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  1. Artikel: Preventive and inhibitive effects of Yiwei Xiaoyu granules on the development and progression of spasmolytic polypeptide-expressing metaplasia lesions.

    Chen, Wan-Qun / Tian, Feng-Liang / Zhang, Jin-Wei / Yang, Xiao-Jun / Li, Yan-Ping

    World journal of gastrointestinal oncology

    2021  Band 13, Heft 11, Seite(n) 1741–1754

    Abstract: ... Xiaoyu granules (YWXY) in SPEM lesions.: Methods: Gastric mucosa biopsies were collected from chronic ...

    Abstract Background: Spasmolytic polypeptide-expressing metaplasia (SPEM) is a potential preneoplastic lesion.
    Aim: To elucidate the microRNA (miR)-7-mediated preventive and inhibitive effects of Yiwei Xiaoyu granules (YWXY) in SPEM lesions.
    Methods: Gastric mucosa biopsies were collected from chronic atrophic gastritis patients and healthy people with signed informed consent. YWXY was administered to the mice with induced SPEM by tamoxifen, and the gastric mucosa was harvested on the tenth day of the experiment. Then immunohistochemistry and immunofluorescence were performed to validate the SPEM, lesions and the potential mechanism was investigated. RNA transcripts were detected with reverse transcription-quantitative polymerase chain reaction.
    Results: The expression of miR-7 was downregulated in the SPEM lesions, and expression of trefoil factor 2 (TFF2) and clusterin was high in the human gastric mucosa.
    Conclusion: miR-7 downregulation is an early event in SPEM through regulation of TFF2 in human gastric mucosa. YWXY is able to inhibit the cell proliferation and restore the expression of miR-7 by mediating TFF2 in the SPEM mouse model.
    Sprache Englisch
    Erscheinungsdatum 2021-10-15
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 2573696-6
    ISSN 1948-5204
    ISSN 1948-5204
    DOI 10.4251/wjgo.v13.i11.1741
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Effects of Fu Fang Yi Mu Cao capsules combined with Yiqi Xiaoyu decoction on lochia.

    Zhang, Liqiao / Yang, Chunyan / Dong, Wei / Du, Yaqing / Wang, Ruiping

    American journal of translational research

    2021  Band 13, Heft 11, Seite(n) 12868–12874

    Abstract: ... Xiaoyu (YX) decoction on persistent lochia after birth.: Methods: In this retrospective analysis, 120 ...

    Abstract Objective: To investigate the effects of Fu Fang Yi Mu Cao (FFYMC) capsules combined with Yiqi Xiaoyu (YX) decoction on persistent lochia after birth.
    Methods: In this retrospective analysis, 120 patients with lochia treated in our hospital from January 2014 to October 2020 were enrolled as study subjects. Sixty of each were randomly allocated into the study group (60 cases, treated with FFYMC capsules and YX decoction) and the control group (60 cases, treated with YX decoction). The two groups were compared in terms of efficacy, volume of lochia and changes in Traditional Chinese Medicine Syndrome Score (TCMSS) before and after intervention, and the incidence of adverse reactions.
    Results: (1) The total effective rate in the study group was 100.00%, which was significantly higher than that in the control group (P<0.05); (2) The difference in volume of lochia between two groups before the intervention was not statistically significant (P>0.05), and was significantly lower in the study group than in the control group at day 4 and day 7 of the intervention (P<0.05); (3) The difference in TCMSS between two groups before the treatment was not statistically significant (P>0.05). TCMSS was lower in the study group than in the control group after treatment (P<0.05); (4) The decreased height of uterine fundus in the study group was higher than that in the control group at 5 d after treatment (P<0.05); (5) The plasma viscosity in the study group was significantly lower than that in the control group (P<0.05); (6) The total incidence of adverse reactions in the study group was 8.33%, which was not significantly different from the control group which was 11.67% (P>0.05).
    Conclusion: FFYMC capsule and YX decoction could improve the treatment effect for primiparas with lochia in terms of reducing volume of lochia and improving clinical symptoms with high safety.
    Sprache Englisch
    Erscheinungsdatum 2021-11-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
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  3. Artikel ; Online: Xiaoyu Jiangzhi capsule protects against heart failure via Ca2+/CaMKII signaling pathways in mice

