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  1. Artikel ; Online: Neural correlates of willingness to pay for items: A meta-analysis of functional magnetic resonance imaging studies.

    Wang, Yiwen / Yao, Xiaoqiang

    Physiology & behavior

    2024  Band 278, Seite(n) 114481

    Abstract: Willingness to pay (WTP) pervades every marketplace transaction, therefore, understanding how the brain makes bidding decisions is essential in consumer neuroscience. Although some neuroimaging studies have investigated the neural networks of WTP, ... ...

    Abstract Willingness to pay (WTP) pervades every marketplace transaction, therefore, understanding how the brain makes bidding decisions is essential in consumer neuroscience. Although some neuroimaging studies have investigated the neural networks of WTP, systematic understanding remains limited. This study identified reliable neural networks activated by the WTP across different reward types and assessed common and distinct neural networks for different reward types (food and other) bids. We conducted an activation likelihood estimation (ALE) meta-analysis on WTP across different reward types (25 studies; 254 foci; 705 participants), and to compared neural representations of WTP for food reward (22 studies; 232 foci; 628 participants) and other rewards (7 studies, 61 foci; 177 participants). The ALE results revealed that the brain centers of WTP for different rewards mainly consist of the bilateral inferior frontal gyrus (IFG), bilateral insula, bilateral anterior cingulate cortex (ACC), along with the left caudate. This suggests that neural networks encoding WTP for different rewards consist of brain regions associated with reward processing, cost-benefit calculations, and goal-directed action activities. In addition, consistent activation of the bilateral IFG and bilateral insula for food but no other rewards bids suggest their involvement in the neural network of appetite. WTP for food and other rewards commonly activated ACC, suggesting a common region encoding bids for different rewards. Our findings provide novel insights into neural networks associated with WTP for food and other rewards bids and the mechanisms underlying WTP across different reward types.
    Mesh-Begriff(e) Humans ; Brain/physiology ; Magnetic Resonance Imaging ; Prefrontal Cortex/physiology ; Neuroimaging ; Head ; Reward ; Brain Mapping
    Sprache Englisch
    Erscheinungsdatum 2024-02-16
    Erscheinungsland United States
    Dokumenttyp Meta-Analysis ; Journal Article
    ZDB-ID 3907-x
    ISSN 1873-507X ; 0031-9384
    ISSN (online) 1873-507X
    ISSN 0031-9384
    DOI 10.1016/j.physbeh.2024.114481
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: TRP Channels in Oxidative Stress Signalling

    Lin-Hua Jiang / Xiaoqiang Yao / Bilal Çiğ

    Cells, Vol 12, Iss 1251, p

    2023  Band 1251

    Abstract: It is well established that the accumulation of high levels of reactive oxygen species (ROS), due to excessive generation of ROS and/or impaired antioxidant capacity of cells, can result in oxidative stress and cause oxidative damage to cells and their ... ...

    Abstract It is well established that the accumulation of high levels of reactive oxygen species (ROS), due to excessive generation of ROS and/or impaired antioxidant capacity of cells, can result in oxidative stress and cause oxidative damage to cells and their functions [.]
    Schlagwörter n/a ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2023-04-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: TRP Channels in Oxidative Stress Signalling.

    Jiang, Lin-Hua / Yao, Xiaoqiang / Çiğ, Bilal

    Cells

    2023  Band 12, Heft 9

    Abstract: It is well established that the accumulation of high levels of reactive oxygen species (ROS), due to excessive generation of ROS and/or impaired antioxidant capacity of cells, can result in oxidative stress and cause oxidative damage to cells and their ... ...

    Abstract It is well established that the accumulation of high levels of reactive oxygen species (ROS), due to excessive generation of ROS and/or impaired antioxidant capacity of cells, can result in oxidative stress and cause oxidative damage to cells and their functions [...].
    Mesh-Begriff(e) Reactive Oxygen Species ; Oxidative Stress ; Antioxidants/metabolism ; Signal Transduction
    Chemische Substanzen Reactive Oxygen Species ; Antioxidants
    Sprache Englisch
    Erscheinungsdatum 2023-04-26
    Erscheinungsland Switzerland
    Dokumenttyp Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells12091251
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Free iliac crest grafting technology for the management of critical-sized tibial bone defect.

    Cheng, Xiaoqiang / Yao, Yilun / Liu, Kang / Wu, Lei / Yang, Wengbo

    BMC musculoskeletal disorders

    2024  Band 25, Heft 1, Seite(n) 201

    Abstract: Objective: To introduce the method and experience of treating critical-sized tibial bone defect by taking large iliac crest bone graft.: Methods: From January 2020 to January 2022, iliac crest bone grafting was performed in 20 patients (10 men and 10 ...

