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  1. Artikel ; Online: The advancement of artificial intelligence in biomedical research and health innovation: challenges and opportunities in emerging economies.

    da Silva, Renan Gonçalves Leonel

    Globalization and health

    2024  Band 20, Heft 1, Seite(n) 44

    Abstract: The advancement of artificial intelligence (AI), algorithm optimization and high-throughput experiments has enabled scientists to accelerate the discovery of new chemicals and materials with unprecedented efficiency, resilience and precision. Over the ... ...

    Abstract The advancement of artificial intelligence (AI), algorithm optimization and high-throughput experiments has enabled scientists to accelerate the discovery of new chemicals and materials with unprecedented efficiency, resilience and precision. Over the recent years, the so-called autonomous experimentation (AE) systems are featured as key AI innovation to enhance and accelerate research and development (R&D). Also known as self-driving laboratories or materials acceleration platforms, AE systems are digital platforms capable of running a large number of experiments autonomously. Those systems are rapidly impacting biomedical research and clinical innovation, in areas such as drug discovery, nanomedicine, precision oncology, and others. As it is expected that AE will impact healthcare innovation from local to global levels, its implications for science and technology in emerging economies should be examined. By examining the increasing relevance of AE in contemporary R&D activities, this article aims to explore the advancement of artificial intelligence in biomedical research and health innovation, highlighting its implications, challenges and opportunities in emerging economies. AE presents an opportunity for stakeholders from emerging economies to co-produce the global knowledge landscape of AI in health. However, asymmetries in R&D capabilities should be acknowledged since emerging economies suffers from inadequacies and discontinuities in resources and funding. The establishment of decentralized AE infrastructures could support stakeholders to overcome local restrictions and opens venues for more culturally diverse, equitable, and trustworthy development of AI in health-related R&D through meaningful partnerships and engagement. Collaborations with innovators from emerging economies could facilitate anticipation of fiscal pressures in science and technology policies, obsolescence of knowledge infrastructures, ethical and regulatory policy lag, and other issues present in the Global South. Also, improving cultural and geographical representativeness of AE contributes to foster the diffusion and acceptance of AI in health-related R&D worldwide. Institutional preparedness is critical and could enable stakeholders to navigate opportunities of AI in biomedical research and health innovation in the coming years.
    Mesh-Begriff(e) Artificial Intelligence ; Biomedical Research ; Humans ; Developing Countries
    Sprache Englisch
    Erscheinungsdatum 2024-05-21
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2185774-X
    ISSN 1744-8603 ; 1744-8603
    ISSN (online) 1744-8603
    ISSN 1744-8603
    DOI 10.1186/s12992-024-01049-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: From lab to society

    Renan Gonçalves Leonel daSilva / Alessandro Blasimme

    Bioengineering & Translational Medicine, Vol 9, Iss 1, Pp n/a-n/a (2024)

    Fostering clinical translation of molecular systems engineering

    2024  

    Abstract: Abstract Over the last decade, bioengineering has seen a sustained growth in scientific publications, patents, and clinical trials. As the field attempts to bridge the gap between discovery and clinical application, a broader societal dialogue is needed ... ...

    Abstract Abstract Over the last decade, bioengineering has seen a sustained growth in scientific publications, patents, and clinical trials. As the field attempts to bridge the gap between discovery and clinical application, a broader societal dialogue is needed to build public trust and address potential ethical, societal, and regulatory challenges. In this essay, we discuss societal aspects linked to the clinical use of biomedical engineering approaches and technologies, with a specific focus on molecular systems engineering. Drawing on data from interviews with 24 scientists, we identified four key aspects for fostering societal support for translational efforts in this domain: (1) effective science communication and internal awareness; (2) open societal dialogue; (3) fair and equitable access to new technologies; and (4) adequate science and technology policies. We conclude that molecular systems engineering would benefit from anticipating future challenges with the view of building a robust bond of trust with lay publics, regulators, and society at large.
    Schlagwörter biomedical engineering ; engagement ; molecular systems engineering ; science policy ; society ; trust ; Chemical engineering ; TP155-156 ; Biotechnology ; TP248.13-248.65 ; Therapeutics. Pharmacology ; RM1-950
    Thema/Rubrik (Code) 170
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel: Organ chip research in Europe: players, initiatives, and policies.

    da Silva, Renan Gonçalves Leonel / Blasimme, Alessandro

    Frontiers in bioengineering and biotechnology

    2023  Band 11, Seite(n) 1237561

    Abstract: Background: ...

