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  1. Artikel: Internal m7G methylation: A novel epitranscriptomic contributor in brain development and diseases.

    Xia, Xiaohuan / Wang, Yi / Zheng, Jialin C

    Molecular therapy. Nucleic acids

    2023  Band 31, Seite(n) 295–308

    Abstract: In recent years, N7-methylguanosine (m7G) methylation, originally considered as messenger RNA (mRNA) 5' caps modifications, has been identified at defined internal positions within multiple types of RNAs, including transfer RNAs, ribosomal RNAs, miRNA, ... ...

    Abstract In recent years, N7-methylguanosine (m7G) methylation, originally considered as messenger RNA (mRNA) 5' caps modifications, has been identified at defined internal positions within multiple types of RNAs, including transfer RNAs, ribosomal RNAs, miRNA, and mRNAs. Scientists have put substantial efforts to discover m7G methyltransferases and methylated sites in RNAs to unveil the essential roles of m7G modifications in the regulation of gene expression and determine the association of m7G dysregulation in various diseases, including neurological disorders. Here, we review recent findings regarding the distribution, abundance, biogenesis, modifiers, and functions of m7G modifications. We also provide an up-to-date summary of m7G detection and profile mapping techniques, databases for validated and predicted m7G RNA sites, and web servers for m7G methylation prediction. Furthermore, we discuss the pathological roles of METTL1/WDR-driven m7G methylation in neurological disorders. Last, we outline a roadmap for future directions and trends of m7G modification research, particularly in the central nervous system.
    Sprache Englisch
    Erscheinungsdatum 2023-01-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2662631-7
    ISSN 2162-2531
    ISSN 2162-2531
    DOI 10.1016/j.omtn.2023.01.003
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Deciphering the behavior and potential mechanism of biochar at different pyrolysis temperatures to alleviate membrane biofouling.

    Yang, Xiaohuan / Xia, Silian / Hao, Litu / Tian, Duanyun / Wang, Lianxu / Chen, Rong

    The Science of the total environment

    2024  Band 924, Seite(n) 171638

    Abstract: Biofouling limits applications of membrane technology in wastewater treatment, but dosing additives to membrane tanks is an effective method to alleviate biofouling. In this study, biochar derived from corncob and pyrolyzed at 300, 500, and 700°C was ... ...

    Abstract Biofouling limits applications of membrane technology in wastewater treatment, but dosing additives to membrane tanks is an effective method to alleviate biofouling. In this study, biochar derived from corncob and pyrolyzed at 300, 500, and 700°C was dosed to determine the underlying anti-biofouling mechanism. The effects of the biochar on the membrane properties and foulant behavior were systematically investigated. The results showed that biochar delayed the occurrence of the fouling transition (0.5-3.0 h), and decreased the flux decline rate, thus achieving a higher water flux (3.1-3.7 times of the control group). Biochar altered membrane surface properties, and increased the membrane surface charge, roughness, and hydrophilicity, which all contributed to higher membrane permeability. Moreover, adding biochar reduced the number of foulants in the fouling layer, particularly protein substances. The flux model fit and the XDLVO theory further revealed the mitigating effect of biochar on membrane biofouling. At the initial intermediate-blocking stage, the effect of biochar on membrane fouling was determined by its properties, and adsorption capacity to the foulants, BC500 presented the best mitigation performance. At the later cake-filtration stage, the role of biochar in membrane fouling was strongly associated with protein content in the fouling layer, and the minimum rate of flux decline occurred in BC300. This study promotes the understanding and development of biochar to alleviate membrane biofouling.
    Mesh-Begriff(e) Biofouling/prevention & control ; Pyrolysis ; Temperature ; Membranes, Artificial ; Water Purification/methods ; Charcoal
    Chemische Substanzen biochar ; Membranes, Artificial ; Charcoal (16291-96-6)
    Sprache Englisch
    Erscheinungsdatum 2024-03-12
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171638
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 949: Hefte anzeigen Standort:
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  3. Artikel: Pyrimidine metabolism regulator-mediated molecular subtypes display tumor microenvironmental hallmarks and assist precision treatment in bladder cancer.

    Wu, Zixuan / Li, Xiaohuan / Gu, Zhenchang / Xia, Xinhua / Yang, Jing

    Frontiers in oncology

    2023  Band 13, Seite(n) 1102518

    Abstract: Background: Bladder cancer (BLCA) is a common urinary system malignancy with a significant morbidity and death rate worldwide. Non-muscle invasive BLCA accounts for over 75% of all BLCA cases. The imbalance of tumor metabolic pathways is associated with ...