    Jianwei Wu / Yafang Tan / Dongyuan Kang / Juan Yu / Jianyong Qi / Jiashin Wu / Minzhou Zhang

    Journal of Traditional Chinese Medical Sciences, Vol 9, Iss 3, Pp 289-

    2022  Band 297

    Abstract: ... of many cardiovascular diseases. The traditional Chinese medicine (TCM) Xiaoyu Jiangzhi capsule (XYC) has long been in use ...

    Abstract Objective: Heart failure (HF), a worldwide health condition, is the result of many cardiovascular diseases. The traditional Chinese medicine (TCM) Xiaoyu Jiangzhi capsule (XYC) has long been in use in China to treat hyperlipidemia and inhibit platelet aggregation. This study explores the effects of XYC on heart failure (HF) and its detailed mechanisms. Methods: Isoproterenol (ISO, 30 mg/kg) was injected intraperitoneally for 7 days to copy a HF model of 10–12 weeks old, 20–30 g male mice. We then compared the CON (control) group, ISO (HF model) group, MET (metoprolol) group, and XYC group. Cardiac systolic function and left wall thickness were evaluated by echocardiograph. Using western blot analysis, we detected the proteins of calmodulin dependent protein kinase II (CaMKII) and sarco/endoplasmic reticulum Ca2+-ATPase (Serca). Furthermore, tsA201 cells were cultured and the human CaV1.2 calcium channel current (hCaV1.2) were detected by patch clamp experiments. Results: XYC reduced HF, inhibiting the protein expression of CaMKII, but Serca did not change significantly. Moreover, XYC inhibited the peak amplitude of the hCaV1.2 current, depolarizing shifted the activation curve 27.6 mV, and shifted the inactivation curve toward a positive potential 17.6 mV. The fraction recovered from inaction was reduced in XYC group compared with that in CON group. Conclusion: XYC could inhibit ISO-induced HF by reducing the Ca2+/CaMKII signaling pathway in mice.
    Schlagwörter Heart failure ; CaV1.2 channel ; Patch clamp ; CaMKII ; Serca ; Traditional Chinese medicine ; Miscellaneous systems and treatments ; RZ409.7-999
    Thema/Rubrik (Code) 572
    Sprache Englisch
    Erscheinungsdatum 2022-07-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  4. Artikel: The Xiaoyu Jiangzhi Capsule protects against heart failure via Ca2+/CaMKII signaling pathways in mice

    Wu, Jianwei / Tan, Yafang / Kang, Dongyuan / Yu, Juan / Qi, Jianyong / Wu, Jiashin / Zhang, Minzhou

    Beijing University of Chinese Medicine Journal of traditional Chinese medical sciences. 2022 June 05,

    2022  

    Abstract: ... The Chinese medicine Xiaoyu Jiangzhi Capsule (XYC) has long been in use in China to treat hyperlipidemia and ...