    Abstract Background:
    Sprache Englisch
    Erscheinungsdatum 2023-09-04
    Erscheinungsland Switzerland
    Dokumenttyp Systematic Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1237561
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: From lab to society: Fostering clinical translation of molecular systems engineering.

    da Silva, Renan Gonçalves Leonel / Blasimme, Alessandro

    Bioengineering & translational medicine

    2023  Band 9, Heft 1, Seite(n) e10564

    Abstract: Over the last decade, bioengineering has seen a sustained growth in scientific publications, patents, and clinical trials. As the field attempts to bridge the gap between discovery and clinical application, a broader societal dialogue is needed to build ... ...

    Abstract Over the last decade, bioengineering has seen a sustained growth in scientific publications, patents, and clinical trials. As the field attempts to bridge the gap between discovery and clinical application, a broader societal dialogue is needed to build public trust and address potential ethical, societal, and regulatory challenges. In this essay, we discuss societal aspects linked to the clinical use of biomedical engineering approaches and technologies, with a specific focus on molecular systems engineering. Drawing on data from interviews with 24 scientists, we identified four key aspects for fostering societal support for translational efforts in this domain: (1) effective science communication and internal awareness; (2) open societal dialogue; (3) fair and equitable access to new technologies; and (4) adequate science and technology policies. We conclude that molecular systems engineering would benefit from anticipating future challenges with the view of building a robust bond of trust with lay publics, regulators, and society at large.
    Sprache Englisch
    Erscheinungsdatum 2023-06-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2380-6761
    ISSN 2380-6761
    DOI 10.1002/btm2.10564
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Long Covid requires a global response centred on equity and dialogue.

    Au, Larry / Capotescu, Cristian / Curi, Amanda / Gonçalves Leonel da Silva, Renan / Eyal, Gil

    Global health action

    2023  Band 16, Heft 1, Seite(n) 2244757

    Abstract: Long Covid, or Post-Covid Conditions, is a global health problem. Yet we know strikingly little about the different experiences of Long Covid patients cross-nationally. To address this shortcoming, we conducted an online survey of Long Covid patients ... ...

    Abstract Long Covid, or Post-Covid Conditions, is a global health problem. Yet we know strikingly little about the different experiences of Long Covid patients cross-nationally. To address this shortcoming, we conducted an online survey of Long Covid patients active on social media in the U.S. (
    Mesh-Begriff(e) Humans ; COVID-19/epidemiology ; Post-Acute COVID-19 Syndrome ; Global Health ; Social Media ; Surveys and Questionnaires
    Sprache Englisch
    Erscheinungsdatum 2023-08-18
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2540569-X
    ISSN 1654-9880 ; 1654-9880
    ISSN (online) 1654-9880
    ISSN 1654-9880
    DOI 10.1080/16549716.2023.2244757
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: How Do Molecular Systems Engineering Scientists Frame the Ethics of Their Research?

    da Silva, Renan Gonçalves Leonel / Blasimme, Alessandro / Vayena, Effy / Ormond, Kelly E

    AJOB empirical bioethics

    2024  , Seite(n) 1–10

    Abstract: Background: There are intense discussions about the ethical and societal implications of biomedical engineering, but little data to suggest how scientists think about the ethics of their work. The aim of this study is to describe how scientists frame ... ...

    Abstract Background: There are intense discussions about the ethical and societal implications of biomedical engineering, but little data to suggest how scientists think about the ethics of their work. The aim of this study is to describe how scientists frame the ethics of their research, with a focus on the field of molecular systems engineering.
    Methods: Semi-structured qualitative interviews were conducted during 2021-2022, as part of a larger study. This analysis includes a broad question about how participants view ethics as related to their work, with follow up probes about the topics they consider most important. Interviews were transcribed, inductively coded by two researchers to consensus, and analyzed thematically.
    Results: Twenty-four scientists participated in the study. Interviewees hold positions as professors, principal investigators, and senior staff researchers in universities or research institutes in the United States and Europe. Among those scientists who reported reflecting on ethical considerations in their work, many equated ethics with research ethics topics (e.g., safety, replicability), or with regulation and guidelines. Participants expressed the view that ethical issues are primarily relevant for clinical trials of bioengineered products, or for those working with animal or human subjects. Scientists described their research as "too early" or "not examining anything living" with regard to ethical reflection. Finally, many felt that ethics is seen as territory for experts and therefore beyond scientists' competencies.
    Conclusions: Molecular systems engineering scientists currently focus on regulatory aspects as the framework for their ethical analyses. They describe using a framework to define when life arises, as a means to determine when further ethical engagement is warranted. Further research is needed to investigate how scientists relate to the ethics of their scientific work, and build consensus around concepts of life, autonomous behavior, and physiological relevance of bioengineered systems.
    Sprache Englisch
    Erscheinungsdatum 2024-01-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2763190-4
    ISSN 2329-4523 ; 2329-4515
    ISSN (online) 2329-4523
    ISSN 2329-4515
    DOI 10.1080/23294515.2024.2302994
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Long Covid requires a global response centred on equity and dialogue

