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  1. Artikel ; Online: Research progress of autoimmune diseases based on induced pluripotent stem cells.

    Ren, Rutong / Jiang, Jinhe / Li, Xinxin / Zhang, Guirong

    Frontiers in immunology

    2024  Band 15, Seite(n) 1349138

    Abstract: Autoimmune diseases can damage specific or multiple organs and tissues, influence the quality of life, and even cause disability and death. A 'disease in a dish' can be developed based on patients-derived induced pluripotent stem cells (iPSCs) and iPSCs- ... ...

    Abstract Autoimmune diseases can damage specific or multiple organs and tissues, influence the quality of life, and even cause disability and death. A 'disease in a dish' can be developed based on patients-derived induced pluripotent stem cells (iPSCs) and iPSCs-derived disease-relevant cell types to provide a platform for pathogenesis research, phenotypical assays, cell therapy, and drug discovery. With rapid progress in molecular biology research methods including genome-sequencing technology, epigenetic analysis, '-omics' analysis and organoid technology, large amount of data represents an opportunity to help in gaining an in-depth understanding of pathological mechanisms and developing novel therapeutic strategies for these diseases. This paper aimed to review the iPSCs-based research on phenotype confirmation, mechanism exploration, drug discovery, and cell therapy for autoimmune diseases, especially multiple sclerosis, inflammatory bowel disease, and type 1 diabetes using iPSCs and iPSCs-derived cells.
    Mesh-Begriff(e) Humans ; Induced Pluripotent Stem Cells ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Animals ; Drug Discovery ; Cell- and Tissue-Based Therapy/methods
    Sprache Englisch
    Erscheinungsdatum 2024-04-24
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1349138
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Identification of potential extracellular vesicle protein markers altered in osteosarcoma from public databases.

    Zhang, Jinhe / Li, Huiyan

    Proteomics. Clinical applications

    2023  Band 17, Heft 4, Seite(n) e2200084

    Abstract: Purpose: Extracellular vesicles (EVs) have become promising biomarkers for cancer management. Particularly, the molecular cargo such as proteins carried by EVs are similar to their cells of origin, providing important information that can be used for ... ...

    Abstract Purpose: Extracellular vesicles (EVs) have become promising biomarkers for cancer management. Particularly, the molecular cargo such as proteins carried by EVs are similar to their cells of origin, providing important information that can be used for cancer diagnostics, prognosis, and treatment monitoring. However, to date, molecular analysis on EVs is still challenging, limited by the availability of efficient analytical technologies, largely due to the small size of EVs. In this work, we developed a computational workflow for in silico identification of potential EV protein markers from genomic and proteomic databases, and applied it for the discovery of osteosarcoma (OS) EV protein markers.
    Experimental design: Both mRNA and protein data were computed and compared from publicly accessible databases, and top markers with high differential expression levels were selected.
    Results: Thirty nine markers were identified overexpressed and seven found to be downregulated. These identified markers have been found to be associated with OS on different aspects in literature, demonstrating the usability of this workflow.
    Conclusions and clinical relevance: This work provides a list of potential EV protein markers that are either overexpressed or downregulated in OS for further experimental validation for improved clinical management of OS.
    Mesh-Begriff(e) Humans ; Proteomics ; Osteosarcoma/genetics ; Osteosarcoma/metabolism ; Biomarkers/metabolism ; Extracellular Vesicles/genetics ; Extracellular Vesicles/metabolism ; Bone Neoplasms/genetics ; Bone Neoplasms/metabolism
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2023-01-03
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2261788-7
    ISSN 1862-8354 ; 1862-8346
    ISSN (online) 1862-8354
    ISSN 1862-8346
    DOI 10.1002/prca.202200084
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  3. Artikel: Relationship between Nitrogen Dynamics and Key Microbial Nitrogen-Cycling Genes in an Intensive Freshwater Aquaculture Pond.

    Yan, Yifeng / Zhou, Junbo / Du, Chenghao / Yang, Qian / Huang, Jinhe / Wang, Zhaolei / Xu, Jun / Zhang, Min

    Microorganisms

    2024  Band 12, Heft 2

    Abstract: Intensive aquaculture in high-density hybrid snakehead [ ...

    Abstract Intensive aquaculture in high-density hybrid snakehead [
    Sprache Englisch
    Erscheinungsdatum 2024-01-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms12020266
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  4. Artikel ; Online: The Spatiotemporal Patterns and Driving Factors of Culture and Tourism Listed Companies in China

    Wenjie Hu / Jinhe Zhang / Leying Zhou / Yi Sun

    Sustainability, Vol 15, Iss 7686, p

    2023  Band 7686

    Abstract: The integration of culture and tourism is the key measure for China in transforming and upgrading the tourism industry. It could promote the sustainable development by reducing the consumption of tourism resources. During the implementation of this ... ...

