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  1. Article ; Online: Propolis-Based Nanostructured Lipid Carriers for α-Mangostin Delivery: Formulation, Characterization, and In Vitro Antioxidant Activity Evaluation.

    Suhandi, Cecep / Wilar, Gofarana / Lesmana, Ronny / Zulhendri, Felix / Suharyani, Ine / Hasan, Nurhasni / Wathoni, Nasrul

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 16

    Abstract: α-Mangostin (a xanthone derivative found in the pericarp ... ...

    Abstract α-Mangostin (a xanthone derivative found in the pericarp of
    MeSH term(s) Antioxidants/pharmacology ; Propolis ; Ascomycota ; Excipients ; Water ; Lipids
    Chemical Substances Antioxidants ; mangostin (U6RIV93RU1) ; Propolis (9009-62-5) ; Excipients ; Water (059QF0KO0R) ; Lipids
    Language English
    Publishing date 2023-08-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28166057
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  2. Article: Unusual presentation of oral hemangioma in tongue and the potential use of propolis as an adjunctive treatment.

    Susan, Susan / Ravalia, Munir / Zulhendri, Felix

    Clinical case reports

    2021  Volume 9, Issue 12, Page(s) e05243

    Abstract: Tongue hemangioma is a rare case of vascular tumors that causes symptoms such as pain, bleeding, difficulty in chewing, speaking, and breathing. We report a case of an oral lobular capillary hemangioma on the dorsal surface of the tongue treated with ... ...

    Abstract Tongue hemangioma is a rare case of vascular tumors that causes symptoms such as pain, bleeding, difficulty in chewing, speaking, and breathing. We report a case of an oral lobular capillary hemangioma on the dorsal surface of the tongue treated with surgical excision and postoperative application of propolis extract.
    Language English
    Publishing date 2021-12-22
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.5243
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  3. Article ; Online: Understanding the Roles of Selenium on Thyroid Hormone-Induced Thermogenesis in Adipose Tissue.

    Ruswandi, Yasmin Anissa R / Lesmana, Ronny / Rosdianto, Aziiz Mardanarian / Gunadi, Julia Windi / Goenawan, Hanna / Zulhendri, Felix

    Biological trace element research

    2023  Volume 202, Issue 6, Page(s) 2419–2441

    Abstract: Brown adipose tissue (BAT) and white adipose tissue (WAT) are known to regulate lipid metabolism. A lower amount of BAT compared to WAT, along with adipose tissue dysfunction, can result in obesity. Studies have shown that selenium supplementation ... ...

    Abstract Brown adipose tissue (BAT) and white adipose tissue (WAT) are known to regulate lipid metabolism. A lower amount of BAT compared to WAT, along with adipose tissue dysfunction, can result in obesity. Studies have shown that selenium supplementation protects against adipocyte dysfunction, decreases WAT triglycerides, and increases BAT triiodothyronine (T
    MeSH term(s) Thermogenesis/drug effects ; Selenium/pharmacology ; Humans ; Thyroid Hormones/metabolism ; Animals ; Iodide Peroxidase/metabolism ; Adipose Tissue, Brown/metabolism ; Adipose Tissue, Brown/drug effects ; Adipose Tissue/metabolism ; Adipose Tissue/drug effects ; Adipose Tissue, White/metabolism ; Adipose Tissue, White/drug effects ; Iodothyronine Deiodinase Type II
    Chemical Substances Selenium (H6241UJ22B) ; Thyroid Hormones ; Iodide Peroxidase (EC 1.11.1.8) ; Iodothyronine Deiodinase Type II (EC 1.11.1.-)
    Language English
    Publishing date 2023-09-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 445336-0
    ISSN 1559-0720 ; 0163-4984
    ISSN (online) 1559-0720
    ISSN 0163-4984
    DOI 10.1007/s12011-023-03854-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2323: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Physiological Roles of Hippo Signaling Pathway and Autophagy in Dementia.