    Abstract Objective: To introduce the method and experience of treating critical-sized tibial bone defect by taking large iliac crest bone graft.
    Methods: From January 2020 to January 2022, iliac crest bone grafting was performed in 20 patients (10 men and 10 women) with critical-sized tibial bone defect. The mean length of bone defect was 13.59 ± 3.41. Bilateral iliac crest grafts were harvested, including the inner and outer plates of the iliac crest and iliac spine. The cortical bone screw was used to integrate two iliac bone blocks into one complex. Locking plate was used to fix the graft-host complex, supplemented with reconstruction plate to increase stability when necessary. Bone healing was evaluated by cortical bone fusion on radiographs at follow-up, iliac pain was assessed by VAS score, and lower limb function was assessed by ODI score. Complications were also taken into consideration.
    Results: The average follow-up time was 27.4 ± 5.6 (Range 24-33 months), the mean VAS score was 8.8 ± 1.9, the mean ODI score was 11.1 ± 1.8, and the number of cortical bone fusion in the bone graft area was 3.5 ± 0.5. Satisfactory fusion was obtained in all cases of iliac bone transplant-host site. No nonunion, shift or fracture was found in all cases. No infection and bone resorption were observed that need secondary surgery. One patient had dorsiflexion weakness of the great toe. Hypoesthesia of the dorsal foot was observed in 2 patients. Ankle stiffness and edema occurred in 3 patients. Complications were significantly improved by physical therapy and rehabilitation training.
    Conclusion: For the cases of critical-sized tibial bone defect, the treatment methods are various. In this paper, we have obtained satisfactory results by using large iliac bone graft to treat bone defect. This approach can not only restore the integrity of the tibia, but also obtain good stability with internal fixation, and operation skills are more acceptable for surgeons. Therefore, it provides an alternative surgical method for clinicians.
    Mesh-Begriff(e) Male ; Humans ; Female ; Tibia/diagnostic imaging ; Tibia/surgery ; Ilium/transplantation ; Fractures, Bone ; Fracture Fixation, Internal ; Plastic Surgery Procedures ; Bone Transplantation/methods ; Treatment Outcome
    Sprache Englisch
    Erscheinungsdatum 2024-03-07
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2041355-5
    ISSN 1471-2474 ; 1471-2474
    ISSN (online) 1471-2474
    ISSN 1471-2474
    DOI 10.1186/s12891-024-07335-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Relationship between anion gap and in-hospital mortality in intensive care patients with liver failure: a retrospective propensity score matching analysis.

    Yu, Wei / Wen, Yao / Shao, Yu / Hu, Tianyang / Wan, Xiaoqiang

    American journal of translational research

    2024  Band 16, Heft 1, Seite(n) 98–108

    Abstract: Objectives: To elucidate the association between anion gap (AG) and in-hospital mortality in intensive care patients with liver failure.: Methods: Demographic and clinical characteristics of intensive care patients with liver failure in the Medical ... ...

    Abstract Objectives: To elucidate the association between anion gap (AG) and in-hospital mortality in intensive care patients with liver failure.
    Methods: Demographic and clinical characteristics of intensive care patients with liver failure in the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database were collected, and binomial logistic and Cox regression was conducted to investigate the association between AG and in-hospital mortality. The area under the receiver operating characteristic (ROC) curve (AUC) was conducted to characterize the performance of AG in predicting in-hospital mortality, and was compared with the albumin corrected anion gap (ACAG) and the End-Stage Liver Disease (MELD) score. The Kaplan-Meier curve was plotted for in-hospital survival analysis of AG and patients with liver failure. The propensity score matching (PSM) analysis was performed to mitigate selection bias.
    Results: AG was an independent risk factor for in-hospital mortality in intensive care patients with liver failure. Before PSM, the AUCs of AG, ACAG, and MELD were 0.666, 0.682, and 0.653, respectively. After PSM, the AUCs of AG, ACAG, and MELD scores were 0.645, 0.657, and 0.645, respectively, and there is no difference in the predictive performance of the three indicators upon comparison. Compared with the low-AG (≤20 mmol/L) group, the hazard ratio (HR) for in-hospital death of the high-AG (>20 mmol/L) group was determined to be 2.1472 (before PSM)/1.8890 (after PSM).
    Conclusions: AG is associated with in-hospital mortality in intensive care patients with liver failure and demonstrates a moderate predictive value, which is comparable to the predictive power of the MELD score. AG may serve as an indirect marker of in-hospital mortality of patients with liver failure by reflecting the degree of metabolic acidosis.
    Sprache Englisch
    Erscheinungsdatum 2024-01-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Efficacy of laser photocoagulation plus ranibizumab in patients with diabetic retinopathy and their effect on VEGF.