    Abstract The integration of culture and tourism is the key measure for China in transforming and upgrading the tourism industry. It could promote the sustainable development by reducing the consumption of tourism resources. During the implementation of this policy, culture and tourism listed companies play a leading role, as they are the major force in the cultural and tourism industry, and their spatiotemporal characteristics shows the level of development of the cultural and tourism industry and the economy in different regions. Taking the culture and tourism companies as the research objects, this paper analyzed the spatiotemporal patterns and evolution mechanism of culture and tourism listed companies over a long time scale. The results showed that: (1) the number of newly added listed companies in the cultural, tourism, and cultural and tourism categories basically showed the same change trend, and the developing process could be divided into three periods, namely embryonic (1978–1992), exploration (1992–2006) and growth (2007–2021). (2) The spatial distribution of Chinese culture and tourism listed companies developed from “single core” to “one core and multiple stars”, and gradually stabilized into a spatial pattern of “three cores”. The center of gravity was located in the southeast of China, moving from south to north in the shape of a “Z”. (3) Traffic service, government financial strength, financial environment and tourism resource endowment are the main factors affecting the spatial distribution of Chinese culture and tourism listed companies. Compared with the impact of a single influencing factor, the interactions between various factors are much stronger, especially the combinations of tourism resource endowment and another three factors, namely traffic service, communication development and economic development.
    Schlagwörter culture and tourism listed company ; tourism ; integration of culture and tourism ; spatial distribution ; factor analysis ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 910
    Sprache Englisch
    Erscheinungsdatum 2023-05-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: Rare perivascular epithelial cell tumor of the colon 18F-FDG PET/CT imaging: A case report.

    Chen, Qianqian / Wang, Peiqi / Zhang, Xiao / Zhang, Jinhe

    Medicine

    2023  Band 102, Heft 20, Seite(n) e33802

    Abstract: Rationale: Neoplasms with perivascular epithelioid cell differentiation (PEComas) are mesenchymal tumors that rarely occur in the colon. Here, we report the occurrence of a malignant PEcoma in the colon using 18F-fluorodeoxyglucose positron emission ... ...

    Abstract Rationale: Neoplasms with perivascular epithelioid cell differentiation (PEComas) are mesenchymal tumors that rarely occur in the colon. Here, we report the occurrence of a malignant PEcoma in the colon using 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT).
    Patient concerns: A 55-year-old woman was admitted to the hospital with abdominal pain for 10 days and a self-induced abdominal mass for 3 days. 18F-FDG PET/CT imaging showed a large hypermetabolic nodule and mass in the right mid-upper abdomen with heterogeneous density and a further increase in metabolism on the delayed scan.
    Diagnoses: PEComa of the colon.
    Interventions: Tumor resection was performed.
    Outcomes: The patient is well after 2 months of treatment, pending further follow-up.
    Lessons: Malignant perivascular epithelioid cell tumors originating in the colon are extremely rare, and our report suggests that PEComa should be considered as a differential diagnosis for 18F-FDG gastrointestinal malignancies. Additionally, 18F-FDG PET/CT may play a key role in the staging and extent of lesions in intestinal malignancies.
    Mesh-Begriff(e) Female ; Humans ; Middle Aged ; Fluorodeoxyglucose F18 ; Positron Emission Tomography Computed Tomography/methods ; Perivascular Epithelioid Cell Neoplasms/diagnostic imaging ; Perivascular Epithelioid Cell Neoplasms/surgery ; Perivascular Epithelioid Cell Neoplasms/pathology ; Colonic Neoplasms/diagnostic imaging ; Colonic Neoplasms/surgery ; Epithelial Cells/pathology ; Radiopharmaceuticals ; Positron-Emission Tomography
    Chemische Substanzen Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
    Sprache Englisch
    Erscheinungsdatum 2023-06-19
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000033802
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel: Unexpected/contrary behavior of aerosol mass concentration in response to the individual components' concentration reduction in Kitakyushu, Japan.

    Zhang, Xi / Murakami, Takuya / Wang, Jinhe / Aikawa, Masahide

    Journal of environmental sciences (China)

    2022  Band 135, Seite(n) 630–639

    Abstract: In the suburbs of Kitakyushu, Japan, the inorganic aerosol mass concentration (IAM) was about 32.7 µg/ ... ...