    Christoper, Andreas / Herman, Herry / Abdulah, Rizky / Zulhendri, Felix / Sanjaya, Ardo / Lesmana, Ronny

    Current aging science

    2023  Volume 16, Issue 2, Page(s) 112–124

    Abstract: Background: Dementia is a neurocognitive disorder associated with the aging brain and mainly affects the hippocampus and cerebral cortex. The Hippo signaling pathway and autophagy proteins have been found to be perturbed in the brain affected by ... ...

    Abstract Background: Dementia is a neurocognitive disorder associated with the aging brain and mainly affects the hippocampus and cerebral cortex. The Hippo signaling pathway and autophagy proteins have been found to be perturbed in the brain affected by dementia processes.
    Objective: This systematic review aims to elaborate on the involvement of the Hippo signaling pathway and autophagy in modulating the progression and severity of dementia in aging.
    Methods: Searches were conducted on MEDLINE, Google Scholar, Scopus, and Web of Science databases.
    Results: The Hippo signaling pathway is dependent upon the transcriptional co-activator YAP/TAZ, which forms complexes with TEAD in the nucleus in order to maintain cell homeostasis. When the expression YAP/TAZ is reduced, transcriptional repression-induced atypical cell death, ballooning cell death, and necrosis will consequently occur in the neurons. Moreover, the autophagic proteins, such as LC3, ATG proteins, and Beclin, are reduced, resulting in the disruption of autophagosome formation and accumulation and the spread of misfolded proteins in the brain suffering from dementia.
    Conclusion: The impairment of the Hippo signaling pathway and autophagy in the dementia process in aging should be considered since it might predict the severity, treatment, and prevention of dementia.
    MeSH term(s) Humans ; Hippo Signaling Pathway ; Signal Transduction ; Protein Serine-Threonine Kinases/metabolism ; YAP-Signaling Proteins ; Phosphoproteins/metabolism ; Transcription Factors/metabolism ; Autophagy ; Dementia
    Chemical Substances Protein Serine-Threonine Kinases (EC 2.7.11.1) ; YAP-Signaling Proteins ; Phosphoproteins ; Transcription Factors
    Language English
    Publishing date 2023-02-06
    Publishing country United Arab Emirates
    Document type Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1874-6128
    ISSN (online) 1874-6128
    DOI 10.2174/1874609816666230206144212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: The use of propolis in dentistry, oral health, and medicine: A review.

    Zulhendri, Felix / Felitti, Rafael / Fearnley, James / Ravalia, Munir

    Journal of oral biosciences

    2021  Volume 63, Issue 1, Page(s) 23–34

    Abstract: Background: Propolis is a resinous product that is collected from plants by bees to cover holes and crevices in their hives. Propolis has potent antibacterial, antiviral, anti-inflammatory, wound healing, and anticancer properties. Propolis has been ... ...

    Abstract Background: Propolis is a resinous product that is collected from plants by bees to cover holes and crevices in their hives. Propolis has potent antibacterial, antiviral, anti-inflammatory, wound healing, and anticancer properties. Propolis has been used therapeutically by humans for centuries, including the treatment of dental caries and mouth infections.
    Highlight: This review article attempts to analyze the potential use of propolis in general dentistry and oral health management.
    Conclusion: Propolis is potentially useful in dentistry and oral health management based on available in vitro, in vivo, and ex vivo studies, as well as human clinical trials.
    MeSH term(s) Animals ; Anti-Infective Agents/therapeutic use ; Bees ; Dental Caries/drug therapy ; Dentistry ; Oral Health ; Propolis/therapeutic use
    Chemical Substances Anti-Infective Agents ; Propolis (9009-62-5)
    Language English
    Publishing date 2021-01-16
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2218267-6
    ISSN 1880-3865 ; 1349-0079
    ISSN (online) 1880-3865
    ISSN 1349-0079
    DOI 10.1016/j.job.2021.01.001
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  6. Article: Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence.