    Abstract Heart failure (HF), a worldwide health condition, is the result of many cardiovascular diseases. The Chinese medicine Xiaoyu Jiangzhi Capsule (XYC) has long been in use in China to treat hyperlipidemia and inhibit platelet aggregation. This study explores the effects of XYC on HF and its detailed mechanisms. Isoproterenol (ISO, 30 mg/kg) was injected intraperitoneally for 7 days to copy a HF model of 10–12 weeks old, 20–30 g male mice. We then compared the CON (control) group, ISO (HF model) group, MET (metoprolol) group, and XYC group. Cardiac systolic function and left wall thickness were evaluated by echocardiograph. Using Western blot analysis, we detected the proteins of calmodulin dependent protein kinase II (CaMKII) and sarco/endoplasmic reticulum Ca²⁺-ATPase (Serca). Furthermore, tsA201 cells were cultured and the human CaV1.2 calcium channel current (hCaV1.2) were detected by patch clamp experiments. XYC reduced HF, inhibiting the protein expression of CaMKII, but Serca did not change significantly. Moreover, XYC inhibited the peak amplitude of the hCaV1.2 current, depolarizing shifted the activation curve 27.6 mV, and shifted the inactivation curve toward a positive potential 17.6 mV. The fraction recovered from inaction was reduced in XYC group compared with that in CON group. XYC could inhibit ISO-induced HF by reducing the Ca²⁺/CaMKII signaling pathway in mice.
    Schlagwörter Oriental traditional medicine ; Western blotting ; calcium channels ; calcium-calmodulin-dependent protein kinase ; calmodulin ; endoplasmic reticulum ; heart failure ; humans ; hyperlipidemia ; isoproterenols ; males ; models ; platelet aggregation ; protein synthesis ; China
    Sprache Englisch
    Erscheinungsverlauf 2022-0605
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ZDB-ID 2834228-8
    ISSN 2095-7548 ; 2589-0395
    ISSN 2095-7548 ; 2589-0395
    DOI 10.1016/j.jtcms.2022.06.002
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Buch ; Online: Crosswind stability of vehicles under nonstationary wind excitation

    Zhang, Xiaoyu

    2015  

    Abstract: This work has studied the crosswind stability of vehicles under nonstationary wind excitation in various scenarios. Railway vehicles running on curved and straight track with varying vehicle speed are studied. Road vehicles are classified into different ... ...

    Abstract This work has studied the crosswind stability of vehicles under nonstationary wind excitation in various scenarios. Railway vehicles running on curved and straight track with varying vehicle speed are studied. Road vehicles are classified into different categories. For each vehicle class, a corresponding worst-case vehicle model has been built. As the wind excitation on the vehicle is a stochastic process, a risk analysis has to be carried out and failure probabilities are computed and analyzed
    Schlagwörter Technology (General)
    Umfang 1 electronic resource (XXI, 178 p. p.)
    Verlag KIT Scientific Publishing
    Erscheinungsort Verlagsort nicht ermittelbar
    Dokumenttyp Buch ; Online
    Anmerkung ENGLISH ; Open Access
    HBZ-ID HT020196675
    ISBN 9783731503767 ; 373150376X
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  6. Artikel: Highly Effective Batch Effect Correction Method for RNA-seq Count Data.

    Zhang, Xiaoyu

    bioRxiv : the preprint server for biology

    2024  

    Abstract: RNA sequencing (RNA-seq) has become a cornerstone in transcriptomics, offering detailed insights into gene expression across diverse biological conditions and sample types. However, RNA-seq data often suffer from batch effects, which are systematic non- ... ...

    Abstract RNA sequencing (RNA-seq) has become a cornerstone in transcriptomics, offering detailed insights into gene expression across diverse biological conditions and sample types. However, RNA-seq data often suffer from batch effects, which are systematic non-biological differences that compromise data reliability and obscure true biological variation. To address these challenges, we introduce ComBat-ref, a refined method of batch effect correction that enhances the statistical power and reliability of differential expression analysis in RNA-seq data. Building on the foundations of ComBat-seq, ComBat-ref employs a negative binomial model to adjust count data but innovates by using a pooled dispersion parameter for entire batches and preserving count data for the reference batch. Our method demonstrated superior performance in both simulated environments and real datasets, such as the growth factor receptor network (GFRN) data and NASA GeneLab transcriptomic datasets, significantly improving sensitivity and specificity over existing methods. By effectively mitigating batch effects while maintaining high detection power, ComBat-ref proves to be a robust tool for enhancing the accuracy and interpretability of RNA-seq data analyses.
    Sprache Englisch
    Erscheinungsdatum 2024-05-05
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.05.02.592266
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Giant lower thoracic oesophageal lipoma.

    Fuzhi, Yang / Xunxia, Zhu / Xiaoyu, Chen / Xuelin, Zhang / Xiaoyong, Shen

    ANZ journal of surgery

    2024  

    Sprache Englisch
    Erscheinungsdatum 2024-04-25
    Erscheinungsland Australia
    Dokumenttyp Letter
    ZDB-ID 2050749-5
    ISSN 1445-2197 ; 1445-1433 ; 0004-8682
    ISSN (online) 1445-2197
    ISSN 1445-1433 ; 0004-8682
    DOI 10.1111/ans.19013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 180: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Artikel ; Online: The resilience of ecosystems to drought.