    Abstract In the suburbs of Kitakyushu, Japan, the inorganic aerosol mass concentration (IAM) was about 32.7 µg/m
    Mesh-Begriff(e) Air Pollutants/analysis ; Particulate Matter/analysis ; Japan ; Environmental Monitoring ; Water/chemistry ; Aerosols/analysis
    Chemische Substanzen Air Pollutants ; Particulate Matter ; Water (059QF0KO0R) ; Aerosols
    Sprache Englisch
    Erscheinungsdatum 2022-09-28
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1092300-7
    ISSN 1878-7320 ; 1001-0742
    ISSN (online) 1878-7320
    ISSN 1001-0742
    DOI 10.1016/j.jes.2022.09.024
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  7. Artikel ; Online: Estimating the nonlinear response of landscape patterns to ecological resilience using a random forest algorithm

    Xiaobin Ma / Jinhe Zhang / Peijia Wang / Leying Zhou / Yi Sun

    Ecological Indicators, Vol 153, Iss , Pp 110409- (2023)

    Evidence from the Yangtze River Delta

    2023  

    Abstract: Ecological resilience (ER) is considered a key factor in resolving complex human and natural systems conflicts and managing risk during the period of rapid development. However, the importance of landscape patterns for ER is not given enough attention in ...

    Abstract Ecological resilience (ER) is considered a key factor in resolving complex human and natural systems conflicts and managing risk during the period of rapid development. However, the importance of landscape patterns for ER is not given enough attention in previous studies. Therefore, we selected the Yangtze River Delta region as the study area, incorporated landscape patterns into the assessment of ER and proposed the way for identifying ecological sources based on the combination of ecosystem services and landscape patterns. Combining the multidimensional ecological resilience assessment indicators system, we calculated the ER for the Yangtze River Delta region and explored the importance and nonlinear effects of landscape patterns on the ER using a random forest regression model. The results showed that the comparative analysis of ecosystem services and landscape patterns enhanced the scientificity of ecological source identification. We identified 94 ecological sources mainly in the southern of the Yangtze River Delta region, including important mountain ranges and water bodies. In addition, the ER was significantly strengthened by considering the landscape patterns. The random forest regression results indicated the nonlinear relationship between the landscape patterns and the other elements in terms of ER. This study can contribute to a comprehensive and integrated approach to the identification of ecological sources and the evaluation of ER, which can promote the conservation of regional ecological functions.
    Schlagwörter Landscape patterns ; MSPA ; Random forest regression algorithm ; Ecological resilience ; Ecosystem services ; Yangtze River Delta region ; Ecology ; QH540-549.5
    Thema/Rubrik (Code) 910 ; 710
    Sprache Englisch
    Erscheinungsdatum 2023-09-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Study on the kinetics of formation process of emulsion of heavy oil and its functional group components.

    Liu, Jinhe / Sun, Chengdi / Lun, Zengmin / Li, Yao / Tang, Xinyu / Zhang, Qingxuan / Yang, Pujiang

    Scientific reports

    2024  Band 14, Heft 1, Seite(n) 8916

    Abstract: Enhanced oil recovery (EOR) by in situ formation of oil-in-water emulsion in heavy oil cold production technology has received growing interest from the petroleum industry. We present an experimental study of emulsification of model oils prepared by ... ...

    Abstract Enhanced oil recovery (EOR) by in situ formation of oil-in-water emulsion in heavy oil cold production technology has received growing interest from the petroleum industry. We present an experimental study of emulsification of model oils prepared by heavy oil and its functional group compositions dissolved into toluene brought into contact with a surfactant solution. The effects of functional group composition, emulsifier concentration, temperature, pH and stirring speed on the emulsification rate of heavy oil was investigated. A second-order kinetic model characterizing the temporal variation of conductivity during the emulsification has been established. The results show that acidic and amphoteric fractions exhibit higher interfacial activity, larger emulsification rate constant and faster emulsification rate. With the increase of emulsifier concentration, the emulsification rate constant increase to the maximum value at a concentration of 0.05 mol/L before decreasing. Temperature increase benefits the emulsification rate and the activation energy of the emulsification process is 40.28 kJ/mol. Higher pH and stirring speed indicate faster emulsification rate. The heterogeneity of emulsions limits the accuracy of dynamic characterization of the emulsification process and the determination method of emulsification rate has always been controversial. The conductivity method we proposed can effectively evaluates the emulsification kinetics. This paper provides theoretical guidance for an in-depth understanding of the mechanism and application of cold recovery technology for heavy oil.
    Sprache Englisch
    Erscheinungsdatum 2024-04-18
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59637-9
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  9. Artikel ; Online: Comparative uptake, translocation and metabolism of phenamacril in crops under hydroponic and soil cultivation conditions.