    Larry Au / Cristian Capotescu / Amanda Curi / Renan Gonçalves Leonel da Silva / Gil Eyal

    Global Health Action, Vol 16, Iss

    2023  Band 1

    Abstract: Long Covid, or Post-Covid Conditions, is a global health problem. Yet we know strikingly little about the different experiences of Long Covid patients cross-nationally. To address this shortcoming, we conducted an online survey of Long Covid patients ... ...

    Abstract Long Covid, or Post-Covid Conditions, is a global health problem. Yet we know strikingly little about the different experiences of Long Covid patients cross-nationally. To address this shortcoming, we conducted an online survey of Long Covid patients active on social media in the U.S. (n = 334, October to December 2021) and Brazil (n = 144, January to April 2022). Our analysis of short answer responses indicates patient dissatisfaction with medical care provided for Long Covid in both the U.S. and Brazil. For Long Covid patients in Brazil, there were additional concerns raised about the lack of local expertise about their condition. Based on these results, we urge policymakers to expand the education of medical professionals in order to raise awareness of Long Covid. Experts in the Global North should also be encouraged to engage in dialogue with patient groups and experts in the Global South, in order to better understand how local contexts shape the experience of Long Covid.
    Schlagwörter long covid ; chronic illness ; global south ; patient experiences ; health communication ; Public aspects of medicine ; RA1-1270
    Sprache Englisch
    Erscheinungsdatum 2023-12-01T00:00:00Z
    Verlag Taylor & Francis Group
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Como a comunidade internacional da medicina de precisão tem se posicionado diante dos desafios impostos pela pandemia da COVID-19?

    Renan Gonçalves Leonel da Silva / Jorge Alberto Bernstein Iriart

    Cadernos de Saúde Pública, Vol 37, Iss

    2021  Band 4

    Abstract: Medicina de precisão pode ser definida como um movimento de transformação da biomedicina contemporânea que orienta a atividade de pesquisa acadêmica, modelos de negócios e o desenvolvimento de produtos e serviços de saúde desenhados individualmente para ... ...

    Abstract Medicina de precisão pode ser definida como um movimento de transformação da biomedicina contemporânea que orienta a atividade de pesquisa acadêmica, modelos de negócios e o desenvolvimento de produtos e serviços de saúde desenhados individualmente para o usuário, baseado em informações genéticas e outros marcadores biomédicos dos pacientes. Ao longo dos últimos anos, essa comunidade tem sido bastante atuante no cenário científico internacional. No entanto, durante a pandemia da COVID-19 ainda não ficou claro quais posicionamentos ou estratégias têm sido adotadas por esses grupos para o enfrentamento da crise sanitária. O objetivo deste artigo é compreender como a comunidade internacional da medicina de precisão está reagindo à pandemia da COVID-19, e em que estão baseadas as suas abordagens e potenciais soluções sugeridas para a mitigação dos efeitos negativos causados pelo aumento das infecções pelo novo coronavírus. Para tanto, foi feita pesquisa documental em 28 documentos provenientes de 18 fontes selecionadas, em que analisou-se as narrativas difundidas pelos profissionais da medicina de precisão em artigos científicos, editoriais, comentários, perspectivas, notícias de jornais e boletins e conferência virtual da Coalizão de Medicina Personalizada (PMC, em inglês). Com isso, buscou-se compreender como esses grupos imaginam uma nova configuração sociotécnica para o enfrentamento da pandemia e de seus efeitos.
    Schlagwörter Medicina de Precisão ; Ciência ; Tecnologia e Sociedade ; Agenda de Pesquisa em Saúde ; COVID-19 ; Medicine ; R ; Public aspects of medicine ; RA1-1270
    Sprache Englisch
    Erscheinungsdatum 2021-04-01T00:00:00Z
    Verlag Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Rethinking approaches of science, technology, and innovation in healthcare during the COVID-19 pandemic: the challenge of translating knowledge infrastructures to public needs.

