limitations in alleviating KD progression. Recently, mesenchymal stem cells (MSCs) have shown great potential in repairing injury through their multidirectional differentiation and self-renewal ability. Of note, MSCs serve as a safe and effective therapeutic strategy for treating KD in preclinical and clinical trials. Functionally, MSCs ameliorate KD progression by regulating the immune response, renal tubular cell apoptosis, tubular epithelial-mesenchymal transition, oxidative stress, angiogenesis, and so on. In addition, MSCs exhibit remarkable efficacy in both acute kidney injury (AKI) and chronic kidney disease (CKD) through paracrine mechanisms. In this review, we outline the biological characteristics of MSCs, discuss the efficacy and mechanisms of MSCs-based therapy for KD, summarize the completed and ongoing clinical trials, as well as analyze limitations and new strategies, aiming to provide new ideas and approaches for the preclinical experiments and clinical trials of MSCs transplantation for KD.
    Mesh-Begriff(e) Humans ; Mesenchymal Stem Cell Transplantation ; Kidney ; Acute Kidney Injury/therapy ; Mesenchymal Stem Cells ; Renal Insufficiency, Chronic
    Sprache Englisch
    Erscheinungsdatum 2023-04-02
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1135816-6
    ISSN 1555-3892 ; 0963-6897
    ISSN (online) 1555-3892
    ISSN 0963-6897
    DOI 10.1177/09636897231164251
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  4. Artikel ; Online: Adaptive Evolution of the Fox Coronavirus Based on Genome-Wide Sequence Analysis

    Chunyu Feng / Yuting Liu / Guangqi Lyu / Songyang Shang / Hongyue Xia / Junpeng Zhang / David M. Irwin / Zhe Wang / Shuyi Zhang

    BioMed Research International, Vol

    2022  Band 2022

    Abstract: Purpose. To report the first complete fox coronavirus (CoV) genome sequence obtained through genome-wide amplifications and to understand the adaptive evolution of fox CoV. Methods. Anal swab samples were collected from 35 foxes to detect the presence of ...

    Abstract Purpose. To report the first complete fox coronavirus (CoV) genome sequence obtained through genome-wide amplifications and to understand the adaptive evolution of fox CoV. Methods. Anal swab samples were collected from 35 foxes to detect the presence of CoV and obtain the virus sequence. Phylogenetic analysis was conducted using MrBayes. The possibility of recombination within these sequences was assessed using GARD. Analysis of the levels of selection pressure experienced by these sequences was assessed using methods on both the PAML and Data Monkey platforms. Results. Of the 35 samples, two were positive, and complete genome sequences for the viruses were obtained. Phylogenetic analysis, using Bayesian methods, of these sequences, together with other CoV sequences, revealed that the fox CoV sequences clustered with canine coronavirus (CCoV) sequences, with sequences from other carnivores more distantly related. In contrast to the feline, ferret and mink CoV sequences that clustered into species-specific clades, the fox CoV fell within the CCoV clade. Minimal evidence for recombination was found among the sequences. A total of 7, 3, 14, and 2 positively selected sites were identified in the M, N, S, and 7B genes, respectively, with 99, 111, and 581 negatively selected sites identified in M, N, and S genes, respectively. Conclusion. The complete genome sequence of fox CoV has been obtained for the first time. The results suggest that the genome sequence of fox CoV may have experienced adaptive evolution in the genes replication, entry, and virulence. The number of sites in each gene that experienced negative selection is far greater than the number that underwent positive selection, suggesting that most of the sequence is highly conserved and important for viral survive. However, positive selection at a few sites likely aided these viruses to adapt to new environments.
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag Hindawi Limited
    Dokumenttyp Artikel ; Online
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  5. Artikel ; Online: Dose-Response Association Between Bilirubin and Cardiovascular Disease: A Systematic Review and Meta-analysis.

    Zuo, Lei / Huang, Jun / Zhang, Hongyue / Huang, Bing / Wu, Xiaoyi / Chen, Li / Xia, Sujian / Dong, Xiaomei / Hao, Guang

    Angiology

    2022  Band 73, Heft 10, Seite(n) 911–919

    Abstract: The association between bilirubin (BIL) and cardiovascular disease (CVD) remains controversial. We performed a meta-analysis of prospective studies to evaluate this association in the general population. We searched PubMed, EMBASE, Web of Science, ... ...