    Zhang, Zhenyu / Li, Xiaoyu

    Global change biology

    2023  Band 29, Heft 13, Seite(n) 3517–3518

    Mesh-Begriff(e) Ecosystem ; Droughts ; Forests ; Trees
    Sprache Englisch
    Erscheinungsdatum 2023-04-25
    Erscheinungsland England
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 1281439-8
    ISSN 1365-2486 ; 1354-1013
    ISSN (online) 1365-2486
    ISSN 1354-1013
    DOI 10.1111/gcb.16724
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Bonn

    Z 6338: Hefte anzeigen

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  9. Artikel ; Online: Temporal inverted internal limiting membrane flap technique for myopic macular hole retinal detachment reconstruction

    Yan Teng / Xiaoyu Zhang

    Journal of International Medical Research, Vol

    2024  Band 52

    Abstract: Objective To examine the effects of the temporal inverted internal limiting membrane (ILM) flap technique for foveal reconstruction in patients with highly myopic macular hole-associated retinal detachment (MHRD). Methods A retrospective case series ... ...

    Abstract Objective To examine the effects of the temporal inverted internal limiting membrane (ILM) flap technique for foveal reconstruction in patients with highly myopic macular hole-associated retinal detachment (MHRD). Methods A retrospective case series analysis of four patients (four eyes) with MHRD was conducted. The foveal optical coherence tomography changes following treatment using the temporal inverted ILM flap technique were evaluated. Results In Patient 1, the ILM bridged the macular hole and residual subretinal fluid on postoperative day 6, and complete retinal reattachment was achieved at 19 months. Patient 2 exhibited reduced retinal detachment, with visible ILM inversion and macular hole closure after 14 days. In Patient 3, macular hole closure and fovea formation had occurred by day 25, and the ILM flap was visible. At 2 months, the outer collagenous layer connection in the central fovea and recovery of the external limiting membrane and ellipsoid zone were observed. Patient 4 had a “white hole” MHRD, with macular hole closure achieved on postoperative day 20, albeit with a suboptimal foveal shape. Conclusion The temporal inverted ILM flap technique in conjunction with vitrectomy facilitates foveal reconstruction in patients with successful treatment of MHRD, and this reconstruction process can be observed by optical coherence tomography.
    Schlagwörter Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag SAGE Publishing
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  10. Artikel ; Online: Induction of Meiotic Initiation in Long-Term Mouse Spermatogonial Stem Cells Under Retinoid Acid and Nutrient Restriction Conditions.

    Zhang, Xiaoyu / Wang, Ning

    Methods in molecular biology (Clifton, N.J.)

    2024  Band 2770, Seite(n) 113–121

    Abstract: Spermatogonial stem cells (SSCs) produce haploid sperm via mitosis and meiosis in vivo. Although the technique to culture mouse SSCs has been well established, induction of meiosis in vitro has remained a challenge. Retinoic acid (RA) is required for ... ...

    Abstract Spermatogonial stem cells (SSCs) produce haploid sperm via mitosis and meiosis in vivo. Although the technique to culture mouse SSCs has been well established, induction of meiosis in vitro has remained a challenge. Retinoic acid (RA) is required for meiosis in vivo; however, RA alone is not sufficient to induce meiosis in vitro. Here, we describe a method in which nutrient restriction and RA synergistically induce meiotic initiation into meiotic prophase I in cultured mouse SSCs.
    Mesh-Begriff(e) Male ; Mice ; Animals ; Meiosis ; Retinoids ; Semen ; Tretinoin/pharmacology ; Stem Cells ; Nutrients ; Spermatogonia ; Spermatogenesis ; Cell Differentiation
    Chemische Substanzen Retinoids ; Tretinoin (5688UTC01R)
    Sprache Englisch
    Erscheinungsdatum 2024-02-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3698-5_9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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