    Abstract Background: Bladder cancer (BLCA) is a common urinary system malignancy with a significant morbidity and death rate worldwide. Non-muscle invasive BLCA accounts for over 75% of all BLCA cases. The imbalance of tumor metabolic pathways is associated with tumor formation and proliferation. Pyrimidine metabolism (PyM) is a complex enzyme network that incorporates nucleoside salvage,
    Methods: Predictive PyMGs were quantified in BLCA samples from the TCGA and GEO datasets. TCGA and GEO provided information on stemness indices (mRNAsi), gene mutations, CNV, TMB, and corresponding clinical features. The prediction model was built using Lasso regression. Co-expression analysis was conducted to investigate the relationship between gene expression and PyM.
    Results: PyMGs were overexpressed in the high-risk sample in the absence of other clinical symptoms, demonstrating their predictive potential for BLCA outcome. Immunological and tumor-related pathways were identified in the high-risk group by GSWA. Immune function and m6a gene expression varied significantly between the risk groups. In BLCA patients, DSG1, C6orf15, SOST, SPRR2A, SERPINB7, MYBPH, and KRT1 may participate in the oncology process. Immunological function and m6a gene expression differed significantly between the two groups. The prognostic model, CNVs, single nucleotide polymorphism (SNP), and drug sensitivity all showed significant gene connections.
    Conclusions: BLCA-associated PyMGs are available to provide guidance in the prognostic and immunological setting and give evidence for the formulation of PyM-related molecularly targeted treatments. PyMGs and their interactions with immune cells in BLCA may serve as therapeutic targets.
    Sprache Englisch
    Erscheinungsdatum 2023-08-17
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1102518
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Comparative chemical characters of

    Sha, Miao / Li, Xiaohuan / Liu, Yu / Tian, Hongyue / Liang, Xu / Li, Xia / Gao, Wenyuan

    Chinese herbal medicines

    2023  Band 15, Heft 3, Seite(n) 439–446

    Abstract: Objective: Pseudostellaria heterophylla: Methods: In this study, the content of polysaccharide in 28 batches of : Results: The polysaccharide content in Guizhou and Jiangsu was higher than that of other production areas, which varied significant ... ...

    Abstract Objective: Pseudostellaria heterophylla
    Methods: In this study, the content of polysaccharide in 28 batches of
    Results: The polysaccharide content in Guizhou and Jiangsu was higher than that of other production areas, which varied significant from different origins. While the content of heterophyllin B in Anhui and Jiangsu was high. The correlation coefficients of HPLC fingerprints for 28 batches samples ranged from 0.877 to 0.990, and the characteristic map can be used to identify and evaluate the quality of
    Conclusion: HPLC fingerprint was established to evaluate the quality and authenticity of
    Sprache Englisch
    Erscheinungsdatum 2023-03-21
    Erscheinungsland Singapore
    Dokumenttyp Journal Article
    ISSN 2589-3610
    ISSN (online) 2589-3610
    DOI 10.1016/j.chmed.2022.10.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Neural stem/progenitor cell‐derived extracellular vesicles

    Xiangyu Li / Yingbo Zhu / Yi Wang / Xiaohuan Xia / Jialin C. Zheng

    MedComm, Vol 4, Iss 1, Pp n/a-n/a (2023)

    A novel therapy for neurological diseases and beyond

    2023  

    Abstract: Abstract As bilayer lipid membrane vesicles secreted by neural stem/progenitor cells (NSCs), NSC‐derived extracellular vesicles (NSC‐EVs) have attracted growing attention for their promising potential to serve as novel therapeutic agents in treatment of ... ...