    Chang, Jinhe / Gao, Kang / Li, Runan / Dong, Fengshou / Zheng, Yongquan / Zhang, Qingming / Li, Yuanbo

    The Science of the total environment

    2024  Band 925, Seite(n) 171670

    Abstract: Many studies investigate the plant uptake and metabolism of xenobiotics by hydroponic experiments, however, plants grown in different conditions (hydroponic vs. soil) may result in different behaviors. To explore the potential differences, a comparative ... ...

    Abstract Many studies investigate the plant uptake and metabolism of xenobiotics by hydroponic experiments, however, plants grown in different conditions (hydroponic vs. soil) may result in different behaviors. To explore the potential differences, a comparative study on the uptake, translocation and metabolism of the fungicide phenamacril in crops (wheat/rice) under hydroponic and soil cultivation conditions was conducted. During 7-14 days of exposure, the translocation factors (TFs) of phenamacril were greatly overestimated in hydroponic-wheat (3.6-5.2) than those in soil-wheat systems (1.1-2.0), with up to 3.3 times of difference between the two cultivation systems, implying it should be cautious to extrapolate the results obtained from hydroponic to field conditions. M-144 was formed in soil pore water (19.1-29.9 μg/L) in soil-wheat systems but not in the hydroponic solution in hydroponics; M-232 was only formed in wheat shoots (89.7-103.0 μg/kg) under soil cultivation conditions, however, it was detected in hydroponic solution (20.1-21.2 μg/L), wheat roots (146.8-166.0 μg/kg), and shoots (239.2-348.1 μg/kg) under hydroponic conditions. The root concentration factors (RCFs) and TFs of phenamacril in rice were up to 2.4 and 3.6 times higher than that in wheat for 28 days of the hydroponic exposure, respectively. These results highlighted that cultivation conditions and plant species could influence the fate of pesticides in crops, which should be considered to better assess the potential accumulation and transformation of pesticides in crops.
    Mesh-Begriff(e) Hydroponics ; Soil ; Crops, Agricultural/metabolism ; Pesticides/metabolism ; Triticum/metabolism ; Oryza/metabolism ; Plant Roots/metabolism ; Soil Pollutants/analysis ; Cyanoacrylates
    Chemische Substanzen phenamacril ; Soil ; Pesticides ; Soil Pollutants ; Cyanoacrylates
    Sprache Englisch
    Erscheinungsdatum 2024-03-12
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171670
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  10. Artikel ; Online: Effect of static magnetic field on gene expression of human umbilical cord mesenchymal stem cells by transcriptome analysis.

    Fang, Fang / Liu, Chunyan / Huang, Qi / Dong, Chao / Zhang, Guirong / Jiang, Jinhe / Lu, Shi

    Advances in medical sciences

    2024  

    Abstract: Purpose: Static magnetic fields (SMFs) induce various biological reactions and have been applied in the biological therapy of diseases, especially in combination with mesenchymal stem cells (MSCs) and tissue engineering. However, the underlying ... ...

    Abstract Purpose: Static magnetic fields (SMFs) induce various biological reactions and have been applied in the biological therapy of diseases, especially in combination with mesenchymal stem cells (MSCs) and tissue engineering. However, the underlying influence of SMFs on MSCs gene expression remains largely unclear. In this study, we aim to investigate the effects of SMFs on gene expression of human MSCs.
    Materials and methods: We exposed human MSCs to two different intensities (0.35 Tesla and 1.0 Tesla) of SMFs and observed the effects of SMFs on cell morphology. Subsequently, RNA-sequencing was performed to explore the gene expression changes.
    Results: Compared with control group cells, no significant differences in cell morphology were observed under a phase contrast inverted microscope, but the transcriptome of SMF-exposed MSCs were significantly changed in both 0.35 Tesla and 1.0 Tesla groups and the differential expressed genes are involved in multiple pathways, such as ubiquitin mediated proteolysis, TNF signaling pathway, NF-kappa B signaling pathway, TGF-beta signaling pathway, metabolic pathways, and apoptosis, which regulate the biological functions of MSCs.
    Conclusions: SMFs stimulation could affect the gene expression of human MSCs and the biological effects vary by the different intensities of SMFs. These data offer the molecular foundation for future application of SMFs in stem cell technology as well as tissue engineering medicine.
    Sprache Englisch
    Erscheinungsdatum 2024-06-04
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2273668-2
    ISSN 1898-4002 ; 1896-1126
    ISSN (online) 1898-4002
    ISSN 1896-1126
    DOI 10.1016/j.advms.2024.06.001
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