    Abstract The association between bilirubin (BIL) and cardiovascular disease (CVD) remains controversial. We performed a meta-analysis of prospective studies to evaluate this association in the general population. We searched PubMed, EMBASE, Web of Science, Cochrane, and Scopus databases through to September 2021. The Newcastle-Ottawa Quality Assessment Scale was used to assess study quality. The pooled effect estimate was calculated by the fixed-effect model or random-effect model. We included 12 prospective studies (368 567 participants). The pooled risk ratio of CVD for the lowest vs highest groups of BIL levels was .75 (95% CI: .58-.97) with high heterogeneity (I
    Mesh-Begriff(e) Bilirubin ; Cardiovascular Diseases/epidemiology ; Coronary Disease ; Humans ; Male ; Prospective Studies ; Risk Factors
    Chemische Substanzen Bilirubin (RFM9X3LJ49)
    Sprache Englisch
    Erscheinungsdatum 2022-01-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 80040-5
    ISSN 1940-1574 ; 0003-3197
    ISSN (online) 1940-1574
    ISSN 0003-3197
    DOI 10.1177/00033197211059693
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  6. Artikel ; Online: Adaptive Evolution of the Fox Coronavirus Based on Genome-Wide Sequence Analysis.

    Feng, Chunyu / Liu, Yuting / Lyu, Guangqi / Shang, Songyang / Xia, Hongyue / Zhang, Junpeng / Irwin, David M / Wang, Zhe / Zhang, Shuyi

    BioMed research international

    2022  Band 2022, Seite(n) 9627961

    Abstract: Purpose: To report the first complete fox coronavirus (CoV) genome sequence obtained through genome-wide amplifications and to understand the adaptive evolution of fox CoV.: Methods: Anal swab samples were collected from 35 foxes to detect the ... ...

    Abstract Purpose: To report the first complete fox coronavirus (CoV) genome sequence obtained through genome-wide amplifications and to understand the adaptive evolution of fox CoV.
    Methods: Anal swab samples were collected from 35 foxes to detect the presence of CoV and obtain the virus sequence. Phylogenetic analysis was conducted using MrBayes. The possibility of recombination within these sequences was assessed using GARD. Analysis of the levels of selection pressure experienced by these sequences was assessed using methods on both the PAML and Data Monkey platforms.
    Results: Of the 35 samples, two were positive, and complete genome sequences for the viruses were obtained. Phylogenetic analysis, using Bayesian methods, of these sequences, together with other CoV sequences, revealed that the fox CoV sequences clustered with canine coronavirus (CCoV) sequences, with sequences from other carnivores more distantly related. In contrast to the feline, ferret and mink CoV sequences that clustered into species-specific clades, the fox CoV fell within the CCoV clade. Minimal evidence for recombination was found among the sequences. A total of 7, 3, 14, and 2 positively selected sites were identified in the M, N, S, and 7B genes, respectively, with 99, 111, and 581 negatively selected sites identified in M, N, and S genes, respectively.
    Conclusion: The complete genome sequence of fox CoV has been obtained for the first time. The results suggest that the genome sequence of fox CoV may have experienced adaptive evolution in the genes replication, entry, and virulence. The number of sites in each gene that experienced negative selection is far greater than the number that underwent positive selection, suggesting that most of the sequence is highly conserved and important for viral survive. However, positive selection at a few sites likely aided these viruses to adapt to new environments.
    Mesh-Begriff(e) Animals ; Bayes Theorem ; Cats ; Coronavirus/genetics ; Coronavirus Infections/genetics ; Coronavirus, Canine/genetics ; Dogs ; Ferrets/genetics ; Genome, Viral/genetics ; Phylogeny ; Sequence Analysis, DNA
    Sprache Englisch
    Erscheinungsdatum 2022-04-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2022/9627961
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  7. Artikel ; Online: Heart Development and Regeneration in Non-mammalian Model Organisms

    Jianhong Xia / Zhongxuan Meng / Hongyue Ruan / Wenguang Yin / Yiming Xu / Tiejun Zhang

    Frontiers in Cell and Developmental Biology, Vol

    2020  Band 8

    Abstract: Cardiovascular disease is a serious threat to human health and a leading cause of mortality worldwide. Recent years have witnessed exciting progress in the understanding of heart formation and development, enabling cardiac biologists to make significant ... ...