    Abstract Abstract As bilayer lipid membrane vesicles secreted by neural stem/progenitor cells (NSCs), NSC‐derived extracellular vesicles (NSC‐EVs) have attracted growing attention for their promising potential to serve as novel therapeutic agents in treatment of neurological diseases due to their unique physicochemical characteristics and biological functions. NSC‐EVs exhibit advantages such as stable physical and chemical properties, low immunogenicity, and high penetration capacity to cross blood–brain barrier to avoid predicaments of the clinical applications of NSCs that include autoimmune responses, ethical/religious concerns, and the problematic logistics of acquiring fetal tissues. More importantly, NSC‐EVs inherit excellent neuroprotective and neuroregenerative potential and immunomodulatory capabilities from parent cells, and display outstanding therapeutic effects on mitigating behavioral alterations and pathological phenotypes of patients or animals with neurological diseases. In this review, we first comprehensively summarize the progress in functional research and application of NSC‐EVs in different neurological diseases, including neurodegenerative diseases, acute neurological diseases, dementia/cognitive dysfunction, and peripheral diseases. Next, we provide our thoughts on current limitations/concerns as well as tremendous potential of NSC‐EVs in clinical applications. Last, we discuss future directions of further investigations on NSC‐EVs and their probable applications in both basic and clinical research.
    Schlagwörter exosomes ; extracellular vesicle ; neural stem/progenitor cell ; neuroinflammation ; neurological disease ; neuroregeneration ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2023-02-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Artikel: Cognitive dysfunction of patients infected with SARS-CoV-2 omicron variant in Shanghai, China.

    Yuan, Ping / Bi, Yong / Luo, Yu / Tao, Quan / Gong, Sugang / Wang, Yi / Xiong, Lize / Xia, Xiaohuan / Zheng, Jialin C

    Translational neurodegeneration

    2023  Band 12, Heft 1, Seite(n) 28

    Mesh-Begriff(e) Humans ; SARS-CoV-2 ; China/epidemiology ; COVID-19 ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/epidemiology ; Cognitive Dysfunction/genetics
    Sprache Englisch
    Erscheinungsdatum 2023-05-24
    Erscheinungsland England
    Dokumenttyp Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2653701-1
    ISSN 2047-9158
    ISSN 2047-9158
    DOI 10.1186/s40035-023-00357-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: SIRT2 regulates apoptosis by inducing mitophagy in sheep cumulus cells.

    Fang, Xiaohuan / Xia, Wei / Qi, Yatian / Yu, Yang / Sun, Qingyi / Zhang, Di / Zhou, Zhenmin / Qin, Tianmiao / Tao, Chenyu / Li, Junjie

    Theriogenology

    2024  Band 218, Seite(n) 163–173

    Abstract: Cumulus cells surrounding oocytes furnish nutritional support crucial for oocyte maturation in vitro, and thereby enhance oocyte quality significantly. Our previous studies affirmed the role of SIRT2 in regulation of mitochondrial function in sheep ... ...

    Abstract Cumulus cells surrounding oocytes furnish nutritional support crucial for oocyte maturation in vitro, and thereby enhance oocyte quality significantly. Our previous studies affirmed the role of SIRT2 in regulation of mitochondrial function in sheep granulosa cells. However, the effect of SIRT2 action on mitophagy in these cells remain unclear. Here, RNA-seq was used to scrutinize pathways where differentially expressed genes (DEGs) are enriched following SIRT2 knockdown in cumulus cells. Prior to SIRT2 knock down, cumulus cells were treated with the mitophagy inhibitor Mdivi-1. Potential mechanisms by which SIRT2 affects apoptosis via mitophagy were explored. Results indicated that DEGs after SIRT2 knockdown were enriched in various pathways including mitochondria, mitophagy, and apoptosis. The expression levels of CASP3/CASP9 were significantly increased after mitophagy activation (P < 0.01), whereas inhibition of mitophagy had no effect on apoptosis (P > 0.05). Pretreatment of cumulus cells with Mdivi-1 prior to SIRT2 knockdown significantly reduced the expression of mitophagy-related genes, the number of autolysosomes, the expression of CASP3/CASP9, and the levels of Ca
    Mesh-Begriff(e) Female ; Animals ; Sheep/genetics ; Mitophagy/genetics ; Cumulus Cells/physiology ; Caspase 3/metabolism ; Sirtuin 2/metabolism ; Oocytes/physiology ; Apoptosis ; DNA, Mitochondrial
    Chemische Substanzen Caspase 3 (EC 3.4.22.-) ; Sirtuin 2 (EC 3.5.1.-) ; DNA, Mitochondrial
    Sprache Englisch
    Erscheinungsdatum 2024-02-03
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 189232-0
    ISSN 1879-3231 ; 0093-691X
    ISSN (online) 1879-3231
    ISSN 0093-691X
    DOI 10.1016/j.theriogenology.2024.02.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 3929: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Artikel ; Online: Human learning of hierarchical graphs.