    da Silva, Renan Gonçalves Leonel / Chammas, Roger / Novaes, Hillegonda Maria Dutilh

    Health research policy and systems

    2021  Band 19, Heft 1, Seite(n) 104

    Abstract: The coronavirus disease 2019 (COVID-19) outbreak made it clear that despite the potential of science, technology, and innovation (ST&I) to positively impact healthcare systems worldwide, as shown by the rapid development of SARS-CoV-2 test diagnostics ... ...

    Abstract The coronavirus disease 2019 (COVID-19) outbreak made it clear that despite the potential of science, technology, and innovation (ST&I) to positively impact healthcare systems worldwide, as shown by the rapid development of SARS-CoV-2 test diagnostics and new mRNA vaccines, healthcare stakeholders have faced significant challenges in responding to the crisis through well-integrated ST&I-oriented health initiatives and policies. Therefore, the pandemic has mobilized experts, industry, and governments to evaluate alternative trajectories to promote a more efficient dialogue between ST&I and public health. This article presents a critical thinking about the contemporary asymmetries in the technical and political infrastructures available for particular approaches in ST&I in health, such as precision medicine, and for public health systems worldwide, uncovering a persistent gap in the translation of knowledge and technologies to adequately coordinated responses to the pandemic. We stimulate the understanding of this process as a matter of translation between platforms of knowledge and policy rationales shaped by different institutionalized frames of organizational practices and agendas. We draw attention to the need to strengthen governance tools for the promotion of ST&I as a strategic component of the post-pandemic agenda in public health, to prepare societies to respond efficiently to future emergencies.
    Mesh-Begriff(e) COVID-19 ; Delivery of Health Care ; Humans ; Pandemics/prevention & control ; Public Health ; SARS-CoV-2 ; Technology
    Sprache Englisch
    Erscheinungsdatum 2021-07-21
    Erscheinungsland England
    Dokumenttyp Letter
    ZDB-ID 2101196-5
    ISSN 1478-4505 ; 1478-4505
    ISSN (online) 1478-4505
    ISSN 1478-4505
    DOI 10.1186/s12961-021-00760-8
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Rethinking approaches of science, technology, and innovation in healthcare during the COVID-19 pandemic

    Renan Gonçalves Leonel da Silva / Roger Chammas / Hillegonda Maria Dutilh Novaes

    Health Research Policy and Systems, Vol 19, Iss 1, Pp 1-

    the challenge of translating knowledge infrastructures to public needs

    2021  Band 9

    Abstract: Abstract The coronavirus disease 2019 (COVID-19) outbreak made it clear that despite the potential of science, technology, and innovation (ST&I) to positively impact healthcare systems worldwide, as shown by the rapid development of SARS-CoV-2 test ... ...

    Abstract Abstract The coronavirus disease 2019 (COVID-19) outbreak made it clear that despite the potential of science, technology, and innovation (ST&I) to positively impact healthcare systems worldwide, as shown by the rapid development of SARS-CoV-2 test diagnostics and new mRNA vaccines, healthcare stakeholders have faced significant challenges in responding to the crisis through well-integrated ST&I-oriented health initiatives and policies. Therefore, the pandemic has mobilized experts, industry, and governments to evaluate alternative trajectories to promote a more efficient dialogue between ST&I and public health. This article presents a critical thinking about the contemporary asymmetries in the technical and political infrastructures available for particular approaches in ST&I in health, such as precision medicine, and for public health systems worldwide, uncovering a persistent gap in the translation of knowledge and technologies to adequately coordinated responses to the pandemic. We stimulate the understanding of this process as a matter of translation between platforms of knowledge and policy rationales shaped by different institutionalized frames of organizational practices and agendas. We draw attention to the need to strengthen governance tools for the promotion of ST&I as a strategic component of the post-pandemic agenda in public health, to prepare societies to respond efficiently to future emergencies.
    Schlagwörter Science ; Technology ; Innovation ; Public health ; Health research ; Health policy ; Public aspects of medicine ; RA1-1270
    Thema/Rubrik (Code) 360
    Sprache Englisch
    Erscheinungsdatum 2021-07-01T00:00:00Z
    Verlag BMC
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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