    Zhou, Xiaoqiang / Yu, Guoxiao / Yao, Li

    American journal of translational research

    2023  Band 15, Heft 1, Seite(n) 193–201

    Abstract: Objective: To investigate the efficacy of laser photocoagulation combined with ranibizumab in patients with diabetic retinopathy and their effect on VEGF.: Methods: The medical records of 98 patients with diabetic retinopathy treated in the First ... ...

    Abstract Objective: To investigate the efficacy of laser photocoagulation combined with ranibizumab in patients with diabetic retinopathy and their effect on VEGF.
    Methods: The medical records of 98 patients with diabetic retinopathy treated in the First People's Hospital of Linping District from February 2020 to January 2022 were collected for a retrospective analysis. Among them, 48 patients treated with laser photocoagulation were a control group (CG), and another 50 treated with laser photocoagulation combined with ranibizumab were an observation group (OG). The treatment efficacy, best corrected visual acuity (BCVA), central macular concave thickness (CMT), and change in neovascularization area were compared between the two groups. Also, the changes in serum vascular endothelial growth factor (VEGF), homocysteine (HCY), vitamin B12 and folic acid were compared. The adverse effects that occurred with treatment were assessed. The relationship of pre-treatment BCVA, CMT, neovascularization area and VEGF levels with clinical outcomes were observed, and their predictive values were analyzed by receiver operating characteristic (ROC) curve.
    Results: The total response rate of patients in the CG was lower than that in the OG (P<0.05). The BCVA, CMT, and neovascularization area were dramatically lower, while vitamin B12 and folic acid were markedly higher in the OG than in the CG after treatment (P<0.05). There was no statistical difference in adverse reactions between the two groups (P>0.05). In patients with effective response, the BCVA, CMT, VEGF and Hcy before treatment were dramatically lower than in those with ineffective response (P<0.05), while the neovascularization area, vitamin B12, and folic acid did not differ between them before treatment (P>0.05). ROC curve analysis revealed that the areas under the curve of BCVA, CMT, VEGF and Hcy were all greater than 0.7 for predicting patient outcomes, and the area under the curve of the combination of the above indexes was 0.945, with a specificity of 92.30% and sensitivity of 88.23%.
    Conclusion: Laser photocoagulation combined with ranibizumab may provide good therapeutic efficacy in diabetic retinopathy, by effectively improving neovascularization and reducing VEGF levels to control further progression of the lesions.
    Sprache Englisch
    Erscheinungsdatum 2023-01-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
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  7. Artikel ; Online: Correction: Fusaric acid inhibits proliferation and induces apoptosis through triggering endoplasmic reticulum stress in MCF-7 human breast cancer cells.

    Zhang, Jun / Yuan, Huikai / Li, Wei / Chen, Shuo / Liu, Siwen / Li, Chunyu / Yao, Xiaoqiang

    Mycotoxin research

    2023  Band 39, Heft 4, Seite(n) 365

    Sprache Englisch
    Erscheinungsdatum 2023-09-04
    Erscheinungsland Germany
    Dokumenttyp Published Erratum
    ZDB-ID 14500-2
    ISSN 1867-1632 ; 0178-7888
    ISSN (online) 1867-1632
    ISSN 0178-7888
    DOI 10.1007/s12550-023-00503-4
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Synergistic effects and competitive relationships between DOC and DOX as acting on DNA molecules: Studied with confocal Raman spectroscopy and molecular docking technology.

    Zhou, Suli / Feng, Xiaoqiang / Bai, Jintao / Sun, Dan / Yao, Baoli / Wang, Kaige

    Heliyon

    2024  Band 10, Heft 9, Seite(n) e30233

    Abstract: Docetaxel (DOC) is one of the second-generation antineoplastic drugs of the taxanes family with excellent antitumor activity. However, the mechanism of DOC inducing tumor cell apoptosis and treating cancer diseases, especially its interaction with DNA in ...

    Abstract Docetaxel (DOC) is one of the second-generation antineoplastic drugs of the taxanes family with excellent antitumor activity. However, the mechanism of DOC inducing tumor cell apoptosis and treating cancer diseases, especially its interaction with DNA in the nucleus, and its adjuvant or combined Doxorubicin (DOX) acting on DNA molecules are unclear. In this study, the interaction mechanism between DOC and DNA, as well as the synergistic effects and competitive relationships among DOC and DOX when they simultaneously interact with DNA molecules were studied by laser confocal Raman spectroscopy combined with UV-visible absorption spectroscopy and molecular docking technology. The spectroscopic results showed that the binding constant of DOC to DNA is 5.25 × 10
    Sprache Englisch
    Erscheinungsdatum 2024-04-23
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e30233
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Preliminary study on the role of the CSMD2 gene in bladder cancer

    Zhijun Yao / Hailang Yang / Xiaoqiang Liu / Ming Jiang / Wen Deng / Bin Fu

    Heliyon, Vol 10, Iss 1, Pp e22593- (2024)

    1481  

    Abstract: Background: CSMD2 has been reported as a potential prognostic factor in several cancers. However, whether CSMD2 affects bladder cancer (BC) remains unclear. Methods: Public data were obtained from the TCGA (https://cancergenome.nih.gov) databases. ... ...