    Zulhendri, Felix / Perera, Conrad O / Tandean, Steven

    Biomedicines

    2021  Volume 9, Issue 9

    Abstract: Propolis has been used therapeutically for centuries. In recent years, research has demonstrated its efficacy as a potential raw material for pharmaceuticals and nutraceuticals. The aim of the present scoping review is to examine the latest experimental ... ...

    Abstract Propolis has been used therapeutically for centuries. In recent years, research has demonstrated its efficacy as a potential raw material for pharmaceuticals and nutraceuticals. The aim of the present scoping review is to examine the latest experimental evidence regarding the potential use of propolis in protecting the brain and treating neurological disorders and injuries. A systematic scoping review methodology was implemented. Identification of the research themes and knowledge gap was performed. After applying the exclusion criteria, a total of 66 research publications were identified and retrieved from Scopus, Web of Science, Pubmed, and Google Scholar. Several key themes where propolis is potentially useful were subsequently identified, namely detoxification, neuroinflammation, ischemia/ischemia-reperfusion injury/traumatic brain injury, Alzheimer's disease, Parkinson's disease, and epilepsy models, depression, cytotoxicity, cognitive improvement, regenerative medicine, brain infection, and adverse effects. In conclusion, propolis is shown to have protective and therapeutic benefits in alleviating symptoms of brain and neurological disorders and injuries, demonstrated by various in vitro studies, animal models, and human clinical trials. Further clinical research into this area is needed.
    Language English
    Publishing date 2021-09-15
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines9091227
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  7. Article ; Online: Unusual presentation of oral hemangioma in tongue and the potential use of propolis as an adjunctive treatment

    Susan Susan / Munir Ravalia / Felix Zulhendri

    Clinical Case Reports, Vol 9, Iss 12, Pp n/a-n/a (2021)

    2021  

    Abstract: Abstract Tongue hemangioma is a rare case of vascular tumors that causes symptoms such as pain, bleeding, difficulty in chewing, speaking, and breathing. We report a case of an oral lobular capillary hemangioma on the dorsal surface of the tongue treated ...

    Abstract Abstract Tongue hemangioma is a rare case of vascular tumors that causes symptoms such as pain, bleeding, difficulty in chewing, speaking, and breathing. We report a case of an oral lobular capillary hemangioma on the dorsal surface of the tongue treated with surgical excision and postoperative application of propolis extract.
    Keywords analgesic ; anti‐inflammatory ; benign tumor ; haemangiomas ; propolis ; vascular ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-12-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Can Propolis Be a Useful Adjuvant in Brain and Neurological Disorders and Injuries? A Systematic Scoping Review of the Latest Experimental Evidence

    Felix Zulhendri / Conrad O. Perera / Steven Tandean

    Biomedicines, Vol 9, Iss 1227, p

    2021  Volume 1227

    Abstract: Propolis has been used therapeutically for centuries. In recent years, research has demonstrated its efficacy as a potential raw material for pharmaceuticals and nutraceuticals. The aim of the present scoping review is to examine the latest experimental ... ...

    Abstract Propolis has been used therapeutically for centuries. In recent years, research has demonstrated its efficacy as a potential raw material for pharmaceuticals and nutraceuticals. The aim of the present scoping review is to examine the latest experimental evidence regarding the potential use of propolis in protecting the brain and treating neurological disorders and injuries. A systematic scoping review methodology was implemented. Identification of the research themes and knowledge gap was performed. After applying the exclusion criteria, a total of 66 research publications were identified and retrieved from Scopus, Web of Science, Pubmed, and Google Scholar. Several key themes where propolis is potentially useful were subsequently identified, namely detoxification, neuroinflammation, ischemia/ischemia-reperfusion injury/traumatic brain injury, Alzheimer’s disease, Parkinson’s disease, and epilepsy models, depression, cytotoxicity, cognitive improvement, regenerative medicine, brain infection, and adverse effects. In conclusion, propolis is shown to have protective and therapeutic benefits in alleviating symptoms of brain and neurological disorders and injuries, demonstrated by various in vitro studies, animal models, and human clinical trials. Further clinical research into this area is needed.
    Keywords adjuvant therapy ; brain ; neurology ; nutraceuticals ; pharmaceuticals ; propolis ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Propolis of stingless bees for the development of novel functional food and nutraceutical ingredients: A systematic scoping review of the experimental evidence