    Abstract Cardiovascular disease is a serious threat to human health and a leading cause of mortality worldwide. Recent years have witnessed exciting progress in the understanding of heart formation and development, enabling cardiac biologists to make significant advance in the field of therapeutic heart regeneration. Most of our understanding of heart development and regeneration, including the genes and signaling pathways, are driven by pioneering works in non-mammalian model organisms, such as fruit fly, fish, frog, and chicken. Compared to mammalian animal models, non-mammalian model organisms have special advantages in high-throughput applications such as disease modeling, drug discovery, and cardiotoxicity screening. Genetically engineered animals of cardiovascular diseases provide valuable tools to investigate the molecular and cellular mechanisms of pathogenesis and to evaluate therapeutic strategies. A large number of congenital heart diseases (CHDs) non-mammalian models have been established and tested for the genes and signaling pathways involved in the diseases. Here, we reviewed the mechanisms of heart development and regeneration revealed by these models, highlighting the advantages of non-mammalian models as tools for cardiac research. The knowledge from these animal models will facilitate therapeutic discoveries and ultimately serve to accelerate translational medicine.
    Schlagwörter heart ; development ; regeneration ; non-mammalian ; cardiovascular disease ; animal model ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2020-10-01T00:00:00Z
    Verlag Frontiers Media S.A.
    Dokumenttyp Artikel ; Online
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  8. Artikel ; Online: Cationic fructan-based pH and intestinal flora dual stimulation nanoparticle with berberine for targeted therapy of IBD.

    Li, Hongyu / Yang, Wenna / Wu, Xiongzhi / Tian, Luyao / Zhang, Weimei / Tian, Hongyue / Liang, Xu / Huang, Luqi / Guo, Lanping / Li, Xia / Gao, Wenyuan

    International journal of biological macromolecules

    2023  Band 256, Heft Pt 2, Seite(n) 127987

    Abstract: Inflammatory bowel disease (IBD) can cause intestinal microbial imbalance and aggravate intestinal inflammation. Mixed fructan is more easily fermented by colonic microorganisms and can be used as colonic drug delivery materials. Here, we constructed a ... ...

    Abstract Inflammatory bowel disease (IBD) can cause intestinal microbial imbalance and aggravate intestinal inflammation. Mixed fructan is more easily fermented by colonic microorganisms and can be used as colonic drug delivery materials. Here, we constructed a mixed fructan based nanoparticle with dual targeted stimulation of pH and intestinal flora to effectively deliver berberine for the treatment of ulcerative colitis (UC). The complex of fructan based nanoparticle and berberine (BBRNPs) significantly ameliorated the inflammatory response of sodium dextran sulfate (DSS)-induced colitis in mice by inhibiting the activation of NF-κB/STAT-3 pathway and increasing tight junction protein expression in vivo. Importantly, BBRNPs improved the responsiveness of colitis microbiome and effectively regulated the relative homeostasis of harmful flora Enterobacteriaceae and Escherichia-shigolla, and beneficial flora Ruminococcaceae and Akkermansiaceae. This study provides a promising strategy for the effective treatment of UC and expands the application of branched fructan in pharmaceutics.
    Mesh-Begriff(e) Mice ; Animals ; Berberine/pharmacology ; Berberine/metabolism ; Gastrointestinal Microbiome ; Inflammatory Bowel Diseases/drug therapy ; Inflammatory Bowel Diseases/metabolism ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/drug therapy ; Colitis, Ulcerative/metabolism ; Colitis/drug therapy ; Colon ; Hydrogen-Ion Concentration ; Dextran Sulfate/adverse effects ; Disease Models, Animal ; Mice, Inbred C57BL
    Chemische Substanzen Berberine (0I8Y3P32UF) ; Dextran Sulfate (9042-14-2)
    Sprache Englisch
    Erscheinungsdatum 2023-11-17
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.127987
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  9. Artikel ; Online: Comparison of the Kirschner Wire Tension Band with a Novel Nickel-Titanium Arched Shape-Memory Alloy Connector in Transverse Patellar Fractures: A Retrospective Study.

