Artikel ; Online: Design, synthesis, and activity evaluation of novel multitargeted l-tryptophan derivatives with powerful antioxidant activity against Alzheimer's disease.
2024 Band 357, Heft 5, Seite(n) e2300603
Abstract: Alzheimer's disease (AD) is a multifactorial neurological disease, and the multitarget directed ligand (MTDL) strategy may be an effective approach to delay its progression. Based on this strategy, 27 derivatives of l-tryptophan, 3a-1-3d-1, were designed, ...
Abstract | Alzheimer's disease (AD) is a multifactorial neurological disease, and the multitarget directed ligand (MTDL) strategy may be an effective approach to delay its progression. Based on this strategy, 27 derivatives of l-tryptophan, 3a-1-3d-1, were designed, synthesized, and evaluated for their biological activity. Among them, IC |
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Mesh-Begriff(e) | Alzheimer Disease/drug therapy ; Humans ; Antioxidants/pharmacology ; Antioxidants/chemical synthesis ; Antioxidants/chemistry ; Drug Design ; Cholinesterase Inhibitors/pharmacology ; Cholinesterase Inhibitors/chemical synthesis ; Cholinesterase Inhibitors/chemistry ; Structure-Activity Relationship ; Blood-Brain Barrier/metabolism ; Butyrylcholinesterase/metabolism ; Animals ; Tryptophan/pharmacology ; Tryptophan/chemistry ; Tryptophan/analogs & derivatives ; Tryptophan/chemical synthesis ; Amyloid beta-Peptides/antagonists & inhibitors ; Amyloid beta-Peptides/metabolism ; Rats ; Acetylcholinesterase/metabolism ; Molecular Structure ; PC12 Cells ; Dose-Response Relationship, Drug ; Models, Molecular |
Chemische Substanzen | Antioxidants ; Cholinesterase Inhibitors ; Butyrylcholinesterase (EC 3.1.1.8) ; Tryptophan (8DUH1N11BX) ; Amyloid beta-Peptides ; Acetylcholinesterase (EC 3.1.1.7) |
Sprache | Englisch |
Erscheinungsdatum | 2024-01-30 |
Erscheinungsland | Germany |
Dokumenttyp | Journal Article |
ZDB-ID | 6381-2 |
ISSN | 1521-4184 ; 0365-6233 ; 1437-1014 |
ISSN (online) | 1521-4184 |
ISSN | 0365-6233 ; 1437-1014 |
DOI | 10.1002/ardp.202300603 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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