    Zulhendri, Felix / Perera, Conrad O. / Chandrasekaran, Kavita / Ghosh, Arabinda / Tandean, Steven / Abdulah, Rizky / Herman, Herry / Lesmana, Ronny

    Journal of functional foods. 2022 Jan., v. 88

    2022  

    Abstract: Propolis is a resinous and complex phytocompounds collected by the bees to serve various critical physical and physiological functions in a beehive. Propolis has been used by humans for centuries to alleviate many ailments including chronic, nutrition- ... ...

    Abstract Propolis is a resinous and complex phytocompounds collected by the bees to serve various critical physical and physiological functions in a beehive. Propolis has been used by humans for centuries to alleviate many ailments including chronic, nutrition-related, and metabolic syndrome-related diseases. The majority of propolis research has been carried out in the propolis harvested from the hives of Apis mellifera. However, a growing body of evidence shows that the propolis from the stingless bees (>600 species) possesses similar biological activities and therapeutic benefits such as antioxidant and anti-inflammatory properties and antimicrobial activity. The aim of this article is to review the experimental evidence of the biological activities of propolis from stingless bees, relevant to the development of high-value functional food and nutraceutical ingredients derived from meliponiculture in 4 continents; Asia, Australia, Africa, and the Americas.
    Keywords Apis mellifera ; antimicrobial properties ; antioxidants ; beehives ; dietary supplements ; functional foods ; meliponiculture ; propolis ; therapeutics ; Africa ; Asia ; Australia
    Language English
    Dates of publication 2022-01
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 2511964-3
    ISSN 1756-4646
    ISSN 1756-4646
    DOI 10.1016/j.jff.2021.104902
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 7830: Show issues

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  10. Article: Propolis in Metabolic Syndrome and Its Associated Chronic Diseases: A Narrative Review

    Zulhendri, Felix / Ravalia, Munir / Kripal, Krishna / Chandrasekaran, Kavita / Fearnley, James / Perera, Conrad O.

    Antioxidants. 2021 Feb. 26, v. 10, no. 3

    2021  

    Abstract: Propolis is a resinous product collected by bees from plants to protect and maintain the homeostasis of their hives. Propolis has been used therapeutically by humans for centuries. This review article attempts to analyze the potential use of propolis in ... ...

    Abstract Propolis is a resinous product collected by bees from plants to protect and maintain the homeostasis of their hives. Propolis has been used therapeutically by humans for centuries. This review article attempts to analyze the potential use of propolis in metabolic syndrome (MetS) and its associated chronic diseases. MetS and its chronic diseases were shown to be involved in at least seven out of the top 10 causes of death in 2019. Patients with MetS are also at a heightened risk of severe morbidity and mortality in the present COVID-19 pandemic. Propolis with its antioxidant and anti-inflammatory properties is potentially useful in ameliorating the symptoms of MetS and its associated chronic diseases. The aim of this article is to provide a comprehensive review on propolis and its therapeutic benefit in MetS and its chronic diseases, with an emphasis on in vitro and in vivo studies, as well as human clinical trials. Moreover, the molecular and biochemical mechanisms of action of propolis are also discussed. Propolis inhibits the development and manifestation of MetS and its chronic diseases by inhibiting of the expression and interaction of advanced glycation end products (AGEs) and their receptors (RAGEs), inhibiting pro-inflammatory signaling cascades, and promoting the cellular antioxidant systems.
    Keywords COVID-19 infection ; antioxidants ; death ; homeostasis ; humans ; metabolic syndrome ; morbidity ; mortality ; propolis ; risk ; therapeutics
    Language English
    Dates of publication 2021-0226
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox10030348
    Database NAL-Catalogue (AGRICOLA)

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