    Xia, Xiaohuan / Klishin, Andrei A / Stiso, Jennifer / Lynn, Christopher W / Kahn, Ari E / Caciagli, Lorenzo / Bassett, Dani S

    Physical review. E

    2024  Band 109, Heft 4-1, Seite(n) 44305

    Abstract: Humans are exposed to sequences of events in the environment, and the interevent transition probabilities in these sequences can be modeled as a graph or network. Many real-world networks are organized hierarchically and while much is known about how ... ...

    Abstract Humans are exposed to sequences of events in the environment, and the interevent transition probabilities in these sequences can be modeled as a graph or network. Many real-world networks are organized hierarchically and while much is known about how humans learn basic transition graph topology, whether and to what degree humans can learn hierarchical structures in such graphs remains unknown. We probe the mental estimates of transition probabilities via the surprisal effect phenomenon: humans react more slowly to less expected transitions. Using mean-field predictions and numerical simulations, we show that surprisal effects are stronger for finer-level than coarser-level hierarchical transitions, and that surprisal effects at coarser levels are difficult to detect for limited learning times or in small samples. Using a serial response experiment with human participants (n=100), we replicate our predictions by detecting a surprisal effect at the finer level of the hierarchy but not at the coarser level of the hierarchy. We then evaluate the presence of a trade-off in learning, whereby humans who learned the finer level of the hierarchy better also tended to learn the coarser level worse, and vice versa. This study elucidates the processes by which humans learn sequential events in hierarchical contexts. More broadly, our work charts a road map for future investigation of the neural underpinnings and behavioral manifestations of graph learning.
    Mesh-Begriff(e) Humans ; Learning ; Male ; Female ; Models, Theoretical ; Probability ; Adult
    Sprache Englisch
    Erscheinungsdatum 2024-05-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.109.044305
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Mitochondrial dysfunction in microglia: a novel perspective for pathogenesis of Alzheimer's disease.

    Li, Yun / Xia, Xiaohuan / Wang, Yi / Zheng, Jialin C

    Journal of neuroinflammation

    2022  Band 19, Heft 1, Seite(n) 248

    Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly globally. Emerging evidence has demonstrated microglia-driven neuroinflammation as a key contributor to the onset and progression of AD, however, the mechanisms that ... ...

    Abstract Alzheimer's disease (AD) is the most common neurodegenerative disease in the elderly globally. Emerging evidence has demonstrated microglia-driven neuroinflammation as a key contributor to the onset and progression of AD, however, the mechanisms that mediate neuroinflammation remain largely unknown. Recent studies have suggested mitochondrial dysfunction including mitochondrial DNA (mtDNA) damage, metabolic defects, and quality control (QC) disorders precedes microglial activation and subsequent neuroinflammation. Therefore, an in-depth understanding of the relationship between mitochondrial dysfunction and microglial activation in AD is important to unveil the pathogenesis of AD and develop effective approaches for early AD diagnosis and treatment. In this review, we summarized current progress in the roles of mtDNA, mitochondrial metabolism, mitochondrial QC changes in microglial activation in AD, and provide comprehensive thoughts for targeting microglial mitochondria as potential therapeutic strategies of AD.
    Mesh-Begriff(e) Aged ; Alzheimer Disease/pathology ; DNA, Mitochondrial/genetics ; Humans ; Microglia/metabolism ; Mitochondria/metabolism ; Neurodegenerative Diseases/metabolism
    Chemische Substanzen DNA, Mitochondrial
    Sprache Englisch
    Erscheinungsdatum 2022-10-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2156455-3
    ISSN 1742-2094 ; 1742-2094
    ISSN (online) 1742-2094
    ISSN 1742-2094
    DOI 10.1186/s12974-022-02613-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Astrocytes: GABAceptive and GABAergic Cells in the Brain.

    Liu, Jianhui / Feng, Xuanran / Wang, Yi / Xia, Xiaohuan / Zheng, Jialin C

    Frontiers in cellular neuroscience

    2022  Band 16, Seite(n) 892497

    Abstract: Astrocytes, the most numerous glial cells in the brain, play an important role in preserving normal neural functions and mediating the pathogenesis of neurological disorders. Recent studies have shown that astrocytes are GABAceptive and GABAergic ... ...

    Abstract Astrocytes, the most numerous glial cells in the brain, play an important role in preserving normal neural functions and mediating the pathogenesis of neurological disorders. Recent studies have shown that astrocytes are GABAceptive and GABAergic astrocytes express GABA
    Sprache Englisch
    Erscheinungsdatum 2022-06-10
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2022.892497
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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