    Abstract Background: CSMD2 has been reported as a potential prognostic factor in several cancers. However, whether CSMD2 affects bladder cancer (BC) remains unclear. Methods: Public data were obtained from the TCGA (https://cancergenome.nih.gov) databases. CSMD2expression and its prognostic value were analyzed using bioinformatics methods. CSMD2 mRNA level in patients with BC and BC cell lines was evaluated via quantitative reverse transcriptase polymerase chain reaction. CSMD2 protein level in patients with BC was evaluated via immunohistochemistry. BC cell lines T24 and UMUC-3 were selected for loss-of-function assays targeting CSMD2. Cell viability was determined by CCK8 and clone formation experiments. Cell migration and invasion were evaluated using Transwell assays. Furthermore, the transcriptome of UMUC-3 with CSMD2 knockdown was sequenced to analyze potential signaling network pathways. Finally, the TIMER2.0 database was employed to identify the correlation between CSMD2 and immune cells in the tumor microenvironment. Results: CSMD2 expression was up-regulated in BC tissues compared to adjacent tissues. High CSMD2 expression was associated with poor survival and could serve as an independent predictor for survival in patients with BC. Furthermore, down-regulation of CSMD2 notably restrained the viability, migration, and invasion abilities of T24 and UMUC-3 cells. Moreover, transcriptomic sequencing after CSMD2 knockdown in UMUC-3 cells revealed its involvement in the regulation of the malignant phenotype in BC. Finally, public databases suggest a connection between CSMD2 and immune cell infiltration in BC. Conclusions: These findings suggest that CSMD2 may promote proliferation and tumorigenicity, and could represent a potential target for improving the prognosis of BC.
    Schlagwörter CSMD2 ; Prognostic marker ; Bladder cancer ; Biomarker ; Immune cells ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Thema/Rubrik (Code) 616
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Transient receptor potential vanilloid 1 involved in the analgesic effects of total flavonoids extracted from Longxuejie ().

    Xiaoqiang, M O / Yating, Chen / Qian, Yin / Haibo, Chen / Qiang, Ban / Jun, L I / Su, Chen / Jinguang, Yao

    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

    2024  Band 44, Heft 3, Seite(n) 437–447

    Abstract: Objective: To evaluate the analgesic effects of total flavonoids of Longxuejie (: Methods: Whole-cell patch clamp technique was used to observe the effects of TFDB on capsaicin-induced TRPV1 currents. Rat experiments : Results: Results showed that ...

    Abstract Objective: To evaluate the analgesic effects of total flavonoids of Longxuejie (
    Methods: Whole-cell patch clamp technique was used to observe the effects of TFDB on capsaicin-induced TRPV1 currents. Rat experiments
    Results: Results showed that TFDB inhibited capsaicin-induced TRPV1 receptor currents in acutely isolated dorsal root ganglion (DRG) neurons of rats and the half inhibitory concentration was (16.7 ± 1.6) mg/L. TFDB (2-20 mg/kg) showed analgesic activity in the phase Ⅱ of formalin test and (0.02-2 mg per paw) reduced capsaicin-induced licking times of rats. TFDB (20 mg/kg) was fully efficacious on complete Freund's adjuvant (CFA)-induced inflammatory thermal hyperalgesia and capsaicin could weaken the analgesic effects. The level of TRPV1 expressions of DRG neurons was also decreased in TFDB-treated CFA-inflammatory pain rats.
    Conclusion: All these results indicated that the analgesic effect of TFDB may contribute to their modulations on both function and expression of TRPV1 channels in DRG neurons.
    Mesh-Begriff(e) Animals ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism ; Rats ; Flavonoids/pharmacology ; Analgesics/pharmacology ; Analgesics/chemistry ; Male ; Rats, Sprague-Dawley ; Ganglia, Spinal/drug effects ; Ganglia, Spinal/metabolism ; Ganglia, Spinal/cytology ; Humans ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/chemistry ; Neurons/drug effects ; Neurons/metabolism ; Pain/drug therapy ; Pain/metabolism
    Chemische Substanzen Trpv1 protein, rat
    Sprache Englisch
    Erscheinungsdatum 2024-05-20
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 603186-9
    ISSN 2589-451X ; 0254-6272 ; 0255-2922
    ISSN (online) 2589-451X ; 0254-6272
    ISSN 0255-2922
    DOI 10.19852/j.cnki.jtcm.20240423.004
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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