    Wang, Yang / Xia, Demeng / Luo, Xi / Zhang, Hongyue / Wu, Jianghong / Zhou, Panyu / Xu, Shuogui

    The journal of knee surgery

    2020  Band 34, Heft 9, Seite(n) 987–996

    Abstract: This study aims to compare the clinical outcomes of the nickel-titanium arched shape-memory alloy connector (hereafter referred to as the ASC) and tension band fixation for the treatment of transverse patellar fractures. We retrospectively analyzed a ... ...

    Abstract This study aims to compare the clinical outcomes of the nickel-titanium arched shape-memory alloy connector (hereafter referred to as the ASC) and tension band fixation for the treatment of transverse patellar fractures. We retrospectively analyzed a total of 257 patients with transverse patellar fractures who were treated at our emergency orthopaedics department from March 2010 to March 2017. Either an ASC or the Kirschner wire (K-wire) tension band had been used to treat these fractures according to surgeons' experience and preference. We compared operative details, postoperative recovery, and postoperative knee function at 6 months. In terms of surgical duration, blood loss, incision length, length of hospital stay, and postoperative complications, patients in the ASC group showed significantly better results than patients in the K-wire group (
    Mesh-Begriff(e) Bone Wires ; Fracture Fixation, Internal ; Fractures, Bone ; Humans ; Nickel ; Patella/surgery ; Retrospective Studies ; Shape Memory Alloys ; Titanium
    Chemische Substanzen Shape Memory Alloys ; Nickel (7OV03QG267) ; Titanium (D1JT611TNE)
    Sprache Englisch
    Erscheinungsdatum 2020-01-02
    Erscheinungsland Germany
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 2075354-8
    ISSN 1938-2480 ; 1538-8506 ; 0899-7403
    ISSN (online) 1938-2480
    ISSN 1538-8506 ; 0899-7403
    DOI 10.1055/s-0039-3402802
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  10. Artikel ; Online: Calcium silicate bioactive ceramics induce osteogenesis through oncostatin M

    Panyu Zhou / Demeng Xia / Zhexin Ni / Tianle Ou / Yang Wang / Hongyue Zhang / Lixia Mao / Kaili Lin / Shuogui Xu / Jiaqiang Liu

    Bioactive Materials, Vol 6, Iss 3, Pp 810-

    2021  Band 822

    Abstract: Immune reactions are a key factor in determining the destiny of bone substitute materials after implantation. Macrophages, the most vital factor in the immune response affecting implants, are critical in bone formation, as well as bone biomaterial- ... ...

    Abstract Immune reactions are a key factor in determining the destiny of bone substitute materials after implantation. Macrophages, the most vital factor in the immune response affecting implants, are critical in bone formation, as well as bone biomaterial-mediated bone repair. Therefore, it is critical to design materials with osteoimmunomodulatory properties to reduce host-to-material inflammatory responses by inducing macrophage polarization. Our previous study showed that calcium silicate (CS) bioceramics could significantly promote osteogenesis. Herein, we further investigated the effects of CS on the behavior of macrophages and how macrophages regulated osteogenesis. Under CS extract stimulation, the macrophage phenotype was converted to the M2 extreme. Stimulation by a macrophage-conditioned medium that was pretreated by CS extracts resulted in a significant enhancement of osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), indicating the important role of macrophage polarization in biomaterial-induced osteogenesis. Mechanistically, oncostatin M (OSM) in the macrophage-conditioned medium promoted osteogenic differentiation of BMSCs through the ERK1/2 and JAK3 pathways. This in vivo study further demonstrated that CS bioceramics could stimulate osteogenesis better than β-TCP implants by accelerating new bone formation at defective sites in the femur. These findings improve our understanding of immune modulation of CS bioactive ceramics and facilitate strategies to improve the in vitro osteogenesis capability of bone substitute materials.
    Schlagwörter Osteoimmune ; Osteogenesis ; Calcium silicate ; Macrophage ; Macrophage polarization ; Materials of engineering and construction. Mechanics of materials ; TA401-492 ; Biology (General) ; QH301-705.5
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2021-03-01T00:00:00Z
    Verlag KeAi Communications Co., Ltd.
    Dokumenttyp Artikel ; Online
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